Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions

Journal of Biological Chemistry

Volumn 284, Issue 15, 2009, Pages 9986-9993

  Sakamoto, Kotaro ^a,d   Ito, Yuji ^a,c   Hatanaka, Takaaki ^a   Soni, Preeti Brijiral ^c   Mori, Toshiyuki ^b,e   Sugimura, Kazuhisa ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^e Takeda San Francisco   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC PH; AFFINITY COLUMN; AFFINITY LIGANDS; BIOCHEMICAL PROPERTIES; CONFORMATIONAL CHANGE; FC-RECEPTORS; FUNCTIONAL DAMAGE; HUMAN IGG; INCUBATION TIME; MODERATE TEMPERATURE; MONOMERIC FORMS; NEUTRAL PH; NON-NATIVE; PEPTIDE MOTIFS; PH CONDITION; PH TREATMENT; PHAGE DISPLAY LIBRARIES; PROTEIN A; THERAPEUTIC ANTIBODIES; VIRAL INACTIVATION;

ACIDS; ANTIBODIES; PH;

AMINES;

FC RECEPTOR; IMMUNOGLOBULIN G; PEPTIDE; LIGAND; PEPTIDE LIBRARY;

ANTIGEN BINDING; ARTICLE; BACTERIOPHAGE T7; BINDING AFFINITY; CHEMICAL ANALYSIS; CONTROLLED STUDY; INCUBATION TIME; NONHUMAN; PEPTIDE ANALYSIS; PH MEASUREMENT; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOLATION; PROTEIN MOTIF; RECEPTOR BINDING; TEMPERATURE MEASUREMENT; AMINO ACID SEQUENCE; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; MOLECULAR GENETICS; PH; SEQUENCE HOMOLOGY; TEMPERATURE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, FC; SEQUENCE HOMOLOGY, AMINO ACID; TEMPERATURE;

EID: 65649121533     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807618200     Document Type: Article

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