Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries

Journal of Antimicrobial Chemotherapy

Volumn 51, Issue 3, 2003, Pages 531-543

  El Zoeiby, Ahmed ^a   Sanschagrin, François ^a   Darveau, André ^a   Brisson, Jean Robert ^b   Levesque, Roger C ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

MurC; Peptide inhibitors; Phage display

Indexed keywords

4 THIAZOLIDINONE DERIVATIVE; ALANINE; AMINO ACID; ANTIINFECTIVE AGENT; BACITRACIN; BACTERIAL DNA; BACTERIAL ENZYME; BACTERIAL PROTEIN; BETA LACTAM; ENZYME INHIBITOR; LACTATE DEHYDROGENASE; LIGASE; LIGASE INHIBITOR; N ACETYLGLUCOSAMINE; PEPTIDE DERIVATIVE; PEPTIDE LIBRARY; PEPTIDOGLYCAN; PROTEIN MURA; PROTEIN MURB; PROTEIN MURC; PYRUVATE KINASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DNA DETERMINATION; DNA EXTRACTION; DNA SEQUENCE; DRUG IDENTIFICATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; EXPRESSION VECTOR; GENE OVEREXPRESSION; GENE TARGETING; IC 50; MASS SPECTROMETRY; MOLECULAR CLONING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PEPTIDE SYNTHESIS; PHAGE DISPLAY; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA;

AMINO ACID SEQUENCE; BACTERIOPHAGE M13; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; ESCHERICHIA COLI; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDE SYNTHASES; PSEUDOMONAS AERUGINOSA; SEQUENCE ANALYSIS, PROTEIN;

EID: 0037339206     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkg010     Document Type: Article

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