Peptides as tools in drug discovery

Current Opinion in Drug Discovery and Development

Volumn 3, Issue 5, 2000, Pages 636-645

  Gron, H ^a   Hyde DeRuyscher, R ^a  

^a Karo Bio USA   (United States)

Author keywords

Functional genomics; High throughput screening; Peptide; Phage display; Surrogate ligand; Target validation

Indexed keywords

ALCOHOL DEHYDROGENASE; BETA GLUCOSIDASE; CONCANAVALIN A; ESTROGEN RECEPTOR; GLYCOGEN PHOSPHORYLASE; HEXOKINASE; LIGAND; PEPTIDE; STREPTAVIDIN; SYNTHETASE;

CRYSTALLOGRAPHY; DRUG TARGETING; GENE; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHAGE DISPLAY; REVIEW; SCREENING;

EID: 0033778575     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (55)

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9. Convergent evolution with combinatorial peptides
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12. Modulation of Erm methyltransferase activity by peptides derived from phage display
13. Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site
14. Crystal structure of the complex between VEGF and a receptor-blocking peptide
15. Peptide exosite inhibitors of Factor VIIa as anticoagulants
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19. Screening of cyclic peptide phage libraries identifies ligands that bind streptavidin with high affinities
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21. A family of concanavalin A-binding peptides from a hexapeptide epitope library
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24. Comparative analyses of mechanistic differences among antiestrogens
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26. Protein clefts in molecular recognition and function
27. Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design
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38. Inhibition of Lyn function in mast cell activation by SH3 domain binding peptides
39. Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening
40. Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
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