Action-potential propagation gated by an axonal I(A)-like K+ conductance in hippocampus

Nature

Volumn 389, Issue 6648, 1997, Pages 286-289

  Debanne, Dominique ^a   Guérineau, Nathalie C ^a   Gähwller, Beat H ^a   Thompson, Scott M ^a  

^a University of Zurich Brain Research Institute   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; HIPPOCAMPUS; HYPERPOLARIZATION; NERVE FIBER MEMBRANE; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMALS; AXONS; CELLS, CULTURED; HIPPOCAMPUS; ION CHANNEL GATING; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PYRAMIDAL CELLS; RATS; REACTION TIME;

ANIMALIA;

EID: 1842406596     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/38502     Document Type: Article

References (21)

1. Eccles, J. C. The Physiology of Synapses (Springer, Berlin 1964).
2. 2+ imaging of CNS axons in culture indicates reliable coupling between single action potentials and distal functional release sites. Neuron 16, 783-795 (1996).
3. LÜscber, C., Streit, J., Quadroni, R. & LÜscher, H.-R. Action potential propagation through embryonic dorsal root ganglion cells in culture. I. Influence of the cell morphology on propagation properties. J. Neurophysiol. 72, 622-633 (1994).
4. Debanne, D., Guérineau, N. C., Gähwiler, B. H. & Thompson, S. M. Physiology and pharmacology of unitary synaptic connections between pairs of cells in areas CA3 and CA1 of rat hippocampal slice cultures. J. Neurophysiol. 73, 1282-1294 ( 1995).
5. Debanne, D., Guérineau, N. C., Gähwiler, B. H. & Thompson, S. M. Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release. J. Physiol. (Lond.)491, 163-176 (1996).
6. Gähwiler, B. H. Organotypic monolayer cultures of nervous tissue. J. Neurosi. Meth. 4, 329-342 (1981).
7. Vincent, P. & Marty, A. Fluctuations in inhibitory postsynaptic currents in Purkinje cells from rat cerebellar slices. J. Physiol. (Lond.) 494, 183-199 (1996).
8. Frotscher, M. & Gähwiler, B. H. Synaptic organization of intracellularly stained CA3 pyramidal neurons in slice cultures of rat hippocampus. Neuroscience 24, 541-551 (1988).
9. Stuart, G. J. & Sakmann, B. Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature 367, 69-72 ( 1994).
10. + channel densities in the soma and axon initial segment of subicular pyramidal neurons. J. Neurosi. 16, 6676-6686 (1996).
11. Bossu, J.-L., Capogna, M., Debasne, D., McKinney, R. A, & Gähwiler, B. H. Somatic voltage-gated potassium currents of rat hippocampal pyramidal cells in organotypic slice cultures. J. Physiol. (Lond.) 495, 367-381 (1996).
12. Stephens, G. J., Garratt, J. C., Robertson, B, & Owen, D. G. On the mechanism of 4-aminopyridine action on the cloned mouse brain potassiurn channel mKv1. 1 J.Physiol. (Lond) 477, 187-196 (1994).
13. Storm, J. F. Potassium currents in hippocampal pyramidal cells. Progr. Brain. Res. 83, 161-187 (1990).
14. Segev, I. Computer study of presynaptic inhibition controlling the spread of action potentials into axonal terminals. J. Neurophysiol. 63, 987-998 (1990).
15. Parnas, I. Differential block at high frequency of branches of a single axon innervating two muscles. J. Neurophysiol. 35, 903-914 (1972).
16. Parnas, I., Hochstein, S. & Parnas, H. Theoretical analysis of parameters leading to frequency modulation along an inhomogeneous axon. J. Neurophysiol. 39, 909-923 (1976).
17. Li, X.-G., Somogyi, P., Ylinen, A. & Buzsáki, G. The hippocampal CA3 network: an in vivo intracellular labeling study. J. Comp. Neurol. 339, 181-208 (1994).
18. + channel proteins in rat central neurons. Neuron 9, 271-284 ( 1992).
19. Kocsis, J. D., Gordon, T. R. & Waxman, S. G. Mammalian optic nerve fibers display two pharmacologically distinct potassium channels. Brain Res. 383, 357-361 (1986).
20. Storm, J. E & Lipowsky, R. Evidence that excitability changes in presynaptic fibers may affect pairedpclse facilitation in hippocampal slices. Soc Neurosci. Abstr. 20, 1339 (1994).
21. Wall, P. D. Do nerve impulses penetrate terminal arborizations? A pre-presynaptic control mechanism. Trends Neurosci. 18, 99-103 (1995).