Progress in phage display: Evolution of the technique and its applications

Cellular and Molecular Life Sciences

Volumn 67, Issue 5, 2010, Pages 749-767

  Bratkovič, Tomaž ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Library design selection strategy; Phage display molecular evolution library screening

Indexed keywords

ADALIMUMAB; ECALLANTIDE; POLYPEPTIDE; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA; PEPTIDE LIBRARY;

AMINO TERMINAL SEQUENCE; BACTERIOPHAGE; CARBOXY TERMINAL SEQUENCE; CODON; EUKARYOTIC CELL; GENETIC TRANSFORMATION; GENETIC VARIABILITY; HOMOLOGOUS RECOMBINATION; IMMUNOGENICITY; INTRON; MOLECULAR EVOLUTION; OPEN READING FRAME; PHAGE DISPLAY; PROCESS OPTIMIZATION; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; TRANSLATION INITIATION; VIRION; VIRUS CAPSID; VIRUS INFECTIVITY; ANIMAL; BIOLOGICAL MODEL; COMBINATORIAL CHEMISTRY; EVALUATION; HIGH THROUGHPUT SCREENING; HUMAN; METHODOLOGY; MOLECULAR CLONING; PHARMACEUTICS; PRODUCTIVITY;

BACTERIA (MICROORGANISMS); MIRIDAE;

ANIMALS; BIOPHARMACEUTICS; CLONING, MOLECULAR; COMBINATORIAL CHEMISTRY TECHNIQUES; EFFICIENCY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, BIOLOGICAL; PEPTIDE LIBRARY;

EID: 77949886815     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0192-2     Document Type: Review

References (159)

1. Pennazio S (2006) The origin of phage virology. Riv Biol 99:103-129
2. Sulakvelidze A, Alavidze Z, Morris JG Jr (2001) Bacteriophage therapy. Antimicrob Agents Chemother 45:649-659
3. 3. Maniatis T, Hardison RC, Lacy E, Lauer J, O'Connell C, Quon D, Sim GK, Efstratiadis A (1978) The isolation of structural genes from libraries of eucaryotic DNA. Cell 15:687-701 (Pubitemid 9052436)
4. 4. Sargent TD, Wu JR, Sala-Trepat JM, Wallace RB, Reyes AA, Bonner J (1979) The rat serum albumin gene: analysis of cloned sequences. Proc Natl Acad Sci USA 76:3256-3260 (Pubitemid 9233268)
5. Zacher AN 3rd, Stock. CA, Golden JW 2nd, Smith GP (1980) A new filamentous phage cloning vector: fd-tet. Gene 9:127-140
6. 6. Hines JC, Ray DS (1980) Construction and characterization of new coliphage M.1.3 cloning vectors. Gene 1.1:207-218 (Pubitemid 11215344)
7. Kay BK, Winter J, McCafferty J (eds) (1996) Phage display of peptides and proteins. A laboratory manual. Academic, San Diego
8. Barbas CFI, Burton DR, Scott JK, Silverman GJ (eds) (2001) Phage display. A laboratory manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
9. Clackson T, Lowman HB (eds) (2004) Phage display. A practical approach. Oxford University Press, New York
10. Sidhu SS (ed) (2005) Phage display in biotechnology and drug discovery. CRC, Boca Raton
11. Aitken R (ed) (2009) Antibody Phage Display. Methods and Protocols. Humana, New York
12. 12. Yan X, Xu Z (2006) Ribosome-display technology: applications for directed evolution of functional proteins. Drug Discov Today 11:911-916 (Pubitemid 44425429)
13. Lipovsek D, Pluckthun A (2004) In vitro protein evolution by ribosome display and mRNA display. J Immunol Methods 290:51-67
14. Daugherty PS (2007) Protein engineering with bacterial display. Curr Opin Struct Biol 17:474-480
15. Pepper LR, Cho YK, Boder ET, Shusta EV (2008) A decade of yeast surface display technology: where are we now? Comb Chem High Throughput Screen 11:127-134
16. Ho M, Pastan I (2009) Mammalian cell display for antibody engineering. Methods MoI Biol 525:337-352 xiv
17. Makela AR, Oker-Blom C (2008) The baculovirus display technology-an evolving instrument for molecular screening and drug delivery. Comb Chem High Throughput Screen 11:86-98
18. Michelfelder S, Lee MK, de Lima-Hahn E, Wilmes T, Kaul F, Muller O, Kleinschmidt JA, Trepei M (2007) Vectors selected from adeno-associated viral display peptide libraries for leukemia cell-targeted cytotoxic gene therapy. Exp Hematol 35:1766-1776
19. Smith GP (1985) Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228:1315-1317
20. Bass S, Greene R, Wells JA (1990) Hormone phage: an enrichment method for variant proteins with altered binding properties. Proteins 8:309-314
21. Russel M, Lowman HB, Clackson T (2004) Introduction to phage biology and phage display. In: Clackson T, Lowman HB (eds) Phage display. A practical approach, vol 266. Oxford University Press, New York, pp 1-26
22. Smith GP (1993) Preface. Surface display and peptide libraries. Gene 128:1-2
23. Smith GP, Petrenko VA (1997) Phage display. Chem Rev 97:391-410
24. 24. Nanduri V, Sorokulova IB, Samoylov AM, Simonian AL, Petrenko VA, Vodyanoy V (2007) Phage as a molecular recognition element in biosensors immobilized by physical adsorption. Biosens Bioelectron 22:986-992 (Pubitemid 44894884)
25. 25. Crameri R, Suter M (1993) Display of biologically active proteins on the surface of filamentous phages: a cDNA cloning system for selection of functional gene products linked to the genetic information responsible for their production. Gene 137:69-75 (Pubitemid 24053734)
26. 26. Crameri R, Jaussi R, Menz G, Blaser K (1994) Display of expression products of cDNA libraries on phage surfaces. A versatile screening system for selective isolation of genes by specific gene-product/Iigand interaction. Eur J Biochem 226:53-58 (Pubitemid 24348668)
27. 27. Faix PH, Burg MA, Gonzales M, Ravey EP, Baird A, Larocca D (2004) Phage display of cDNA libraries: enrichment of cDNA expression using open reading frame selection. .Biotechniques 36:1018-1029 (Pubitemid 38747366)
28. Jespers LS, Messens JH, De Keyser A, Eeckhout D, Van den Brande I, Gansemans YG, Lauwereys MJ, Vlasuk GP, Stanssens PE (1995) Surface expression and ligand-based selection of cDNAs fused to filamentous phage gene VI. Biotechnology (N Y) 13:378-382
29. Fuh G, Sidhu SS (2000) Efficient phage display of polypeptides fused to the carboxy-terminus of the Ml3 gene-3 minor coat protein. FEBS Lett 480:231-234
30. 30. Fuh G, Pisabarro MT, Li Y, Quan C, Lasky LA, Sidhu SS (2000) Analysis of PDZ domain-ligand interactions using carboxylterminal phage display. J Biol Chem 275:21486-21491 (Pubitemid 30481852)
31. Gramatikoff K, Georgiev O, Schaffner W (1994) Direct interaction rescue, a novel filamentous phage technique to study protein-protein interactions. Nucleic Acids Res 22:5761-5762
32. 32. Krebber C, Spada S, Desplancq D, Pluckthun A (1995) Coselection of cognate antibody-antigen pairs by selectivelyinfective phages. FEBS Lett 377:227-231 (Pubitemid 26015073)
33. 33. Fields S, Song O (1989) A novel genetic system to detect protein-protein interactions. Nature 340:245-246 (Pubitemid 19171591)
34. Legrain P, Selig L (2000) Genome-wide protein interaction maps using two-hybrid systems. FEBS Lett 480:32-36
35. Miller J, Stagljar I (2004) Using the yeast two-hybrid system to identify interacting proteins. Methods MoI Biol 261:247-262
36. 36. Gao C, Mao S, Lo CH, Wirsching P, Lerner RA, Janda KD (1999) Making artificial antibodies: a format for phage display of combinatorial heterodimeric arrays. Proc Natl Acad Sci USA 96:6025-6030 (Pubitemid 29256613)
37. Gao C, Mao S, Kaufmann G, Wirsching P, Lerner RA, Janda KD (2002) A method for the generation of combinatorial antibody libraries using pIX phage display. Proc Natl Acad Sci USA 99:12612-12616
38. 38. Kwasnikowski P, Kristensen P, Markiewicz WT (2005) Multivalent display system on filamentous bacteriophage pVII minor coat protein. J Immunol Methods 307:135-143 (Pubitemid 41817274)
39. Weiss GA, Wells JA, Sidhu SS (2000) Mutational analysis of the major coat protein of M13 identifies residues that control protein display. Protein Sci 9:647-654
40. Weiss GA, Sidhu SS (2000) Design and evolution of artificial M13 coat proteins. J Mol Biol 300:213-219
41. Sidhu SS (2001) Engineering M13 for phage display. Biomol Eng 18:57-63
42. Roth TA, Weiss GA, Eigenbrot C, Sidhu SS (2002) A minimized Ml3 coat protein defines the requirements for assembly into the bacteriophage particle. J Mol Biol 322:357-367
43. Held HA, Sidhu SS (2004) Comprehensive mutational analysis of the M13 major coat protein: improved scaffolds for C-terminal phage display. J Mol Biol 340:587-597
44. Sidhu SS, Feld BK, Weiss GA (2007) M.1.3 bacteriophage coat proteins engineered for improved phage display. Methods Mol Biol 352:205-219
45. Krumpe LR, Atkinson AJ, Smythers GW, Kandel A, Schumacher KM, McMahon JB, Makowski L, Mori T (2006) T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries. Proteomics 6:4210-4222
46. Rosenberg A, Griffin K, Studier FW, MeCormick M, Berg J, Novy R, Mierendorf R (1996) T7Select phage display system: a powerful new protein display system based on bacteriophage T7. Innovations 6:1-6
47. Iwasaki K, Trus BL, Wingfield PT, Cheng N, Campusano G, Rao VB, Steven AC (2000) Molecular architecture of bacteriophage T4 capsid: vertex structure and bimodal binding of the stabilizing accessory protein. Soc Virol 271:321-333
48. Ren ZJ, Lewis GK, Wingfield PT, Locke EG, Steven AC, Black LW (1996) Phage display of intact domains at high copy number: a system based on SOC, the small outer capsid protein of bacteriophage T4. Protein Sci 5:1833-1843
49. 49. Ren Z, Black LW (1998) Phage T4 SOC and HOC display of biologically active, full-length proteins on the viral capsid. Gene 215:439-444 (Pubitemid 28382947)
50. Ren ZJ, Baumann RG, Black LW (1997) Cloning of linear DNAs in vivo by overexpressed T4 DNA ligase: construction of a T4 phage hoc gene display vector. Gene 195:303-311
51. Shivachandra SB, Li Q, Peachman KK, Maty as GR, Leppla SH, Alving CR, Rao M, Rao VB (2007) Multicomponent anthrax toxin display and delivery using bacteriophage T4. Vaccine 25:1225-1235
52. 52. Li Q, Shivachandra SB, Leppla SH, Rao VB (2006) Bacteriophage T4 capsid: a unique platform, for efficient surface assembly of macromolecular complexes. J Mol Biol 363:577-588 (Pubitemid 44436261)
53. Efimov VP, Nepluev IV, Mesyanzhinov VV (1995) Bacteriophage T4 as a surface display vector. Virus Genes 10:173-177
54. 54. Hoess RH (2002) Bacteriophage lambda as a vehicle for peptide and protein display. Curr Pharm Biotechnol 3:23-28 (Pubitemid 34233032)
55. Sternberg N, Hoess RH (1995) Display of peptides and proteins on the surface of bacteriophage lambda. Proc Natl Acad Sci USA 92:1609-1613
56. 56. Mikawa YG, Maruyama IN, Brenner S (1996) Surface display of proteins on bacteriophage lambda heads. J MoI Biol 262:21-30 (Pubitemid 26315989)
57. 57. Maruyama IN, Maruyama HI, Brenner S (1994) Lambda foo: a lambda phage vector for the expression of foreign proteins. Proc Natl Acad Sci USA 91:8273-8277 (Pubitemid 2126245)
58. Dunn IS (1996) Total modification of the bacteriophage lambda tail tube major subunit protein with foreign peptides. Gene 183:15-21
59. Marks JD, Hoogenboom HR, Bonnert TP, McCafferty J, Griffiths AD, Winter G (1991) By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J Mol Biol 222:581-597
60. Barbas CF 3rd, Kang AS, Lerner RA, Benkovic SJ (1991) Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci USA 88:7978-7982
61. 61. Hoogenboom HR, Griffiths AD, Johnson KS, Chiswell DJ, Hudson P, Winter G (1991) Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acids Res 19:4133-4137 (Pubitemid 21912784)
62. 62. Waterhouse P, Griffiths AD, Johnson KS, Winter G (1993) Combinatorial infection and in vivo recombination: a strategy for making large phage antibody repertoires. Nucleic Acids Res 21:2265-2266 (Pubitemid 23160762)
63. Sternberg N, Hamilton D (1981) Bacteriophage Pl site-specific recombination. I. Recombination between loxP sites. J Mol Biol 150:467-486
64. 64. Tsurushita N, Fu H, Warren C (1996) Phage display vectors for in vivo recombination of immunoglobulin heavy and light chain genes to make large combinatorial libraries. Gene 172:59-63 (Pubitemid 26175769)
65. Griffiths AD, Williams SC, Hartley O, Tomlinson IM, Waterhouse P, Crosby WL, Kontermann RE, Jones PT, Low NM, Allison TJ, Prospero TD, Hoogenboom HR, Nissim A, Cox JPL, Harrison JL, Zaceolo M, Gherardi E, Winter G (1994) Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J 13:3245-3260
66. 66. Zahra DG, Vancov T, Dunn JM, Hawkins NJ, Ward RL (1999) Selectable in vivo recombination to increase antibody library size-an improved phage display vector system. Gene 227:49-54 (Pubitemid 29071230)
67. Geoffroy F, Sodoyer R, Aujame L (1994) A. new phage display system to construct multicombinatorial libraries of very large antibody repertoires. Gene 151:109-113
68. 68. Sblattero D, Bradbury A (2000) Exploiting recombination in single bacteria to make large phage antibody libraries. Nat Biotechnol 18:75-80 (Pubitemid 30041177)
69. 69. Cen X, Bi Q, Zhu S (2006) Construction of a large phage display antibody library by in vitro package and in vivo recombination. Appl Microbiol Biotechnol 71:767-772 (Pubitemid 44114804)
70. Collins J, Rottgen P (1997) Generation of diversity in combinatorial libraries. EP 9710539.1 (WO 98/33901)
71. 71. Collins J, Horn N, Wadenback J, Szardenings M (2001) Cosmixplexing: a novel recombinatorial approach for evolutionary selection from combinatorial libraries. J Biotechnol 74:317-338 (Pubitemid 34179621)
72. Fisch I, Kontermann RE, Finnern R, Hartley O, Soler-Gonzalez AS, Griffiths AD, Winter G (1996) A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage. Proc Natl. Acad Sci USA. 93:7761-7766
73. Chasteen L, Ayriss J, Pavlik P, Bradbury AR (2006) Eliminating helper phage from phage display. Nucleic Acids Res 34:el45
74. 74. Krebber A, Burmester J, Pluckthun A (1996) Inclusion of an upstream transcriptional terminator in phage display vectors abolishes background expression of toxic fusions with coat protein g3p. Gene 178:71-74 (Pubitemid 26377131)
75. Beekwilder J, Rakonjac J, Jongsma M, Bosch D (1999) A phagemid vector using the E. coli phage shock promoter facilitates phage display of toxic proteins. Gene 228:23-31
76. 76. Jestin JL, Volioti G, Winter G (2001) Improving the display of proteins on filamentous phage. Res Microbiol 152:187-191 (Pubitemid 32222965)
77. 77. Kristensen P, Winter G (1998) Proteolytic selection for protein folding using filamentous bacteriophages. Fold Des 3:321-328 (Pubitemid 28494097)
78. 78. Rondot S, Koch J, Breitling F, Dubel S (2001) A helper phage to improve single-chain antibody presentation in phage display. Nat Biotechnol 19:75-78 (Pubitemid 32051961)
79. Kramer RA, Cox F, van der Horst M, van der Oudenrijn S, Res PC, Bia J, Logtenberg T, de Kruif J (2003) A novel helper phage that improves phage display selection efficiency by preventing the amplification of phages without recombinant protein. Nucleic Acids Res 31:e59
80. Baek H, Suk KH, Kim YH, Cha S (2002) An improved helper phage system for efficient isolation of specific antibody molecules in phage display. Nucleic Acids Res 30:el8
81. Soltes G, Barker H, Marmai K, Pun E, Yuen A, Wiersma EJ (2003) A new helper phage and phagemid vector system improves viral display of antibody Fab fragments and avoids propagation of insert-less virions. J Immunol Methods 274:233-244
82. 82. Soltes G, Hust M, Ng KK, Bansal A, Field J, Stewart DI, Dubel S, Cha S, Wiersma EJ (2007) On the influence of vector design on antibody phage display. J Biotechnol 127:626-637 (Pubitemid 44959123)
83. Olszewski A, Sato K, Aron ZD, Cohen F, Harris A, McDougall BR, Robinson WE Jr, Overman LE, Weiss GA (2004) Guanidine alkaloid analogs as inhibitors of HIV-I Nef interactions with p53, actin, and p561ck. Proc Natl. Acad Sci USA 101:14079-14084
84. Majumdar S, Hajduczki A, Mendez AS, Weiss GA (2008) Phage display of functional, full-length human and viral membrane proteins. Bioorg Med Chem Lett 18:5937-5940
85. van Houten NE, Zwick MB, Menendez A, Scott JK (2006) Filamentous phage as an immunogenic carrier to elicit focused antibody responses against a synthetic peptide. Vaccine 24:4188-4200
86. Zanghi CN, Lankes HA, Bradel-Tretheway B, Wegman J, Dewhurst S (2005) A simple method for displaying recalcitrant proteins on the surface of bacteriophage lambda. Nucleic Acids Res 33:el60
87. 87. Tian F, Tsao ML, Schultz PG (2004) A phage display system with unnatural amino acids. J Am Chem Soc 126:15962-15963 (Pubitemid 39627597)
88. Sandman KE, Benner JS, Noren CJ (2000) Phage display of selenopeptides. J Am Chem Soc 122:960-961
89. 89. Meyer SC, Shomin CD, Gaj T, Ghosh I (2007) Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor of protein kinase A. J Am Chem Soc 129:13812-13813 (Pubitemid 350106063)
90. 90. Woiwode TF, Haggerty JE, Katz R, Gallop MA, Barrett RW, Dower WJ, Cwirla SE (2003) Synthetic compound libraries displayed on the surface of encoded bacteriophage. Chem Biol 10:847-858 (Pubitemid 37171902)
91. 91. Dwyer MA, Lu W, Dwyer JJ, Kossiakoff AA (2000) Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity. Chem Biol 7:263-274 (Pubitemid 30199615)
92. 92. El Zoeiby A, Sanschagrin F, Darveau A, Brisson JR, Levesque RC (2003) Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries. J Antimicrob Chemother 51:531-543 (Pubitemid 36336145)
93. 93. D'Mello F, Howard CR (2001) An improved selection procedure for the screening of phage display peptide libraries. J Immunol Methods 247:191-203 (Pubitemid 32057056)
94. 94. Lunder M, Bratkovic T, Kreft S, Strukelj B (2005) Peptide inhibitor of pancreatic lipase selected by phage display using different elution strategies. J Lipid Res 46:1512-1516 (Pubitemid 43109816)
95. 95. Yu H, Dong X, Sun Y (2004) An alternating elution strategy for screening high affinity peptides from a phage display library. Biochem Eng J 18:169-175 (Pubitemid 38581201)
96. 96. Zhuang G, Katakura Y, Furuta T, Omasa T, Kishimoto M, Suga K (2001) A kinetic model for a biopanning process considering antigen desorption and effective antigen concentration on a solid phase. J Biosci Bioeng 91:474-481 (Pubitemid 32565182)
97. Kretzschmar T, Zimmermann C, Geiser M (1995) Selection procedures for nonmatured phage antibodies: a quantitative comparison and optimization strategies. Anal Biochem 224:413-419
98. 98. Lunder M, Bratkovic T, Urleb U, Kreft S, Strukelj B (2008) Ultrasound in phage display: a new approach to nonspecific elution. Biotechniques 44:893-900 (Pubitemid 352007364)
99. 99. Malmborg AC, Duenas M, Ohlin M, Soderlind E, Borrebaeck CA (1996) Selection of binders from phage displayed antibody libraries using the BIAcore biosensor. J Immunol Methods 198:51-57 (Pubitemid 26348917)
100. Yuan B, Schulz P, Sierks M-R (2006) Improved affinity selection using phage display technology and off-rate based selection. Electron J Biotechnol 9:171-175
101. 101. Matsubara T, Ishikawa D, Taki T, Okahata Y, Sato T (1999) Selection of ganglioside GMl-binding peptides by using a phage library. FEBS Lett 456:253-256 (Pubitemid 29352303)
102. 102. Takakusagi Y, Takakusagi K, Kuramochi K, Kobayashi S, SugawaraF, Sakaguchi K (2007) Identification of ClO biotinylated camptothecin (CFT-IO-B) binding peptides using T7 phage display screen on a QCM device. Bioorg Med Chem 15:7590-7598 (Pubitemid 47575926)
103. 103. Vanhercke T, Ampe C, Tirry L, Denolf P (2005) Rescue and in situ selection and evaluation (RISE): a method for highthroughput panning of phage display libraries. J Biomol Screen 10:108-117 (Pubitemid 40503497)
104. 104. Hogan S, Rookey K, Ladner R (2005) URSA: ultra rapid selection of antibodies from an antibody phage display library. Biotechniques 38:536-538 (Pubitemid 40529426)
105. Morohashi K, Arai T, Saito S, Watanabe M, Sakaguchi K, Sugawara F (2006) A high-throughput phage display screening method using a combination of real-time PCR and affinity chromatography. Comb Chem High Throughput Screen 9:55-61
106. Plieva FM, Galaev IY, Noppe W, Mattiasson B (2008) Cryogel applications in microbiology. Trends Microbiol 16:543-551
107. Noppe W, Plieva F, Galaev IY, Pottel H, Deckmyn H, Mattiasson B (2009) Chromato-panning: an efficient new mode of identifying suitable ligands from phage display libraries. BMC Biotechnol 9:21
108. 108. Castillo J, Goodson B, Winter J (2001) T7 displayed peptides as targets for selecting peptide specific scFvs from M 13 scFv display libraries. J Immunol Methods 257:117-122 (Pubitemid 33001239)
109. Wang WF, Cheng X, Molineux IJ (1999) Isolation and identification of fxsA, an Escherichia coli gene that can suppress F exclusion of bacteriophage T7. J Mol Biol 292:485-499
110. Bowley DR, Jones TM, Burton DR, Lemer RA (2009) Libraries against libraries for combinatorial selection of replicating antigen-antibody pairs. Proc Natl Acad Sci USA 106:1380-1385
111. Grøn H, Hyde-DeRuyscher R (2000) Peptides as tools in drug discovery. Curr Opin Drug Discov Dev 3:636-645
112. 112. Schumacher TN, Mayr LM, Minor DL Jr, Milhollen MA, Burgess MW, Kim PS (1996) Identification of D-peptide ligands through, mirror-image phage display. Science 271:1854-1857 (Pubitemid 3040965)
113. Hawinkels LJ, van Rossenberg SM, de Jonge-Muller ES, Molenaar TJ, Appeldoorn CC, van Berkel TJ, Sier CF, Biessen EA (2007) Efficient degradation-aided selection of protease inhibitors by phage display. Biochem Biophys Res Commun 364:549-555
114. 114. Rowley MJ, O'Connor K, Wijeyewickrema L (2004) Phage display for epitope determination: a paradigm for identifying receptor-ligand interactions. Biotechnol Annu Rev 10:151-188 (Pubitemid 39419992)
115. Schooltink H, Rose-John S (2005) Designing cytokine variants by phage-display. Comb Chem High Throughput Screen 8:173-179
116. Hoogenboom HR (2002) Overview of antibody phage-display technology and its applications. Methods Mol Biol 178:1-37
117. Conrad U, Scheller J (2005) Considerations on antibody-phage display methodology. Comb Chem High Throughput Screen 8:117-126
118. Skerra A (2007) Alternative non-antibody scaffolds for molecular recognition. Curr Opin Biotechnol 18:295-304
119. Gronwall C, Stahl S (2009) Engineered affinity proteins-generation and applications. J Biotechnol 140:254-269
120. 120. Deperthes D (2002) Phage display substrate: a blind method for determining protease specificity. Biol Chem 383:1107-1112 (Pubitemid 35215055)
121. 121. Sedlaček R, Chen E (2005) Screening for protease substrate by polyvalent phage display. Comb Chem High Throughput Screen 8:197-203 (Pubitemid 40388745)
122. Kay BK, Hamilton PT (2001) Identification of enzyme inhibitors from phage-displayed combinatorial peptide libraries. Comb Chem High Throughput Screen 4:535-543
123. Sidhu SS, Koide S (2007) Phage display for engineering and analyzing protein interaction interfaces. Curr Opin Struct Biol 17:481-487
124. Hertveldt K, Belien T, Volckaert G (2009) General M 13 phage display: Ml3 phage display in identification and characterization of protein-protein interactions. Methods Mol Biol 502:321-339
125. 125. Fernandez-Gacio A, Uguen M, Fastrez J (2003) Phage display as a tool for the directed evolution of enzymes. Trends Biotechnol 2.1:408-414 (Pubitemid 37025778)
126. Jung S, Honegger A, Pluckthun A (1999) Selection for improved protein stability by phage display. J MoI Biol 294:163-180
127. 127. Sergeeva A, Kolonin MG, Molldrem JJ, Pasqualini R, Arap W (2006) Display technologies: application for the discovery of drug and gene delivery agents. Adv Drug Deliv Rev 58:1622-1654 (Pubitemid 44830148)
128. Clonis YD (2006) Affinity chromatography matures as bioinformatic and combinatorial tools develop. J Chromatogr A 1101:1-24
129. Noppe W, Plieva FM, Vanhoorelbeke K, Deckmyn H, Tuncel M, Tuncel A, Galaev IY, Mattiasson B (2007) Macroporous monolithic gels, cryogels, with immobilized phages from phagedisplay library as a new platform for fast development of affinity adsorbent capable of target capture from crude feeds. J Biotechnol 131:293-299
130. Mao, C., Liu, A, and Cao, B, (2009) Virus-based chemical and biological sensing. Angew Chem Int Ed Engl 48:6790-6810
131. 131, De Berardinis P, Haigwood NL (2004) New recombinant vaccines based on the use of prokaryotic antigen-display systems. Expert Rev Vaccines 3:673-679
132. 132. Manoutcharian K, Gevorkian G, Cano A, Almagro JC (2001) Phage displayed biomolecules as preventive and therapeutic agents. Curr Pharm Biotechnol 2:217-223 (Pubitemid 32798797)
133. Lee SC, Ibdah R, Van Valkenburgh C, Rowold E, Abegg A, Donnelly A, Klover J, Merlin S, McKeam JP (2001) Phage display mutagenesis of the chimeric dual cytokine receptor agonist myelopoietin. Leukemia 15:1277-1285
134. McConnell SJ, Dinh T, Le MH, Brown SJ, Becherer K, BIumeyer K, Kautzer C, Axelrod F, Spinella DG (1998) Isolation of erythropoietin receptor agonist peptides using evolved phage libraries. Biol Chem 379:1279-1286
135. Hyde-DeRuyscher R, Paige LA, Christensen DJ, Hyde-DeRuyscher N, Lim A, Fredericks ZL, Kranz J, Gallant P, Zhang J, Rocklage SM, Fowlkes DM, Wendler PA, Hamilton PT (2000) Detection of small-molecule enzyme inhibitors with peptides isolated from phage-displayed combinatorial peptide libraries. Chem Biol 7:17-25
136. Monoclonal antibody therapeutics 2009-2024. Market report. Visiongain. 06/08/2009
137. Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495497
138. Bostrom J, Fuh G (2009) Design and construction of synthetic phage-displayed fab libraries. In: Aitken R (ed) Antibody phage display: methods and protocols, vol 562. Humana, New York, pp 1.7-35
139. Lonberg N (2008) Human monoclonal antibodies from transgenic mice. Handb Exp Pharmacol 69-97
140. 140. Jespers LS, Roberts A, Mahler SM, Winter G, Hoogenboom HR (1994) Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen. Biotechnology (N Y) 12:899-903 (Pubitemid 2122346)
141. 141, Lonberg N (2008) Fully human antibodies from, transgenic mouse and phage display platforms. Curr Opin Immunol 20:450-459
142. Williams A, Baird LG (2003) DX-88 and HAE: a developmental perspective. Transfus Apher Sci 29:255-258
143. Levy JH, O'Donnell PS (2006) The therapeutic potential of a kallikrein inhibitor for treating hereditary angioedema. Expert Opin Investig Drugs 15:1077-1090
144. Epstein TG, Bernstein JA (2008) Current and emerging management options for hereditary angioedema in the US. Drugs 68:2561-2573
145. Lehmann A (2008) Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery. Expert Opin Biol Ther 8:1187-1199
146. 146. Nizak C, Monier S, del Nery E, Moutel S, Goud B, Perez F (2003) Recombinant antibodies to the small GTPase Rab6 as conformation sensors. Science 300:984-987 (Pubitemid 36548886)
147. Gao J, Sidhu SS, Wells JA (2009) Two-state selection of conformation-specific antibodies. Proc Natl Acad Sei USA 106:3071-3076
148. Sakamoto K, Ito Y, Hatanaka T, Soni PB, Mori T, Sugimura K (2009) Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions. J Biol Chem 284:9986-9993
149. 149. Emadi S, Barkhordarian H, Wang MS, Schulz P, Sierks MR (2007) Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicity. J Mol Biol 368:1132-1144 (Pubitemid 46574670)
150. Emadi. S, Kasturirangan S, Wang MS, Schulz P, Sierks MR (2009) Detecting morphologically distinct oligomeric forms of alpha-synuclein. J Biol Chem 284:11048-11058
151. 151. Segal DJ, Dreier B, Beerli RR, Barbas CF 3rd (1999) Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences. Proc Natl Acad Sci USA 96:2758-2763 (Pubitemid 29148791)
152. Dreier B, Beerli RR, Segal DJ, Flippin JD, Barbas CF 3rd (2001) Development of zinc finger domains for recognition of the 5'ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem 276:29466-29478
153. Dreier B, Fuller RP, Segal DJ, Lund CV, Biancafort P, Huber A, Koksch B, Barbas CF 3rd (2005) Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem 280:35588-35597
154. Biancafort P, Magnenat L, Barbas CF 3rd (2003) Scanning the human genome with combinatorial transcription factor libraries. Nat Biotechnol 21:269-274
155. 155. Kriplani U, Kay BK (2005) Selecting peptides for use in nanoscale materials using phage-displayed combinatorial peptide libraries. Curr Opin Biotechnol 16:470-475 (Pubitemid 41114853)
156. Khoo X, Hamilton P, O'Toole GA, Snyder BD, Kenan DJ, Grinstaff MW (2009) Directed assembly of PEGylated-peptide coatings for infection-resistant titanium metal. J Am Chem Soc 131:10992-10997
157. Segvich SJ, Smith HC, Kohn DH (2009) The adsorption of preferential binding peptides to apatite-based materials. Biomaterials 30:1287-1298
158. Tomczak MM, Gupta MK, Drummy LF, Rozenzhak SM, Naik RR (2009) Morphological control and assembly of zinc oxide using a biotemplate. Acta Biomater 5:876-882
159. Nam KT, Wartena R, Yoo PJ, Liau FW, Lee YJ, Chiang YM, Hammond PT, Belcher AM (2008) Stamped microbattery electrodes based on self-assembled M13 viruses. Proc Natl Acad Sci USA 105:17227-17231