Antitumor Agents. 3. Design, Synthesis, and Biological Evaluation of New Pyridoisoquinolindione and Dihydrothienoquinolindione Derivatives with Potent Cytotoxic Activity

Journal of Medicinal Chemistry

Volumn 47, Issue 4, 2004, Pages 849-858

  Bolognese, Adele ^a   Correale, Gaetano ^a   Manfra, Michele ^a   Lavecchia, Antonio ^a   Mazzoni, Orazio ^a   Novellino, Ettore ^a   La Colla, Paolo ^b   Sanna, Giuseppina ^b   Loddo, Roberta ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 BROMOPHENYL) 3 ETHOXYCARBONYLPYRIDO[2,3 G]ISOQUINOLINE 5,10 DIONE; 1 (4 CHLOROPHENYL) 3 ETHOXYCARBONYLPYRIDO[2,3 G]ISOQUINOLINE 5,10 DIONE; 1 (4 NITROPHENYL) 3 ETHOXYCARBONYLPYRIDO[2,3 G]ISOQUINOLINE 5,10 DIONE; 3 AMINO 3 ETHOXYCARBONYLDIHYDROTHIENO[2,3 G]QUINOLINE 4,9 DIONE; 3 ETHOXYCARBONYLPYRIDO[2,3 G]ISOQUINOLINE 5,10 DIONE; ANTINEOPLASTIC AGENT; DIHYDROTHIENOQUINOLINEDIONE DERIVATIVE; DOUBLE STRANDED DNA; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DIELS ALDER REACTION; DRUG DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICHAEL ADDITION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE, TUMOR; DNA; DRUG DESIGN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; INTERCALATING AGENTS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 0842325923     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030918b     Document Type: Article

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