Effect of ancillary ligands on the topoisomerases II and transcription inhibition activity of polypyridyl ruthenium(II) complexes

Journal of Inorganic Biochemistry

Volumn 104, Issue 5, 2010, Pages 576-582

  Chen, Xing ^a   Gao, Feng ^a   Zhou, Zhu Xin ^a   Yang, Wei Yan ^a   Guo, Li Tian ^a   Ji, Liang Nian ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

DFT TDDFT calculations; DNA binding; Ruthenium(II) complexes; Topoisomerase inhibition; Transcription inhibition

Indexed keywords

ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); RNA POLYMERASE; RUTHENIUM (4,4' DIMETHYL 2,2' BIPYRIDINE)(PTERIDINOL[6,7 F][1,10]PHENANTHROLINE) 1,13(10H,12H)DIONE; RUTHENIUM (4,7 DIPHENYL 1,10 PHENANTHROLINE)(PTERIDINOL[6,7 F][1,10]PHENANTHROLINE) 1,13(10H,12H)DIONE; RUTHENIUM (5,5' DIMETHYL 2,2' BIPYRIDINE)(PTERIDINOL[6,7 F][1,10]PHENANTHROLINE) 1,13(10H,12H)DIONE; RUTHENIUM (IMIDAZOLE[4,5 F][1,10]PHENANTHROLINE)(PTERIDINOL[6,7 F][1,10]PHENANTHROLINE) 1,13(10H,12H)DIONE; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CALCULATION; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DNA DENATURATION; DNA TRANSCRIPTION; DRUG DESIGN; DRUG DNA BINDING; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENERGY YIELD; ENZYME ACTIVITY; ENZYME INHIBITION; HEAT TREATMENT; HYDROPHOBICITY; LIGAND BINDING; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM CHEMISTRY; TRANSCRIPTION TERMINATION; ULTRAVIOLET SPECTROSCOPY; VISCOSITY;

ANIMALS; CATTLE; DNA; DNA TOPOISOMERASES, TYPE II; DNA-DIRECTED RNA POLYMERASES; HUMANS; LIGANDS; MOLECULAR STRUCTURE; NUCLEIC ACID DENATURATION; RUTHENIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; VIRAL PROTEINS;

EID: 77950689712     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2010.01.010     Document Type: Article

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