Using mast cell knock-in mice to analyze the roles of mast cells in allergic responses in vivo

Chemical Immunology and Allergy

Volumn 87, Issue , 2005, Pages 179-197

  Tsai, Mindy ^a   Grimbaldeston, Michele A ^a   Yu, Mang ^a   Tam, See Ying ^a   Galli, Stephen J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; STEM CELL FACTOR RECEPTOR;

ALLERGIC REACTION; ASTHMA; ATOPIC DERMATITIS; CELL FUNCTION; CELL POPULATION; CHRONIC DISEASE; CONTACT ALLERGY; DELAYED HYPERSENSITIVITY; HUMAN; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNIZATION; IN VIVO STUDY; MAST CELL; MOLECULAR BIOLOGY; MOUSE; MOUSE STRAIN; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY SYSTEM; REVIEW; SYSTEMIC DISEASE; WILD TYPE; ADOPTIVE TRANSFER; ANIMAL; BIOLOGICAL MODEL; CONTACT DERMATITIS; DISEASE MODEL; GENETICS; HYPERSENSITIVITY; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; DERMATITIS, ATOPIC; DERMATITIS, CONTACT; DISEASE MODELS, ANIMAL; HYPERSENSITIVITY; HYPERSENSITIVITY, DELAYED; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; MAST CELLS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL; PROTO-ONCOGENE PROTEINS C-KIT;

EID: 25144521049     PISSN: 16602242     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000087644     Document Type: Review

References (89)

1. Wills-Karp M, Hershey GKK: Immunological mechanisms of allergic disorders; in Paul WE (ed): Fundamental Immunology, ed 5. Philadelphia, Lippincott Williams & Wilkins, 2003, pp 1439-1479.
2. Gould HJ, Sutton BJ, Beavil AJ, Beavil RL, McCloskey N, Coker HA, Fear D, Smurthwaite L: The biology of IgE and the basis of allergic disease. Annu Rev Immunol 2003;21:579-628.
3. Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CMM, Tsai M: Mast cells as 'tunable' effector and immunoregulatory cells: Recent advances. Ann Rev Immunol 2005;23:749-786.
4. Galli SJ, Metcalfe DD, Arber DA, Dvorak AM: Basophils and mast cells and their disorders; in Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U (eds): Williams Hematology, ed 7. New York, McGraw-Hill, 2005.
5. Metcalfe DD, Baram D, Mekori YA: Mast cells. Physiol Rev 1997;77:1033-1079.
6. Kawakami T, Galli SJ: Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2002;2:773-786.
7. Sayama K, Diehn M, Matsuda K, Lunderius C, Tsai M, Tam SY, Botstein D, Brown PO, Galli SJ: Transcriptional response of human mast cells stimulated via the Fc(ε)RI and identification of mast cells as a source of IL-11. BMC Immunol 2002;3:5.
8. Williams CMM, Galli SJ: The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 2000;105:847-859.
9. Mekori YA: The mastocyte: The 'other' inflammatory cell in immunopathogenesis. J Allergy Clin Immunol 2004;114:52-57.
10. Galli SJ, Nakae S, Tsai M: Mast cells in the development of adaptive immune responses. Nat Immunol 2005;6:135-142.
11. Akdis CA, Blaser K: Histamine in the immune regulation of allergic inflammation. J Allergy Clin Immunol 2003;112:15-22.
12. Luster AD, Tager AM: T-cell trafficking in asthma: Lipid mediators grease the way. Nat Rev Immunol 2004;4:711-724.
13. Kashiwakura J, Yokoi H, Saito H, Okayama Y: T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: Comparison of gene expression profiles between human tonsillar and lung-cultured mast cells. J Immunol 2004;173:5247-5257.
14. Kitamura Y: Heterogeneity of mast cells and phenotypic change between subpopulations. Annu Rev Immunol 1989;7:59-76.
15. Williams CMM, Galli SJ: Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 2000;192:455-462.
16. Bryce PJ, Miller ML, Miyajima I, Tsai M, Galli SJ, Oettgen HC: Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immunity 2004;20:381-392.
17. Galli SJ: Complexity and redundancy in the pathogenesis of asthma: Reassessing the roles of mast cells and T cells. J Exp Med 1997;186:343-347.
18. Galli SJ, Zsebo KM, Geissler EN: The kit ligand, stem cell factor. Adv Immunol 1994;55:1-96.
19. Tsai M, Tam SY, Wedemeyer J, Galli SJ: Mast cells derived from embryonic stem cells: A model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo. Int J Hematol 2002;75:345-349.
20. v mice and their increase by bone marrow transplantation. Blood 1978;52:447-452.
21. Stevens J, Loutit JF: Mast cells in spotted mutant mice (W Ph mi). Proc R Soc Lond B Biol Sci 1982;215:405-409.
22. Mallen-St Clair J, Pham CT, Villalta SA, Caughey GH, Wolters PJ: Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest 2004;113:628-634.
23. W-sh mice as a model for investigating mast cell biology in vivo. FASEB J 2005;19:A1717. Abstract no. 1011.
24. Berrozpe G, Timokhina I, Yukl S, Tajima Y, Ono M, Zelenetz AD, Besmer P: The W(sh), W(57), and Ph Kit expression mutations define tissue-specific control elements located between -23 and -154 kb upstream of Kit. Blood 1999;94:2658-2666.
25. Duttlinger R, Manova K, Chu TY, Gyssler C, Zelenetz AD, Bachvarova RF, Besmer P: W-sash affects positive and negative elements controlling c-kit expression: Ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis. Development 1993;118:705-717.
26. sh mice: Age-dependent abolishment of c-kit gene expression. Blood 1994;83:3509-3516.
27. Lantz CS, Boesiger J, Song CH, Mach N, Kobayashi T, Mulligan RC, Nawa Y, Dranoff G, Galli SJ: Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 1998;392:90-93.
28. v mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J Exp Med 1985;162:1025-1043.
29. Wershil BK, Furuta GT, Wang ZS, Galli SJ: Mast cell-dependent neutrophil and mononuclear cell recruitment in immunoglobulin E-induced gastric reactions in mice. Gastroenterology 1996;110:1482-1490.
30. v mice that are genetically deficient in mast cells. J Exp Med 1987;165:615-627.
31. Martin TR, Takeishi T, Katz HR, Austen KF, Drazen JM, Galli SJ: Mast cell activation enhances airway responsiveness to methacholine in the mouse. J Clin Invest 1993;91:1176-1182.
32. Du T, Friend DS, Austen KF, Katz HR: Tissue-dependent differences in the asynchronous appearance of mast cells in normal mice and in congenic mast cell-deficient mice after infusion of normal bone marrow cells. Clin Exp Immunol 1996;103:316-321.
33. Tanzola MB, Robbie-Ryan M, Gutekunst CA, Brown MA: Mast cells exert effects outside the central nervous system to influence experimental allergic encephalomyelitis disease course. J Immunol 2003;171:4385-4391.
34. Wershil BK, Tsai M, Geissler EN, Zsebo KM, Galli SJ: The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function. J Exp Med 1992;175:245-255.
35. Ryan JJ, DeSimone S, Klisch G, Shelburne C, McReynolds LJ, Han K, Kovacs R, Mirmonsef P, Huff TF: IL-4 inhibits mouse mast cell FcεRI expression through a STAT6-dependent mechanism. J Immunol 1998;161:6915-6923.
36. Tsai M, Wedemeyer J, Ganiatsas S, Tam SY, Zon LI, Galli SJ: In vivo immunological function of mast cells derived from embryonic stem cells: An approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo. Proc Natl Acad Sci USA 2000;97:9186-9190.
37. Maurer M, Wedemeyer J, Metz M, Piliponsky AM, Chatterjea D, Clouthier DE, Yanagisawa M, Tsai M, Galli SJ: Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 2004;432:512-516.
38. Martin TR, Galli SJ, Katona IM, Drazen JM: Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice. J Clin Invest 1989;83:1375-1383.
39. Takeishi T, Martin TR, Katona IM, Finkelman FD, Galli SJ: Differences in the expression of the cardiopulmonary alterations associated with anti-immunoglobulin E-induced or active anaphylaxis in mast cell-deficient and normal mice. Mast cells are not required for the cardiopulmonary changes associated with certain fatal anaphylactic responses. J Clin Invest 1991;88:598-608.
40. Miyajima I, Dombrowicz D, Martin TR, Ravetch JV, Kinet JP, Galli SJ: Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and FcγRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest 1997;99:901-914.
41. Strait RT, Morris SC, Yang M, Qu XW, Finkelman FD: Pathways of anaphylaxis in the mouse. J Allergy Clin Immunol 2002;109:658-668.
42. Oettgen HC, Martin TR, Wynshaw-Boris A, Deng C, Drazen JM, Leder P: Active anaphylaxis in IgE-deficient mice. Nature 1994;370:367-370.
43. v mice. Int Arch Allergy Appl Immunol 1986;80:85-94.
44. Jacoby W, Cammarata PV, Findlay S, Pincus SH: Anaphylaxis in mast cell-deficient mice. J Invest Dermatol 1984;83:302-304.
45. Ha TY, Reed ND: Systemic anaphylaxis in mast-cell-deficient mice of W/Wv and Sl/Sld genotypes. Exp Cell Biol 1987;55:63-68.
46. Kimura S, Nagata M, Takeuchi M, Takano K, Harada M: Anti-granulocyte antibody suppression of active and passive anaphylactic shock in WBB6F1-W/Wv mice. Cell Mol Life Sci 1997;53:663-666.
47. Okunuki H, Teshima R, Sakushima J, Akiyama H, Goda Y, Toyoda M, Sawada JI: Induction of active systemic anaphylaxis by oral sensitization with ovalbumin in mast-cell-deficient mice. Immunol Lett 2000;74:233-237.
48. Ando A, Martin TR, Galli SJ: Effects of chronic treatment with the c-kit ligand, stem cell factor, on immunoglobulin E-dependent anaphylaxis in mice. Genetically mast cell-deficient Sl/Sld mice acquire anaphylactic responsiveness, but the congenic normal mice do not exhibit augmented responses. J Clin Invest 1993;92:1639-1649.
49. 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells. J Immunol 1987;139:2605-2614.
50. Wershil BK, Wang ZS, Gordon JR, Galli SJ: Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent. Partial inhibition of the reaction with antiserum against tumor necrosis factor-α. J Clin Invest 1991;87:446-453.
51. Furuta GT, Schmidt-Choudhury A, Wang MY, Wang ZS, Lu L, Furlano RI, Wershil BK: Mast cell-dependent tumor necrosis factor-α production participates in allergic gastric inflammation in mice. Gastroenterology 1997;113:1560-1569.
52. Gordon JR, Galli SJ: Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the FcεRI. Role for mast cell-derived transforming growth factor-β and tumor necrosis factor-α. J Exp Med 1994;180:2027-2037.
53. Ujike A, Ishikawa Y, Ono M, Yuasa T, Yoshino T, Fukumoto M, Ravetch JV, Takai T: Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG. J Exp Med 1999;189:1573-1579.
54. Cara DC, Ebbert KV, McCafferty DM: Mast cell-independent mechanisms of immediate hypersensitivity: A role for platelets. J Immunol 2004;172:4964-4971.
55. Latour S, Bonnerot C, Fridman WH, Daeron M: Induction of tumor necrosis factor-α production by mast cells via FcγR. Role of the FcγRIIIγ subunit. J Immunol 1992;149:2155-2162.
56. Finkelman FD, Rothenberg ME, Brandt EB, Morris SC, Strait RT: Molecular mechanisms of anaphylaxis: Lessons from studies with mouse models. J Allergy Clin Immunol 2005;115:449-457.
57. Choi IW, Kim YS, Kim DK, Choi JH, Seo KH, Im SY, Kwon KS, Lee MS, Ha TY, Lee HK: Platelet-activating factor-mediated NF-κB dependency of a late anaphylactic reaction. J Exp Med 2003;198:145-151.
58. Arase N, Arase H, Hirano S, Yokosuka T, Sakurai D, Saito T: IgE-mediated activation of NK cells through FcγRIII. J Immunol 2003;170:3054-3058.
59. Perdue MH, Masson S, Wershil BK, Galli SJ: Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient W/Wv mice by bone marrow transplantation. J Clin Invest 1991;87:687-693.
60. Redegeld FA, van der Heijden MW, Kool M, Heijdra BM, Garssen J, Kraneveld AD, Van Loveren H, Roholl P, Saito T, Verbeek JS, Claassens J, Koster AS, Nijkamp FP: Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Nat Med 2002;8:694-701.
61. Yu M, Tsai M, Tam SY, Galli SJ: Mast cells contribute to multiple features of a model of chronic asthma in mice. J Allergy Clin Immunol 2005;115:S188. Abstract no. 749.
62. Kobayashi T, Miura T, Haba T, Sato M, Serizawa I, Nagai H, Ishizaka K: An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model. J Immunol 2000;164:3855-3861.
63. Kung TT, Stelts D, Zurcher JA, Jones H, Umland SP, Kreutner W, Egan RW, Chapman RW: Mast cells modulate allergic pulmonary eosinophilia in mice. Am J Respir Cell Mol Biol 1995;12:404-409.
64. Nogami M, Suko M, Okudaira H, Miyamoto T, Shiga J, Ito M, Kasuya S: Experimental pulmonary eosinophilia in mice by Ascaris suum extract. Am Rev Respir Dis 1990;141:1289-1295.
65. Okudaira H, Nogami M, Matsuzaki G, Dohi M, Suko M, Kasuya S, Takatsu K: T-cell-dependent accumulation of eosinophils in the lung and its inhibition by monoclonal anti-interleukin-5. Int Arch Allergy Appl Immunol 1991;94:171-173.
66. Brusselle GG, Kips JC, Tavernier JH, van der Heyden JG, Cuvelier CA, Pauwels RA, Bluethmann H: Attenuation of allergic airway inflammation in IL-4-deficient mice. Clin Exp Allergy 1994;24:73-80.
67. Takeda K, Hamelmann E, Joetham A, Shultz LD, Larsen GL, Irvin CG, Gelfand EW: Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med 1997;186:449-454.
68. Liu LY, Swenson CA, Kelly EA, Kita H, Jarjour NN, Busse WW: Comparison of the effects of repetitive low-dose and single-dose antigen challenge on airway inflammation. J Allergy Clin Immunol 2003;111:818-825.
69. Kraneveld AD, van der Kleij HP, Kool M, van Houwelingen AH, Weitenberg AC, Redegeld FA, Nijkamp FP: Key role for mast cells in nonatopic asthma. J Immunol 2002;169:2044-2053.
70. Van Houwelingen AH, Kool M, de Jager SC, Redegeld FA, van Heuven-Nolsen D, Kraneveld AD, Nijkamp FP: Mast cell-derived TNF-α primes sensory nerve endings in a pulmonary hypersensitivity reaction. J Immunol 2002;168:5297-5302.
71. Tilley SL, Tsai M, Williams CM, Wang ZS, Erikson CJ, Galli SJ, Koller BH: Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice. J Immunol 2003;171:331-337.
72. Zhong H, Shlykov SG, Molina JG, Sanborn BM, Jacobson MA, Tilley SL, Blackburn MR: Activation of murine lung mast cells by the adenosine A3 receptor. J Immunol 2003;171:338-345.
73. Ryzhov S, Goldstein AE, Matafonov A, Zeng D, Biaggioni I, Feoktistov I: Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: An A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J Immunol 2004;172:7726-7733.
74. Gerard NP, Gerard C: Complement in allergy and asthma. Curr Opin Immunol 2002;14:705-708.
75. Grabbe S, Schwarz T: Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today 1998;19:37-44.
76. Cooms RPA, Gell PGH: The Classification of Allergic Reactions Underlying Disease. Oxford, Blackwell Scientific, 1963, pp 317-337.
77. d mast cell-deficient mice. J Immunol 1983;131:2687-2694.
78. Biedermann T, Kneilling M, Mailhammer R, Maier K, Sander CA, Kollias G, Kunkel SL, Hultner L, Rocken M: Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. J Exp Med 2000;192:1441-1452.
79. Thomas WR, Schrader JW: Delayed hypersensitivity in mast-cell-deficient mice. J Immunol 1983;130:2565-2567.
80. Galli SJ, Hammel I: Unequivocal delayed hypersensitivity in mast cell-deficient and beige mice. Science 1984;226:710-713.
81. d mice. J Immunol 1985;135:879-885.
82. Mekori YA, Weitzman GL, Galli SJ: Reevaluation of reserpine-induced suppression of contact sensitivity. Evidence that reserpine interferes with T lymphocyte function independently of an effect on mast cells. J Exp Med 1985;162:1935-1953.
83. Villa I, Skokos D, Tkaczyk C, Peronet R, David B, Huerre M, Mecheri S: Capacity of mouse mast cells to prime T cells and to induce specific antibody responses in vivo. Immunology 2001;102: 165-172.
84. Galli SJ, Dvorak AM, Dvorak HF: Basophils and mast cells: Morphologic insights into their biology, secretory patterns, and function. Prog Allergy 1984;34:1-141.
85. Dvorak HF, Galli SJ, Dvorak AM: Cellular and vascular manifestations of cell-mediated immunity. Hum Pathol 1986;17:122-137.
86. Galli SJ, Askenase PW: Cutaneous basophil hypersensitivity; in Abramoff P, Phillips SM, Escobar MR (eds): The Reticuloendothelial System: A Comprehensive Treatise, vol IX: Hypersensitivity. New York, Plenum, 1986, pp 321-369.
87. Damsgaard TE, Olesen AB, Sorensen FB, Thestrup-Pedersen K, Schiotz PO: Mast cells and atopic dermatitis. Stereological quantification of mast cells in atopic dermatitis and normal human skin. Arch Dermatol Res 1997;289:256-260.
88. Alenius H, Laouini D, Woodward A, Mizoguchi E, Bhan AK, Castigli E, Oettgen HC, Geha RS: Mast cells regulate IFN-γ expression in the skin and circulating IgE levels in allergen-induced skin inflammation. J Allergy Clin Immunol 2002;109:106-113.
89. Tam SY, Tsai M, Snouwaert JN, Kalesnikoff J, Scherrer D, Nakae S, Chatterjea D, Bouley DM, Galli SJ: RabGEF 1 is a negative regulator of mast cell activation and skin inflammation. Nat Immunol 2004;5:844-852.