2-N-Methyl modifications and SAR studies of manzamine A

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 14, 2008, Pages 6702-6706

  Ibrahim, Mohamed A ^a   Shilabin, Abbas G ^a   Prasanna, Sivaprakasam ^b   Jacob, Melissa ^b   Khan, Shabana I ^b   Doerksen, Robert J ^b   Hamann, Mark T ^a,b,c,d  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c School of Pharmacy   (United States)

^d Triton Biopharma AG   (Canada)

Author keywords

Antimalarial agent; Manzamine A; Methylation; SAR

Indexed keywords

2 N METHYLMANZAMINE A; GLYCOGEN SYNTHASE KINASE 3BETA; MANZAMINE A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; METHYLATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CARBAZOLES; CARBOLINES; CERCOPITHECUS AETHIOPS; ERYTHROCYTES; FIBROBLASTS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY; METHYLATION; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

MAMMALIA;

EID: 47349083836     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.079     Document Type: Article

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