Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction

Journal of Cell Biology

Volumn 151, Issue 4, 2000, Pages 931-943

  Lecanda, F ^a   Warlow, P M ^a   Sheikh, S ^a   Furlan, F ^a   Steinberg, T H ^a   Civitelli, R ^a  

^a BARNES JEWISH HOSPITAL   (United States)

Author keywords

Connexin43; Connexin45; Gene knock out; Osteoblast differentiation; Skeletal development

Indexed keywords

COLLAGEN; CONNEXIN 43; GAP JUNCTION PROTEIN; OSTEOCALCIN; OSTEOPONTIN;

ANIMAL MODEL; ARTICLE; BONE MINERALIZATION; CELL COMMUNICATION; CELL MIGRATION; EMBRYO; GAP JUNCTION; GENE MUTATION; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN DEFECT;

ANIMALS; BONE AND BONES; CELL DIVISION; CONNEXIN 43; CRANIOFACIAL ABNORMALITIES; EMBRYONIC AND FETAL DEVELOPMENT; GENOTYPE; GESTATIONAL AGE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; NEURAL CREST; OSTEOBLASTS; OSTEOGENESIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKULL;

ANIMALIA;

EID: 0034645070     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.151.4.931     Document Type: Article

References (40)

1. Roles for alpha 1 connexin in morphogenesis of chick embryos revealed using a novel antisense approach
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
3. Multiple calvarial defects in lmx1b mutant mice
4. Msx1 controls inductive signaling in mammalian tooth morphogenesis
5. Differentiation of human bone marrow osteogenic stromal cells in vitro: Induction of the osteoblast phenotype by dexamethasone
6. Connexin43 mediates direct intercellular communication in human osteoblastic cell networks
7. The triple origin of skull in higher vertebrates: A study in quail-chick chimeras
8. The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression
9. Cell-to-cell communication in osteoblastic networks: Cell line-dependent hormonal regulation of gap junction function
10. Toward a molecular understanding of skeletal development
11. Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
12. Slow ventricular conduction in mice heterozygous for a connexin43 null mutation
13. The membranous skeleton: The role of cell condensations in vertebrate skeletogenesis
14. Divide, accumulate, differentiate: Cell condensation in skeletal development revisited
15. Gap junction-mediated cell-cell communication modulates mouse neural crest migration
16. A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis
17. Genetics of skeletogenesis
18. The genetic transformation of bone biology
19. Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43
20. Connexin46 is retained as monomers in a trans-Golgi compartment of osteoblastic cells
21. Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2
22. Gap junctional communication modulates gene expression in osteoblastic cells
23. Premature suture closure and ectopic cranial bone in mice expressing Msx-2 transgenes in the developing skull
24. Cx43 gap junction gene expression and gap junctional communication in mouse neural crest cells
25. Differential staining of cartilage and bone: Whole mount fetuses by alcian blue and alizarin red S
26. Antisense oligonucleotide blockade of connexin expression during embryonic bone formation: Evidence of functional compensation within a multigene family
27. Cardiac malformation in neonatal mice lacking connexin43
28. Phosphate transport in osteoblasts from normal and X-linked hypophosphatemic mice
29. Altered osteoblast gluconeogenesis in X-linked hypophosphatemic mice is associated with a depressed intracellular pH
30. Characterization of gap junctions between osteoblast-like cells in culture
31. Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells
32. Murine osteoclasts and spleen cell polykaryons are distinguished by mRNA phenotyping
33. Msx-2/Hox 8.1: A transcriptional regulator of the rat osteocalcin promoter
34. Selective dye and ionic permeability of gap junction channels formed by connexin45
35. Heart defects in connexin43-deficient mice
36. Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis
37. Cyclic stretch enhances gap junctional communication between osteoblastic cells