메뉴 건너뛰기




Volumn 62, Issue 2, 2010, Pages 92-102

The T-box transcription factor Tbx2: Its role in development and possible implication in cancer

Author keywords

Cancer; Cell cycle; Embryonic development; Senescence; T box genes; Tbx2

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; COLLAGEN TYPE 1; PROTEIN TBX 2; PROTEIN TBX 3; PROTEIN TBX 4; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TBX5; UNCLASSIFIED DRUG; T BOX DOMAIN PROTEIN 2; T-BOX DOMAIN PROTEIN 2; TRANSCRIPTION FACTOR;

EID: 77949766590     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.275     Document Type: Review
Times cited : (95)

References (109)
  • 4
    • 0347417012 scopus 로고    scopus 로고
    • T-box genes in early embryogenesis
    • Showell, C., Binder, O., and Conlon, F. L. (2004) T-box genes in early embryogenesis. Dev. Dyn. 229, 201-218.
    • (2004) Dev. Dyn. , vol.229 , pp. 201-218
    • Showell, C.1    Binder, O.2    Conlon, F.L.3
  • 7
    • 0032510049 scopus 로고    scopus 로고
    • Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6
    • Chapman, D. L. and Papaioannou, V. E. (1998) Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature 391, 695-697.
    • (1998) Nature , vol.391 , pp. 695-697
    • Chapman, D.L.1    Papaioannou, V.E.2
  • 9
    • 0029165111 scopus 로고
    • The T protein encoded by Brachyury is a tissue-specific transcription factor
    • Kispert, A., Koschorz, B., and Herrmann, B. G. (1995) The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO J. 14, 4763-4772.
    • (1995) EMBO J. , vol.14 , pp. 4763-4772
    • Kispert, A.1    Koschorz, B.2    Herrmann, B.G.3
  • 10
    • 0035445835 scopus 로고    scopus 로고
    • Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome
    • Ghosh, T. K., Packham, E. A., Bonser, A. J., Robinson, T. E., Cross, S. J., and Brook, J. D. (2001) Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome. Hum. Mol. Genet. 10, 1983-1994.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1983-1994
    • Ghosh, T.K.1    Packham, E.A.2    Bonser, A.J.3    Robinson, T.E.4    Cross, S.J.5    Brook, J.D.6
  • 11
    • 0031812415 scopus 로고    scopus 로고
    • Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific trp-1 promoter
    • Carreira, S., Dexter, T. J., Yavuzer, U., Easty, D. J., and Goding, C. R. (1998) Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific trp-1 promoter. Mol. Cell. Biol. 18, 5099-5108.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5099-5108
    • Carreira, S.1    Dexter, T.J.2    Yavuzer, U.3    Easty, D.J.4    Goding, C.R.5
  • 12
    • 0037135545 scopus 로고    scopus 로고
    • The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator
    • Lingbeek, M. E., Jacobs, J. J. L., and van Lohuizen, M. (2002) The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator. J. Biol. Chem. 277, 26120-26127.
    • (2002) J. Biol. Chem. , vol.277 , pp. 26120-26127
    • Lingbeek, M.E.1    Jacobs, J.J.L.2    Van Lohuizen, M.3
  • 14
    • 0039706410 scopus 로고    scopus 로고
    • Crystallographic structure of the T-domain-DNA complex of the Brachyury transcription factor
    • Müller, C. W. and Herrmann, B. G. (1997) Crystallographic structure of the T-domain-DNA complex of the Brachyury transcription factor. Nature 389, 884-888.
    • (1997) Nature , vol.389 , pp. 884-888
    • Müller, C.W.1    Herrmann, B.G.2
  • 15
    • 0036120604 scopus 로고    scopus 로고
    • Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome
    • DOI 10.1016/S0969-2126(02)00722-0, PII S0969212602007220
    • Coll, M., Seidman, J. G., and Müller, C. W. (2002) Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome. Structure 10, 343-356. (Pubitemid 34230622)
    • (2002) Structure , vol.10 , Issue.3 , pp. 343-356
    • Coll, M.1    Seidman, J.G.2    Muller, C.W.3
  • 16
    • 0029831088 scopus 로고    scopus 로고
    • Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm
    • Conlon, F. L., Sedgwick, S. G., Weston, K. M., and Smith, J. C. (1996) Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm. Development 122, 2427-2435.
    • (1996) Development , vol.5122 , pp. 2427-2435
    • Conlon, F.L.1    Sedgwick, S.G.2    Weston, K.M.3    Smith, J.C.4
  • 18
    • 0037160529 scopus 로고    scopus 로고
    • Murine Tbx2 contains domains that activate and repress gene transcription
    • DOI 10.1016/S0378-1119(01)00878-2, PII S0378111901008782
    • Paxton, C., Zhao, H., Chin, Y., Langner, K., and Reecy, J. (2002) Murine Tbx2 contains domains that activate and repress gene transcription. Gene 283, 117-124. (Pubitemid 34178515)
    • (2002) Gene , vol.283 , Issue.1-2 , pp. 117-124
    • Paxton, C.1    Zhao, H.2    Chin, Y.3    Langner, K.4    Reecy, J.5
  • 19
    • 29144512222 scopus 로고    scopus 로고
    • A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
    • Murakami, M., Nakagawa, M., Olson, E. N., and Nakagawa, O. (2005) A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc. Natl. Acad. Sci. USA 102, 18034-18039.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 18034-18039
    • Murakami, M.1    Nakagawa, M.2    Olson, E.N.3    Nakagawa, O.4
  • 21
    • 0035937414 scopus 로고    scopus 로고
    • A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins
    • DOI 10.1016/S0092-8674(01)00282-3
    • Lamolet, B., Pulichino, A.-M., Lamonerie, T., Gauthier, Y., Brue, T., Enjalbert, A., and Drouin, J. (2001) A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 104, 849-859. (Pubitemid 32289278)
    • (2001) Cell , vol.104 , Issue.6 , pp. 849-859
    • Lamolet, B.1    Pulichino, A.-M.2    Lamonerie, T.3    Gauthier, Y.4    Brue, T.5    Enjalbert, A.6    Drouin, J.7
  • 23
    • 16244385939 scopus 로고    scopus 로고
    • Functional specificity of the xenopus T-domain protein brachyury is conferred by its ability to interact with smad1
    • DOI 10.1016/j.devcel.2005.03.001, PII S1534580705000821
    • Messenger, N. J., Kabitschke, C., Andrews, R., Grimmer, D., Núñez Miguel, R., Blundell, T. L., Smith, J. C., and Wardle, F. C. (2005) Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1. Dev. Cell 8, 599-610. (Pubitemid 40450748)
    • (2005) Developmental Cell , vol.8 , Issue.4 , pp. 599-610
    • Messenger, N.J.1    Kabitschke, C.2    Andrews, R.3    Grimmer, D.4    Miguel, R.N.5    Blundell, T.L.6    Smith, J.C.7    Wardle, F.C.8
  • 25
    • 17344369067 scopus 로고    scopus 로고
    • Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation
    • Stoller, J. Z. and Epstein, J. A. (2005) Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation. Hum. Mol. Genet. 14, 885-892.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 885-892
    • Stoller, J.Z.1    Epstein, J.A.2
  • 26
    • 0035504693 scopus 로고    scopus 로고
    • A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: Relevance to mutations in Tbx3 that cause ulnar-mammary syndrome
    • Carlson, H., Ota, S., Campbell, C. E., and Hurlin, P. J. (2001) A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome. Hum. Mol. Genet. 10, 2403-2413.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 2403-2413
    • Carlson, H.1    Ota, S.2    Campbell, C.E.3    Hurlin, P.J.4
  • 27
    • 1842839997 scopus 로고    scopus 로고
    • Identification of the TBX5 transactivating domain and the nuclear localization signal
    • DOI 10.1016/j.gene.2004.01.017, PII S0378111904000381
    • Zaragoza, M. V., Lewis, L. E., Sun, G., Wang, E., Li, L., Said-Salman, I., Feucht, L., and Huang, T. (2004) Identification of the TBX5 transactivating domain and the nuclear localization signal. Gene 330, 9-18. (Pubitemid 38490413)
    • (2004) Gene , vol.330 , Issue.1-2 , pp. 9-18
    • Zaragoza, M.V.1    Lewis, L.E.2    Sun, G.3    Wang, E.4    Li, L.5    Said-Salman, I.6    Feucht, L.7    Huang, T.8
  • 28
    • 0035169810 scopus 로고    scopus 로고
    • Cloning and characterization of the T-box gene Tbx6 in Xenopus laevis
    • Uchiyama, H., Kobayashi, T., Yamashita, A., Ohno, S., and Yabe, S. (2001) Cloning and characterization of the T-box gene Tbx6 in Xenopus laevis. Dev. Growth Differ. 43, 657-669.
    • (2001) Dev. Growth Differ. , vol.43 , pp. 657-669
    • Uchiyama, H.1    Kobayashi, T.2    Yamashita, A.3    Ohno, S.4    Yabe, S.5
  • 29
    • 0030470254 scopus 로고    scopus 로고
    • Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning
    • Zhang, J. and King, M. L. (1996) Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning. Development 122, 4119-4129. (Pubitemid 27033904)
    • (1996) Development , vol.122 , Issue.12 , pp. 4119-4129
    • Zhang, J.1    King, M.L.2
  • 30
    • 33846232336 scopus 로고    scopus 로고
    • Differential regulation of Tbx5 protein expression and sub-cellular localization during heart development
    • Bimber, B., Dettman, R. W., and Simon, H.-G. (2007) Differential regulation of Tbx5 protein expression and sub-cellular localization during heart development. Dev. Biol. 302, 230-242.
    • (2007) Dev. Biol. , vol.302 , pp. 230-242
    • Bimber, B.1    Dettman, R.W.2    Simon, H.-G.3
  • 31
  • 32
    • 1042278119 scopus 로고    scopus 로고
    • TBX2/TBX3 Transcriptional Factor Homologue Controls Olfactory Adaptation in Caenorhabditis elegans
    • DOI 10.1002/neu.10299
    • Miyahara, K., Suzuki, N., Ishihara, T., Tsuchiya, E., and Katsura, I. (2004) TBX2/TBX3 transcriptional factor homologue controls olfactory adaptation in Caenorhabditis elegans. J. Neurobiol. 58, 392-402. (Pubitemid 38199126)
    • (2004) Journal of Neurobiology , vol.58 , Issue.3 , pp. 392-402
    • Miyahara, K.1    Suzuki, N.2    Ishihara, T.3    Tsuchiya, E.4    Katsura, I.5
  • 33
    • 0028241951 scopus 로고
    • An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus
    • Bollag, R. J., Siegfried, Z., Cebra-Thomas, J. A., Garvey, N., Davison, E. M., and Silver, L. M. (1994) An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. Nat. Genet. 7, 383-388.
    • (1994) Nat. Genet. , vol.7 , pp. 383-388
    • Bollag, R.J.1    Siegfried, Z.2    Cebra-Thomas, J.A.3    Garvey, N.4    Davison, E.M.5    Silver, L.M.6
  • 34
    • 0029100025 scopus 로고
    • Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the drosophila omb gene
    • Campbell, C., Goodrich, K., Casey, G., and Beatty, B. (1995) Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the drosophila omb gene. Genomics 28, 255-260.
    • (1995) Genomics , vol.28 , pp. 255-260
    • Campbell, C.1    Goodrich, K.2    Casey, G.3    Beatty, B.4
  • 35
    • 0029400966 scopus 로고
    • Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family
    • Law, D. J., Gebuhr, T., Garvey, N., Agulnik, S. I., and Silver, L. M. (1995) Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family. Mamm. Genome 6, 793-797.
    • (1995) Mamm. Genome , vol.6 , pp. 793-797
    • Law, D.J.1    Gebuhr, T.2    Garvey, N.3    Agulnik, S.I.4    Silver, L.M.5
  • 36
    • 0034722673 scopus 로고    scopus 로고
    • Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1, and TBX2
    • Sinha, S., Abraham, S., Gronostajski, R. M., and Campbell, C. E. (2000) Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1, and TBX2. Gene 258, 15-29.
    • (2000) Gene , vol.258 , pp. 15-29
    • Sinha, S.1    Abraham, S.2    Gronostajski, R.M.3    Campbell, C.E.4
  • 37
    • 0033621059 scopus 로고    scopus 로고
    • Transcription repression by Xenopus et and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome
    • He, M.-L., Wen, L., Campbell, C. E., Wu, J. Y., and Rao, Y. (1999) Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome. Proc. Natl. Acad. Sci. USA 96, 10212-10217.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10212-10217
    • He, M.-L.1    Wen, L.2    Campbell, C.E.3    Wu, J.Y.4    Rao, Y.5
  • 39
    • 11244281377 scopus 로고    scopus 로고
    • T-box genes and heart development: Putting the "T" in heart
    • Plageman, T. F., Jr. and Yutzey, K. E. (2005) T-box genes and heart development: putting the "T" in heart. Dev. Dyn. 232, 11-20.
    • (2005) Dev. Dyn. , vol.232 , pp. 11-20
    • Plageman Jr., T.F.1    Yutzey, K.E.2
  • 41
    • 4444363371 scopus 로고    scopus 로고
    • The role of Tbx2 and Tbx3 in mammary development and tumorigenesis
    • DOI 10.1023/B:JOMG.0000037156.64331.3f, Embryonic Genes in Mammary Gland Development and Tumorigenesis
    • Rowley, M., Grothey, E., and Couch, F. J. (2004) The role of Tbx2 and Tbx3 in mammary development and tumorigenesis. J. Mammary Gland Biol. Neoplasia 9, 109-118. (Pubitemid 39177497)
    • (2004) Journal of Mammary Gland Biology and Neoplasia , vol.9 , Issue.2 , pp. 109-118
    • Rowley, M.1    Grothey, E.2    Couch, F.J.3
  • 42
    • 8444252934 scopus 로고    scopus 로고
    • Tbx2 is essential for patterning the atrioventricular canal and for morphogenensis of the outflow tract during heart development
    • DOI 10.1242/dev.01378
    • Harrelson, Z., Kelly, R. G., Goldin, S. N., Gibson-Brown, J. J., Bollag, R. J., Silver, L. M., and Papaioannou, V. E. (2004) Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development 131, 5041-5052. (Pubitemid 39485361)
    • (2004) Development , vol.131 , Issue.20 , pp. 5041-5052
    • Harrelson, Z.1    Kelly, R.G.2    Goldin, S.N.3    Gibson-Brown, J.J.4    Bollag, R.J.5    Silver, L.M.6    Papaioannou, V.E.7
  • 43
    • 21044459960 scopus 로고    scopus 로고
    • Architectural plan for the heart: Early patterning and delineation of the chambers and the nodes
    • Christoffels, V. M., Burch, J. B. E., and Moorman, A. F. M. (2004) Architectural plan for the heart: early patterning and delineation of the chambers and the nodes. Trends Cardiovasc. Med. 14, 301-307.
    • (2004) Trends Cardiovasc. Med. , vol.14 , pp. 301-307
    • Christoffels, V.M.1    Burch, J.B.E.2    Moorman, A.F.M.3
  • 44
    • 28844438924 scopus 로고    scopus 로고
    • T-box transcription factors and their roles in regulatory hierarchies in the developing heart
    • Stennard, F. A. and Harvey, R. P. (2005) T-box transcription factors and their roles in regulatory hierarchies in the developing heart. Development 132, 4897-4910.
    • (2005) Development , vol.132 , pp. 4897-4910
    • Stennard, F.A.1    Harvey, R.P.2
  • 45
    • 1842561719 scopus 로고    scopus 로고
    • T-Box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    • Christoffels, V. M., Hoogaars, W. M. H., Tessari, A., Clout, D. E. W., Moorman, A. F. M., and Campione, M. (2004) T-Box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev. Dyn. 229, 763-770.
    • (2004) Dev. Dyn. , vol.229 , pp. 763-770
    • Christoffels, V.M.1    Hoogaars, W.M.H.2    Tessari, A.3    Clout, D.E.W.4    Moorman, A.F.M.5    Campione, M.6
  • 46
    • 0037093383 scopus 로고    scopus 로고
    • Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: Implications for cardiac chamber formation
    • DOI 10.1101/gad.222902
    • Habets, P. E. M. H., Moorman, A. F. M., Clout, D. E. W., van Roon, M. A., Lingbeek, M., van Lohuizen, M., Campione, M., and Christoffels, V. M. (2002) Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev. 16, 1234-1246. (Pubitemid 34553104)
    • (2002) Genes and Development , vol.16 , Issue.10 , pp. 1234-1246
    • Habets, P.E.M.H.1    Moorman, A.F.M.2    Clout, D.E.W.3    Van Roon, M.A.4    Lingbeek, M.5    Van Lohuizen, M.6    Campione, M.7    Christoffels, V.M.8
  • 48
    • 0034551683 scopus 로고    scopus 로고
    • Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: Evidence for BMP2 induction of Tbx2
    • Yamada, M., Revelli, J.-P., Eichele, G., Barron, M., and Schwartz, R. J. (2000) Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Dev. Biol. 228, 95-105.
    • (2000) Dev. Biol. , vol.228 , pp. 95-105
    • Yamada, M.1    Revelli, J.-P.2    Eichele, G.3    Barron, M.4    Schwartz, R.J.5
  • 50
    • 0029850112 scopus 로고    scopus 로고
    • Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
    • Zhang, H. and Bradley, A. (1996) Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122, 2977-2986. (Pubitemid 26371964)
    • (1996) Development , vol.122 , Issue.10 , pp. 2977-2986
    • Zhang, H.1    Bradley, A.2
  • 51
    • 21044454606 scopus 로고    scopus 로고
    • T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis
    • DOI 10.1242/dev.01832
    • Cai, C.-L., Zhou, W., Yang, L., Bu, L., Qyang, Y., Zhang, X., Li, X., Rosenfeld, M. G., Chen, J., and Evans, S. (2005) T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132, 2475-2487. (Pubitemid 40872815)
    • (2005) Development , vol.132 , Issue.10 , pp. 2475-2487
    • Cai, C.-L.1    Zhou, W.2    Yang, L.3    Bu, L.4    Qyang, Y.5    Zhang, X.6    Li, X.7    Rosenfeld, M.G.8    Chen, J.9    Evans, S.10
  • 53
    • 0027586904 scopus 로고
    • Mutation of N-myc in mice: What does the phenotype tell us?
    • Davis, A. and Bradley, A. (1993) Mutation of N-myc in mice: what does the phenotype tell us? Bioessays 15, 273-275.
    • (1993) Bioessays , vol.15 , pp. 273-275
    • Davis, A.1    Bradley, A.2
  • 56
    • 17944378083 scopus 로고    scopus 로고
    • A murine model of Holt-Oram syndrome defines roles of the T-Box transcription factor Tbx5 in cardiogenesis and disease
    • DOI 10.1016/S0092-8674(01)00493-7
    • Bruneau, B. G., Nemer, G., Schmitt, J. P., Charron, F., Robitaille, L., Caron, S., Conner, D. A., Gessler, M., Nemer, M., Seidman, C. E., and Seidman, J. G. (2001) A murine model of Holt-Oram syndrome defines roles of the T-Box transcription factor Tbx5 in cardiogenesis and disease. Cell 106, 709-721. (Pubitemid 32900662)
    • (2001) Cell , vol.106 , Issue.6 , pp. 709-721
    • Bruneau, B.G.1    Nemer, G.2    Schmitt, J.P.3    Charron, F.4    Robitaille, L.5    Caron, S.6    Conner, D.A.7    Gessler, M.8    Nemer, M.9    Seidman, C.E.10    Seidman, J.G.11
  • 57
    • 0034931034 scopus 로고    scopus 로고
    • Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
    • Hiroi, Y., Kudoh, S., Monzen, K., Ikeda, Y., Yazaki, Y., Nagai, R., and Komuro, I. (2001) Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat. Genet. 28, 276-280.
    • (2001) Nat. Genet. , vol.28 , pp. 276-280
    • Hiroi, Y.1    Kudoh, S.2    Monzen, K.3    Ikeda, Y.4    Yazaki, Y.5    Nagai, R.6    Komuro, I.7
  • 58
    • 34250761203 scopus 로고    scopus 로고
    • Nervous tissue and the central nervous system
    • Martin J. Lange, Kristine A. Queck, editors. 6th edn. McGraw-Hill Publishers, North America
    • Van De Graaff, K. M. (2002) "Nervous tissue and the central nervous system". Martin J. Lange, Kristine A. Queck, editors. In Human Anatomy, 6th edn. pp. 372-374, McGraw-Hill Publishers, North America.
    • (2002) Human Anatomy , pp. 372-374
    • Van De Graaff, K.M.1
  • 59
    • 33751318012 scopus 로고    scopus 로고
    • Regional Morphogenesis in the Hypothalamus: A BMP-Tbx2 Pathway Coordinates Fate and Proliferation through Shh Downregulation
    • DOI 10.1016/j.devcel.2006.09.021, PII S1534580706004497
    • Manning, L., Ohyama, K., Saeger, B., Hatano, O., Wilson, S. A., Logan, M., and Placzek, M. (2006) Regional morphogenesis in the hypothalamus: a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation. Dev. Cell 11, 873-885. (Pubitemid 44804274)
    • (2006) Developmental Cell , vol.11 , Issue.6 , pp. 873-885
    • Manning, L.1    Ohyama, K.2    Saeger, B.3    Hatano, O.4    Wilson, S.A.5    Logan, M.6    Placzek, M.7
  • 60
    • 0041508221 scopus 로고    scopus 로고
    • Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node
    • DOI 10.1242/dev.00590
    • Jeong, Y. and Epstein, D. J. (2003) Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node. Development 130, 3891-3902. (Pubitemid 37039092)
    • (2003) Development , vol.130 , Issue.16 , pp. 3891-3902
    • Jeong, Y.1    Epstein, D.J.2
  • 61
    • 0035184055 scopus 로고    scopus 로고
    • Early eye development in vertebrates
    • Chow, R. L. and Lang, R. A. (2001) Early eye development in vertebrates. Annu. Rev. Cell Dev. Biol. 17, 255-296.
    • (2001) Annu. Rev. Cell Dev. Biol. , vol.17 , pp. 255-296
    • Chow, R.L.1    Lang, R.A.2
  • 62
    • 0035656203 scopus 로고    scopus 로고
    • Expression of drosophila omb-related T-box genes in the developing human and mouse neural retina
    • Sowden, J. C., Holt, J. K. L., Meins, M., Smith, H. K., and Bhattacharya, S. S. (2001) Expression of drosophila omb-related T-box genes in the developing human and mouse neural retina. Invest. Ophthalmol. Vis. Sci. 42, 3095-3102.
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 3095-3102
    • Sowden, J.C.1    Holt, J.K.L.2    Meins, M.3    Smith, H.K.4    Bhattacharya, S.S.5
  • 63
    • 33846583365 scopus 로고    scopus 로고
    • The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup
    • Behesti, H., Holt, J. K. L., and Sowden, J. C. (2006) The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup. BMC Dev. Biol. 6, 62.
    • (2006) BMC Dev. Biol. , vol.6 , pp. 62
    • Behesti, H.1    Holt, J.K.L.2    Sowden, J.C.3
  • 64
    • 69049102950 scopus 로고    scopus 로고
    • Loss of Tbx2 delays optic vesicle invagination leading to small optic cups
    • Behesti, H., Papaioannou, V. E., and Sowden, J. C. (2009) Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. Dev. Biol. 333, 360-372.
    • (2009) Dev. Biol. , vol.333 , pp. 360-372
    • Behesti, H.1    Papaioannou, V.E.2    Sowden, J.C.3
  • 65
    • 0034645070 scopus 로고    scopus 로고
    • Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction
    • Lecanda, F., Warlow, P. M., Sheikh, S., Furlan, F., Steinberg, T. H., and Civitelli, R. (2000) Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J. Cell Biol. 151, 931-944.
    • (2000) J. Cell Biol. , vol.151 , pp. 931-944
    • Lecanda, F.1    Warlow, P.M.2    Sheikh, S.3    Furlan, F.4    Steinberg, T.H.5    Civitelli, R.6
  • 66
    • 0037904675 scopus 로고    scopus 로고
    • Negative transcriptional regulation of Connexin 43 by Tbx2 in rat immature coronal sutures and ROS 17/2.8 cells in culture
    • Borke, J. L., Chen, J.-R., Yu, J. C., Bollag, R. J., Orellana, M. F., and Isales, C. M. (2003) Negative transcriptional regulation of Connexin 43 by Tbx2 in rat immature coronal sutures and ROS 17/2.8 cells in culture. Cleft Palate Craniofac. J. 40, 284-290.
    • (2003) Cleft Palate Craniofac. J. , vol.40 , pp. 284-290
    • Borke, J.L.1    Chen, J.-R.2    Yu, J.C.3    Bollag, R.J.4    Orellana, M.F.5    Isales, C.M.6
  • 69
    • 35048876778 scopus 로고    scopus 로고
    • A role for Tbx2 in the regulation of the α2(1) collagen gene in human fibroblasts
    • Teng, H., Davis, E., Abrahams, A., Mowla, S., Parker, M. I., and Prince, S. (2007) A role for Tbx2 in the regulation of the α2(1) collagen gene in human fibroblasts. J. Cell Biochem. 102, 618-625.
    • (2007) J. Cell Biochem. , vol.102 , pp. 618-625
    • Teng, H.1    Davis, E.2    Abrahams, A.3    Mowla, S.4    Parker, M.I.5    Prince, S.6
  • 70
    • 0035179017 scopus 로고    scopus 로고
    • Patterning mechanisms controlling vertebrate limb development
    • Capdevila, J. and Izpisúa Belmonte, J. C. (2001) Patterning mechanisms controlling vertebrate limb development. Annu. Rev. Cell Dev. Biol. 17, 87-132.
    • (2001) Annu. Rev. Cell Dev. Biol. , vol.17 , pp. 87-132
    • Capdevila, J.1    Izpisúa Belmonte, J.C.2
  • 71
    • 0345874463 scopus 로고    scopus 로고
    • Finger or toe: The molecular basis of limb identity
    • Logan, M. (2003) Finger or toe: the molecular basis of limb identity. Development 130, 6401-6410.
    • (2003) Development , vol.130 , pp. 6401-6410
    • Logan, M.1
  • 73
    • 0029977495 scopus 로고    scopus 로고
    • Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity
    • Gibson-Brown, J. J., Agulnik, S. I., Chapman, D. L., Alexiou, M., Garvey, N., Silver, L. M., and Papaioannou, V. E. (1996) Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity. Mech. Dev. 56, 93-101.
    • (1996) Mech. Dev. , vol.56 , pp. 93-101
    • Gibson-Brown, J.J.1    Agulnik, S.I.2    Chapman, D.L.3    Alexiou, M.4    Garvey, N.5    Silver, L.M.6    Papaioannou, V.E.7
  • 75
    • 0031707028 scopus 로고    scopus 로고
    • Differential regulation of T-box and homeobox transcription factors suggests roles in controlling chick limb-type identity
    • Logan, M., Simon, H.-G., and Tabin, C. (1998) Differential regulation of T-box and homeobox transcription factors suggests roles in controlling chick limb-type identity. Development 125, 2825-2835. (Pubitemid 28410207)
    • (1998) Development , vol.125 , Issue.15 , pp. 2825-2835
    • Logan, M.1    Simon, H.-G.2    Tabin, C.3
  • 76
    • 0345873191 scopus 로고    scopus 로고
    • Tbx genes specify posterior digit identity through Shh and BMP signaling
    • DOI 10.1016/S1534-5807(03)00401-5, PII S1534580703004015
    • Suzuki, T., Takeuchi, J., Koshiba-Takeuchi, K., and Ogura, T. (2004) Tbx genes specify posterior digit identity through Shh and BMP signaling. Dev. Cell 6, 43-53. (Pubitemid 38089204)
    • (2004) Developmental Cell , vol.6 , Issue.1 , pp. 43-53
    • Suzuki, T.1    Takeuchi, J.2    Koshiba-Takeuchi, K.3    Ogura, T.4
  • 77
    • 33947135836 scopus 로고    scopus 로고
    • Characterization of a novel ectodermal signaling centre regulating Tbx2 and Shh in the vertebrate limb
    • Nissim, S., Allard, P., Bandyopadhyay, A., Harfe, B. D., and Tabin, C. J. (2007) Characterization of a novel ectodermal signaling centre regulating Tbx2 and Shh in the vertebrate limb. Dev. Biol. 304, 9-21.
    • (2007) Dev. Biol. , vol.304 , pp. 9-21
    • Nissim, S.1    Allard, P.2    Bandyopadhyay, A.3    Harfe, B.D.4    Tabin, C.J.5
  • 78
    • 0037797436 scopus 로고    scopus 로고
    • Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    • Davenport, T. G., Jerome-Majewska, L. A., and Papaioannou, V. E. (2003) Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development 130, 2263-2273.
    • (2003) Development , vol.130 , pp. 2263-2273
    • Davenport, T.G.1    Jerome-Majewska, L.A.2    Papaioannou, V.E.3
  • 79
    • 0036129964 scopus 로고    scopus 로고
    • Hormone/growth factor interactions mediating epithelial/stromal communication in mammary gland development and carcinogenesis
    • Imagawa, W., Pedchenko, V. K., Helber, J., and Zhang, H. (2002) Hormone/growth factor interactions mediating epithelial/stromal communication in mammary gland development and carcinogenesis. J. Steroid Biochem. Mol. Biol. 80, 213-230.
    • (2002) J. Steroid Biochem. Mol. Biol. , vol.80 , pp. 213-230
    • Imagawa, W.1    Pedchenko, V.K.2    Helber, J.3    Zhang, H.4
  • 80
    • 0035489712 scopus 로고    scopus 로고
    • Signaling Pathways in Mammary Gland Development
    • DOI 10.1016/S1534-5807(01)00064-8, PII S1534580701000648
    • Hennighausen, L. and Robinson, G. W. (2001) Signaling pathways in mammary gland development. Dev. Cell 1, 467-475. (Pubitemid 33586099)
    • (2001) Developmental Cell , vol.1 , Issue.4 , pp. 467-475
    • Hennighausen, L.1    Robinson, G.W.2
  • 82
    • 28444475509 scopus 로고    scopus 로고
    • Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53 independent pathway
    • Jerome-Majewska, L. A., Jenkins, G. P., Ernstoff, E., Zindy, F., Sherr, C. J., and Papaioannou, V. E. (2005) Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53 independent pathway. Dev. Dyn. 234, 922-933.
    • (2005) Dev. Dyn. , vol.234 , pp. 922-933
    • Jerome-Majewska, L.A.1    Jenkins, G.P.2    Ernstoff, E.3    Zindy, F.4    Sherr, C.J.5    Papaioannou, V.E.6
  • 84
    • 33747882661 scopus 로고    scopus 로고
    • MITF: Master regulator of melanocyte development and melanoma oncogene
    • Levy, C., Khaled, M., and Fisher, D. E. (2006) MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol. Med. 12, 406-414.
    • (2006) Trends Mol. Med. , vol.12 , pp. 406-414
    • Levy, C.1    Khaled, M.2    Fisher, D.E.3
  • 85
    • 0034698141 scopus 로고    scopus 로고
    • The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes
    • Carreira, S., Liu, B., and Goding, C. R. (2000) The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes. J. Biol. Chem. 275, 21920-21927.
    • (2000) J. Biol. Chem. , vol.275 , pp. 21920-21927
    • Carreira, S.1    Liu, B.2    Goding, C.R.3
  • 86
    • 0033810599 scopus 로고    scopus 로고
    • Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation of mouse melanocytes in culture
    • Sarangarajan, R., Zhao, Y., Babcock, G., Cornelius, J., Lamoreux, M. L., and Boissy, R. E. (2000) Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation of mouse melanocytes in culture. Pigment Cell Res. 13, 337-344.
    • (2000) Pigment Cell Res. , vol.13 , pp. 337-344
    • Sarangarajan, R.1    Zhao, Y.2    Babcock, G.3    Cornelius, J.4    Lamoreux, M.L.5    Boissy, R.E.6
  • 88
    • 3442883903 scopus 로고    scopus 로고
    • TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines
    • DOI 10.1158/0008-5472.CAN-04-0615
    • Fan, W., Huang, X., Chen, C., Gray, J., and Huang, T. (2004) TBX3 and its isoform TBX312a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines. Cancer Res. 64, 5132-5139. (Pubitemid 39006530)
    • (2004) Cancer Research , vol.64 , Issue.15 , pp. 5132-5139
    • Fan, W.1    Huang, X.2    Chen, C.3    Gray, J.4    Huang, T.5
  • 90
    • 4644307290 scopus 로고    scopus 로고
    • Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms
    • Hansel, D. E., Rahman, A., House, M., Ashfaq, R., Berg, K., Yeo, C. J., and Maitra, A. (2004) Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms. Clin. Cancer Res. 10, 6152-6158.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6152-6158
    • Hansel, D.E.1    Rahman, A.2    House, M.3    Ashfaq, R.4    Berg, K.5    Yeo, C.J.6    Maitra, A.7
  • 91
    • 16844387097 scopus 로고    scopus 로고
    • Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas
    • DOI 10.1158/0008-5472.CAN-04-3045
    • Vance, K. W., Carreira, S., Brosch, G., and Goding, C. R. (2005) Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. Cancer Res. 65, 2260-2268. (Pubitemid 40490135)
    • (2005) Cancer Research , vol.65 , Issue.6 , pp. 2260-2268
    • Vance, K.W.1    Carreira, S.2    Brosch, G.3    Goding, C.M.4
  • 94
    • 13444254019 scopus 로고    scopus 로고
    • Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells
    • DOI 10.1016/j.canlet.2004.07.051, PII S0304383504006470
    • Ito, A., Asamoto, M., Hokaiwado, N., Takahashi, S., and Shirai, T. (2005) Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells. Cancer Lett. 219, 105-112. (Pubitemid 40203177)
    • (2005) Cancer Letters , vol.219 , Issue.1 , pp. 105-112
    • Ito, A.1    Asamoto, M.2    Hokaiwado, N.3    Takahashi, S.4    Shirai, T.5
  • 96
    • 28544450672 scopus 로고    scopus 로고
    • Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients
    • Lomnytska, M., Dubrovska, A., Hellman, U., Volodko, N., and Souchelnytskyi, S. (2006) Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients. Int. J. Cancer 118, 412-421.
    • (2006) Int. J. Cancer , vol.118 , pp. 412-421
    • Lomnytska, M.1    Dubrovska, A.2    Hellman, U.3    Volodko, N.4    Souchelnytskyi, S.5
  • 97
    • 0035393582 scopus 로고    scopus 로고
    • Structural analysis of the 17q22-23 amplicon identifies several independent targets of amplification in breast cancer cell lines and tumors
    • Wu, G.-J., Sinclair, C., Hinson, S., Ingle, J. N., Roche, P. C., and Couch, F. J. (2001) Structural analysis of the 17q22-23 amplicon identifies several independent targets of amplification in breast cancer cell lines and tumors. Cancer Res. 61, 4951-4955. (Pubitemid 32681516)
    • (2001) Cancer Research , vol.61 , Issue.13 , pp. 4951-4955
    • Wu, G.-J.1    Sinclair, C.2    Hinson, S.3    Ingle, J.N.4    Roche, P.C.5    Couch, F.J.6
  • 99
    • 13244253702 scopus 로고    scopus 로고
    • Genes differentially expressed in human lung fibroblast cells transformed by glycidyl methacrylate
    • Yin, X. J., Xu, J. N., Zou, C. Q., He, F. S., and Fang, F. D. (2004) Genes differentially expressed in human lung fibroblast cells transformed by glycidyl methacrylate. Biomed. Environ. Sci. 17, 432-441.
    • (2004) Biomed. Environ. Sci. , vol.17 , pp. 432-441
    • Yin, X.J.1    Xu, J.N.2    Zou, C.Q.3    He, F.S.4    Fang, F.D.5
  • 100
    • 0038277105 scopus 로고    scopus 로고
    • Tumor cell senescence in cancer treatment
    • Roninson, I. B. (2003) Tumor cell senescence in cancer treatment. Cancer Res. 63, 2705-2715. (Pubitemid 36667137)
    • (2003) Cancer Research , vol.63 , Issue.11 , pp. 2705-2715
    • Roninson, I.B.1
  • 101
    • 0033013980 scopus 로고    scopus 로고
    • Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
    • Stein, G. H., Drullinger, L. F., Soulard, A., and Dulic, V. (1999) Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell Biol. 19, 2109-2117.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 2109-2117
    • Stein, G.H.1    Drullinger, L.F.2    Soulard, A.3    Dulic, V.4
  • 103
    • 1642396456 scopus 로고    scopus 로고
    • WAF1 Cyclin-Dependent Kinase Inhibitor
    • DOI 10.1158/0008-5472.CAN-03-3286
    • Prince, S., Carreira, S., Vance, K. W., Abrahams, A., and Goding, C. R. (2004) Tbx2 directly represses the expression of the p21WAF1 cyclin-dependent kinase inhibitor. Cancer Res. 64, 1669-1674. (Pubitemid 38428688)
    • (2004) Cancer Research , vol.64 , Issue.5 , pp. 1669-1674
    • Prince, S.1    Carreira, S.2    Vance, K.W.3    Abrahams, A.4    Goding, C.R.5
  • 104
    • 54249133490 scopus 로고    scopus 로고
    • Tbx3 represses E-cadherin expression and enhances melanoma invasiveness
    • Rodriguez, M., Aladowicz, E., Lanfrancone, L., and Goding, C. R. (2008) Tbx3 represses E-cadherin expression and enhances melanoma invasiveness. Cancer Res. 68, 7872-7881.
    • (2008) Cancer Res. , vol.68 , pp. 7872-7881
    • Rodriguez, M.1    Aladowicz, E.2    Lanfrancone, L.3    Goding, C.R.4
  • 105
    • 19544362066 scopus 로고    scopus 로고
    • Adhesion, migration and communication in melanocytes and melanoma
    • DOI 10.1111/j.1600-0749.2005.00235.x
    • Haass, N. K., Smalley, K. S., Li, L., and Herlyn, M. (2005) Adhesion, migration and communication in melanocytes and melanoma. Pigment Cell Res. 18, 150-159. (Pubitemid 40733333)
    • (2005) Pigment Cell Research , vol.18 , Issue.3 , pp. 150-159
    • Haass, N.K.1    Smalley, K.S.M.2    Li, L.3    Herlyn, M.4
  • 106
    • 38949083839 scopus 로고    scopus 로고
    • Ectopic Tbx2 expression results in polyploidy and cisplatin resistance
    • DOI 10.1038/sj.onc.1210701, PII 1210701
    • Davis, E., Teng, H., Bilican, B., Parker, I., Liu, B., Carreira, S., Goding, C. R., and Prince, S. (2008) Ectopic Tbx2 expression results in polyploidy and cisplatin resistance. Oncogene 27, 976-984. (Pubitemid 351225380)
    • (2008) Oncogene , vol.27 , Issue.7 , pp. 976-984
    • Davis, E.1    Teng, H.2    Bilican, B.3    Parker, M.I.4    Liu, B.5    Carriera, S.6    Goding, C.R.7    Prince, S.8
  • 108
    • 0035886017 scopus 로고    scopus 로고
    • Neither p21WAF1 nor 14-3-3r prevents G2 progression to mitotic catastrophe in human colon carcinoma cells after DNA damage, but p21WAF1 induces stable G1 arrest in resulting tetraploid cells
    • Andreassen, P. R., Lacroix, F. B., Lohez, O. D., and Margolis, R. L. (2001) Neither p21WAF1 nor 14-3-3r prevents G2 progression to mitotic catastrophe in human colon carcinoma cells after DNA damage, but p21WAF1 induces stable G1 arrest in resulting tetraploid cells. Cancer Res. 61, 7660-7668.
    • (2001) Cancer Res. , vol.61 , pp. 7660-7668
    • Andreassen, P.R.1    Lacroix, F.B.2    Lohez, O.D.3    Margolis, R.L.4
  • 109
    • 33745281202 scopus 로고    scopus 로고
    • Cell cycle regulation of the T-box transcription factor tbx2
    • Bilican, B. and Goding, C. R. (2006) Cell cycle regulation of the T-box transcription factor tbx2. Exp. Cell Res. 312, 2358-2366.
    • (2006) Exp. Cell Res. , vol.312 , pp. 2358-2366
    • Bilican, B.1    Goding, C.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.