Secretory phospholipase A2 type III enhances α-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity

Journal of Lipid Research

Volumn 51, Issue 5, 2010, Pages 957-966

  Yang, Xiaoguang ^a   Sheng, Wenwen ^b   He, Yan ^b   Cui, Jiankun ^a   Haidekker, Mark A ^c   Sun, Grace Y ^a,b   Lee, James C M ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

^c University of Georgia   (United States)

Author keywords

Alzheimer's disease; Amyloid peptide; Arachidonic acid

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ARACHIDONIC ACID; BETA SECRETASE 2; LYSOPHOSPHATIDYLCHOLINE; PALMITIC ACID; PHOSPHOLIPASE A2 GROUP III; SECRETORY PHOSPHOLIPASE A2; ASPARTIC PROTEINASE; BACE PROTEIN, RAT; SECRETASE;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEMBRANE FLUIDITY; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SECRETION; ANIMAL; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; HYDROLYSIS; METABOLISM; RAT; SECRETION; TUMOR CELL LINE;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ARACHIDONIC ACID; ASPARTIC ACID ENDOPEPTIDASES; CELL DIFFERENTIATION; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GROUP III PHOSPHOLIPASES A2; HUMANS; HYDROLYSIS; LYSOPHOSPHATIDYLCHOLINES; MEMBRANE FLUIDITY; NEURONS; PALMITIC ACID; RATS;

EID: 77951068851     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M002287     Document Type: Article

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