A novel nervous system β subunit that downregulates human large conductance calcium-dependent potassium channels

Journal of Neuroscience

Volumn 20, Issue 10, 2000, Pages 3563-3570

  Weiger, Thomas M ^a,c,d   Holmqvist, Mats H ^a,b   Levitan, Irwin B ^a,d   Clark, Frederick T ^b   Sprague, Scott ^b   Huang, Wann Jeng ^b   Ge, Pei ^b   Wang, Chichung ^b   Lawson, Deborah ^b   Jurman, Mark E ^b   Glucksmann, M Alexandra ^b   Silos Santiago, Inmaculada ^b   DiStefano, Peter S ^b   Curtis, Rory ^b  

^a BRANDEIS UNIVERSITY   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF SALZBURG   (Austria)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Calcium dependent potassium channel; In situ hybridization; Maxi K; Potassium channel; Slowpoke; subunit

Indexed keywords

CALCIUM; POTASSIUM; POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; MOLECULAR CLONING; MONKEY; MOUSE; NERVE CELL EXCITABILITY; NERVOUS SYSTEM; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY;

EID: 19244382387     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-10-03563.2000     Document Type: Article

References (40)

1. Adelman JP, Shen K-Z, Kavanaugh MP, Warren RA, Wu Y-N, Lagrutta A, Bond CT, North RA (1992) Calcium-activated potassium channels expressed from cloned complementary DNAs. Neuron 9:209-216.
2. + channel in rat peptidergic nerve terminals. J Physiol (Lond) 475:241-254.
3. Butler A, Tsunoda S, McCobb DP, Wei A, Salkoff L (1993) mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science 261:221-224.
4. 2+ channels in mammalian central neurons. Trends Neurosci 18:89-98.
5. Dworetzky SI, Trojnacki JT, Gribkoff VK (1994) Cloning and expression of a human large-conductance calcium-activated potassium channel. Mol Brain Res 27:189-193.
6. Dworetzky SI, Boissard CG, Lum-Ragan JT, McKay MC, Post-Munson DJ, Trojnacki JT, Chang C-P, Gribkoff VK (1996) Phenotypic alteration of a human BK (hSlo) channel by hSlob subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. J Neurosci 16:4543-4550.
7. Garcia-Calvo M, Knaus H-G, McManus OB, Giangiacomo KM, Kaczorowski GJ, Garcia ML (1994) Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle. J Biol Chem 269:676-682.
8. Gho M, Ganetzky B (1992) Analysis of repolarization of presynaptic motor terminals in Drosophila larvae using potassium channel-blocking drugs and mutations. J Exp Biol 170:93-111.
9. Hanner M, Vianna-Jorge R, Kamassah A, Schmalhofer WA, Knaus H-G, Kaczorowski GJ, Garcia ML (1998) The β subunit of the high conductance calcium-activated potassium channel. J Biol Chem 273:16289-16296.
10. + (BK) channels in rat hippocampal neurones produced by pore block from an associated particle. J Physiol (Lond) 508:721-734.
11. Isom LL, De Jongh KS, Catterall WA (1994) Auxiliary subunits of voltage-gated ion channels. Neuron 12:1183-1194.
12. Jan LY, Jan YN (1997) Voltage-gated and inwardly rectifying potassium channels. J Physiol (Lond) 505:267-282.
13. Kaczorowski GJ, Knaus HG, Leonard RJ, McManus OB, Garcia ML (1996) High-conductance calcium-activated potassium channels; structure, pharmacology, and function. J Bioenerg Biomembr 28:255-267.
14. + channel from smooth muscle. J Biol Chem 269:17274-17278.
15. + channels in rat brain: targeting to axons and nerve terminals. J Neurosci 16:955-963.
16. McManus OB, Helms LMH, Pallanck L, Ganetzky B, Swanson R, Leonard RJ (1995) Functional role of the β subunit of high conductance calcium-activated potassium channels. Neuron 14:645-650.
17. Oberst C, Weiskirchen R, Hartl M, Bister K (1997) Suppression in transformed avian fibroblasts of a gene (CO6) encoding a membrane protein related to mammalian potassium channel regulatory subunits. Oncogene 14:1109-1116.
18. Pallanck L, Ganetzky B (1994) Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke. Hum Mol Genet 3:1239-1243.
19. Pan Y, Lloyd C, Zhou H, Dolich S, Deeds J, Gonzalo JA, Vath J, Gosselin M, Ma J, Dussault B, Woolf E, Alperin G, Culpepper J, Gutierrez-Ramos JC, Gearing D (1997) Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 387:611-617.
20. + channels altered by presence of β-subunit. Nature 369:289-294.
21. + channel α-and β-subunit polypeptides in rat brain. J Neurosci 15:5360-5371.
22. Robitaille R, Charlton MP (1992) Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels. J Neurosci 12:297-305.
23. Robitaille R, Garcia ML, Kaczorowski GJ, Charlton MP (1993) Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release. Neuron 11:645-655.
24. Schopperle WM, Holmqvist MH, Zhou Y, Wang J, Wang Z, Griffith LC, Keselman I, Kusinitz F, Dagan D, Levitan IB (1998) Slob, a novel protein that interacts with the slowpoke calcium-dependent potassium channel. Neuron 20:565-573.
25. Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY (1988) Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature 331:137-142.
26. Solaro CR, Lingle CJ (1992) Trypsin-sensitive, rapid inactivation of a calcium-activated potassium channel. Science 257:1694-1698.
27. + current in rat adrenal chromaffin cells. J Neurosci 15:6110-6123.
28. Stahl A, Hirsch DJ, Gimeno RE, Punreddy S, Ge P, Watson N, Patel S, Kotler M, Raimondi A, Tartaglia L, Lodish HF (1999) Identification of the major intestinal fatty acid transport protein. Mol Cell 4:299-308.
29. Trimmer JS (1998) Regulation of ion channel expression by cytoplasmic subunits. Curr Opin Neurobiol 8:370-374.
30. + channel isoforms from human brain. Neuron 13:1315-1330.
31. + channel β-subunit from human brain. Proc Natl Acad Sci USA 93:9200-9205.
32. Valverde MA, Rojas P, Amigo J, Cosmelli D, Orio P, Bahamonde MI, Mann GE, Vergara C, Latorre R (1999) Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Science 285:1929-1931.
33. Vergara C, Latorre R, Marrion NV, Adelman JP (1998) Calcium-activated potassium channels. Curr Opin Neurobiol 8:321-329.
34. + channels: an additional transmembrane region at the N terminus. Proc Natl Acad Sci USA 93:14922-14927.
35. + channels: a transmembrane β-subunit homolog. Proc Natl Acad Sci USA 96:4137-4142.
36. Wanner SG, Koch RO, Koschak A, Trieb M, Garcia ML, Kaczorowski GJ, Knaus HG (1999) High-conductance calcium-activated potassium channels in rat brain: pharmacology, distribution, and subunit composition. Biochemistry 38:5392-5400.
37. Xia X-M, Hirschberg B, Smolik S, Forte M, Adelman JP (1998) dSlo interacting protein 1, a novel protein that interacts with large-conductance calcium-activated potassium channels. J Neurosci 18:2360-2369.
38. 2+-and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells. J Neurosci 19:5255-5264.
39. Zhou XB, Schlossmann J, Hofmann F, Ruth P, Korth M (1998) Regulation of stably expressed and native BK channels from human myometrium by cGMP-and cAMP-dependent protein kinase. Pflügers Arch 436:725-734.
40. Zhou Y, Schopperle WM, Murrey H, Jaramillo H, Dagan D, Griffith LC, Levitan IB (1999) A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals. Neuron 22:809-818.