Inhibition of topoisomerases by antitumor prostaglandins

Bioscience, Biotechnology and Biochemistry

Volumn 62, Issue 10, 1998, Pages 2073-2075

  Suzuki, Keitarou ^a   Shono, Fumiko ^a   Uyeda, Masaru ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Antitumor; Inhibition; Prostaglandin; Topoisomerase

Indexed keywords

ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; PROSTAGLANDIN;

ARTICLE; DRUG ANTAGONISM; ENZYMOLOGY; FEMALE; HUMAN; IC 50; PLACENTA;

ANTINEOPLASTIC AGENTS; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; PLACENTA; PROSTAGLANDINS;

EID: 0032176019     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.62.2073     Document Type: Article

References (22)

1. 2 in vitro and in vivo. Cancer Res, 46, 3538-3542 (1986).
2. 2. Gynecologic Oncology, 41, 36-40 (1991).
3. Ohno, K., Fukushima, M., Fujiwara, M., and Narumiya, S., Induction of 68,000-dalton heat shock proteins by cyclopentenone prostaglandins: Its association with prostaglandin-induced G1 block in cell cycle progression. J. Biol. Chem., 263, 19764-19770 (1988).
4. Ohno, K., Sakai, T., Fukushima, M., Narumiya, S., and Fujiwara, M., Site and mechanism of growth inhibition by prostaglandins: IV: Effect of cyclopentenone prostaglandins on cell cycle progression of G1-enriched HeLa S3 cells. J. Pharmacol. Exp. Ther., 245, 294-298 (1988).
5. 2 is a ligand for the adipocyte determination factor PPAR gamma. Cell, 83, 803-812 (1995).
6. 2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation. J. Biol. Chem., 271, 9376-9383 (1996).
7. 2-mediated apoptosis of human colorectal carcinoma cells. Mol. Cell. Biol, 16, 6654-6650 (1996).
8. 2 in human Pl-21 myeloid leukemia and RC-K8 pre-B lymphoma cells. Prostaglandins, 52, 143-156 (1996).
9. Rossi, A., Elia, G., and Santoro, M. G., Inhibition of nuclear factor kappa B by prostaglandin Aj: an effect associated with heat shock transcription factor activation. Proc. Natl. Acad. Sci. U.S.A., 94, 746-750 (1997).
10. Suzuki, M., Mori, M., Niwa, T., Hirata, R., Furuta, K., Ishikawa, T., and Noyori, R., Chemical implications for antitumor and antiviral prostaglandins: reaction of zl^prostaglandin Ai and prostaglandin A] methyl esters with thiols. J. Am. Chem. Soc., 119, 2376-2385 (1997).
11. Suzuki, K., Siddique, T., Nishimura, H., Sekimoto, J., and Uyeda, M., Inhibition of DNA topoisomerases by microbial inhibitors. J. Enz, Inhib., 13, 41-55 (1998).
12. Suzuki, K., Sekimoto, J., Siddique, T., Kamiya, A., and Uyeda, M., Macrostatin, a novel macromolecular inhibitor of topoisomerases produced by Streptomyces avermitilis No. C-127. J. Enz. Inhib. (1998) in press.
13. Wang, J. C., DNA topoisomerases. Annu. Rev. Biochem., 54, 665-697 (1985).
14. D’Arpa, P., and Liu, L.F., Topoisomerase-targeting antitumor drugs. Biochim. Biophys. Acta, 989, 163-177 (1989).
15. Liu, L. F., DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58, 351-357 (1989).
16. Ferro, A. M., and Olivera, B. M., Poly (ADP-ribosylation) of DNA topoisomerase I from calf thymus. J. Biol. Chem., 259, 547-554 (1984).
17. Schomburg, U., and Grosse, F., Purification and characterization of DNA topoisomerase II from calf thymus associated with polypeptides of 175 and 150 kDa. Eur. J. Biochem., 160, 451-457 (1986).
18. Fukushima, M., and Kato, T., “Icosanoids and Cancer”, eds. Thaler-Dao, H., Crastes de Paulet, A., and Paoletti, R., Raven Press, New York, p. 275-289 (1984).
19. 2 formed in human plasma. Proc. Natl. Acad. Sci. U.S.A., 81, 1317-1321 (1984).
20. 2-induced growth inhibition. Biochem. Biophys. Res. Commun., 139, 808-815 (1986).
21. 2 exerting cell growth inhibition. Biochem. Biophys. Res. Commun., 127, 739-745 (1985).
22. 2, antitumor and antiviral activities and the mechanisms involved. Eicosanoids, 3, 189-199 (1990).