Antimalarial and antitubercular nostocarboline and eudistomin derivatives: Synthesis, in vitro and in vivo biological evaluation

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 4, 2010, Pages 1464-1476

  Bonazzi, Simone ^a   Barbaras, Damien ^b   Patiny, Luc ^a   Scopelliti, Rosario ^a   Schneider, Patricia ^a   Cole, Stewart T ^a   Kaiser, Marcel ^c   Brun, Reto ^c   Gademann, Karl ^a  

^a EPFL   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Antiplasmodial agents; Malaria; Natural products

Indexed keywords

2 ALLYL 6 BROMO 9H BETA CARBOLIN 2 IUM BROMIDE; 2 ALLYL 6 CHLORO 9H BETA CARBOLIN 2 IUM BROMIDE; 2 BENZYL 6 BROMO 9H BETA CARBOLIN 2 IUM BROMIDE; 2 BENZYL 6 CHLORO 9H BETA CARBOLIN 2 IUM BROMIDE; 2 BUTENE 1,4 DIYL HOMO DIMER; 2 BUTYL 6 BROMO 9H BETA CARBOLIN 2 IUM IODIDE; 2 BUTYL 6 CHLORO 9H BETA CARBOLIN 2 IUM IODIDE; 2 BUTYN 1,4 DIYL HOMO DIMER; 4 4' BIS(METHANYL)BIPHENYL HOMO DIMER; 6 BROMO 2 (4 FLUORO BENZYL) 9H BETA CARBOLIN 2 IUM BROMIDE; 6 BROMO 2 (4 METHOXYCARBONYL BUTYL) 9H BETA CARBOLIN 2 IUM BROMIDE; 6 BROMO 2 ETHYL 9H BETA CARBOLIN 2 IUM IODIDE; 6 BROMO 2 METHYL 9H BETA CARBOLIN 2 IUM IODIDE; 6 CHLORO 2 (4 FLUORO BENZYL) 9H BETA CARBOLIN 2 IUM BROMIDE; 6 CHLORO 2 (4 METHOXYCARBONYL BUTYL) 9H BETA CARBOLIN 2 IUM BROMIDE; 6 CHLORO 2 (4 NITRO BENZYL) 9H BETA CARBOLIN 2 IUM BROMIDE; 6 CHLORO 2 ETHYL 9H BETA CARBOLIN 2 IUM IODIDE; ANTIMALARIAL AGENT; BIS(ETHANYL)ETHER HOMO DIMER; CARBOLINE DERIVATIVE; DECAN 1,10 DIYL HOMO DIMER; DODECAN 1,12 DIYL HOMO DIMER; EUDISTOMIN DERIVATIVE; HEXAN 1,6 DIYL HOMO DIMER; NOSTOCARBOLINE; OCTAN 1,8 DIYL HOMO DIMER; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; XYLO 1,3 DIYL HOMO DIMER; XYLO 1,4 DIYL HOMO DIMER;

ALKYLATION; AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA DONOVANI; MALARIA; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; MYOBLAST; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; RAT; SUBSTITUTION REACTION; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE;

ANIMALS; ANTIMALARIALS; ANTITUBERCULAR AGENTS; CARBOLINES; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; LEISHMANIA DONOVANI; MAGNETIC RESONANCE SPECTROSCOPY; MYCOBACTERIUM; PLASMODIUM FALCIPARUM; RATS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRYPANOSOMA;

CORYNEBACTERIUM GLUTAMICUM; LEISHMANIA DONOVANI; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; RATTUS; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

EID: 75849129828     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.013     Document Type: Article

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