The gene cluster for spectinomycin biosynthesis and the aminoglycoside-resistance function of spcM in Streptomyces spectabilis

Current Microbiology

Volumn 57, Issue 4, 2008, Pages 371-374

  Kim, Kyoung Rok ^a   Kim, Tae Jong ^a   Suh, Joo Won ^a  

^a Myong Ji University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; DNA METHYLTRANSFERASE; SPECTINOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BIOSYNTHESIS; CHEMICAL STRUCTURE; ENTEROBACTERIACEAE; ESCHERICHIA COLI; GENE CLUSTER; GENE EXPRESSION; GENE SEQUENCE; HYPOTHESIS; METHYLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOMYCETACEAE;

AMINO ACID SEQUENCE; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GENES, BACTERIAL; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SPECTINOMYCIN; STREPTOMYCES;

ENTEROBACTERIACEAE; ESCHERICHIA COLI; STREPTOMYCES SPECTABILIS;

EID: 50249136542     PISSN: 03438651     EISSN: 14320991     Source Type: Journal    
DOI: 10.1007/s00284-008-9204-y     Document Type: Article

References (18)

1. E Azucena S Mobashery 2001 Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition Drug Resist Update 4 106 117
2. E Cundliffe 1989 How antibiotic-producing organisms avoid suicide Annu Rev Microbiol 43 207 233
3. C-G Hyun SS Kim JK Sohng 2000 An efficient approach for cloning the dNDP-glucose synthase gene from actinomycetes and its application in Streptomyces spectabilis, a spectinomycin producer FEMS Microbiol Lett 183 183 189
4. S Jana J Deb 2006 Molecular understanding of aminoglycoside action and resistance Appl Microbiol Biotechnol 70 140 150
5. Y-Y Jo S-H Kim Y-Y Yang 2003 Functional analysis of spectinomycin biosynthetic genes from Streptomyces spectabilis ATCC 27741 J Microbiol Biotechnol 13 906 911
6. Kieser T, Bibb MJ, Buttner MJ, et al (2000) Practical Streptomyces genetics. The John Innes Foundation, Colney, Norwich, England
7. I Lind 1997 Antimicrobial resistance in Neisseria gonorrhoeae Clin Infect Dis 1 Suppl s93 s97
8. D Lyutzkanova J Distler J Altenbuchner 1997 A spectinomycin resistance determinant from the spectinomycin producer Streptomyces flavopersicus Microbiology 143 2135 2143
9. S Magnet JS Blanchard 2005 Molecular insights into aminoglycoside action and resistance Chem Rev 105 477 498
10. A Marchler-Bauer SH Bryant 2004 CD-Search: protein domain annotations on the fly Nucleic Acids Res 32 W327 W331
11. Mitscher LA, Martin LL, Feller DR, et al (1971) The biosynthesis of spectinomycin. J Chem Soc Chem Commun: 1541-1542
12. K Poole 2004 Efflux-mediated multiresistance in Gram-negative bacteria Clin Microbiol Infect 10 12 26
13. K Poole 2005 Aminoglycoside resistance in Pseudomonas aeruginosa Antimicrob Agents Chemother 49 479 487
14. TA Tatusova TL Madden 1999 BLAST 2 Sequences: a new tool for comparing protein and nucleotide sequences FEMS Microbiol Lett 174 247 250
15. J Vara M Lewandowska-Skarbek YG Wang 1989 Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus) J Bacteriol 171 5872 5881
16. JB Walker 2002 Enzymatic synthesis of aminoglycoside antibiotics: Novel adenosylmethionine:2-deoxystreptamine N-methyltransferase activities in hygromycin B- and spectinomycin-producing Streptomyces spp. and uses of the methylated products Appl Environ Microbiol 68 2404 2410
17. GD Wright 1999 Aminoglycoside-modifying enzymes Curr Opin Microbiol 2 499 503
18. X-Q Zhao K-R Kim L-W Sang 2005 Genetic organization of a 50-kb gene cluster isolated from Streptomyces kanamyceticus for kanamycin biosynthesis and characterization of kanamycin acetyltransferase J Microbiol Biotechnol 15 346 353