Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles

Molecular Cancer

Volumn 6, Issue , 2007, Pages

  Duale, Nur ^a   Lindeman, Birgitte ^a   Komada, Mitsuko ^a   Olsen, Ann Karin ^a   Andreassen, Ashild ^a   Soderlund, Erik J ^a   Brunborg, Gunnar ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; ESTRADIOL RECEPTOR; ESTRADIOL RECEPTOR 1; LARGE TUMOR SUPPRESSOR HOMOLOG 2 PROTEIN; MICRORNA; NEOGENIN HOMOLOG I; PROTEIN LATS2; PROTEIN NEO I; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CLUSTER ANALYSIS; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG RESPONSE; GENE EXPRESSION PROFILING; GENE TARGETING; GERM CELL TUMOR; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BINDING; QUALITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TESTIS CANCER; TUMOR SUPPRESSOR GENE; UPREGULATION; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; MALE; TESTIS TUMOR;

ANTINEOPLASTIC AGENTS; CISPLATIN; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; TESTICULAR NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 34748915836     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-6-53     Document Type: Article

References (81)

1. Bosl GJ Motzer RJ Testicular germ-cell cancer N Engl J Med 1997, 337:242-253. 10.1056/NEJM199707243370406 9227931
2. Mikuz G [WHO classification of testicular tumors] Verh Dtsch Ges Pathol 86:67-75. 12647353
3. Skakkebaek NE Possible carcinoma-in-situ of the testis Lancet 1972, 2:516-517. 10.1016/S0140-6736(72)91909-5 4115573
4. Looijenga LH de Munnik H Oosterhuis JW molecular model for the development of germ cell cancer Int J Cancer 1999, 83:809-814. 10.1002/ (SICI)1097-0215(19991210)83:6<809::AID-IJC20>3.0.CO;2-0 10597200
5. Pera MF Blasco Lafita MJ Mills J Cultured stem-cells from human testicular teratomas: The nature of human embryonal carcinoma, and its comparison with two types of yolk-sac carcinoma Int J Cancer 1987, 40:334-343. 10.1002/ijc.2910400309 2442105
6. Bronson DL Andrews PW Solter D Cervenka J Lange PH Fraley EE Cell line derived from a metastasis of a human testicular germ cell tumor Cancer Res 1980, 40:2500-2506. 7388807
7. Masters JR Koberle B Curing metastatic cancer: Lessons from testicular germ-cell tumours Nat Rev Cancer 2003, 3:517-525. 10.1038/nrc1120 12835671
8. Mayer F Honecker F Looijenga LH Bokemeyer C Towards an understanding of the biological basis of response to cisplatin-based chemotherapy in germ-cell tumors Ann Oncol 2003, 14:825-832.10.1093/annonc/mdg242 12796018
9. Mayer F Stoop H Scheffer GL Scheper R Oosterhuis JW Looijenga LH Bokemeyer C Molecular determinants of treatment response in human germ cell tumors Clin Cancer Res 2003, 9:767-773. 12576448
10. Burger H Nooter K Boersma AW Kortland CJ Stoter G Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines Br J Cancer 1998, 77:1562-1567. 9635829
11. Spierings DC de Vries EG Vellenga E de Jong S The attractive Achilles heel of germ cell tumours: An inherent sensitivity to apoptosis-inducing stimuli J Pathol 2003, 200:137-148. 10.1002/path.1373 12754734
12. Einhorn LH Chemotherapeutic and surgical strategies for germ cell tumors Chest Surg Clin N Am 2002, 12:695-706. 12471872
13. Koberle B Masters JR Hartley JA Wood RD Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours Curr Biol 1999, 9:273-276.10.1016/ S0960-9822(99)80118-3 10074455
14. Welsh C Day R McGurk C Masters JR Wood RD Koberle B Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines Int J Cancer 2004, 20;110:352-361. 10.1002/ijc.20134
15. Gonzalez VM Fuertes MA Alonso C Perez JM Is cisplatin-induced cell death always produced by apoptosis? Mol Pharmacol 2001, 59:657-663. 11259608
16. Trimmer EE Zamble DB Lippard SJ Essigmann JM Human testis-determining factor SRY binds to the major DNA adduct of cisplatin and a putative target sequence with comparable affinities Biochemistry 1998, 37:352-362. 10.1021/bi971675q 9425057
17. Zamble DB Mikata Y Eng CH Sandman KE Lippard SJ Testis-specific HMG-domain protein alters the responses of cells to cisplatin J Inorg Biochem 2002, 91:451-462. 10.1016/S0162-0134(02)00472-5 12175937
18. Jansen J Olsen AK Wiger R Naegeli H de Boer P van Der HF Holme JA Brunborg G Mullenders L Nucleotide excision repair in rat male germ cells: Low level of repair in intact cells contrasts with high dual incision activity in vitro Nucleic Acids Res 2001, 29:1791-1800. 31314 11292852 10.1093/nar/29.8.1791
19. Olsen AK Duale N Bjoras M Larsen CT Wiger R Holme JA Seeberg EC Brunborg G Limited repair of 8-hydroxy-7,8-dihydroguanine residues in human testicular cells Nucleic Acids Res 2003, 31:1351-1363.150234 12582255 10.1093/nar/gkg216
20. Hayes KR Vollrath AL Zastrow GM McMillan BJ Craven M Jovanovich S Rank DR Penn S Walisser JA Reddy JK Thomas RS Bradfield CA EDGE: A centralized resource for the comparison, analysis, and distribution of toxicogenomic information Mol Pharmacol 2005, 67:1360-1368. 10.1124/ mol.104.009175 15662043
21. Scherf U Ross DT Waltham M Smith LH Lee JK Tanabe L Kohn KW Reinhold WC Myers TG Andrews DT Scudiero DA Eisen MB Sausville EA Pommier Y Botstein D Brown PO Weinstein JN A gene expression database for the molecular pharmacology of cancer Nat Genet 2000, 24:236-244. 10.1038/73439 10700175
22. Steiner G Suter L Boess F Gasser R de Vera MC Albertini S Ruepp S Discriminating different classes of toxicants by transcript profiling Environ Health Perspect 2004, 112:1236-1248. 1277117 15345370
23. Ashburner M Ball CA Blake JA Botstein D Butler H Cherry JM Davis AP Dolinski K Dwight SS Eppig JT Harris MA Hill DP Issel-Tarver L Kasarskis A Lewis S Matese JC Richardson JE Ringwald M Rubin GM Sherlock G Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium Nat Genet 2000, 25:25-29. 10.1038/75556 10802651
24. PANTHER-database http://www.pantherdb.org/
25. Gyorffy B Surowiak P Kiesslich O Denkert C Schafer R Dietel M Lage H Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations Int J Cancer 2006, 118:1699-1712. 10.1002/ijc.21570 16217747
26. GeneTools http://www.genetools.microarray.ntnu.no/adb/
27. Beisvag V Junge FK Bergum H Jolsum L Lydersen S Gunther CC Ramampiaro H Langaas M Sandvik AK Laegreid A GeneTools - application for functional annotation and statistical hypothesis testing BMC Bioinformatics 2006, 7:470-470 10.1186/1471-2105-7-470
28. Thomas PD Kejariwal A Guo N Mi H Campbell MJ Muruganujan A Lazareva-Ulitsky B Applications for protein sequence-function evolution data: MRNA/protein expression analysis and coding SNP scoring tools Nucleic Acids Res 2006, 34:W645-W650. 1538848 16912992 10.1093/nar/gkl229
29. Skotheim RI Lind GE Monni O Nesland JM Abeler VM Fossa SD Duale N Brunborg G Kallioniemi O Andrews PW Lothe RA Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development Cancer Res 2005, 65:5588-5598. 10.1158/ 0008-5472.CAN-05-0153 15994931
30. Zamble DB Jacks T Lippard SJ p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells Proc Natl Acad Sci USA 1998, 95:6163-6168. 27612 9600935 10.1073/pnas.95.11.6163
31. Curtin JC Dragnev KH Sekula D Christie AJ Dmitrovsky E Spinella MJ Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function Oncogene 2001, 20:2559-2569. 10.1038/sj.onc.1204370 11420666
32. Lutzker SG Mathew R Taller DR A p53 dose-response relationship for sensitivity to DNA damage in isogenic teratocarcinoma cells Oncogene 2001, 20:2982-2986. 10.1038/sj.onc.1204394 11420711
33. Burger H Nooter K Boersma AW van Wingerden KE Looijenga LH Jochemsen AG Stoter G Distinct p53-independent apoptotic cell death signalling pathways in testicular germ cell tumour cell lines Int J Cancer 1999, 81:620-628. 10.1002/ (SICI)1097-0215(19990517)81:4<620::AID-IJC19>3.0.CO;2-S 10225454
34. Kersemaekers AM Mayer F Molier M van Weeren PC Oosterhuis JW Bokemeyer C Looijenga LH Role of P53 and MDM2 in treatment response of human germ cell tumors J Clin Oncol 2002, 20:1551-1561. 10.1200/JCO.20.6.1551 11896104
35. Kerley-Hamilton JS Pike AM Li N DiRenzo J Spinella MJ A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embryonal carcinoma Oncogene 2005, 24:6090-6100. 10.1038/sj.onc.1208755 15940259
36. Voorhoeve PM le Sage C Schrier M Gillis AJ Stoop H Nagel R Liu YP van Duijse J Drost J Griekspoor A Zlotorynski E Yabuta N De Vita G Nojima H Looijenga LH Agami R A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors Cell 2006, 124:1169-1181. 10.1016/j.cell.2006.02.037 16564011
37. Christoph F Kempkensteffen C Weikert S Krause H Schostak M Miller K Schrader M Frequent epigenetic inactivation of p53 target genes in seminomatous and nonseminomatous germ cell tumors Cancer Lett 2007, 247:137-142. 10.1016/j.canlet.2006.03.028 16697107
38. Zhao F Xuan Z Liu L Zhang MQ TRED: A Transcriptional Regulatory Element Database and a platform for in silico gene regulation studies Nucleic Acids Res 2005, 33:D103-D107. 539958 15608156 10.1093/nar/gki004
39. Lenhard B Wasserman WW TFBS: Computational framework for transcription factor binding site analysis Bioinformatics 2002, 18:1135-1136. 10.1093/ bioinformatics/18.8.1135 12176838
40. Sandelin A Alkema W Engstrom P Wasserman WW Lenhard B JASPAR: An open-access database for eukaryotic transcription factor binding profiles Nucleic Acids Res 2004, 32:D91-D94. 308747 14681366 10.1093/nar/ gkh012
41. Krek A Grun D Poy MN Wolf R Rosenberg L Epstein EJ MacMenamin P da PI Gunsalus KC Stoffel M Rajewsky N Combinatorial microRNA target predictions Nat Genet 2005, 37:495-500. 10.1038/ng1536 15806104
42. Lewis BP Burge CB Bartel DP Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 2005, 120:15-20. 10.1016/j.cell.2004.12.035 15652477
43. Schwarze SR DePrimo SE Grabert LM Fu VX Brooks JD Jarrard DF Novel pathways associated with bypassing cellular senescence in human prostate epithelial cells J Biol Chem 2002, 277:14877-14883. 10.1074/ jbc.M200373200 11836256
44. Chang BD Swift ME Shen M Fang J Broude EV Roninson IB Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent Proc Natl Acad Sci USA 2002, 99:389-394. 117570 11752408 10.1073/pnas.012602599
45. Tusher VG Tibshirani R Chu G Significance analysis of microarrays applied to the ionizing radiation response Proc Natl Acad Sci USA 2001, 98:5116-5121. 33173 11309499 10.1073/pnas.091062498
46. Eisen MB Spellman PT Brown PO Botstein D Cluster analysis and display of genome-wide expression patterns Proc Natl Acad Sci USA 1998, 95:14863-14868. 24541 9843981 10.1073/pnas.95.25.14863
47. Roninson IB Dokmanovic M Induction of senescence-associated growth inhibitors in the tumor-suppressive function of retinoids J Cell Biochem 2003, 88:83-94. 10.1002/jcb.10320 12461777
48. Michael D Oren M The p53-Mdm2 module and the ubiquitin system Semin Cancer Biol 2003, 13:49-58. 10.1016/S1044-579X(02)00099-8 12507556
49. Vogelstein B Lane D Levine AJ Surfing the p53 network Nature 2000, 408:307-310. 10.1038/35042675 11099028
50. Li Y Pei J Xia H Ke H Wang H Tao W Lats2, a putative tumor suppressor, inhibits G1/S transition Oncogene 2003, 22:4398-4405. 10.1038/ sj.onc.1206603 12853976
51. Lee RC Ambros V An extensive class of small RNAs in Caenorhabditis elegans Science 2001, 294:862-864. 10.1126/science.1065329 11679672
52. Lewis BP Shih IH Jones-Rhoades MW Bartel DP Burge CB Prediction of mammalian microRNA targets Cell 2003, 115:787-798. 10.1016/ S0092-8674(03)01018-3 14697198
53. Bernstein E Kim SY Carmell MA Murchison EP Alcorn H Li MZ Mills AA Elledge SJ Anderson KV Hannon GJ Dicer is essential for mouse development Nat Genet 2003, 35:215-217. 10.1038/ng1253 14528307
54. Kanellopoulou C Muljo SA Kung AL Ganesan S Drapkin R Jenuwein T Livingston DM Rajewsky K Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing Genes Dev 2005, 19:489-501. 548949 15713842 10.1101/gad.1248505
55. Kent OA Mendell JT A small piece in the cancer puzzle: MicroRNAs as tumor suppressors and oncogenes Oncogene 2006, 25:6188-6196. 10.1038/ sj.onc.1209913 17028598
56. Spierings DC de Vries EG Vellenga E de Jong S The attractive Achilles heel of germ cell tumours: An inherent sensitivity to apoptosis-inducing stimuli J Pathol 2003, 200:137-148. 10.1002/path.1373 12754734
57. di Pietro A Vries EG Gietema JA Spierings DC de Jong S Testicular germ cell tumours: The paradigm of chemo-sensitive solid tumours Int J Biochem Cell Biol 2005, 37:2437-2456.10.1016/j.biocel.2005.06.014 16099193
58. Coureuil M Fouchet P Prat M Letallec B Barroca V Dos SC Racine C Allemand I Caspase-independent death of meiotic and postmeiotic cells overexpressing p53: Calpain involvement Cell Death Differ 2006, 13:1927-1937. 10.1038/sj.cdd.4401887 16528385
59. XDel Bello B Moretti D Gamberucci A Maellaro E Cross-talk between calpain and caspase-3/-7 in cisplatin-induced apoptosis of melanoma cells: A major role of calpain inhibition in cell death protection and p53 status Oncogene 26:2717-2726. 10.1038/sj.onc.1210079 17130844
60. Schwarze SR Fu VX Desotelle JA Kenowski ML Jarrard DF The identification of senescence-specific genes during the induction of senescence in prostate cancer cells Neoplasia 2005, 7:816-823. 1501939 16229804 10.1593/neo.05250
61. Wang X Wong SC Pan J Tsao SW Fung KH Kwong DL Sham JS Nicholls JM Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells Cancer Res 1998, 58:5019-5022. 9823301
62. Chang BD Xuan Y Broude EV Zhu H Schott B Fang J Roninson IB Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs Oncogene 1999, 18:4808-4818. 10.1038/sj.onc.1203078 10490814
63. Chang BD Broude EV Dokmanovic M Zhu H Ruth A Xuan Y Kandel ES Lausch E Christov K Roninson IB A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents Cancer Res 1999, 59:3761-3767. 10446993
64. Chang BD Broude EV Fang J Kalinichenko TV Abdryashitov R Poole JC Roninson IB p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells Oncogene 2000, 20;19:2165-2170. 10.1038/sj.onc.1203573
65. Chang BD Watanabe K Broude EV Fang J Poole JC Kalinichenko TV Roninson IB Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases Proc Natl Acad Sci USA 2000, 97:4291-4296. 10760295 10.1073/ pnas.97.8.4291
66. Spierings DC de Vries EG Stel AJ te RN Vellenga E de Jong S Low p21Waf1/ Cip1 protein level sensitizes testicular germ cell tumor cells to Fas-mediated apoptosis Oncogene 2004, 23:4862-4872. 10.1038/ sj.onc.1207617 15122333
67. Dotto GP p21(WAF1/Cip1): More than a break to the cell cycle? Biochim Biophys Acta 2000, 1471:M43-M56. 10967424
68. Roninson IB Oncogenic functions of tumour suppressor p21(Waf1/Cip1/ Sdi1): Association with cell senescence and tumour-promoting activities of stromal fibroblasts Cancer Lett 2002, 179:1-14. 10.1016/ S0304-3835(01)00847-3 11880176
69. Untergasser G Koch HB Menssen A Hermeking H Characterization of epithelial senescence by serial analysis of gene expression: identification of genes potentially involved in prostate cancer Cancer Res 2002, 62:6255-6262. 12414655
70. Roninson IB Broude EV Chang BD If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells Drug Resist Updat 2001, 4:303-313.10.1054/drup.2001.0213 11991684
71. Lock RB Stribinskiene L Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival Cancer Res 1996, 56:4006-4012. 8752171
72. Rebbaa A Zheng X Chou PM Mirkin BL Caspase inhibition switches doxorubicin-induced apoptosis to senescence Oncogene 2003, 22:2805-2811. 10.1038/sj.onc.1206366 12743603
73. Schmitt CA Fridman JS Yang M Lee S Baranov E Hoffman RM Lowe SW A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy Cell 2002, 109:335-346. 10.1016/ S0092-8674(02)00734-1 12015983
74. Norwegian Microarray Consortium http://www.mikromatrise.no/
75. Dysvik B Jonassen I J-Express: Exploring gene expression data using Java Bioinformatics 2001, 17:369-370. 10.1093/bioinformatics/17.4.369 11301307
76. GEO http://www.ncbi.nlm.nih.gov/geo/
77. Brazma A Hingamp P Quackenbush J Sherlock G Spellman P Stoeckert C Aach J Ansorge W Ball CA Causton HC Gaasterland T Glenisson P Holstege FC Kim IF Markowitz V Matese JC Parkinson H Robinson A Sarkans U Schulze-Kremer S Stewart J Taylor R Vilo J Vingron M Minimum information about a microarray experiment (MIAME)-toward standards for microarray data Nat Genet 2001, 29:365-371. 10.1038/ng1201-365 11726920
78. Raychaudhuri S Stuart JM Altman RB Principal components analysis to summarize microarray experiments: Application to sporulation time series Pac Symp Biocomput 2000:455-466. 10902193
79. Wang X Seed B A PCR primer bank for quantitative gene expression analysis Nucleic Acids Res 2003, 31:e154. 291882 14654707 10.1093/nar/ gng154
80. Wei CL Wu Q Vega VB Chiu KP Ng P Zhang T Shahab A Yong HC Fu Y Weng Z Liu J Zhao XD Chew JL Lee YL Kuznetsov VA Sung WK Miller LD Lim B Liu ET Yu Q Ng HH Ruan Y A global map of p53 transcription-factor binding sites in the human genome Cell 2006, 124:207-219. 10.1016/j.cell.2005.10.043 16413492
81. Barenco M Tomescu D Brewer D Callard R Stark J Hubank M Ranked prediction of p53 targets using hidden variable dynamic modeling Genome Biol 2006, 7:R25. 1557743 16584535 10.1186/gb-2006-7-3-r25