Structural basis of APH(3′)-IIIa-mediated resistance to N1-Substituted Aminoglycoside Antibiotics

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 7, 2009, Pages 3049-3055

  Fong, Desiree H ^a   Berghuis, Albert M ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b Bellini Pavilion   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXYSTREPTAMINE; 3' AMINOGLYCOSIDE O PHOSPHOTRANSFERASE TYPE IIIA; 4 AMINO 2 HYDROXYBUTYRATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ADENYLYLIMIDODIPHOSPHATE; AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BUTIROSIN; BUTIROSIN A; FRAMYCETIN; HYDROXYBUTYRIC ACID; ISEPAMICIN; KANAMYCIN A; NETILMICIN; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERICIDAL ACTIVITY; CRYSTAL STRUCTURE; DRUG INACTIVATION; ENZYME BINDING; ENZYME INACTIVATION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMIKACIN; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIA; BUTIROSIN SULFATE; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, BACTERIAL; KANAMYCIN KINASE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

EID: 67649910468     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00062-09     Document Type: Article

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