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Volumn 13, Issue 1-2, 2010, Pages 44-56

The long road to colorectal cancer therapy: Searching for the right signals

Author keywords

Biomarkers; c MET; Colorectal cancer; Hedgehog signaling; IGF 1R; Monoclonal antibodies; Signaling pathways; Src family; Tyrosine kinase inhibitors; Wnt signaling

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 1 [4 (3 AMINO 1H INDAZOL 4 YL)PHENYL] 3 (2 FLUORO 5 METHYLPHENYL)UREA; 2 (1H INDAZOL 4 YL) 6 (4 METHANESULFONYL 1 PIPERAZINYLMETHYL) 4 MORPHOLINOTHIENO[3,2 D]PYRIMIDINE; 5 (4 BROMO 2 CHLOROANILINO) 4 FLUORO 1 METHYL 1H BENZIMIDAZOLE 6 CARBOHYDROXAMIC ACID 2 HYDROXYETHYL ESTER; AFLIBERCEPT; AMG 102; AMG 479; AXITINIB; BAY 734506; BEVACIZUMAB; BGT 226; BIOLOGICAL MARKER; BOSUTINIB; CEDIRANIB; CETUXIMAB; DASATINIB; DULANERMIN; GDC 0449; GDC 0973; GDC 0980; GEFITINIB; IMC 1121B; IMC 18F1; LAPATINIB; LINIFANIB; MOTESANIB; N (5 CHLORO 1,3 BENZODIOXOL 4 YL) 7 [2 (4 METHYL 1 PIPERAZINYL)ETHOXY] 5 (TETRAHYDRO 2H PYRAN 4 YLOXY) 4 QUINAZOLINAMINE; NIMOTUZUMAB; PANITUMUMAB; PAZOPANIB; PERIFOSINE; PRO 95780; PROTEIN TYROSINE KINASE; RAMUCIRUMAB; SONIC HEDGEHOG PROTEIN; SORAFENIB; SUNITINIB; TB 403; UNCLASSIFIED DRUG; UNINDEXED DRUG; WNT PROTEIN; XL 765; [1 (4 OXO 8 PHENYL 4H 1 BENZOPYRAN 2 YL)MORPHOLINIO]METHOXYSUCCINYLARGINYLGLYCYLASPARTYLSERINE ACETATE;

EID: 77950867091     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drup.2009.01.002     Document Type: Article
Times cited : (27)

References (191)
  • 1
    • 0032555020 scopus 로고    scopus 로고
    • Incidence of hereditary non-polyposis colorectal cancer and the feasibility of molecular screening for the disease
    • Aaltonen L.A., Salovaara R., Kristo P., Canzian F., Hemminki A., Peltomaki P., et al. Incidence of hereditary non-polyposis colorectal cancer and the feasibility of molecular screening for the disease. New Engl. J. Med. 338 (1998) 1481-1487
    • (1998) New Engl. J. Med. , vol.338 , pp. 1481-1487
    • Aaltonen, L.A.1    Salovaara, R.2    Kristo, P.3    Canzian, F.4    Hemminki, A.5    Peltomaki, P.6
  • 2
    • 0037080135 scopus 로고    scopus 로고
    • Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis
    • Aligayer H., Boyd D.D., Heiss M.M., Abdalla E.K., Curley S.A., and Gallick G.E. Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. Cancer 94 (2002) 344-351
    • (2002) Cancer , vol.94 , pp. 344-351
    • Aligayer, H.1    Boyd, D.D.2    Heiss, M.M.3    Abdalla, E.K.4    Curley, S.A.5    Gallick, G.E.6
  • 3
    • 66149147757 scopus 로고    scopus 로고
    • Initial safety report of NSABP C-08: a randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer
    • Allegra C.J., Yothers G., O'Connell M.J., et al. Initial safety report of NSABP C-08: a randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer. J. Clin. Oncol. 27 (2009) 3385-3390
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3385-3390
    • Allegra, C.J.1    Yothers, G.2    O'Connell, M.J.3
  • 4
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado R.G., Wolf M., Peeters M., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 26 (2008) 1626-1634
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 5
    • 2542615200 scopus 로고    scopus 로고
    • Multicenter international study of oxaliplatin/5-fluorouracil/leucovorin in the adjuvant treatment of colon cancer (MOSAIC) investigators
    • André T., Boni C., et al. Multicenter international study of oxaliplatin/5-fluorouracil/leucovorin in the adjuvant treatment of colon cancer (MOSAIC) investigators. New Engl. J. Med. 350 (2004) 2343-2351
    • (2004) New Engl. J. Med. , vol.350 , pp. 2343-2351
    • André, T.1    Boni, C.2
  • 6
    • 70349319634 scopus 로고    scopus 로고
    • Chemotherapy for operable and advanced colorectal cancer
    • Aschele C., Bergamo F., and Lonardi S. Chemotherapy for operable and advanced colorectal cancer. Cancer Treat. Rev. 35 (2009) 509-516
    • (2009) Cancer Treat. Rev. , vol.35 , pp. 509-516
    • Aschele, C.1    Bergamo, F.2    Lonardi, S.3
  • 7
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
    • 10.1200/JCO.2009.24.6116
    • Bardelli A., and Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J. Clin. Oncol. (2010) 10.1200/JCO.2009.24.6116
    • (2010) J. Clin. Oncol.
    • Bardelli, A.1    Siena, S.2
  • 8
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • Barker N., and Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat. Rev. Drug Discov. 5 (2006) 997-1014
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 9
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker N., van Es J.H., Kuipers J., et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449 (2007) 1003-1007
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1    van Es, J.H.2    Kuipers, J.3
  • 10
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker N., Ridgway R.A., van Es J.H., et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457 (2009) 608-611
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1    Ridgway, R.A.2    van Es, J.H.3
  • 11
    • 43249110658 scopus 로고    scopus 로고
    • Determinants of resistance to anti-epidermal growth factor receptor agents
    • Baselga J., and Rosen N. Determinants of resistance to anti-epidermal growth factor receptor agents. J. Clin. Oncol. 26 (2008) 1582-1584
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1582-1584
    • Baselga, J.1    Rosen, N.2
  • 12
    • 56749091913 scopus 로고    scopus 로고
    • Immunostaining of LGr5, an intestinal stem cell marker, in normal and premalignant human gatrointestinal tissue
    • Becker L., Huang Q., and Mashimo H. Immunostaining of LGr5, an intestinal stem cell marker, in normal and premalignant human gatrointestinal tissue. Scientific World J. 23 (2008) 1168-1176
    • (2008) Scientific World J. , vol.23 , pp. 1168-1176
    • Becker, L.1    Huang, Q.2    Mashimo, H.3
  • 13
    • 48649104080 scopus 로고    scopus 로고
    • Temozolomide preferentially depletes cancer stem cells in glioblastoma
    • Beier D., Rohrl S., Pillai D.R., et al. Temozolomide preferentially depletes cancer stem cells in glioblastoma. Cancer Res. 68 (2008) 5706-5715
    • (2008) Cancer Res. , vol.68 , pp. 5706-5715
    • Beier, D.1    Rohrl, S.2    Pillai, D.R.3
  • 14
    • 0034687278 scopus 로고    scopus 로고
    • A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells
    • Benistant C., Chapuis H., and Roche S. A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. Oncogene 19 (2000) 5083-5090
    • (2000) Oncogene , vol.19 , pp. 5083-5090
    • Benistant, C.1    Chapuis, H.2    Roche, S.3
  • 15
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G., and Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat. Rev. Cancer 8 (2008) 592-603
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 16
    • 73349132710 scopus 로고    scopus 로고
    • The forest and the trees: pathways and proteins as colorectal cancer biomarkers
    • Bertagnolli M.M. The forest and the trees: pathways and proteins as colorectal cancer biomarkers. J. Clin. Oncol. 27 (2009) 5866-5867
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5866-5867
    • Bertagnolli, M.M.1
  • 17
    • 36749002116 scopus 로고    scopus 로고
    • Rational combination of targeted therapies as a strategy to overcome the mechanisms of resistance to inhibitors of EGFR signaling
    • Bianco R., Damiano V., Gelardi T., Daniele G., Ciardiello F., and Tortora G. Rational combination of targeted therapies as a strategy to overcome the mechanisms of resistance to inhibitors of EGFR signaling. Curr. Pharm. Des. 13 (2007) 3358-3367
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 3358-3367
    • Bianco, R.1    Damiano, V.2    Gelardi, T.3    Daniele, G.4    Ciardiello, F.5    Tortora, G.6
  • 18
    • 61449239114 scopus 로고    scopus 로고
    • Impact of FcγRIIa-FcγRIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan
    • Bibeau F., Lopez-Crapez E., Di Fiore F., et al. Impact of FcγRIIa-FcγRIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J. Clin. Oncol. 27 (2009) 1122-1129
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1122-1129
    • Bibeau, F.1    Lopez-Crapez, E.2    Di Fiore, F.3
  • 20
    • 68949146819 scopus 로고    scopus 로고
    • Nimotuzumab: a novel anti-EGFR monoclonal antibody that retains anti-EGFR activity while minimizing skin toxicity
    • Boland W.K., and Bebb G. Nimotuzumab: a novel anti-EGFR monoclonal antibody that retains anti-EGFR activity while minimizing skin toxicity. Expert Opin. Biol. Ther. 9 (2009) 1199-1206
    • (2009) Expert Opin. Biol. Ther. , vol.9 , pp. 1199-1206
    • Boland, W.K.1    Bebb, G.2
  • 22
    • 43149117058 scopus 로고    scopus 로고
    • Hyperinduction of Wnt activity: a new paradigm for the treatment of colorectal cancer?
    • Bordonaro M., Lazarova D.L., and Sartorelli A.C. Hyperinduction of Wnt activity: a new paradigm for the treatment of colorectal cancer?. Oncol. Res. 17 (2008) 1-9
    • (2008) Oncol. Res. , vol.17 , pp. 1-9
    • Bordonaro, M.1    Lazarova, D.L.2    Sartorelli, A.C.3
  • 23
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: a review
    • Bos J.L. Ras oncogenes in human cancer: a review. Cancer Res. 49 (1989) 4682-4689
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 24
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: migrating cancer stem cells-an integrated concept of malignant tumour progression
    • Brabletz T., Jung A., Spaderna S., Hlubek F., and Kirchner T. Opinion: migrating cancer stem cells-an integrated concept of malignant tumour progression. Nat. Rev. Cancer 5 (2005) 744-749
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 25
    • 34547172596 scopus 로고    scopus 로고
    • A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
    • Carpten J.D., Faber A.L., Horn C., et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448 (2007) 439-444
    • (2007) Nature , vol.448 , pp. 439-444
    • Carpten, J.D.1    Faber, A.L.2    Horn, C.3
  • 26
    • 67349152647 scopus 로고    scopus 로고
    • Treatment in advanced colorectal cancer: what, when and how?
    • Chau I., and Cunningham D. Treatment in advanced colorectal cancer: what, when and how?. Br. J. Cancer 100 (2009) 1704-1719
    • (2009) Br. J. Cancer , vol.100 , pp. 1704-1719
    • Chau, I.1    Cunningham, D.2
  • 27
    • 70350002279 scopus 로고    scopus 로고
    • Adverse effects of anticancer agents that target the VEGF pathway
    • Chen H.X., and Cleck J.N. Adverse effects of anticancer agents that target the VEGF pathway. Nat. Rev. Clin. Oncol. 6 (2009) 465-477
    • (2009) Nat. Rev. Clin. Oncol. , vol.6 , pp. 465-477
    • Chen, H.X.1    Cleck, J.N.2
  • 28
    • 58249122326 scopus 로고    scopus 로고
    • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
    • Chen B., Dodge M.E., Tang W., et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5 (2009) 100-107
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 100-107
    • Chen, B.1    Dodge, M.E.2    Tang, W.3
  • 29
    • 77950862641 scopus 로고    scopus 로고
    • New treatment strategies for metastatic colorectal cancer
    • Chu E. New treatment strategies for metastatic colorectal cancer. CMP Med. (2008)
    • (2008) CMP Med.
    • Chu, E.1
  • 30
    • 2342527188 scopus 로고    scopus 로고
    • Inherited colorectal cancer registries in the United States
    • Church J., Kiringoda R., and LaGuardia L. Inherited colorectal cancer registries in the United States. Dis. Colon Rectum 47 (2004) 674-678
    • (2004) Dis. Colon Rectum , vol.47 , pp. 674-678
    • Church, J.1    Kiringoda, R.2    LaGuardia, L.3
  • 31
    • 77953807967 scopus 로고    scopus 로고
    • Optimizing the management of metastatic colorectal cancer
    • 10.1016/jcritrevonc.2009.09.008
    • Comella P., Casaretti R., Avallone A., and Franco L. Optimizing the management of metastatic colorectal cancer. Crit. Rev. Oncol. Hematol. (2009) 10.1016/jcritrevonc.2009.09.008
    • (2009) Crit. Rev. Oncol. Hematol.
    • Comella, P.1    Casaretti, R.2    Avallone, A.3    Franco, L.4
  • 32
    • 44449151030 scopus 로고    scopus 로고
    • Drug development of MET inhibitors: targeting oncogene addiction and expedience
    • Comoglio P.M., Giordano S., and Trusolino L. Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat. Rev. Drug Discov. 7 (2008) 504-516
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 504-516
    • Comoglio, P.M.1    Giordano, S.2    Trusolino, L.3
  • 33
    • 57749173152 scopus 로고    scopus 로고
    • VEGF inhibition: insights from preclinical and clinical studies
    • Crawford Y., and Ferrara N. VEGF inhibition: insights from preclinical and clinical studies. Cell Tissue Res. 335 (2009) 261-269
    • (2009) Cell Tissue Res. , vol.335 , pp. 261-269
    • Crawford, Y.1    Ferrara, N.2
  • 34
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y., Kasman I., Yu L., Zhong C., Wu X., Modrusan Z., Kaminker J., and Ferrara N. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 15 (2009) 21-34
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3    Zhong, C.4    Wu, X.5    Modrusan, Z.6    Kaminker, J.7    Ferrara, N.8
  • 35
    • 42349093952 scopus 로고    scopus 로고
    • Cancer stem cells: implications for the progression and treatment of metastatic disease
    • Croker A.K., and Allan A.L. Cancer stem cells: implications for the progression and treatment of metastatic disease. J. Cell. Mol. Med. 12 (2008) 374-390
    • (2008) J. Cell. Mol. Med. , vol.12 , pp. 374-390
    • Croker, A.K.1    Allan, A.L.2
  • 36
    • 33646182727 scopus 로고    scopus 로고
    • Organizing cell renewal in the intestine: stem cells, signals and combinatorial control
    • Crosnier C., Stamataki D., and Lewis J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat. Rev. Genet. 7 (2006) 349-359
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 349-359
    • Crosnier, C.1    Stamataki, D.2    Lewis, J.3
  • 37
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M., You H., Levine A.J., and Mak T.W. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat. Rev. Cancer 6 (2006) 184-192
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 38
    • 34547193404 scopus 로고    scopus 로고
    • Phenotypic characterization of human colorectal cancer stem cells
    • Dalerba P., Dylla S.J., and Park I.K. Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl. Acad. Sci. (U.S.A.) 104 (2007) 10158-10163
    • (2007) Proc. Natl. Acad. Sci. (U.S.A.) , vol.104 , pp. 10158-10163
    • Dalerba, P.1    Dylla, S.J.2    Park, I.K.3
  • 40
    • 2542463425 scopus 로고    scopus 로고
    • SRC gene expression in human cancer: the role of transcriptional activation
    • Dehm S.M., and Bonham K. SRC gene expression in human cancer: the role of transcriptional activation. Biochem. Cell Biol. 82 (2004) 263-274
    • (2004) Biochem. Cell Biol. , vol.82 , pp. 263-274
    • Dehm, S.M.1    Bonham, K.2
  • 41
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F., Martini M., Molinari F., et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J. Clin. Oncol. 26 (2008) 5705-5712
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 42
    • 49149107236 scopus 로고    scopus 로고
    • Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy
    • Dylla S.J., Beviglia L., Park I.K., et al. Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One 3 (2008) e2428
    • (2008) PLoS One , vol.3
    • Dylla, S.J.1    Beviglia, L.2    Park, I.K.3
  • 43
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos J.M., Lee C.R., Cruz-Munoz W., Bjarnason G.A., Christensen J.G., and Kerbel R.S. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15 (2009) 232-239
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 44
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E.R., and Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 61 (1990) 759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 45
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N., and Kerbel R.S. Angiogenesis as a therapeutic target. Nature 438 (2005) 967-974
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 46
    • 65349172418 scopus 로고    scopus 로고
    • Adjuvant therapy with the monoclonal antibody Edrecolomab plus fluorouracil-based therapy does not improve overall survival of patients with stage III colon cancer
    • Fields A.L., Keller A., Schwartzberg L., et al. Adjuvant therapy with the monoclonal antibody Edrecolomab plus fluorouracil-based therapy does not improve overall survival of patients with stage III colon cancer. J. Clin. Oncol. 27 (2009) 1941-1947
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1941-1947
    • Fields, A.L.1    Keller, A.2    Schwartzberg, L.3
  • 47
    • 58149242890 scopus 로고    scopus 로고
    • A phase II study of gefitinib, 5-fluorouracil, leucovorin, and oxaliplatin in previously untreated patients with metastatic colorectal cancer
    • Fisher G.A., et al. A phase II study of gefitinib, 5-fluorouracil, leucovorin, and oxaliplatin in previously untreated patients with metastatic colorectal cancer. Clin. Cancer Res. 14 (2008) 7074-7079
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7074-7079
    • Fisher, G.A.1
  • 48
  • 49
    • 77950866554 scopus 로고    scopus 로고
    • (Abstr 2558)
    • Frost A., et al. J. Clin Oncol. 26 May (20) suppl. (2008) (Abstr 2558)
    • (2008) J. Clin Oncol. , vol.26 , Issue.May 20 SUPPL
    • Frost, A.1
  • 50
    • 39149123820 scopus 로고    scopus 로고
    • A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug. SF1126, with antitumor and antiangiogenic activity
    • Garlich J.R., De P., Dey N., et al. A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug. SF1126, with antitumor and antiangiogenic activity. Cancer Res. 68 (2008) 206-215
    • (2008) Cancer Res. , vol.68 , pp. 206-215
    • Garlich, J.R.1    De, P.2    Dey, N.3
  • 52
    • 41049085170 scopus 로고    scopus 로고
    • Choose your own path: specificity in Ras GTPase signaling
    • Goldfinger L.E. Choose your own path: specificity in Ras GTPase signaling. Mol. Biosyst. 4 (2008) 293-299
    • (2008) Mol. Biosyst. , vol.4 , pp. 293-299
    • Goldfinger, L.E.1
  • 53
    • 53049087109 scopus 로고    scopus 로고
    • Genomic and epigenetic instability in colorectal cancer pathogenesis
    • Grady W.M., and Carethers J.M. Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology 135 (2008) 1079-1099
    • (2008) Gastroenterology , vol.135 , pp. 1079-1099
    • Grady, W.M.1    Carethers, J.M.2
  • 54
    • 0036085845 scopus 로고    scopus 로고
    • Campbell De Morgan's 'Observations on cancer', and their relevance today
    • Grange J.M., Stanford J.L., and Stanford C.A. Campbell De Morgan's 'Observations on cancer', and their relevance today. J. R. Soc. Med. 95 (2002) 296-299
    • (2002) J. R. Soc. Med. , vol.95 , pp. 296-299
    • Grange, J.M.1    Stanford, J.L.2    Stanford, C.A.3
  • 56
    • 57649135172 scopus 로고    scopus 로고
    • A role for VEGF as a negative regulator of pericyte function and vessel maturation
    • Greenberg J.I., Shields D.J., Barillas S.G., et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 456 (2008) 809-813
    • (2008) Nature , vol.456 , pp. 809-813
    • Greenberg, J.I.1    Shields, D.J.2    Barillas, S.G.3
  • 57
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta P.B., Onder T.T., Jiang G., Tao K., Kuperwasser C., Weinberg R.A., and Lander E.S. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138 (2009) 645-659
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7
  • 59
    • 23844548194 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1)
    • (Abstract)
    • Hecht J.R., Trarbach T., Jaeger E., et al. A randomized, double-blind, placebo-controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1). J. Clin. Oncol. 23 (2005) LBA3 (Abstract)
    • (2005) J. Clin. Oncol. , vol.23
    • Hecht, J.R.1    Trarbach, T.2    Jaeger, E.3
  • 60
    • 64049090889 scopus 로고    scopus 로고
    • Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR
    • Heinemann V., Stintzing S., Kirchner T., Boeck S., and Jung A. Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR. Cancer Treat. Rev. 35 (2009) 262-271
    • (2009) Cancer Treat. Rev. , vol.35 , pp. 262-271
    • Heinemann, V.1    Stintzing, S.2    Kirchner, T.3    Boeck, S.4    Jung, A.5
  • 61
    • 0036016095 scopus 로고    scopus 로고
    • ZD1839: targeting the epidermal growth factor receptor in cancer therapy
    • Herbst R.S. ZD1839: targeting the epidermal growth factor receptor in cancer therapy. Expert Opin. Investig. Drugs 11 (2002) 837-849
    • (2002) Expert Opin. Investig. Drugs , vol.11 , pp. 837-849
    • Herbst, R.S.1
  • 62
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann P.C., Huber S.L., Herrler T., Aicher A., Ellwart J.W., Guba M., Bruns C.J., and Heeschen C. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1 (2007) 313-323
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6    Bruns, C.J.7    Heeschen, C.8
  • 63
    • 62749203737 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine
    • Hewish M., Chau I., and Cunningham D. Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine. Recent Pat. Anticancer Drug Discov. 4 (2009) 54-72
    • (2009) Recent Pat. Anticancer Drug Discov. , vol.4 , pp. 54-72
    • Hewish, M.1    Chau, I.2    Cunningham, D.3
  • 65
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch H.A., Iliopoulos D., Tsichlis P.N., and Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 69 (2009) 7507-7511
    • (2009) Cancer Res. , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 66
    • 36749045682 scopus 로고    scopus 로고
    • Tankyrase function at telomeres, spindle poles, and beyond
    • Hsiao S.J., and Smith S. Tankyrase function at telomeres, spindle poles, and beyond. Biochimie 90 (2008) 83-92
    • (2008) Biochimie , vol.90 , pp. 83-92
    • Hsiao, S.J.1    Smith, S.2
  • 67
    • 70349277438 scopus 로고    scopus 로고
    • Monoclonal antibodies targeting vascular endothelial growth factor: current status and future challenges in cancer therapy
    • Hsu J.Y., and Wakelee H.A. Monoclonal antibodies targeting vascular endothelial growth factor: current status and future challenges in cancer therapy. BioDrugs 23 (2009) 289-304
    • (2009) BioDrugs , vol.23 , pp. 289-304
    • Hsu, J.Y.1    Wakelee, H.A.2
  • 68
  • 70
    • 67449164582 scopus 로고    scopus 로고
    • Phase I trial of pazopanib in patients with advanced cancer
    • Hurwitz H.I., Dowlati A., Saini S., et al. Phase I trial of pazopanib in patients with advanced cancer. Clin. Cancer Res. 15 (2009) 4220-4227
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4220-4227
    • Hurwitz, H.I.1    Dowlati, A.2    Saini, S.3
  • 71
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: the complexity of targeted inhibitors
    • Hynes N.E., and Lane H.A. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer 5 (2005) 341-354
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 73
    • 34447339050 scopus 로고    scopus 로고
    • TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas
    • Jalving M., de Jong S., Koornstra J.J., et al. TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas. Clin. Cancer Res. 12 (2006) 4350-4356
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4350-4356
    • Jalving, M.1    de Jong, S.2    Koornstra, J.J.3
  • 75
    • 46149092748 scopus 로고    scopus 로고
    • Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment
    • Jiang B.H., and Liu L.Z. Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist. Updat. 11 (2008) 63-76
    • (2008) Drug Resist. Updat. , vol.11 , pp. 63-76
    • Jiang, B.H.1    Liu, L.Z.2
  • 76
    • 41949139438 scopus 로고    scopus 로고
    • Comparative lesion sequencing provides insights into tumor evolution
    • Jones S., Chen W.D., Parmigiani G., et al. Comparative lesion sequencing provides insights into tumor evolution. Proc. Natl. Acad. Sci. (U.S.A.) 105 (2008) 4283-4288
    • (2008) Proc. Natl. Acad. Sci. (U.S.A.) , vol.105 , pp. 4283-4288
    • Jones, S.1    Chen, W.D.2    Parmigiani, G.3
  • 78
    • 20444412646 scopus 로고    scopus 로고
    • Therapeutic targeting of the tumor microenvironment
    • Joyce J.A. Therapeutic targeting of the tumor microenvironment. Cancer Cell 7 (2005) 513-520
    • (2005) Cancer Cell , vol.7 , pp. 513-520
    • Joyce, J.A.1
  • 79
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F., Hurwitz H.I., Fehrenbacher L., Meropol N.J., Novotny W.F., Lieberman G., Griffing S., and Bergsland E. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. 21 (2003) 60-65
    • (2003) J. Clin. Oncol. , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3    Meropol, N.J.4    Novotny, W.F.5    Lieberman, G.6    Griffing, S.7    Bergsland, E.8
  • 80
    • 0034721665 scopus 로고    scopus 로고
    • Transducing the hedgehog signal
    • Kalderon D. Transducing the hedgehog signal. Cell 103 (2000) 371-374
    • (2000) Cell , vol.103 , pp. 371-374
    • Kalderon, D.1
  • 81
    • 33847326735 scopus 로고    scopus 로고
    • Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome
    • Kammula U.S., Kuntz E.J., Francone T.D., et al. Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. Cancer Lett. 248 (2007) 219-228
    • (2007) Cancer Lett. , vol.248 , pp. 219-228
    • Kammula, U.S.1    Kuntz, E.J.2    Francone, T.D.3
  • 82
    • 31344472398 scopus 로고    scopus 로고
    • Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia
    • Karakosta A., Golias C., Charalabopoulos A., Peschos D., Batistatou A., and Charalabopoulos K. Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia. J. Exp. Clin. Cancer Res. 24 (2005) 505-514
    • (2005) J. Exp. Clin. Cancer Res. , vol.24 , pp. 505-514
    • Karakosta, A.1    Golias, C.2    Charalabopoulos, A.3    Peschos, D.4    Batistatou, A.5    Charalabopoulos, K.6
  • 83
    • 70349758510 scopus 로고    scopus 로고
    • Src kinases as therapeutic targets for cancer
    • Kim L.C., Song L., and Haura E.B. Src kinases as therapeutic targets for cancer. Nat. Rev. Clin. Oncol. 6 (2009) 587-595
    • (2009) Nat. Rev. Clin. Oncol. , vol.6 , pp. 587-595
    • Kim, L.C.1    Song, L.2    Haura, E.B.3
  • 84
    • 33845423933 scopus 로고    scopus 로고
    • Molecular biology of colorectal cancer: new targets
    • Kitisin K., and Mishra L. Molecular biology of colorectal cancer: new targets. Semin. Oncol. 33 (2006) S14-23
    • (2006) Semin. Oncol. , vol.33
    • Kitisin, K.1    Mishra, L.2
  • 85
    • 33646383684 scopus 로고    scopus 로고
    • A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
    • Knight Z.A., Gonzalez B., Feldman M.E., et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 125 (2006) 733-747
    • (2006) Cell , vol.125 , pp. 733-747
    • Knight, Z.A.1    Gonzalez, B.2    Feldman, M.E.3
  • 86
    • 75149130051 scopus 로고    scopus 로고
    • Targeting the cancer kinome through polypharmacology
    • Knight Z.A., Lin H., and Shokat K.M. Targeting the cancer kinome through polypharmacology. Nat. Rev. Cancer 10 (2010) 130-137
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 130-137
    • Knight, Z.A.1    Lin, H.2    Shokat, K.M.3
  • 88
    • 33749637207 scopus 로고    scopus 로고
    • Results of an interim analysis of a multinational randomized, double-blind, phase III study in patients (pts) with previously treated metastatic colorectal cancer (mCRC) receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo (CONFIRM 2)
    • (Abstract)
    • Koehne C., Bajetta E., Lin E., Van Cutsem E., Hecht J., Douillard J., Moore M., et al. Results of an interim analysis of a multinational randomized, double-blind, phase III study in patients (pts) with previously treated metastatic colorectal cancer (mCRC) receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo (CONFIRM 2). J. Clin. Oncol. 24 (2006) 3508 (Abstract)
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3508
    • Koehne, C.1    Bajetta, E.2    Lin, E.3    Van Cutsem, E.4    Hecht, J.5    Douillard, J.6    Moore, M.7
  • 89
    • 34347369084 scopus 로고    scopus 로고
    • Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
    • Konstantinopoulos P.A., Karamouzis M.V., and Papavassiliou A.G. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets. Nat. Rev. Drug Discov. 6 (2007) 541-555
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 541-555
    • Konstantinopoulos, P.A.1    Karamouzis, M.V.2    Papavassiliou, A.G.3
  • 90
    • 37549010730 scopus 로고    scopus 로고
    • Src continues aging: current and future clinical directions
    • Kopetz S., Shah A.N., and Gallick G.E. Src continues aging: current and future clinical directions. Clin. Cancer Res. 13 (2007) 7232-7236
    • (2007) Clin. Cancer Res. , vol.13 , pp. 7232-7236
    • Kopetz, S.1    Shah, A.N.2    Gallick, G.E.3
  • 92
    • 67650674112 scopus 로고    scopus 로고
    • Ramucirumab, a fully human mAb to the transmembrane signaling tyrosine kinase VEGFR-2 for the potential treatment of cancer
    • Krupitskaya Y., and Wakelee H.A. Ramucirumab, a fully human mAb to the transmembrane signaling tyrosine kinase VEGFR-2 for the potential treatment of cancer. Curr. Opin. Invest. Drugs 10 (2009) 597-605
    • (2009) Curr. Opin. Invest. Drugs , vol.10 , pp. 597-605
    • Krupitskaya, Y.1    Wakelee, H.A.2
  • 93
    • 72449149848 scopus 로고    scopus 로고
    • The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38
    • LaBonte M.J., Manegold P.C., Wilson P.M., Fazzone W., Louie S.G., Lenz H.J., and Ladner R.D. The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38. Int. J. Cancer 125 (2009) 2957-2969
    • (2009) Int. J. Cancer , vol.125 , pp. 2957-2969
    • LaBonte, M.J.1    Manegold, P.C.2    Wilson, P.M.3    Fazzone, W.4    Louie, S.G.5    Lenz, H.J.6    Ladner, R.D.7
  • 94
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • Laurent-Puig P., Cayre A., Manceau G., Buc E., Bachet J.B., Lecomte T., et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J. Clin. Oncol. 27 (2009) 5924-5930
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3    Buc, E.4    Bachet, J.B.5    Lecomte, T.6
  • 95
    • 46149123415 scopus 로고    scopus 로고
    • Progress and challenges in the identification of biomarkers for EGFR and VEGFR targeting anticancer agents
    • Le Tourneau C., Vidal L., and Siu L.L. Progress and challenges in the identification of biomarkers for EGFR and VEGFR targeting anticancer agents. Drug Resist. Updat. 11 (2008) 99-109
    • (2008) Drug Resist. Updat. , vol.11 , pp. 99-109
    • Le Tourneau, C.1    Vidal, L.2    Siu, L.L.3
  • 96
    • 33846239456 scopus 로고    scopus 로고
    • Beyond tumorigenesis: cancer stem cells in metastasis
    • Li F., Tiede B., Massague J., and Kang Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res. 17 (2007) 3-14
    • (2007) Cell Res. , vol.17 , pp. 3-14
    • Li, F.1    Tiede, B.2    Massague, J.3    Kang, Y.4
  • 97
    • 44049100934 scopus 로고    scopus 로고
    • Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
    • Li X., Lewis M.T., Huang J., et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J. Natl. Cancer Inst. 100 (2008) 672-679
    • (2008) J. Natl. Cancer Inst. , vol.100 , pp. 672-679
    • Li, X.1    Lewis, M.T.2    Huang, J.3
  • 98
    • 70350653741 scopus 로고    scopus 로고
    • Nuclear EGFR contributes to acquired resistance to cetuximab
    • Li C., Iida M., Dunn E.F., Ghia A.J., and Wheeler D.L. Nuclear EGFR contributes to acquired resistance to cetuximab. Oncogene 28 (2009) 3801-3813
    • (2009) Oncogene , vol.28 , pp. 3801-3813
    • Li, C.1    Iida, M.2    Dunn, E.F.3    Ghia, A.J.4    Wheeler, D.L.5
  • 99
    • 70349254065 scopus 로고    scopus 로고
    • Clinical practice. Screening for colorectal cancer
    • Lieberman D.A. Clinical practice. Screening for colorectal cancer. New Engl. J. Med. 361 (2009) 1179-1187
    • (2009) New Engl. J. Med. , vol.361 , pp. 1179-1187
    • Lieberman, D.A.1
  • 100
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lievre A., Bachet J.B., Boige V., Cayre A., Le Corre D., Buc E., et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J. Clin. Oncol. 26 (2008) 374-379
    • (2008) J. Clin. Oncol. , vol.26 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3    Cayre, A.4    Le Corre, D.5    Buc, E.6
  • 101
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu P., Cheng H., Roberts T.M., and Zhao J.J. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat. Rev. Drug Discov. 8 (2009) 627-644
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 102
    • 74949119167 scopus 로고    scopus 로고
    • Phase I study of intravenous vascular endothelial growth factor Trap. Aflibercept, in patients with advanced solid tumors
    • Lockhart A.C., Rothenberg M.L., Dupont J., Cooper W., Chevalier P., Sternas L., et al. Phase I study of intravenous vascular endothelial growth factor Trap. Aflibercept, in patients with advanced solid tumors. J. Clin. Oncol. 28 (2009) 207-214
    • (2009) J. Clin. Oncol. , vol.28 , pp. 207-214
    • Lockhart, A.C.1    Rothenberg, M.L.2    Dupont, J.3    Cooper, W.4    Chevalier, P.5    Sternas, L.6
  • 103
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
    • LoPiccolo J., Blumenthal G.M., Bernstein W.B., and Dennis P.A. Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist. Updat. 11 (2008) 32-50
    • (2008) Drug Resist. Updat. , vol.11 , pp. 32-50
    • LoPiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 104
    • 34247849335 scopus 로고    scopus 로고
    • Target practice: lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer
    • Los M., Roodhart J.M., and Voest E.E. Target practice: lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer. Oncologist 12 (2007) 443-450
    • (2007) Oncologist , vol.12 , pp. 443-450
    • Los, M.1    Roodhart, J.M.2    Voest, E.E.3
  • 105
    • 66849140563 scopus 로고    scopus 로고
    • PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
    • Loupakis F., Pollina L., Stasi I., Ruzzo A., Scartozzi M., Santini D., et al. PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer. J. Clin. Oncol. 27 (2009) 2622-2629
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2622-2629
    • Loupakis, F.1    Pollina, L.2    Stasi, I.3    Ruzzo, A.4    Scartozzi, M.5    Santini, D.6
  • 106
    • 67650924286 scopus 로고    scopus 로고
    • Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis and medicolegal ramifications
    • Lynch H.T., Lynch P.M., Lanspa S.J., Snyder C.L., Lynch J.F., and Boland C.R. Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis and medicolegal ramifications. Clin. Genet. 76 (2009) 1-18
    • (2009) Clin. Genet. , vol.76 , pp. 1-18
    • Lynch, H.T.1    Lynch, P.M.2    Lanspa, S.J.3    Snyder, C.L.4    Lynch, J.F.5    Boland, C.R.6
  • 107
    • 0038724909 scopus 로고    scopus 로고
    • c-Met: structure, functions and potential for therapeutic inhibition
    • Ma P.C., Maulik G., Christensen J., and Salgia R. c-Met: structure, functions and potential for therapeutic inhibition. Cancer Metast. Rev. 22 (2003) 309-325
    • (2003) Cancer Metast. Rev. , vol.22 , pp. 309-325
    • Ma, P.C.1    Maulik, G.2    Christensen, J.3    Salgia, R.4
  • 108
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: components, mechanisms and diseases
    • MacDonald B.T., Tamai K., and He X. Wnt/beta-catenin signaling: components, mechanisms and diseases. Dev. Cell 17 (2009) 9-26
    • (2009) Dev. Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 109
    • 59849123146 scopus 로고    scopus 로고
    • FDA holds court on post hoc data linking KRAS status to drug response
    • Mack G.S. FDA holds court on post hoc data linking KRAS status to drug response. Nat. Biotechnol. 27 (2009) 110-112
    • (2009) Nat. Biotechnol. , vol.27 , pp. 110-112
    • Mack, G.S.1
  • 110
    • 65549105835 scopus 로고    scopus 로고
    • Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines
    • Mahalingam D., Keane M., Pirianov G., Mehmet H., Samali A., and Szegezdi E. Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines. Br. J. Cancer 100 (2009) 1415-1424
    • (2009) Br. J. Cancer , vol.100 , pp. 1415-1424
    • Mahalingam, D.1    Keane, M.2    Pirianov, G.3    Mehmet, H.4    Samali, A.5    Szegezdi, E.6
  • 111
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira S.M., Stauffer F., Brueggen J., et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol. Cancer Ther. 7 (2008) 1851-1863
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3
  • 112
    • 69849108427 scopus 로고    scopus 로고
    • Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges
    • Mandrekar S.J., and Sargent D.J. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J. Clin. Oncol. 27 (2009) 4027-4034
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4027-4034
    • Mandrekar, S.J.1    Sargent, D.J.2
  • 115
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J., and Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 21 (2003) 2787-2799
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 116
    • 70350433282 scopus 로고    scopus 로고
    • Progression-free survival in bevacizumab-based first-line treatment for patients with metastatic colorectal cancer: is it a really good end point?
    • (author reply e134-135)
    • Montagnani F., Migali C., and Fiorentini G. Progression-free survival in bevacizumab-based first-line treatment for patients with metastatic colorectal cancer: is it a really good end point?. J. Clin. Oncol. 27 (2009) e132-133 (author reply e134-135)
    • (2009) J. Clin. Oncol. , vol.27
    • Montagnani, F.1    Migali, C.2    Fiorentini, G.3
  • 117
    • 32244432266 scopus 로고    scopus 로고
    • Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients
    • Monzo M., Moreno I., Artells R., et al. Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients. Cancer Lett. 233 (2006) 117-123
    • (2006) Cancer Lett. , vol.233 , pp. 117-123
    • Monzo, M.1    Moreno, I.2    Artells, R.3
  • 118
    • 27944467499 scopus 로고    scopus 로고
    • Resistance to epidermal growth factor receptor-targeted therapy
    • Morgillo F., and Lee H.Y. Resistance to epidermal growth factor receptor-targeted therapy. Drug Resist. Updat. 8 (2005) 298-310
    • (2005) Drug Resist. Updat. , vol.8 , pp. 298-310
    • Morgillo, F.1    Lee, H.Y.2
  • 119
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin P.J., Sparks A.B., Korinek V., Barker N., Clevers H., Vogelstein B., and Kinzler K.W. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275 (1997) 1787-1790
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 120
    • 33846020023 scopus 로고    scopus 로고
    • Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib
    • Mross K., Steinbild S., Baas F., et al. Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib. Eur. J. Cancer 43 (2007) 55-63
    • (2007) Eur. J. Cancer , vol.43 , pp. 55-63
    • Mross, K.1    Steinbild, S.2    Baas, F.3
  • 121
    • 34648814084 scopus 로고    scopus 로고
    • Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision
    • Nakamura T., Tsuchiya K., and Watanabe M. Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision. J. Gastroenterol. 42 (2007) 705-710
    • (2007) J. Gastroenterol. , vol.42 , pp. 705-710
    • Nakamura, T.1    Tsuchiya, K.2    Watanabe, M.3
  • 122
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien C.A., Pollett A., Gallinger S., and Dick J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445 (2007) 106-110
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 123
    • 67650296948 scopus 로고    scopus 로고
    • Oxaliplatin or irinotecan as adjuvant therapy for colon cancer: the results are in
    • O'Connell M.J. Oxaliplatin or irinotecan as adjuvant therapy for colon cancer: the results are in. J. Clin. Oncol. 27 (2009) 3082-3084
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3082-3084
    • O'Connell, M.J.1
  • 124
    • 71249164372 scopus 로고    scopus 로고
    • Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines
    • Olaussen K.A., Commo F., Tailler M., et al. Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines. Oncogene 28 (2009) 4249-4260
    • (2009) Oncogene , vol.28 , pp. 4249-4260
    • Olaussen, K.A.1    Commo, F.2    Tailler, M.3
  • 126
    • 55049130752 scopus 로고    scopus 로고
    • Innovations in chemotherapy for metastatic colorectal cancer: an update of recent clinical trials
    • O'Neil B.H., and Goldberg R.M. Innovations in chemotherapy for metastatic colorectal cancer: an update of recent clinical trials. Oncologist 13 (2008) 1074-1083
    • (2008) Oncologist , vol.13 , pp. 1074-1083
    • O'Neil, B.H.1    Goldberg, R.M.2
  • 127
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M., Allen E., Hudock J., et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15 (2009) 220-231
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 128
    • 3843123047 scopus 로고    scopus 로고
    • Frequency of hereditary non-polyposis colorectal cancer and other colorectal cancer familial forms in Spain: a multicentre, prospective, nationwide study
    • Pinol V., Andreu M., Castells A., Paya A., Bessa X., and Rodrigo J. Frequency of hereditary non-polyposis colorectal cancer and other colorectal cancer familial forms in Spain: a multicentre, prospective, nationwide study. Eur. J. Gastroenterol. Hepatol. 16 (2004) 39-45
    • (2004) Eur. J. Gastroenterol. Hepatol. , vol.16 , pp. 39-45
    • Pinol, V.1    Andreu, M.2    Castells, A.3    Paya, A.4    Bessa, X.5    Rodrigo, J.6
  • 129
    • 19544375032 scopus 로고    scopus 로고
    • Wnt control of stem cells and differentiation in the intestinal epithelium
    • Pinto D., and Clevers H. Wnt control of stem cells and differentiation in the intestinal epithelium. Exp. Cell Res. 306 (2005) 357-363
    • (2005) Exp. Cell Res. , vol.306 , pp. 357-363
    • Pinto, D.1    Clevers, H.2
  • 130
    • 43949083039 scopus 로고    scopus 로고
    • Advances in neoadjuvant therapy for colorectal cancer with liver metastases
    • Pozzo C., Barone C., and Kemeny N.E. Advances in neoadjuvant therapy for colorectal cancer with liver metastases. Cancer Treat. Rev. 34 (2008) 293-301
    • (2008) Cancer Treat. Rev. , vol.34 , pp. 293-301
    • Pozzo, C.1    Barone, C.2    Kemeny, N.E.3
  • 131
    • 55249120960 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of motesanib in combination with gemcitabine for the treatment of patients with solid tumours
    • Price T.J., Lipton L., McGreivy J., McCoy S., Sun Y.N., and Rosenthal M.A. Safety and pharmacokinetics of motesanib in combination with gemcitabine for the treatment of patients with solid tumours. Br. J. Cancer 99 (2008) 1387-1394
    • (2008) Br. J. Cancer , vol.99 , pp. 1387-1394
    • Price, T.J.1    Lipton, L.2    McGreivy, J.3    McCoy, S.4    Sun, Y.N.5    Rosenthal, M.A.6
  • 132
    • 75649085336 scopus 로고    scopus 로고
    • More is less-combining targeted therapies in metastatic colorectal cancer
    • Punt C.J., and Tol J. More is less-combining targeted therapies in metastatic colorectal cancer. Nat. Rev. Clin. Oncol. 6 (2009) 731-733
    • (2009) Nat. Rev. Clin. Oncol. , vol.6 , pp. 731-733
    • Punt, C.J.1    Tol, J.2
  • 133
    • 15544381570 scopus 로고    scopus 로고
    • Self-renewal and cancer of the gut: two sides of a coin
    • Radtke F., and Clevers H. Self-renewal and cancer of the gut: two sides of a coin. Science 307 (2005) 1904-1909
    • (2005) Science , vol.307 , pp. 1904-1909
    • Radtke, F.1    Clevers, H.2
  • 134
    • 41649101428 scopus 로고    scopus 로고
    • The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice
    • Rennel E., Waine E., Guan H., et al. The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice. Br. J. Cancer 98 (2008) 1250-1257
    • (2008) Br. J. Cancer , vol.98 , pp. 1250-1257
    • Rennel, E.1    Waine, E.2    Guan, H.3
  • 136
    • 73349114941 scopus 로고    scopus 로고
    • KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial
    • Richman S.D., Seymour M.T., Chambers P., et al. KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J. Clin. Oncol. 27 (2009) 5931-5937
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5931-5937
    • Richman, S.D.1    Seymour, M.T.2    Chambers, P.3
  • 138
    • 65549140672 scopus 로고    scopus 로고
    • Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
    • Rodilla V., Villanueva A., Obrador-Hevia A., et al. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc. Natl. Acad. Sci. (U.S.A.) 106 (2009) 6315-6320
    • (2009) Proc. Natl. Acad. Sci. (U.S.A.) , vol.106 , pp. 6315-6320
    • Rodilla, V.1    Villanueva, A.2    Obrador-Hevia, A.3
  • 139
    • 33751549095 scopus 로고    scopus 로고
    • Targeting the Hedgehog pathway in cancer
    • Rubin L.L., and de Sauvage F.J. Targeting the Hedgehog pathway in cancer. Nat. Rev. Drug Discov. 5 (2006) 1026-1033
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 1026-1033
    • Rubin, L.L.1    de Sauvage, F.J.2
  • 140
    • 35348992639 scopus 로고    scopus 로고
    • The genetics of hereditary colon cancer
    • Rustgi A.K. The genetics of hereditary colon cancer. Genes Dev. 21 (2007) 2525-2538
    • (2007) Genes Dev. , vol.21 , pp. 2525-2538
    • Rustgi, A.K.1
  • 141
    • 0034129240 scopus 로고    scopus 로고
    • Population-based molecular detection of hereditary nonpolyposis colorectal cancer
    • Salovaara R., Loukola A., Kristo P., et al. Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J. Clin. Oncol. 18 (2000) 2193-2200
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2193-2200
    • Salovaara, R.1    Loukola, A.2    Kristo, P.3
  • 142
    • 36048992408 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
    • Saltz L.B., Rosen L.S., Marshall J.L., et al. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J. Clin. Oncol. 25 (2007) 4793-4799
    • (2007) J. Clin. Oncol. , vol.25 , pp. 4793-4799
    • Saltz, L.B.1    Rosen, L.S.2    Marshall, J.L.3
  • 143
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y., Wang Z., Bardelli A., et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304 (2004) 554
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 144
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov D.D., Guertin D.A., Ali S.M., and Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 (2005) 1098-1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 145
    • 67349123408 scopus 로고    scopus 로고
    • Single LGr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato T., Vries R.G., Snippert H.J., et al. Single LGr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459 (2009) 262-265
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3
  • 147
    • 65349124782 scopus 로고    scopus 로고
    • When wishful thinking leads to a misty-eyed appraisal: the story of the adjuvant colon cancer trials with edrecolomab
    • Schmoll H.J., and Arnold D. When wishful thinking leads to a misty-eyed appraisal: the story of the adjuvant colon cancer trials with edrecolomab. J. Clin. Oncol. 27 (2009) 1926-1929
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1926-1929
    • Schmoll, H.J.1    Arnold, D.2
  • 148
    • 69949107753 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor genetic variability in cancer
    • Schneider B.P., Radovich M., and Miller K.D. The role of vascular endothelial growth factor genetic variability in cancer. Clin. Cancer Res. 15 (2009) 5297-5302
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5297-5302
    • Schneider, B.P.1    Radovich, M.2    Miller, K.D.3
  • 149
    • 67650759744 scopus 로고    scopus 로고
    • Evolving treatment of advanced colon cancer
    • Segal N.H., and Saltz L.B. Evolving treatment of advanced colon cancer. Annu. Rev. Med. 60 (2009) 207-219
    • (2009) Annu. Rev. Med. , vol.60 , pp. 207-219
    • Segal, N.H.1    Saltz, L.B.2
  • 150
    • 70350724552 scopus 로고    scopus 로고
    • The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts
    • Shannon A.M., Telfer B.A., Smith P.D., et al. The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts. Clin. Cancer Res. 15 (2009) 6619-6629
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6619-6629
    • Shannon, A.M.1    Telfer, B.A.2    Smith, P.D.3
  • 151
    • 37249003928 scopus 로고    scopus 로고
    • Oncogene addiction: setting the stage for molecularly targeted cancer therapy
    • Sharma S.V., and Settleman J. Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev. 21 (2007) 3214-3231
    • (2007) Genes Dev. , vol.21 , pp. 3214-3231
    • Sharma, S.V.1    Settleman, J.2
  • 152
    • 77951907727 scopus 로고    scopus 로고
    • A phase I study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors
    • 10.1093/annonc/mdp489
    • Sharma S., Abhyankar V., Burgess R.E., et al. A phase I study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors. Ann. Oncol. (2009) 10.1093/annonc/mdp489
    • (2009) Ann. Oncol.
    • Sharma, S.1    Abhyankar, V.2    Burgess, R.E.3
  • 153
    • 55949096784 scopus 로고    scopus 로고
    • Role of the microenvironment in tumor growth and in refractractoriness/resistance to anti-angiogenic therapies
    • Shojaei F., and Ferrara N. Role of the microenvironment in tumor growth and in refractractoriness/resistance to anti-angiogenic therapies. Drug Resist. Updat. 11 (2008) 219-230
    • (2008) Drug Resist. Updat. , vol.11 , pp. 219-230
    • Shojaei, F.1    Ferrara, N.2
  • 154
    • 70349939382 scopus 로고    scopus 로고
    • Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
    • Siena S., Sartore-Bianchi A., Di Nicolantonio F., Balfour J., and Bardelli A. Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J. Natl. Cancer Inst. 101 (2009) 1308-1324
    • (2009) J. Natl. Cancer Inst. , vol.101 , pp. 1308-1324
    • Siena, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Balfour, J.4    Bardelli, A.5
  • 155
    • 66149148652 scopus 로고    scopus 로고
    • Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine
    • Snippert H.J., van Es J.H., van den Born M., et al. Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology 136 (2009) 2187-2194
    • (2009) Gastroenterology , vol.136 , pp. 2187-2194
    • Snippert, H.J.1    van Es, J.H.2    van den Born, M.3
  • 156
    • 17144388591 scopus 로고    scopus 로고
    • Technology evaluation: nimotuzumab, the Center of Molecular Immunology/YM BioSciences/Oncoscience
    • Spicer J. Technology evaluation: nimotuzumab, the Center of Molecular Immunology/YM BioSciences/Oncoscience. Curr. Opin. Mol. Ther. 7 (2005) 182-191
    • (2005) Curr. Opin. Mol. Ther. , vol.7 , pp. 182-191
    • Spicer, J.1
  • 158
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J., and Beachy P.A. The Hedgehog and Wnt signalling pathways in cancer. Nature 411 (2001) 349-354
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 160
    • 0037386758 scopus 로고    scopus 로고
    • c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases
    • Takeuchi H., Bilchik A., Saha S., et al. c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases. Clin. Cancer Res. 9 (2003) 1480-1488
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1480-1488
    • Takeuchi, H.1    Bilchik, A.2    Saha, S.3
  • 162
    • 41549167668 scopus 로고    scopus 로고
    • A randomised phase III study on capecitabine, oxaliplatin and bevacizumab with or without cetuximab in first-line advanced colorectal cancer, the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG). An interim analysis of toxicity
    • Tol J., Koopman M., Rodenburg C.J., Cats A., Creemers G.J., Schrama J.G., et al. A randomised phase III study on capecitabine, oxaliplatin and bevacizumab with or without cetuximab in first-line advanced colorectal cancer, the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG). An interim analysis of toxicity. Ann. Oncol. 19 (2008) 734-738
    • (2008) Ann. Oncol. , vol.19 , pp. 734-738
    • Tol, J.1    Koopman, M.2    Rodenburg, C.J.3    Cats, A.4    Creemers, G.J.5    Schrama, J.G.6
  • 163
    • 73349099049 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
    • Tolcher A.W., Sarantopoulos J., Patnaik A., et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J. Clin. Oncol. 27 (2009) 5800-5807
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5800-5807
    • Tolcher, A.W.1    Sarantopoulos, J.2    Patnaik, A.3
  • 164
    • 34447104400 scopus 로고    scopus 로고
    • Overcoming resistance to molecularly targeted anticancer therapies: rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies
    • Tortora G., Bianco R., Daniele G., Ciardiello F., McCubrey J.A., Ricciardi M.R., et al. Overcoming resistance to molecularly targeted anticancer therapies: rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies. Drug Resist. Updat. 10 (2007) 81-100
    • (2007) Drug Resist. Updat. , vol.10 , pp. 81-100
    • Tortora, G.1    Bianco, R.2    Daniele, G.3    Ciardiello, F.4    McCubrey, J.A.5    Ricciardi, M.R.6
  • 165
    • 0036551486 scopus 로고    scopus 로고
    • Scatter-factor and semaphorin receptors: cell signalling for invasive growth
    • Trusolino L., and Comoglio P.M. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat. Rev. Cancer 2 (2002) 289-300
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 289-300
    • Trusolino, L.1    Comoglio, P.M.2
  • 166
    • 34447264101 scopus 로고    scopus 로고
    • Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial
    • (Abstract)
    • Van Cutsem E., Nowacki M., Lang I., et al. Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial. J. Clin. Oncol. 25 (2007) 4000 (Abstract)
    • (2007) J. Clin. Oncol. , vol.25 , pp. 4000
    • Van Cutsem, E.1    Nowacki, M.2    Lang, I.3
  • 167
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E., Peeters M., Siena S., Humblet Y., Hendlisz A., Neyns B., et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. 25 (2007) 1658-1664
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3    Humblet, Y.4    Hendlisz, A.5    Neyns, B.6
  • 168
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E., Köhne C.H., et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. New Engl. J. Med. 360 (2009) 1408-1417
    • (2009) New Engl. J. Med. , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Köhne, C.H.2
  • 169
    • 62449325426 scopus 로고    scopus 로고
    • Treatment of colorectal liver metastases: a review
    • Van den Eynde M., and Hendlisz A. Treatment of colorectal liver metastases: a review. Rev. Recent Clin. Trials 4 (2009) 56-62
    • (2009) Rev. Recent Clin. Trials , vol.4 , pp. 56-62
    • Van den Eynde, M.1    Hendlisz, A.2
  • 171
    • 27844485675 scopus 로고    scopus 로고
    • Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease
    • Van Es J.H., and Clevers H. Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends Mol. Med. 11 (2005) 496-502
    • (2005) Trends Mol. Med. , vol.11 , pp. 496-502
    • Van Es, J.H.1    Clevers, H.2
  • 173
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2 (2002) 489-501
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 174
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
    • Von Hoff D.D., LoRusso P.M., Rudin C.M., et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. New Engl. J. Med. 361 (2009) 1164-1172
    • (2009) New Engl. J. Med. , vol.361 , pp. 1164-1172
    • Von Hoff, D.D.1    LoRusso, P.M.2    Rudin, C.M.3
  • 175
    • 0037109014 scopus 로고    scopus 로고
    • ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy
    • Wakeling A.E., Guy S.P., Woodburn J.R., Ashton S.E., Curry B.J., Barker A.J., and Gibson K.H. ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 62 (2002) 5749-5754
    • (2002) Cancer Res. , vol.62 , pp. 5749-5754
    • Wakeling, A.E.1    Guy, S.P.2    Woodburn, J.R.3    Ashton, S.E.4    Curry, B.J.5    Barker, A.J.6    Gibson, K.H.7
  • 176
    • 0036348616 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor-1 as an anti-cancer target: blocking transformation and inducing apoptosis
    • Wang Y., and Sun Y. Insulin-like growth factor receptor-1 as an anti-cancer target: blocking transformation and inducing apoptosis. Curr. Cancer Drug Targets 2 (2002) 191-207
    • (2002) Curr. Cancer Drug Targets , vol.2 , pp. 191-207
    • Wang, Y.1    Sun, Y.2
  • 177
    • 0037110602 scopus 로고    scopus 로고
    • Overexpression of the insulin-like growth factor I receptor in human colon carcinomas
    • Weber M.M., Fottner C., Liu S.B., Jung M.C., Engelhardt D., and Baretton G.B. Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. Cancer 95 (2002) 2086-2095
    • (2002) Cancer , vol.95 , pp. 2086-2095
    • Weber, M.M.1    Fottner, C.2    Liu, S.B.3    Jung, M.C.4    Engelhardt, D.5    Baretton, G.B.6
  • 178
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes-the Achilles heal of cancer
    • Weinstein I.B. Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 297 (2002) 63-64
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 179
    • 70350331904 scopus 로고    scopus 로고
    • BB, a novel epidermal growth factor receptor inhibitor
    • Wheeler D.L., and Dunn E.F. BB, a novel epidermal growth factor receptor inhibitor. Cancer Biol. Ther. 8 (2009) 1648-1650
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 1648-1650
    • Wheeler, D.L.1    Dunn, E.F.2
  • 180
    • 68449084677 scopus 로고    scopus 로고
    • The role of Src in solid tumors
    • Wheeler D.L., Iida M., and Dunn E.F. The role of Src in solid tumors. Oncologist 14 (2009) 667-678
    • (2009) Oncologist , vol.14 , pp. 667-678
    • Wheeler, D.L.1    Iida, M.2    Dunn, E.F.3
  • 181
    • 55749088393 scopus 로고    scopus 로고
    • Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
    • Wilhelm S.M., Adnane L., Newell P., Villanueva A., Llovet J.M., and Lynch M. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol. Cancer Ther. 7 (2008) 3129-3140
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3129-3140
    • Wilhelm, S.M.1    Adnane, L.2    Newell, P.3    Villanueva, A.4    Llovet, J.M.5    Lynch, M.6
  • 182
    • 69549147378 scopus 로고    scopus 로고
    • A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: results of NSABP Protocol C-08
    • (Abstract)
    • Wolmark N., Yothers G., O'Connell M.J., et al. A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: results of NSABP Protocol C-08. J. Clin. Oncol. 27 (2009) LBA4 (Abstract)
    • (2009) J. Clin. Oncol. , vol.27
    • Wolmark, N.1    Yothers, G.2    O'Connell, M.J.3
  • 183
    • 33846008439 scopus 로고    scopus 로고
    • Colorectal cancer: a model for epigenetic tumorigenesis
    • Wong J.J., Hawkins N.J., and Ward R.L. Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56 (2007) 140-148
    • (2007) Gut , vol.56 , pp. 140-148
    • Wong, J.J.1    Hawkins, N.J.2    Ward, R.L.3
  • 184
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • Wood J.M., Bold G., Buchdunger E., Cozens R., Ferrari S., Frei J., et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 60 (2000) 2178-2189
    • (2000) Cancer Res. , vol.60 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3    Cozens, R.4    Ferrari, S.5    Frei, J.6
  • 185
    • 0000201363 scopus 로고    scopus 로고
    • 6-Amino-4-(3-methyiphenylamino)-quinazoline: an EGF receptor tyrosine kinase inhibitor with activity in a range of human tumour xenografts
    • Woodburn J.R., Barker A.J., Wakeling A., et al. 6-Amino-4-(3-methyiphenylamino)-quinazoline: an EGF receptor tyrosine kinase inhibitor with activity in a range of human tumour xenografts. Proc. Am. Soc. Clin. Oncol. (1996) 390
    • (1996) Proc. Am. Soc. Clin. Oncol. , pp. 390
    • Woodburn, J.R.1    Barker, A.J.2    Wakeling, A.3
  • 186
    • 0035793091 scopus 로고    scopus 로고
    • Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
    • Xiao G.H., Jeffers M., Bellacosa A., Mitsuuchi Y., Van de Woude G.F., and Testa J.R. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc. Natl. Acad. Sci. (U.S.A.) 98 (2001) 247-252
    • (2001) Proc. Natl. Acad. Sci. (U.S.A.) , vol.98 , pp. 247-252
    • Xiao, G.H.1    Jeffers, M.2    Bellacosa, A.3    Mitsuuchi, Y.4    Van de Woude, G.F.5    Testa, J.R.6
  • 187
    • 70350225520 scopus 로고    scopus 로고
    • Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer
    • Xu L., Duda D.G., di Tomaso E., Ancukiewicz M., Chung D.C., Lauwers G.Y., et al. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res. 69 (2009) 7905-7910
    • (2009) Cancer Res. , vol.69 , pp. 7905-7910
    • Xu, L.1    Duda, D.G.2    di Tomaso, E.3    Ancukiewicz, M.4    Chung, D.C.5    Lauwers, G.Y.6
  • 188
    • 69049085535 scopus 로고    scopus 로고
    • Phase I, dose escalation and pharmacokinetic study of cediranib (RECENTIN), a highly potent and selective VEGFR signaling inhibitor, in Japanese patients with advanced solid tumors
    • Yamamoto N., Tamura T., Yamamoto N., et al. Phase I, dose escalation and pharmacokinetic study of cediranib (RECENTIN), a highly potent and selective VEGFR signaling inhibitor, in Japanese patients with advanced solid tumors. Cancer Chemother. Pharmacol. 64 (2009) 1165-1172
    • (2009) Cancer Chemother. Pharmacol. , vol.64 , pp. 1165-1172
    • Yamamoto, N.1    Tamura, T.2    Yamamoto, N.3
  • 189
    • 43949111293 scopus 로고    scopus 로고
    • c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases
    • Zeng Z.S., Weiser M.R., Kuntz E., Chen C.T., Khan S.A., Forslund A., et al. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Lett. 265 (2008) 258-269
    • (2008) Cancer Lett. , vol.265 , pp. 258-269
    • Zeng, Z.S.1    Weiser, M.R.2    Kuntz, E.3    Chen, C.T.4    Khan, S.A.5    Forslund, A.6
  • 190
    • 58249116119 scopus 로고    scopus 로고
    • Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp
    • Zhang Y., Laterra J., and Pomper M.G. Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. Neoplasia 11 (2009) 96-101
    • (2009) Neoplasia , vol.11 , pp. 96-101
    • Zhang, Y.1    Laterra, J.2    Pomper, M.G.3


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