Two-Step in vitro antibody affinity maturation enables estradiol-17β assays with more than 10-fold higher sensitivity

Analytical Chemistry

Volumn 82, Issue 3, 2010, Pages 1027-1038

  Kobayashi, Norihiro ^a   Oyama, Hiroyuki ^a   Kato, Yoshinori ^a   Goto, Junichi ^b   Söderlind, Eskil ^c   Borrebaeck, Carl A K ^d  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

^c SalinatorAB   (Sweden)

^d LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY MATURATION; ANTI-HAPTEN ANTIBODIES; ANTIBODY AFFINITY; COMPLEMENTARITY-DETERMINING REGIONS; CROSS-REACTIVITY; DOSE-RESPONSE CURVES; ENDOGENOUS STEROIDS; ENZYME LINKED IMMUNOSORBENT ASSAY; ERROR PRONES; FAB FRAGMENTS; GENE FRAGMENTS; IN-VITRO; LIMIT OF DETECTION; PHAGE DISPLAY; RANDOM POINTS; SINGLE-CHAIN FV; WILD TYPES;

ASSAYS; CLONING; ENCODING (SYMBOLS); GENE ENCODING; POLYMERASE CHAIN REACTION;

ANTIBODIES;

ESTRADIOL; HAPTEN; PEPTIDE LIBRARY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL; ARTICLE; CHEMISTRY; CROSS REACTION; GENETIC ENGINEERING; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MOUSE; MUTATION; NUCLEOTIDE SEQUENCE; RADIOIMMUNOASSAY; SENSITIVITY AND SPECIFICITY; SURFACE PLASMON RESONANCE;

ANIMALS; BASE SEQUENCE; CROSS REACTIONS; ESTRADIOL; GENETIC ENGINEERING; HAPTENS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY; RADIOIMMUNOASSAY; SENSITIVITY AND SPECIFICITY; SINGLE-CHAIN ANTIBODIES; SURFACE PLASMON RESONANCE;

EID: 76149118418     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac902283n     Document Type: Article

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