Carbonic anhydrase inhibitors: Bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII

Journal of Medicinal Chemistry

Volumn 51, Issue 11, 2008, Pages 3230-3237

  D'Ambrosio, Katia ^a   Vitale, Rosa Maria ^b   Dogné, Jean Michel ^c   Masereel, Bernard ^c   Innocenti, Alessio ^d   Scozzafava, Andrea ^d   De Simone, Giuseppina ^a   Supuran, Claudiu T ^d  

^a CNR   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF NAMUR   (Belgium)

^d UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITRO BENZENESULFONAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; NITRO DERIVATIVE; SULFONAMIDE;

ARTICLE; CRYSTAL STRUCTURE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HYPOXIA; MOLECULAR DYNAMICS; MOLECULAR MODEL; REDUCTION; SEQUENCE ALIGNMENT; TUMOR; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASMS; NITRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 44949169465     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800121c     Document Type: Article

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