메뉴 건너뛰기




Volumn 18, Issue 8, 2008, Pages 2658-2661

Novel bisbenzimidazoles with antileishmanial effectiveness

Author keywords

Bisbenzamidine; Bisbenzimidazole; Human African trypanosomiasis; Leishmaniasis; Pentamidine; Pneumocystis carinii pneumonia

Indexed keywords

ANTILEISHMANIAL AGENT; BENZIMIDAZOLE DERIVATIVE; PENTAMIDINE;

EID: 41849100009     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.020     Document Type: Article
Times cited : (38)

References (28)
  • 9
    • 41849137157 scopus 로고    scopus 로고
    • Walzer, P.; Cushion, M. T.; Mayence, A.; Huang, T. L.; Vanden Eynde, J. J. WO Patent 2006021833, 2006.
    • Walzer, P.; Cushion, M. T.; Mayence, A.; Huang, T. L.; Vanden Eynde, J. J. WO Patent 2006021833, 2006.
  • 19
    • 41849142221 scopus 로고    scopus 로고
    • note
    • 2: MW experimental: m/z 489.2275; MW calculated: m/z 489.2291. Mp (°C): >300 °C. Yield: 94%.
  • 24
    • 41849093996 scopus 로고    scopus 로고
    • note
    • Reported values are means of 2-4 determinations.
  • 25
    • 7244238109 scopus 로고    scopus 로고
    • 10 organism nuclei with the vast majority (about 95%) of the life cycle forms present as trophic forms with the remainder (about 5%) being composed of cysts. P. carinii preparations were evaluated for microbial contamination, ATP content, karyotype, and host cell content prior to use in the ATP assay. See
    • 10 organism nuclei with the vast majority (about 95%) of the life cycle forms present as trophic forms with the remainder (about 5%) being composed of cysts. P. carinii preparations were evaluated for microbial contamination, ATP content, karyotype, and host cell content prior to use in the ATP assay. See,. Cushion M.T., Walzer P.D., Collins M.S., Rebholz S., Vanden Eynde J.J., Mayence A., and Huang T.L. Antimicrob. Agents Chemother. 48 (2004) 4209
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 4209
    • Cushion, M.T.1    Walzer, P.D.2    Collins, M.S.3    Rebholz, S.4    Vanden Eynde, J.J.5    Mayence, A.6    Huang, T.L.7
  • 26
    • 41849088737 scopus 로고    scopus 로고
    • note
    • 3 bloodstream-form trypomastigotes of the strain Trypanosoma brucei rhodesiense STIB 900, which is known to be susceptible to all currently drugs. After 3 days of incubation, parasite growth is assessed fluorimetrically after the addition of resazurin. Fluorescence is measured after 24 h at 37 °C. See, http://www.who.int/tdr/grants/workplans/pdf/.
  • 27
    • 0033991437 scopus 로고    scopus 로고
    • 6 cells/ml). Controls with corresponding dilutions of DMSO indicated that growth of the parasite was not altered under those experimental conditions. The plates were incubated at 26 °C for 72 h and growth of Leishmania promastigotes was determined by Alamar blue assay. See
    • 6 cells/ml). Controls with corresponding dilutions of DMSO indicated that growth of the parasite was not altered under those experimental conditions. The plates were incubated at 26 °C for 72 h and growth of Leishmania promastigotes was determined by Alamar blue assay. See,. Mikus J., and Steverding D. Parasitol. Int. 48 (2000) 265
    • (2000) Parasitol. Int. , vol.48 , pp. 265
    • Mikus, J.1    Steverding, D.2
  • 28
    • 0025784808 scopus 로고
    • The compounds were tested on Vero cells (monkey kidney fibroblast) by a Neutral Red assay. See
    • The compounds were tested on Vero cells (monkey kidney fibroblast) by a Neutral Red assay. See,. Babich H., and Borenfreund E. Appl. Environ. Microbiol. 57 (1991) 2101
    • (1991) Appl. Environ. Microbiol. , vol.57 , pp. 2101
    • Babich, H.1    Borenfreund, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.