Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome

Structure

Volumn 10, Issue 3, 2002, Pages 343-356

  Coll, Miquel ^a,b   Seidman, Jonathan G ^c   Müller, Christoph W ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^b INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Holt Oram syndrome; T box; TBX3 DNA complex; Transcription factor; Ulnar Mammary syndrome

Indexed keywords

DNA; DOUBLE STRANDED DNA; MONOMER; PALINDROMIC DNA; T BOX TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIGEORGE SYNDROME; DNA BINDING; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; GENETIC DISORDER; HOLT ORAM SYNDROME; HUMAN; INVERTEBRATE; MORPHOGENESIS; NONHUMAN; ORGANOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; SPECIES DIFFERENCE; ULNAR MAMMARY SYNDROME; VERTEBRATE; XENOPUS LAEVIS;

ABNORMALITIES, MULTIPLE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA; DNA-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SYNDROME; T-BOX DOMAIN PROTEINS; WATER;

INVERTEBRATA; VERTEBRATA; XENOPUS LAEVIS;

EID: 0036120604     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00722-0     Document Type: Article

References (44)

1. T-box genes: What they do and how they do it
2. Phylogenetic analysis of T-Box genes demonstrates the importance of amphioxus for understanding evolution of the vertebrate genome
3. Evolution of mouse T-box genes by tandem duplication and cluster dispersion
4. Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds
5. The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity
6. T-box genes and the formation of vertebrate forelimb- and hindlimb specific pattern
7. Tbx5 is essential for heart development
8. Tbx5 and the retinotectum projection
9. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
10. Mutations in human TBX5 cause limb and cardiac malformations in Holt-Oram syndrome
11. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
12. DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1
13. Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice
14. TBX1 is responsible for cardiovascular defects in velocardio- facial/DiGeorge syndrome
15. Senescence bypass screen identifies TBX2, which represses cdkn2a (p19ARF) and is amplified in a subset of human breast cancers
16. The T protein encoded by Brachyury is a tissue-specific transcription factor
17. The Brachyury gene encodes a novel DNA binding protein
18. The T-box transcription factor Brachyury regulates expression of eFGF through binding to a non-palindromic response element
19. Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter
20. Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2
21. Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
22. The T transcription factor functions as a dimer and exhibits a common human polymorphism Gly-177-Asp in the conserved DNA-binding domain
23. Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm
24. Bix4 is activated directly by VegT and mediates endoderm formation in Xenopus development
25. A pituitary cell-restricted T box factor, Tpit activates POMC transcription in cooperation with Pitx homeoproteins
26. The immunoglobulin fold: Structural classification, sequence patterns and common core
27. DNA-binding by Ig-fold proteins
28. The spectrum of mutations in TBX3: Genotype/phenotype relationship in ulnar-mammary syndrome
29. Three-dimensional structure of the Stat3β homodimer bound to DNA
30. Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations
31. The atomic structure of protein-protein recognition sites
32. Kinetic studies of Fos.Jun.DNA complex formation: DNA binding prior to dimerization
33. Processing of X-ray diffraction data collected in oscillation mode
34. AMoRe: A new package for molecular replacement
35. Crystallography & NMR system: A new software for macromolecular structure determination
36. TURBO-Frodo
37. Procheck: A program to check the stereochemical quality of protein structures
38. Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
39. A-form conformational motifs in ligand-bound DNA structures
40. Setor: Hardware-lighted three-dimensional solid model representations of macromolecules
41. GRASP - Graphical representation and analysis of surface properties
42. Molscript: A program to produce both detailed and schematic plots of protein structures
43. The assessment of the geometry of dinucleotide steps in double-helical DNA; a new local calculation scheme
44. Improved methods for building protein models in electron density maps and the location of errors in these models