Unraveling the complexities of the mechanism of action of dioxins

Toxicological Sciences

Volumn 95, Issue 2, 2007, Pages 297-299

  Walker, Nigel J ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3,3',4,4',5 PENTACHLOROBIPHENYL; AROMATIC HYDROCARBON RECEPTOR; CARCINOGEN; CYTOCHROME P450 1B1; DIOXIN; DRUG METABOLIZING ENZYME; HYPOXIA INDUCIBLE FACTOR 1BETA; INTERLEUKIN 1BETA; LIGAND; POLYCHLORINATED BIPHENYL; XENOBIOTIC AGENT;

AMINO ACID METABOLISM; BINDING SITE; BIOASSAY; CANCER RISK; CELL GROWTH; DNA DAMAGE; DNA HYBRIDIZATION; DOSIMETRY; EDITORIAL; FOOD COMPOSITION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; HEALTH HAZARD; HISTOPATHOLOGY; HUMAN; LIGAND BINDING; LIPID METABOLISM; LIVER CARCINOGENESIS; LIVER CELL; LIVER TOXICITY; METABOLITE; MICROARRAY ANALYSIS; NITROGEN METABOLISM; NONHUMAN; OVARIECTOMY; PLEIOTROPY; POLLUTANT; RECEPTOR BINDING; RISK ASSESSMENT; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; TISSUE DISTRIBUTION; TOXICITY TESTING;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; RECEPTORS, ARYL HYDROCARBON; SPECIES SPECIFICITY; TETRACHLORODIBENZODIOXIN;

EID: 33846534355     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl170     Document Type: Editorial

References (18)

1. Boverhof, D. R., Burgoon, L. D., Tashiro, C., Sharratt, B., Chittim, B., Harkema, J. R., Mendrick, D. L., and Zacharewski, T. R. (2006). Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in sprague dawley rats and C57BL/6 mice. Toxicol. Sci. 94, 398-416.
2. Frueh, F. W., Hayashibara, K. C., Brown, P. O., and Whitlock, J. P., Jr (2001). Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression. Toxicol. Lett. 122, 189-203.
3. Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M.,Wade, C. E., Dittenber, D. A., Kalnins, R. P., Frauson, L. E., Park, C. N., Barnard, S. D., et al. (1978). Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol. Appl. Pharmacol. 46, 279-303.
4. Lucier, G.W., Tritscher, A., Goldsworthy, T., Foley, J., Clark, G., Goldstein, J., and Maronpot, R. (1991). Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis. Cancer Res. 51, 1391-1397.
5. Martinez, J. M., Afshari, C. A., Bushel, P. R., Masuda, A., Takahashi, T., and Walker, N. J. (2002). Differential toxicogenomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin in malignant and nonmalignant human airway epithelial cells. Toxicol. Sci. 69, 409-423.
6. National Toxicology Program (2006). NTP technical report on the toxicology and carcinogenesis studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in female Harlan Sprague-Dawley rats (Gavage Studies). Natl. Toxicol. Program. Tech. Rep. Ser. 521, 4-232.
7. Ovando, B. J., Vezina, C. M., McGarrigle, B. P., and Olson, J. R. (2006). Hepatic gene downregulation following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Sci. 94, 428-438.
8. Poland, A., and Knutson, J. C. (1982). 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity. Ann. Rev. Pharmacol. Toxicol. 22, 517-554.
9. Puga, A., Maier, A., and Medvedovic, M. (2000). The transcriptional signature of dioxin in human hepatoma HepG2 cells. Biochem. Pharmacol. 60, 1129-1142.
10. Schmidt, J. V., and Bradfield, C. A. (1996). Ah receptor signaling pathways. Annu. Rev. Cell Dev. Biol. 12, 55-89.
11. Sutter, T. R., Guzman, K., Dold, K. M., and Greenlee, W. F. (1991). Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1 beta. Science 254, 415-418.
12. Sutter, T. R., Tang, Y. M., Hayes, C. L., Wo, Y.-Y. P., Jabs, E.W., Li, X., Ying, H., Cody, C.W., and Greenlee, W. F. (1994). Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. J. Biol. Chem. 269, 13092-13099.
13. Teeguarden, J., and Walker, N. J. (2003). Experimental carcinogenicity of dioxins. In Dioxins and Health, 2nd ed. (A. Schecter and T. Gasiewicz, Eds.), Wiley and Sons, USA.
14. Vezina, C. M., Walker, N. J., and Olson, J. R. (2004). Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: Effect on hepatic gene expression. Environ. Health Perspect. 112, 1636-1644.
15. Walker, N. J., Crockett, P. W., Nyska, A., Brix, A. E., Jokinen, M. P., Sells, D. M., Hailey, J. R., Easterling, M., Haseman, J. K., Yin, M., et al. (2005). Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds". Environ. Health Perspect. 113, 43-48.
16. Wyde, M. E., Cambre, T., Lebetkin, M., Eldridge, S. R., and Walker, N. J. (2002). Promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin and 17beta-estradiol in male Sprague-Dawley rats. Toxicol. Sci. 68, 295-303.
17. Wyde, M. E., Eldridge, S. R., Lucier, G. W., and Walker, N. J. (2001a). Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced tumor promotion by 17 beta-estradiol in female Sprague-Dawley rats. Toxicol. Appl. Pharmacol. 173, 7-17.
18. Wyde, M. E., Wong, V. A., Kim, A. H., Lucier, G. W., and Walker, N. J. (2001b). Induction of hepatic 8-oxo-deoxyguanosine adducts by 2,3,7,8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent. Chem. Res. Toxicol. 14, 849-855.