Activation of large-conductance Ca2+-activated K+ channels depresses basal synaptic transmission in the hippocampal CA1 area in APP (swe/ind) TgCRND8 mice

Neurobiology of Aging

Volumn 31, Issue 4, 2010, Pages 591-604

  Ye, Hui ^a,b   Jalini, Shirin ^b   Mylvaganam, Shanthini ^a,b   Carlen, Peter ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alzheimer's disease; Calcium chelator; Field EPSP; Hippocampus; Large conductance Ca2+ activated K+ (BK) channels; Synaptic transmission.

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CHARYBDOTOXIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PAXILLINE; TETRODOTOXIN;

ACTION POTENTIAL; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ENZYME ACTIVATION; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SENILE PLAQUE; SYNAPTIC TRANSMISSION;

ACTION POTENTIALS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CALCIUM SIGNALING; CHELATING AGENTS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; HIPPOCAMPUS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURAL INHIBITION; NEURAL PATHWAYS; NEURONS; OXIDATIVE STRESS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; SYNAPTIC TRANSMISSION;

EID: 77049103601     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.05.012     Document Type: Article

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