메뉴 건너뛰기




Volumn 151, Issue 4, 2010, Pages 401-411

Toxicological application of primary hepatocyte cell cultures of Atlantic cod (Gadus morhua) - Effects of BNF, PCDD and Cd

Author keywords

Atlantic cod primary hepatocyte culture; Bioassay; BNF; Cd; CYP1A; Exposure; HO 1; MT; PCDD

Indexed keywords

BETA NAPHTHOFLAVONE; CADMIUM; CYTOCHROME P450 1A; GLUCURONOSYLTRANSFERASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HEAT SHOCK PROTEIN 70; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; METALLOTHIONEIN; POLYCHLORINATED DIBENZODIOXIN; TRANSFERRIN; UNCLASSIFIED DRUG; VITELLOGENIN; VITELLOGENIN B;

EID: 77949310484     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpc.2010.01.003     Document Type: Article
Times cited : (35)

References (64)
  • 3
    • 0030439094 scopus 로고    scopus 로고
    • Contaminant accumulation and biomarker responses in flounder (Platichthys flesus L.) and Atlantic cod (Gadus morhua L.) exposed by caging to polluted sediments in Sørfjorden, Norway
    • Beyer J., Sandvik M., Hylland K., Fjeld E., Egaas E., Aas E., Skåre J.U., and Gokdøyr A. Contaminant accumulation and biomarker responses in flounder (Platichthys flesus L.) and Atlantic cod (Gadus morhua L.) exposed by caging to polluted sediments in Sørfjorden, Norway. Aquat. Toxicol. 36 (1996) 75-98
    • (1996) Aquat. Toxicol. , vol.36 , pp. 75-98
    • Beyer, J.1    Sandvik, M.2    Hylland, K.3    Fjeld, E.4    Egaas, E.5    Aas, E.6    Skåre, J.U.7    Gokdøyr, A.8
  • 4
    • 43349090130 scopus 로고    scopus 로고
    • The heme oxygenase-carbon monoxide system: regulation and role in stress response and organ failure
    • Bauer M., Huse K., Settmacher U., and Claus R.A. The heme oxygenase-carbon monoxide system: regulation and role in stress response and organ failure. Intensive Care Med. 34 (2008) 640-648
    • (2008) Intensive Care Med. , vol.34 , pp. 640-648
    • Bauer, M.1    Huse, K.2    Settmacher, U.3    Claus, R.A.4
  • 5
    • 33751194683 scopus 로고    scopus 로고
    • The effect of aryl hydrocarbon receptor lignads on the expression of AhR, AhRR, ARNT, Hif1α, CYP1A1 and NQO1 genes in rat liver
    • Brauze D., Widerak M., Cwykiel J., Szyfter K., and Baer-Dubowska W. The effect of aryl hydrocarbon receptor lignads on the expression of AhR, AhRR, ARNT, Hif1α, CYP1A1 and NQO1 genes in rat liver. Toxicol. Lett. 167 (2006) 212-220
    • (2006) Toxicol. Lett. , vol.167 , pp. 212-220
    • Brauze, D.1    Widerak, M.2    Cwykiel, J.3    Szyfter, K.4    Baer-Dubowska, W.5
  • 6
    • 8444247983 scopus 로고    scopus 로고
    • Regulation of heat shock genes in isolated hepatocytes from an Antarctic fish, Trematomus bernacchii
    • Buckley B., Place S.P., and Hofmann G.E. Regulation of heat shock genes in isolated hepatocytes from an Antarctic fish, Trematomus bernacchii. J. Exp. Biol. 207 (2004) 3649-3656
    • (2004) J. Exp. Biol. , vol.207 , pp. 3649-3656
    • Buckley, B.1    Place, S.P.2    Hofmann, G.E.3
  • 7
    • 0034060274 scopus 로고    scopus 로고
    • Characterization of CYP1A1 and CYP1A3 gene expression in rainbow trout (Oncorhynchus mykiss)
    • Cao Z., Hong J., Peterson R.E., and Aiken J.M. Characterization of CYP1A1 and CYP1A3 gene expression in rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 49 (2000) 101-109
    • (2000) Aquat. Toxicol. , vol.49 , pp. 101-109
    • Cao, Z.1    Hong, J.2    Peterson, R.E.3    Aiken, J.M.4
  • 8
    • 0036175228 scopus 로고    scopus 로고
    • Understanding the human health effects of chemical mixtures
    • Carpenter D.O., Arcaro K., and Spink D.C. Understanding the human health effects of chemical mixtures. Environ. Health Perspect. 110 1 (2002) 25-42
    • (2002) Environ. Health Perspect. , vol.110 , Issue.1 , pp. 25-42
    • Carpenter, D.O.1    Arcaro, K.2    Spink, D.C.3
  • 10
    • 48749121190 scopus 로고    scopus 로고
    • Changes in transferring and hepcidin genes expression in the liver of the fish Pseudosciaena crocea following exposure to cadmium
    • Chen J., Shi Y.H., and Li M.Y. Changes in transferring and hepcidin genes expression in the liver of the fish Pseudosciaena crocea following exposure to cadmium. Arch. Toxicol. 82 (2008) 525-530
    • (2008) Arch. Toxicol. , vol.82 , pp. 525-530
    • Chen, J.1    Shi, Y.H.2    Li, M.Y.3
  • 11
    • 0000196439 scopus 로고    scopus 로고
    • Cadmium blocks hypoxia-inducible factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependant degradation of HIF-1α
    • Chun Y., Choi E., Kim G., Choi H., Kim C., Lee M., Kim M., and Park J. Cadmium blocks hypoxia-inducible factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependant degradation of HIF-1α. Eur. J. Biochem. 267 (2000) 4198-4204
    • (2000) Eur. J. Biochem. , vol.267 , pp. 4198-4204
    • Chun, Y.1    Choi, E.2    Kim, G.3    Choi, H.4    Kim, C.5    Lee, M.6    Kim, M.7    Park, J.8
  • 12
    • 0035872478 scopus 로고    scopus 로고
    • Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7
    • Coumoul X., Diry M., Robillot C., and Barouki R. Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7. Cancer Res. 61 (2001) 3942-3948
    • (2001) Cancer Res. , vol.61 , pp. 3942-3948
    • Coumoul, X.1    Diry, M.2    Robillot, C.3    Barouki, R.4
  • 14
    • 3543036976 scopus 로고    scopus 로고
    • Recombinant cell bioassay systems for the detection and relative quantification of halogenated dioxins and related chemicals
    • Denison M.S., Zhao B., Baston D.S., Clark G.C., Murata H., and Han D. Recombinant cell bioassay systems for the detection and relative quantification of halogenated dioxins and related chemicals. Talanta 63 (2004) 1123-1133
    • (2004) Talanta , vol.63 , pp. 1123-1133
    • Denison, M.S.1    Zhao, B.2    Baston, D.S.3    Clark, G.C.4    Murata, H.5    Han, D.6
  • 15
    • 0035129176 scopus 로고    scopus 로고
    • Cadmium-binding to transferrin in the plasma of the common carp Cyrinus carpio
    • De smet H., Brust R., and Moens L. Cadmium-binding to transferrin in the plasma of the common carp Cyrinus carpio. Comp. Biochem. Physiol. C 128 (2001) 45-53
    • (2001) Comp. Biochem. Physiol. C , vol.128 , pp. 45-53
    • De smet, H.1    Brust, R.2    Moens, L.3
  • 16
    • 38749111070 scopus 로고    scopus 로고
    • β-naphtoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats
    • Dewa Y., Nishimura J., Muguruma M., Jin M., Saegusa Y., Okamura T., Tasaki M., Umemura T., and Mitsumori K. β-naphtoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats. Toxicology 244 (2008) 179-189
    • (2008) Toxicology , vol.244 , pp. 179-189
    • Dewa, Y.1    Nishimura, J.2    Muguruma, M.3    Jin, M.4    Saegusa, Y.5    Okamura, T.6    Tasaki, M.7    Umemura, T.8    Mitsumori, K.9
  • 17
    • 4444366272 scopus 로고    scopus 로고
    • Modulation of aryl hydrocarmon receptor-regulated gene expression by arsenite, cadmium, and chromium
    • Elbekai R.H., and El-Kadi A.O.S. Modulation of aryl hydrocarmon receptor-regulated gene expression by arsenite, cadmium, and chromium. Toxicology 202 (2004) 249-269
    • (2004) Toxicology , vol.202 , pp. 249-269
    • Elbekai, R.H.1    El-Kadi, A.O.S.2
  • 18
    • 33847078849 scopus 로고    scopus 로고
    • Toxicogenomic responses in rainbow trout (Oncorhynchus mykiss) hepatocytes exposed to model chemicals and a synthetic mixture
    • Finne E.F., Cooper G.A., Koop B.F., Hylland K., and Tollefsen K.E. Toxicogenomic responses in rainbow trout (Oncorhynchus mykiss) hepatocytes exposed to model chemicals and a synthetic mixture. Aquat. Toxicol. 81 (2007) 293-303
    • (2007) Aquat. Toxicol. , vol.81 , pp. 293-303
    • Finne, E.F.1    Cooper, G.A.2    Koop, B.F.3    Hylland, K.4    Tollefsen, K.E.5
  • 21
    • 85056057853 scopus 로고    scopus 로고
    • Receptor-mediated mechanisms of toxicity
    • Di Giulio, and Hinton D.E. (Eds), Taylor and Francis Group, Boca Raton Florida, USA
    • Hahn M.E., and Hestermann E.V. Receptor-mediated mechanisms of toxicity. In: Di Giulio, and Hinton D.E. (Eds). The Toxicology of Fishes (2008), Taylor and Francis Group, Boca Raton Florida, USA 235-272
    • (2008) The Toxicology of Fishes , pp. 235-272
    • Hahn, M.E.1    Hestermann, E.V.2
  • 22
    • 38549166269 scopus 로고    scopus 로고
    • Functional properties of the four Atlantic salmon (Salmon salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms
    • Hansson M.C., and Hahn M.E. Functional properties of the four Atlantic salmon (Salmon salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms. Aquat. Toxicol. 86 (2008) 121-130
    • (2008) Aquat. Toxicol. , vol.86 , pp. 121-130
    • Hansson, M.C.1    Hahn, M.E.2
  • 23
    • 33745656989 scopus 로고    scopus 로고
    • Regulating the regulator: Factors that control levels and activity of the aryl hydrocarbon receptor
    • Harper P.A., Riddick A.B., and Okey A.B. Regulating the regulator: Factors that control levels and activity of the aryl hydrocarbon receptor. Biochem. Pharmacol. 72 (2006) 267-279
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 267-279
    • Harper, P.A.1    Riddick, A.B.2    Okey, A.B.3
  • 24
    • 0027954394 scopus 로고
    • Response of hepatic xenobic metabolizing enzymes in rainnbow trout (Oncorhyncus mykiss) and cod (Gadus morhua) to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (2, 3, 7, 8-TCDD)
    • Hektoen H., Bernhoft A., Ingebrigtsen K., Skaare J.U., and Goksøyr A. Response of hepatic xenobic metabolizing enzymes in rainnbow trout (Oncorhyncus mykiss) and cod (Gadus morhua) to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (2, 3, 7, 8-TCDD). Aquat. Toxicol. 28 (1994) 97-106
    • (1994) Aquat. Toxicol. , vol.28 , pp. 97-106
    • Hektoen, H.1    Bernhoft, A.2    Ingebrigtsen, K.3    Skaare, J.U.4    Goksøyr, A.5
  • 25
    • 0034843792 scopus 로고    scopus 로고
    • Relative potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners to induce cytochrome P4501A mRNA in a zebrafish liver cell line
    • Henry T.R., Nesbit D.J., Heideman W., and Peterson R.E. Relative potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners to induce cytochrome P4501A mRNA in a zebrafish liver cell line. Environ. Toxicol. Chem. 20 5 (2001) 1053-1058
    • (2001) Environ. Toxicol. Chem. , vol.20 , Issue.5 , pp. 1053-1058
    • Henry, T.R.1    Nesbit, D.J.2    Heideman, W.3    Peterson, R.E.4
  • 26
    • 85045455029 scopus 로고    scopus 로고
    • Liver toxicity
    • Di Giulio, and Hinton D.E. (Eds), Taylor and Francis Group, Boca Raton Florida, USA
    • Hinton D.E., Segner H., Au D.W.T., Kullman S.W., and Hardman R.C. Liver toxicity. In: Di Giulio, and Hinton D.E. (Eds). The Toxicology of Fishes (2008), Taylor and Francis Group, Boca Raton Florida, USA 327-400
    • (2008) The Toxicology of Fishes , pp. 327-400
    • Hinton, D.E.1    Segner, H.2    Au, D.W.T.3    Kullman, S.W.4    Hardman, R.C.5
  • 27
    • 0027946666 scopus 로고
    • Immunohistochemical localization of CYP1A and CYP3A-like isoezymes in hepatic and extrahepatic tissues of Atlantic cod (Gadus morhua L.), a marine fish
    • Husøy A., Myers M.S., Willis M.L., Collier T.K., Celander M., and Goksøyr A. Immunohistochemical localization of CYP1A and CYP3A-like isoezymes in hepatic and extrahepatic tissues of Atlantic cod (Gadus morhua L.), a marine fish. Toxicol. Appl. Pharmacol. 129 (1994) 294-308
    • (1994) Toxicol. Appl. Pharmacol. , vol.129 , pp. 294-308
    • Husøy, A.1    Myers, M.S.2    Willis, M.L.3    Collier, T.K.4    Celander, M.5    Goksøyr, A.6
  • 28
    • 0030292719 scopus 로고    scopus 로고
    • Cellular localization of cytocrome P450 (CYP1A) induction and histology in Atlantic cod (Gadus morhua L.) and European flounder (Platichthys flesus) after environmental exposure to contaminants by caging in Sørfjorden, Norway
    • Husøy A., Myers M.S., and Goksøyr A. Cellular localization of cytocrome P450 (CYP1A) induction and histology in Atlantic cod (Gadus morhua L.) and European flounder (Platichthys flesus) after environmental exposure to contaminants by caging in Sørfjorden, Norway. Aquat. Toxicol. 36 (1996) 53-73
    • (1996) Aquat. Toxicol. , vol.36 , pp. 53-73
    • Husøy, A.1    Myers, M.S.2    Goksøyr, A.3
  • 34
    • 43849108607 scopus 로고    scopus 로고
    • Transcriptional effects of PFOS in isolated hepatocytes from Atlantic salmon Salmo salar L.
    • Krøvel A.V., Søfteland L., Torstensen B., and Olsvik P.A. Transcriptional effects of PFOS in isolated hepatocytes from Atlantic salmon Salmo salar L. Comp. Biochem. Physiol. C 148 (2008) 14-22
    • (2008) Comp. Biochem. Physiol. C , vol.148 , pp. 14-22
    • Krøvel, A.V.1    Søfteland, L.2    Torstensen, B.3    Olsvik, P.A.4
  • 35
    • 39549123399 scopus 로고    scopus 로고
    • Regulation of heme oxygenase-1 mRNA deadenylation and turnover in NIH3T3 cells by nitosative or alkylation stress
    • Leautaud V., and Demple B. Regulation of heme oxygenase-1 mRNA deadenylation and turnover in NIH3T3 cells by nitosative or alkylation stress. BMC Mol. Biol. 8 (2007) 1-14
    • (2007) BMC Mol. Biol. , vol.8 , pp. 1-14
    • Leautaud, V.1    Demple, B.2
  • 36
    • 16644386406 scopus 로고    scopus 로고
    • Isolation and culture of primary human hepatocytes
    • Methods in Molecular Biology. Helgason C.D., and Miller C.L. (Eds), Humana Press, New Jersey, USA
    • LeCluyse E.L., Alexandre E., Hamilton G.A., Viollon-Abadie C., Coon D.J., Jolley S., and Richert L. Isolation and culture of primary human hepatocytes. In: Helgason C.D., and Miller C.L. (Eds). Methods in Molecular Biology. Basic Cell Culture Protocols vol. 290 (2005), Humana Press, New Jersey, USA 207-229
    • (2005) Basic Cell Culture Protocols , vol.290 , pp. 207-229
    • LeCluyse, E.L.1    Alexandre, E.2    Hamilton, G.A.3    Viollon-Abadie, C.4    Coon, D.J.5    Jolley, S.6    Richert, L.7
  • 37
    • 33744521129 scopus 로고    scopus 로고
    • Effects of 12 metal ions in iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1α) and HIF-regulated genes
    • Li Q., Chen H., Huang X., and Costa M. Effects of 12 metal ions in iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1α) and HIF-regulated genes. Toxicol. Appl. Pharmacol. 213 (2006) 245-255
    • (2006) Toxicol. Appl. Pharmacol. , vol.213 , pp. 245-255
    • Li, Q.1    Chen, H.2    Huang, X.3    Costa, M.4
  • 38
  • 39
    • 20044386351 scopus 로고    scopus 로고
    • Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology
    • Mandal P.K. Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology. J. Comp. Physiol. 175B (2005) 221-230
    • (2005) J. Comp. Physiol. , vol.175 B , pp. 221-230
    • Mandal, P.K.1
  • 40
    • 34247498338 scopus 로고    scopus 로고
    • Interactions between estrogen- and Ah-receptor signalling pathway in primary culture of salmon hepatocytes exposed to nonylphenol and 3, 3′, 4, 4′- tetrachlorobiphenyl (congener 77)
    • Mortensen A.S., and Arukwe A. Interactions between estrogen- and Ah-receptor signalling pathway in primary culture of salmon hepatocytes exposed to nonylphenol and 3, 3′, 4, 4′- tetrachlorobiphenyl (congener 77). Comp. Hepatol. 6 (2007) 2
    • (2007) Comp. Hepatol. , vol.6 , pp. 2
    • Mortensen, A.S.1    Arukwe, A.2
  • 41
    • 51449111251 scopus 로고    scopus 로고
    • Polychlorinated dibenzo-p-dioxin and dibenzofurans (PCDD/Fs) in marine mussels from French coasts: levels, patterns and temporal trends from 1981 to 2005
    • Munschy C., Guiot N., Heas-Moisan K., Tixier C., and Tronczynski J. Polychlorinated dibenzo-p-dioxin and dibenzofurans (PCDD/Fs) in marine mussels from French coasts: levels, patterns and temporal trends from 1981 to 2005. Chemosphere 73 (2008) 945-953
    • (2008) Chemosphere , vol.73 , pp. 945-953
    • Munschy, C.1    Guiot, N.2    Heas-Moisan, K.3    Tixier, C.4    Tronczynski, J.5
  • 42
    • 77949285158 scopus 로고    scopus 로고
    • NIFES
    • NIFES, 2009. http://www.nifes.no/index.php?page_id=167.
    • (2009)
  • 43
    • 49849103986 scopus 로고    scopus 로고
    • Effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on heme oxigenases-1, biliverdin IXα reductase and δ-aminolevulinic acid synthetase 1 in rats with wild-type or variant AH receptor
    • Niittynen M., Tuomieto J.T., and Pohjanvirta R. Effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on heme oxigenases-1, biliverdin IXα reductase and δ-aminolevulinic acid synthetase 1 in rats with wild-type or variant AH receptor. Toxicology 250 (2008) 12-142
    • (2008) Toxicology , vol.250 , pp. 12-142
    • Niittynen, M.1    Tuomieto, J.T.2    Pohjanvirta, R.3
  • 44
    • 33745220555 scopus 로고    scopus 로고
    • Caging techniques for field exposures of fish to chemical contaminants
    • Oikari A. Caging techniques for field exposures of fish to chemical contaminants. Aquat. Toxicol. 78 (2006) 370-381
    • (2006) Aquat. Toxicol. , vol.78 , pp. 370-381
    • Oikari, A.1
  • 45
  • 46
    • 56949096503 scopus 로고    scopus 로고
    • Selection of reference genes for qRT-PCR examination of wild populations of Atlantic cod Gadus morhua
    • Olsvik P.A., Søfteland L., and Lie K.K. Selection of reference genes for qRT-PCR examination of wild populations of Atlantic cod Gadus morhua. BMC Res Notes. 16 1 (2008) 47
    • (2008) BMC Res Notes. , vol.16 , Issue.1 , pp. 47
    • Olsvik, P.A.1    Søfteland, L.2    Lie, K.K.3
  • 48
    • 12244312781 scopus 로고    scopus 로고
    • Quantitative PCR analysis of CYP1A induction in Atlantic salmon (Salmo salar)
    • Rees C.B., McCormick S.D., and Heuvel V. Quantitative PCR analysis of CYP1A induction in Atlantic salmon (Salmo salar). Aquat. Toxicol. 62 (2003) 67-78
    • (2003) Aquat. Toxicol. , vol.62 , pp. 67-78
    • Rees, C.B.1    McCormick, S.D.2    Heuvel, V.3
  • 49
    • 59149103094 scopus 로고    scopus 로고
    • Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor
    • Reichard J.F., Dalton T.P., Shertzer H.G., and Puga A. Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor. Dose-Response 3 3 (2005) 306-331
    • (2005) Dose-Response , vol.3 , Issue.3 , pp. 306-331
    • Reichard, J.F.1    Dalton, T.P.2    Shertzer, H.G.3    Puga, A.4
  • 50
    • 0031571650 scopus 로고    scopus 로고
    • Characterization of the aromatic hydrocarbon receptor gene and its expression in Atlantic tomcod
    • Roy N.K., and Wirgin I. Characterization of the aromatic hydrocarbon receptor gene and its expression in Atlantic tomcod. Arch. Biochem. Biophys. 344 (1997) 373-386
    • (1997) Arch. Biochem. Biophys. , vol.344 , pp. 373-386
    • Roy, N.K.1    Wirgin, I.2
  • 51
    • 35448999693 scopus 로고    scopus 로고
    • Effect of starvation on global gene expression and proteolysis in rainbow trout (Oncorhynchus mykiss)
    • Salem M., Siverstein J., Rexroad III C.E., and Yao J. Effect of starvation on global gene expression and proteolysis in rainbow trout (Oncorhynchus mykiss). BMC Genomics 8 (2007) 328
    • (2007) BMC Genomics , vol.8 , pp. 328
    • Salem, M.1    Siverstein, J.2    Rexroad III, C.E.3    Yao, J.4
  • 52
    • 33744939176 scopus 로고    scopus 로고
    • Oxidative stress response of Eurpopean flounder (Platichtys flesus) to cadmium determined by a custom cDNA microarray
    • Schroeder D.L., Williams T.D., Lyons B.P., and Chipman J.K. Oxidative stress response of Eurpopean flounder (Platichtys flesus) to cadmium determined by a custom cDNA microarray. Mar. Environ. Res. 62 (2006) 33-44
    • (2006) Mar. Environ. Res. , vol.62 , pp. 33-44
    • Schroeder, D.L.1    Williams, T.D.2    Lyons, B.P.3    Chipman, J.K.4
  • 53
    • 32044434954 scopus 로고    scopus 로고
    • Vitellogenin in the blood plasma of male cod (Gadus morhua): a sign of oestrogenic endocrine disruption in the open sea?
    • Scott A., Katsiadaki I., Witthams P.R., Hylland K., Davies I.M., McIntosh A.D., and Thain J. Vitellogenin in the blood plasma of male cod (Gadus morhua): a sign of oestrogenic endocrine disruption in the open sea?. Mar. Environ. Res. 61 (2006) 149-170
    • (2006) Mar. Environ. Res. , vol.61 , pp. 149-170
    • Scott, A.1    Katsiadaki, I.2    Witthams, P.R.3    Hylland, K.4    Davies, I.M.5    McIntosh, A.D.6    Thain, J.7
  • 54
    • 33744939176 scopus 로고    scopus 로고
    • Oxidative stress response of European flounder (Platichthys flesus) to cadmium determined by a custom cDNA microarray
    • Sheader D.L., Williams T., Lyons B.P., and Chipman J.K. Oxidative stress response of European flounder (Platichthys flesus) to cadmium determined by a custom cDNA microarray. Mar. Environ. Res. 62 (2006) 33-44
    • (2006) Mar. Environ. Res. , vol.62 , pp. 33-44
    • Sheader, D.L.1    Williams, T.2    Lyons, B.P.3    Chipman, J.K.4
  • 56
    • 0034465797 scopus 로고    scopus 로고
    • Activation of estrogen receptor alpha by the heavy metal cadmium
    • Stoica A., Katzenellenbogen B.S., and Martin M.B. Activation of estrogen receptor alpha by the heavy metal cadmium. Mol. Endocrinol. 14 (2000) 545-553
    • (2000) Mol. Endocrinol. , vol.14 , pp. 545-553
    • Stoica, A.1    Katzenellenbogen, B.S.2    Martin, M.B.3
  • 57
    • 70350707747 scopus 로고    scopus 로고
    • Factorial design for multiple endpoint toxicity evaluation in Atlantic salmon (Salmo salar L.) hepatocytes
    • Søfteland L., Eide I., and Olsvik P.A. Factorial design for multiple endpoint toxicity evaluation in Atlantic salmon (Salmo salar L.) hepatocytes. Toxicol. In Vitro 23 (2009) 1455-1464
    • (2009) Toxicol. In Vitro , vol.23 , pp. 1455-1464
    • Søfteland, L.1    Eide, I.2    Olsvik, P.A.3
  • 58
    • 0037290663 scopus 로고    scopus 로고
    • Fish bioaccumulation and biomarkers in environmental risk assessment: a review
    • van der Oost R., Beyer J., and Vermeulen N.P.E. Fish bioaccumulation and biomarkers in environmental risk assessment: a review. Environ. Toxicol. Pharmacol. 13 (2003) 57-149
    • (2003) Environ. Toxicol. Pharmacol. , vol.13 , pp. 57-149
    • van der Oost, R.1    Beyer, J.2    Vermeulen, N.P.E.3
  • 59
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantiative RT-PCR data by geometric averaging of multiple internal control genes
    • Research0034.1-0034.11
    • Vandesompele J., Preter K.D., Pattyn F., Poppe B., Roy N.V., Paepe A.D., and Speleman F. Accurate normalization of real-time quantiative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3 7 (2002) Research0034.1-0034.11
    • (2002) Genome Biol. , vol.3 , Issue.7
    • Vandesompele, J.1    Preter, K.D.2    Pattyn, F.3    Poppe, B.4    Roy, N.V.5    Paepe, A.D.6    Speleman, F.7
  • 61
    • 33846534355 scopus 로고    scopus 로고
    • Toxicological highlight: unravelling the complexities of the mechanism of action of dioxins
    • Walker N.J. Toxicological highlight: unravelling the complexities of the mechanism of action of dioxins. Toxicol. Sci. 95 (2007) 297-299
    • (2007) Toxicol. Sci. , vol.95 , pp. 297-299
    • Walker, N.J.1
  • 62
    • 0036320934 scopus 로고    scopus 로고
    • 2-regulated gene expression
    • 2-regulated gene expression. FASEB J. 16 (2002) 1151-1162
    • (2002) FASEB J. , vol.16 , pp. 1151-1162
    • Wenger, R.H.1
  • 63
    • 84951601886 scopus 로고
    • Cross-validatory estimation of the number of components in factor and principal components models
    • Wold S. Cross-validatory estimation of the number of components in factor and principal components models. Technometrics 20 (1978) 397-405
    • (1978) Technometrics , vol.20 , pp. 397-405
    • Wold, S.1
  • 64
    • 0027979778 scopus 로고
    • Establishment and characterization of differentiated nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor α
    • Wu J., Merlino G., and Fausto N. Establishment and characterization of differentiated nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor α. Proc. Natl Acad. Sci. USA 91 (1994) 674-678
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 674-678
    • Wu, J.1    Merlino, G.2    Fausto, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.