Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

Molecular and Cellular Biology

Volumn 26, Issue 8, 2006, Pages 3319-3326

  Petermann, Eva ^a   Maya Mendoza, Apolinar ^b   Zachos, George ^c,d   Gillespie, David A F ^c,d   Jackson, Dean A ^b   Caldecott, Keith W ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; SINGLE STRANDED DNA; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA RECOMBINATION; DNA REPLICATION; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CHICKENS; CHROMOSOMES; DNA REPLICATION; DNA, SINGLE-STRANDED; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOBLOTTING; KINETICS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RNA, SMALL INTERFERING; S PHASE; STAUROSPORINE;

ANIMALIA; METAZOA; VERTEBRATA;

EID: 33645825609     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.26.8.3319-3326.2006     Document Type: Article

References (30)

1. Casper, A. M., P. Nghiem, M. F. Arlt, and T. W. Glover. 2002. ATR regulates fragile site stability. Cell 111:779-789.
2. Cha, R. S., and N. Kleckner. 2002. ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 297:602-606.
3. Cobb, J. A., L. Bjergbaek, K. Shimada, C. Frei, and S. M. Gasser. 2003. DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J. 22:4325-4336.
4. de Vries, H. I., L. Uyetake, W. Lemstra, J. F. Brunsting, T. T. Su, H. H. Kampinga, and O. C. Sibon. 2005. Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable. J. Cell Sci. 118:1833-1842.
5. Feijoo, C., C. Hall-Jackson, R. Wu, D. Jenkins, J. Leitch, D. M. Gilbert, and C. Smythe. 2001. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J. Cell Biol. 154:913-923.
6. Fogarty, P., S. D. Campbell, R. Abu-Shumays, B. S. Phalle, K. R. Yu, G. L. Uy, M. L. Goldberg, and W. Sullivan. 1997. The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity. Curr. Biol. 7:418-426.
7. Graves, P. R., L. Yu, J. K. Schwarz, J. Gales, E. A. Sausville, P. M. O'Connor, and H. Piwnica-Worms. 2000. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J. Biol. Chem. 275:5600-5605.
8. Henry-Mowatt, J., D. Jackson, J. Y. Masson, P. A. Johnson, P. M. Clements, F. E. Benson, L. H. Thompson, S. Takeda, S. C. West, and K. W. Caldecott. 2003. XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol. Cell 11:1109-1117.
9. Jackson, D. A., and P. R. Cook. 1986. A cell-cycle-dependent DNA polymerase activity that replicates intact DNA in chromatin. J. Mol. Biol. 192: 65-76.
10. Jackson, D. A., and P. R. Cook. 1986. Replication occurs at a nucleoskeleton. EMBO J. 5:1403-1410.
11. Jackson, D. A., and A. Pombo. 1998. Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells. J. Cell Biol. 140:1285-1295.
12. Jackson, D. A., J. Yuan, and P. R. Cook. 1988. A gentle method for preparing cyto- and nucleo-skeletons and associated chromatin. J. Cell Sci. 90:365-378.
13. Jiang, K., E. Pereira, M. Maxfield, B. Russell, D. M. Goudelock, and Y. Sanchez. 2003. Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. J. Biol. Chem. 278:25207-25217.
14. Kastan, M. B., and J. Bartek. 2004. Cell-cycle checkpoints and cancer. Nature 432:316-323.
15. Kumagai, A., Z. Guo, K. H. Emami, S. X. Wang, and W. G. Dunphy. 1998. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. J. Cell Biol. 142:1559-1569.
16. 2/M DNA damage checkpoint. Genes Dev. 14:1448-1459.
17. Lopes, M., C. Cotta-Ramusino, A. Pellicioli, G. Liberi, P. Plevani, M. Muzi-Falconi, C. S. Newlon, and M. Foiani. 2001. The DNA replication checkpoint response stabilizes stalled replication forks. Nature 412:557-561.
18. Lopez-Girona, A., K. Tanaka, X. B. Chen, B. A. Baber, C. H. McGowan, and P. Russell. 2001. Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast. Proc. Natl. Acad. Sci. USA 98:11289-11294.
19. Lucca, C., F. Vanoli, C. Cotta-Ramusino, A. Pellicioli, G. Liberi, J. Haber, and M. Foiani. 2004. Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing. Oncogene 23:1206-1213.
20. Marheineke, K., and O. Hyrien. 2004. Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint. J. Biol. Chem. 279:28071-28081.
21. Sancar, A., L. A. Lindsey-Boltz, K. Unsal-Kacmaz, and S. Linn. 2004. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73:39-85.
22. Shechter, D., V. Costanzo, and J. Gautier. 2004. ATR and ATM regulate the timing of DNA replication origin firing. Nat. Cell Biol. 6:648-655.
23. Sibon, O. C., V. A. Stevenson, and W. E. Theurkauf. 1997. DNA-replication checkpoint control at the Drosophila midblastula transition. Nature 388: 93-97.
24. Syljuasen, R. G., C. S. Sorensen, L. T. Hansen, K. Fugger, C. Lundin, F. Johansson, T. Helleday, M. Sehested, J. Lukas, and J. Bartek. 2005. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol. Cell. Biol. 25:3553-3562.
25. -/- mice. Genes Dev. 14:1439-1447.
26. Zachos, G., M. D. Rainey, and D. A. F. Gillespie. 2003. Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. EMBO J. 22:713-723.
27. Zachos, G., M. D. Rainey, and D. A. F. Gillespie. 2005. Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures. Mol. Cell. Biol. 25:563-574.
28. Zhang, Y. W., D. M. Otterness, G. G. Chiang, W. Xie, Y. C. Liu, F. Mercurio, and R. T. Abraham. 2005. Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol. Cell 19:607-618.
29. Zhao, H., J. L. Watkins, and H. Piwnica-Worms. 2002. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc. Natl. Acad. Sci. USA 99:14795-14800.
30. 2/M checkpoint. Mol. Cell. Biol. 24:7140-7150.