Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 4, 2008, Pages 1378-1381

  Lavrado, João ^a   Paulo, Alexandra ^a   Gut, Jiri ^b   Rosenthal, Philip J ^b   Moreira, Rui ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

4 Aminoquinolines; Antiplasmodial; Cryptolepine; Malaria; Quinolines

Indexed keywords

CHLOROQUINE; CRYPTOLEPINE DERIVATIVE; FUNCTIONAL GROUP; INDOLOQUINOLINE DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; ENDOTHELIAL CELLS; HUMANS; INDOLE ALKALOIDS; INHIBITORY CONCENTRATION 50; PLASMODIUM FALCIPARUM; QUINOLINES;

PLASMODIUM FALCIPARUM;

EID: 38949089316     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.015     Document Type: Article

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23. 50 values were determined from graphics of degree of cell injury over inhibitor concentrations with GraphPad Prism software. Experimental details are provided as Supporting Information.