Isolation of a gene encoding a novel spectinomycin phosphotransferase from Legionella pneumophila

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 6, 1997, Pages 1385-1388

  Suter, Todd M ^a   Viswanathan, V K ^a   Cianciotto, Nicholas P ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOCYCLITOL; AMINOGLYCOSIDE ANTIBIOTIC AGENT; HYGROMYCIN; KANAMYCIN; PHOSPHOTRANSFERASE; SPECTINOMYCIN; STREPTOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; GENE ISOLATION; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; NONHUMAN; PRIORITY JOURNAL; RESTRICTION MAPPING; SEQUENCE HOMOLOGY;

EID: 0030983278     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.6.1385     Document Type: Article

References (30)

1. Altenbuchner, J., D. Lyutzanova, and J. Distler. Unpublished data.
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1987. Current protocols in molecular biology. Wiley, New York, N.Y.
3. Barker, J. E., and I. D. Farrell. 1990. The effects of single and combined antibiotics on the growth of Legionella pneumophila using time-kill studies. J. Antimicrob. Chemother. 26:45-53.
4. Blasquez, J., J. Davies, and F. Moreno. 1991. Mutations in the aphA-2 gene of transposon Tn5 mapping within the regions highly conserved in aminoglycoside phosphotransferases strongly reduce aminoglycoside resistance. Mol. Microbiol. 5:1511-1518.
5. Cianciotto, N., B. I. Eisenstein, N. C. Engleberg, and H. Shuman. 1989. Genetics and molecular pathogenesis of Legionella pneumophila, an intracellular parasite of macrophages. Mol. Biol. Med. 6:409-424.
6. Cianciotto, N. P., J. M. Bangsborg, B. I. Eisenstein, and N. C. Engleberg. 1990. Identification of mip-like genes in the genus Legionella. Infect. Immun. 58:2912-2918.
7. Dowling, J. N., D. A. McDevitt, and A. W. Pasculle. 1985. Isolation and preliminary characterization of erythromycin-resistant variants of Legionella micdadei and Legionella pneumophila. Antimicrob. Agents Chemother. 27: 272-274.
8. Edelstein, P. H. 1995. Antimicrobial chemotherapy for Legionnaires' disease: a review. Clin. Infect. Dis. 21(Suppl. 3):S265-S276.
9. Fields, B. S. 1996. The molecular ecology of legionellae. Trends Microbiol. 4:286-290.
10. Fu, K. P., and H. C. Neu. 1979. Inactivation of β-lactam antibiotics by Legionella pneumophila. Antimicrob. Agents Chemother. 16:561-564.
11. Fujii, T., K. Sato, K. Miyata, M. Inoue, and S. Mitsuhashi. 1986. Biochemical properties of β-lactamase produced by Legionella gormanii. Antimicrob. Agents Chemother. 29:925-926.
12. Haas, M. J., and J. E. Dowding. 1975. Aminoglycoside-modifying enzymes. Methods Enzymol. 43:611-628.
13. Hollingshead, S., and D. Vapnek. 1985. Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenyltransferase. Plasmid 13: 17-30.
14. Horwitz, M. A. 1992. Interactions between macrophages and Legionella pneumophila. Curr. Top. Microbiol. Immunol. 181:265-282.
15. Hoshiko, S., C. Nojiri, K. Matsunaga, K. Katsumata, E. Satoh, and K. Nagaoka. 1988. Nucleotide sequence of the ribostamycin phosphotransferase gene and its control region in Streptomyces ribosidificus. Gene 68:285-296.
16. Kaster, K. R., S. G. Burgett, R. N. Rao, and T. D. Ingolia. 1983. Analysis of bacterial hygromycin B resistance gene by transcriptional and translational fusions and by DNA sequencing. Nucleic Acids Res. 11:6895-6911.
17. Kocabiyik, S., and M. H. Perlin. 1992. Altered substrate specificity by substitutions at Tyr218 in bacterial aminoglycoside 3′-phosphotransferase-II. FEMS Microbiol. Lett. 93:199-202.
18. Leskiw, B. K., E. J. Lawlor, J. M. Fernandez-Abalos, and K. F. Chater. 1991. TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants. Proc. Natl. Acad. Sci. USA 88:2461-2465.
19. Martin, P., E. Jullien, and P. Courvalin. 1988. Nucleotide sequence of Acinetobacter baumannii aphA-6 gene: evolutionary and functional implications of sequence homologies with nucleotide-binding proteins, kinases and other aminoglycoside-modifying enzymes. Mol. Microbiol. 2:615-625.
20. Moffie, B. G., and R. P. Mouton. 1988. Sensitivity and resistance of Legionella pneumophila to some antibiotics and combinations of antibiotics. J. Antimicrob. Chemother. 22:457-462.
21. Murphy, E. 1985. Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3″) (9). Mol. Gen. Genet. 200:33-39.
22. Oka, A., H. Sugisak, and M. Takanami. 1981. Nucleotide sequence of the kanamycin resistance transposon Tn903. J. Mol., Biol. 147:217-226.
23. Pissowotzki, K., K. Mansouri, and W. Piepersberg. 1991. Genetics of streptomycin production in Streptomyces griseus: molecular structure and putative function of genes strELMB2N. Mol. Gen. Genet. 231:113-123.
24. Pope, C. D. 1996. Ph.D. thesis. Northwestern University, Evanston, Ill.
25. Salauze, D., and J. Davies. 1991. Isolation and characterization of an aminoglycoside phosphotransferase from neomycin-producing Micromonospora chalcea: comparison with that of Streptomyces fradiae and other producers of 4,6-disubstituted 2-deoxystreptamine antibiotics. J. Antibiot. 44:1432-1443.
26. Shaw, K. J., P. N. Rather, R. S. Hare, and G. H. Miller. 1993. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol. Rev. 57:138-163.
27. Thompson, C. J., and G. S. Gray. 1983. Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases encoded by resistance plasmids. Proc. Natl. Acad. Sci. USA 80:5190-5194.
28. Thompson, P. R., D. W. Hughes, and G. D. Wright. 1996. Mechanism of aminoglycoside 3′-phosphotransferase type IIIa: His188 is not a phosphate accepting residue. Chem. Biol. 3:747-755.
29. Thornsberry, C., and L, A. Kirven. 1978. β-Lactamase of the Legionnaires' bacterium. Curr. Microbiol. 1:51-54.
30. Winn, W. C., Jr. 1988. Legionnaires disease: historical perspective. Clin. Microbiol. Rev. 1:60-81.