Telomere shortening sensitizes cancer cells to selected cytotoxic agents: In vitro and in vivo studies and putative mechanisms

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Uziel, Orit ^a,b   Beery, Einat ^a,b   Dronichev, Vladimir ^a,b   Samocha, Katty ^a,b   Gryaznov, Sergei ^c   Weiss, Lola ^d   Slavin, Shimon ^d   Kushnir, Michal ^e   Nordenberg, Yardena ^a,b   Rabinowitz, Claudette ^f   Rinkevich, Baruch ^f   Zehavi, Tania ^g   Lahav, Meir ^a,b  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c GERON CORPORATION   (United States)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^e ROSETTA GENOMICS LTD   (Israel)

^f NATIONAL INSTITUTE OF OCEANOGRAPHY   (Israel)

^g MEIR MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYTOTOXIC AGENT; DNA; DOXORUBICIN; MICRORNA; TELOMERASE; VINCRISTINE; ANTINEOPLASTIC AGENT; GRN163; OLIGONUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CANCER CELL; CANCER THERAPY; CELL FUNCTION; CELL MIGRATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME INHIBITION; EWING SARCOMA; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICAL INFORMATION; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PHENOTYPE; TELOMERE; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; CELL MOTION; CELL STRAIN K 562; CELL SURVIVAL; COMET ASSAY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENETICS; METABOLISM; NEOPLASM; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; CISPLATIN; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; K562 CELLS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; OLIGONUCLEOTIDES; TELOMERASE; TELOMERE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77949352905     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009132     Document Type: Article

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