Active site mapping of yeast Aspartyl-tRNA synthetase by in vivo selection of enzyme mutations lethal for cell growth

Journal of Molecular Biology

Volumn 288, Issue 2, 1999, Pages 231-242

  Ador, Laurent ^a   Camasses, Alain ^b   Erbs, Philippe ^c   Cavarelli, Jean ^d   Moras, Dino ^d   Gangloff, Jean ^a   Eriani, Gilbert ^a  

^a CNRS   (France)

^b IPCB   (France)

^c IRCAD   (France)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Aminoacyl tRNA synthetase; Genetic selection; Structure function relationships; tRNA discrimination

Indexed keywords

ADENOSINE TRIPHOSPHATE; ASPARTATE TRANSFER RNA LIGASE; DIMER;

ARTICLE; CELL GROWTH; ENZYME ACTIVE SITE; GENETIC CONSERVATION; LETHAL MUTANT; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; YEAST;

EID: 0033617251     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.2679     Document Type: Article

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