Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1α) and HIF-regulated genes

Toxicology and Applied Pharmacology

Volumn 213, Issue 3, 2006, Pages 245-255

  Li, Qin ^a   Chen, Haobin ^a   Huang, Xi ^a   Costa, Max ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cap43; HIF 1 ; HRE; IRP 1; Metal ions

Indexed keywords

ALUMINUM; ARSENIC; CADMIUM; CAP43 PROTEIN; CHROMIUM; COBALT; CUPRIC ION; FERRITIN; FERROUS ION; HYPOXIA INDUCIBLE FACTOR 1BETA; IRON REGULATORY PROTEIN 1; MANGANESE; METAL ION; METALLOTHIONEIN; NICKEL; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN; PROTEIN IRE1; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; VANADIUM;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; FERRITIN BLOOD LEVEL; GENE CONTROL; HOMEOSTASIS; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; LUNG CARCINOMA; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TIME;

ARSENIC; CELL CYCLE PROTEINS; CELL LINE, TUMOR; FERRITINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IRON; IRON REGULATORY PROTEIN 1; METALS, HEAVY; PROTEINS;

EID: 33744521129     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.11.006     Document Type: Article

References (52)

1. Araya M., Olivares M., Pizarro F., Gonzalez M., Speisky H., and Uauy R. Copper exposure and potential biomarkers of copper metabolism. Biometals 16 (2003) 199-204
2. Beattie J.H., Owen H.L., Wallace S.M., Arthur J.R., Kwun I.S., Hawksworth G.M., and Wallace H.M. Metallothionein overexpression and resistance to toxic stress. Toxicol. Lett. 157 (2005) 69-78
3. Chen H., Davidson T.L., Singleton S., Garrick M.D., and Costa M. Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol. Appl. (2005) 275-287
4. Chun Y.S., Choi E., Kim G.T., Lee M.J., Lee M.J., Lee S.E., Kim M.S., and Park J.W. Zinc induces the accumulation of hypoxia-inducible factor (HIF)-1alpha, but inhibits the nuclear translocation of HIF-1beta, causing HIF-1 inactivation. Biochem. Biophys. Res. Commun. 268 (2000) 652-656
5. Constable A., Quick S., Gray N.K., and Hentze M.W. Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 4554-4558
6. Costa M., Davidson T.L., Chen H., Ke Q., Zhang P., Yan Y., Huang C., and Kluz T. Nickel carcinogenesis: epigenetics and hypoxia signaling. Mutat. Res. 592 (2005) 79-88
7. Davidson T., Salnikow K., and Costa M. Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Mol. Pharmacol. 64 (2003) 1485-1493
8. Dayal H., Gupta S., Trieff N., Maierson D., and Reich D. Symptom clusters in a community with chronic exposure to chemicals in two superfund sites. Arch. Environ. Health 50 (1995) 108-111
9. Diagomanolin V., Farhang M., Ghazi-Khansari M., and Jafarzadeh N. Heavy metals (Ni, Cr, Cu) in the Karoon waterway river, Iran. Toxicol. Lett. 151 (2004) 63-68
10. Dubrovskaya V.A., and Wetterhahn K.E. Effects of Cr(VI) on the expression of the oxidative stress genes in human lung cells. Carcinogenesis 19 (1998) 1401-1407
11. Fang R., and Aust A.E. Induction of ferritin synthesis in human lung epithelial cells treated with crocidolite asbestos. Arch. Biochem. Biophys. 340 (1997) 369-375
12. Gao N., Ding M., Zheng J.Z., Zhang Z., Leonard S.S., Liu K.J., Shi X., and Jiang B.H. Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J. Biol. Chem. 277 (2002) 31963-31971
13. Gao N., Jiang B.H., Leonard S.S., Corum L., Zhang Z., Roberts J.R., Antonini J., Zheng J.Z., Flynn D.C., Castranova V., and Shi X. p38 signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells. J. Biol. Chem. 277 (2002) 45041-45048
14. Gao N., Shen L., Zhang Z., Leonard S.S., He H., Zhang X.G., Shi X., and Jiang B.H. Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells. Mol. Cell. Biochem. 255 (2004) 33-45
15. Henkel G., and Krebs B. Metallothioneins: zinc, cadmium, mercury, and copper thiolates and selenolates mimicking protein active site features-structural aspects and biological implications. Chem. Rev. 104 (2004) 801-824
16. Hirsila M., Koivunen P., Xu L., Seeley T., Kivirikko K.I., and Myllyharju J. Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway. FASEB J. 19 (2005) 1308-1310
17. Horiguchi H., Sato M., Konno N., and Fukushima M. Long-term cadmium exposure induces anemia in rats through hypoinduction of erythropoietin in the kidneys. Arch. Toxicol. 71 (1996) 11-19
18. Hossain M.A., Bouton C.M., Pevsner J., and Laterra J. Induction of vascular endothelial growth factor in human astrocytes by lead. Involvement of a protein kinase C/activator protein-1 complex-dependent and hypoxia-inducible factor 1-independent signaling pathway. J. Biol. Chem. 275 (2000) 27874-27882
19. Hwang J.T., Lee M., Jung S.N., Lee H.J., Kang I., Kim S.S., and Ha J. AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis 25 (2004) 2497-2507
20. Ivan M., Kondo K., Yang H., Kim W., Valiando J., Ohh M., Salic A., Asara J.M., Lane W.S., and Kaelin Jr. W.G. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 (2001) 464-468
21. Jaakkola P., Mole D.R., Tian Y.M., Wilson M.I., Gielbert J., Gaskell S.J., Kriegsheim A., Hebestreit H.F., Mukherji M., Schofield C.J., Maxwell P.H., Pugh C.W., and Ratcliffe P.J. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 (2001) 468-472
22. Jaeckel P., Krauss G., Menge S., Schierhorn A., Rucknagel P., and Krauss G.J. Cadmium induces a novel metallothionein and phytochelatin 2 in an aquatic fungus. Biochem. Biophys. Res. Commun. 333 (2005) 150-155
23. Joshi J.G., and Zimmerman A. Ferritin: an expanded role in metabolic regulation. Toxicology 48 (1988) 21-29
24. Kwik-Uribe C.L., Reaney S., Zhu Z., and Smith D. Alterations in cellular IRP-dependent iron regulation by in vitro manganese exposure in undifferentiated PC12 cells. Brain Res. 973 (2003) 1-15
25. Li J., Davidson G., Huang Y., Jiang B.H., Shi X., Costa M., and Huang C. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res. 64 (2004) 94-101
26. Martelli A., and Moulis J.M. Zinc and cadmium specifically interfere with RNA-binding activity of human iron regulatory protein 1. J. Inorg. Biochem. 98 (2004) 1413-1420
27. Martin F., Linden T., Katschinski D.M., Oehme F., Flamme I., Mukhopadhyay C.K., Eckhardt K., Troger J., Barth S., Camenisch G., and Wenger R.H. Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation. Blood 105 (2005) 4613-4619
28. Morgan E.H., and Oates P.S. Mechanisms and regulation of intestinal iron absorption. Blood Cells Mol. Diseases 29 (2002) 384-399
29. Oshiro S., Kawahara M., Mika S., Muramoto K., Kobayashi K., Ishige R., Nozawa K., Hori M., Yung C., Kitajima S., and Kuroda Y. Aluminum taken up by transferrin-independent iron uptake affects the iron metabolism in rat cortical cells. J. Biochem. (Tokyo) 123 (1998) 42-46
30. Oshiro S., Nozawa K., Hori M., Zhang C., Hashimoto Y., Kitajima S., and Kawamura K. Modulation of iron regulatory protein-1 by various metals. Biochem. Biophys. Res. Commun. 290 (2002) 213-218
31. Piquemal D., Joulia D., Balaguer P., Basset A., Marti J., and Commes T. Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells. Biochim. Biophys. Acta 1450 (1999) 364-373
32. Riley M.R., Boesewetter D.E., Turner R.A., Kim A.M., Collier J.M., and Hamilton A. Comparison of the sensitivity of three lung derived cell lines to metals from combustion derived particulate matter. Toxicol. In Vitro 19 (2005) 411-419
33. Roff M., Bagon D.A., Chambers H., Dilworth E.M., and Warren N. Dermal exposure to electroplating fluids and metalworking fluids in the UK. Ann. Occup. Hyg. 48 (2004) 209-217
34. Rolfs A., Kvietikova I., Gassmann M., and Wenger R.H. Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J. Biol. Chem. 272 (1997) 20055-20062
35. Salnikow K., Su W., Blagosklonny M.V., and Costa M. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism. Cancer Res. 60 (2000) 3375-3378
36. Salnikow K., Davidson T., Zhang Q., Chen L.C., Su W., and Costa M. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res. 63 (2003) 3524-3530
37. Sato M., and Kondoh M. Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals. Tohoku J. Exp. Med. 196 (2002) 9-22
38. Semenza G.L. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15 (1999) 551-578
39. Skinner H.D., Zhong X.S., Gao N., Shi X., and Jiang B.H. Arsenite induces p70S6K1 activation and HIF-1alpha expression in prostate cancer cells. Mol. Cell. Biochem. 255 (2004) 19-23
40. Templeton D.M., and Liu Y. Genetic regulation of cell function in response to iron overload or chelation. Biochim. Biophys. Acta 1619 (2003) 113-124
41. van Heerden D., Vosloo A., and Nikinmaa M. Effects of short-term copper exposure on gill structure, metallothionein and hypoxia-inducible factor-1alpha (HIF-1alpha) levels in rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 69 (2004) 271-280
42. van Vliet A.H., Ketley J.M., Park S.F., and Penn C.W. The role of iron in Campylobacter gene regulation, metabolism and oxidative stress defense. FEMS Microbiol. Rev. 26 (2002) 173-186
43. Walther U.I., Walther S.C., Liebl B., Reichl F.X., Kehe K., Nilius M., and Hickel R. Cytotoxicity of ingredients of various dental materials and related compounds in L2- and A549 cells. J. Biomed. Mater. Res. 63 (2002) 643-649
44. Wang G.L., and Semenza G.L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82 (1993) 3610-3615
45. Wang G.L., Jiang B.H., Rue E.A., and Semenza G.L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 5510-5514
46. Wang X., Ghio A.J., Yang F., Dolan K.G., Garrick M.D., and Piantadosi C.A. Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells. Am. J. Physiol.: Lung Cell. Mol. Physiol. 282 (2002) L987-L995
47. Ward R.J., Zhang Y., and Crichton R.R. Aluminium toxicity and iron homeostasis. J. Inorg. Biochem. 87 (2001) 9-14
48. Wenger R.H. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 16 (2002) 1151-1162
49. Yuan Y., Hilliard G., Ferguson T., and Millhorn D.E. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J. Biol. Chem. 278 (2003) 15911-15916
50. Zhao J., Yan Y., Salnikow K., Kluz T., and Costa M. Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol. Appl. Pharmacol. 194 (2004) 60-68
51. Zheng W., and Zhao Q. Iron overload following manganese exposure in cultured neuronal, but not neuroglial cells. Brain Res. 897 (2001) 175-179
52. Zheng W., Zhao Q., Slavkovich V., Aschner M., and Graziano J.H. Alteration of iron homeostasis following chronic exposure to manganese in rats. Brain Res. 833 (1999) 125-132