Erratum: Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells (Molecular and Cellular Biology (2010) 30:3 (694-710) DOI: 10.1128/MCB.00253-09);Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells

Molecular and Cellular Biology

Volumn 30, Issue 3, 2010, Pages 694-710

  Adon, Arsene M ^a   Zeng, Xiangbin ^a   Harrison, Mary K ^a   Sannem, Stacy ^a   Kiyokawa, Hiroaki ^b   Kaldis, Philipp ^c   Saavedra, Harold I ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; MUTANT PROTEIN; NUCLEOPLASMIN; PROTEIN P53; THREONINE;

ANIMAL CELL; ARTICLE; CENTROSOME; CHROMOSOMAL INSTABILITY; EMBRYO; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE DELETION; GENOMIC INSTABILITY; KNOCKOUT MOUSE; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

EID: 75149125333     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00488-20     Document Type: Erratum

References (77)

1. Albertson, D. G., C. Collins, F. McCormick, and J. W. Gray. 2003. Chromosome aberrations in solid tumors. Nat. Genet. 34:369-376.
2. 1/S phase transition. Nat. Cell Biol. 7:831-836.
3. Ball, K. L., S. Lain, R. Fahraeus, C. Smythe, and D. P. Lane. 1997. Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxyterminal domain of p21WAF1. Curr. Biol. 7:71-80.
4. Bearss, D. J., R. J. Lee, D. A. Troyer, R. G. Pestell, and J. J. Windle. 2002. Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties. Cancer Res. 62:2077-2084.
5. Berthet, C., E. Aleem, V. Coppola, L. Tessarollo, and P. Kaldis. 2003. Cdk2 knockout mice are viable. Curr. Biol. 13:1775-1785.
6. Berthet, C., K. D. Klarmann, M. B. Hilton, H. C. Suh, J. R. Keller, H. Kiyokawa, and P. Kaldis. 2006. Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev. Cell 10:563-573.
7. Reference deleted.
8. Castedo, M., A. Coquelle, I. Vitale, S. Vivet, S. Mouhamad, S. Viaud, L. Zitvogel, and G. Kroemer. 2006. Selective resistance of tetraploid cancer cells against DNA damage-induced apoptosis. Ann. N. Y. Acad. Sci. 1090: 35-49.
9. Cha, H., C. Hancock, S. Dangi, D. Maiguel, F. Carrier, and P. Shapiro. 2004. Phosphorylation regulates nucleophosmin targeting to the centrosome during mitosis as detected by cross-reactive phosphorylation-specific MKK1/ MKK2 antibodies. Biochem. J. 378:857-865.
10. Chen, Z., V. B. Indjeian, M. McManus, L. Wang, and B. D. Dynlacht. 2002. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev. Cell 3:339-350.
11. Coleman, W. B., and G. J. Tsongalis. 1999. The role of genomic instability in human carcinogenesis. Anticancer Res. 19:4645-4664.
12. Doxsey, S. 2002. Duplicating dangerously: linking centrosome duplication and aneuploidy. Mol. Cell 10:439-440.
13. Duensing, A., L. Ghanem, R. A. Steinman, Y. Liu, and S. Duensing. 2006. p21(Waf1/Cip1) deficiency stimulates centriole overduplication. Cell Cycle 5:2899-2902.
14. Duensing, A., Y. Liu, M. Tseng, M. Malumbres, M. Barbacid, and S. Duensing. 2006. Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene 25:2943-2949.
15. Duesberg, P., R. Li, R. Sachs, A. Fabarius, M. B. Upender, and R. Hehlmann. 2007. Cancer drug resistance: the central role of the karyotype. Drug Resist. Updat. 10:51-58.
16. Duesberg, P., and D. Rasnick. 2000. Aneuploidy, the somatic mutation that makes cancer a species of its own. Cell Motil. Cytoskeleton 47:81-107.
17. Duesberg, P., D. Rasnick, R. Li, L. Winters, C. Rausch, and R. Hehlmann. 1999. How aneuploidy may cause cancer and genetic instability. Anticancer Res. 19:4887-4906.
18. Faragher, A. J., and A. M. Fry. 2003. Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles. Mol. Biol. Cell 14:2876-2889.
19. Fisk, H. A., and M. Winey. 2001. The mouse Mps1p-like kinase regulates centrosome duplication. Cell 106:95-104.
20. Fukasawa, K. 2005. Centrosome amplification, chromosome instability and cancer development. Cancer Lett. 230:6-19.
21. Fukasawa, K. 2008. p53, cyclin-dependent kinase and abnormal amplification of centrosomes. Biochim. Biophys. Acta 1786:15-23.
22. Fukasawa, K., T. Choi, R. Kuriyama, S. Rulong, and G. F. Vande Woude. 1996. Abnormal centrosome amplification in the absence of p53. Science 271:1744-1747.
23. Fukasawa, K., F. Wiener, G. F. Vande Woude, and S. Mai. 1997. Genomic instability and apoptosis are frequent in p53 deficient young mice. Oncogene 15:1295-1302.
24. Geng, Y., W. Whoriskey, M. Y. Park, R. T. Bronson, R. H. Medema, T. Li, R. A. Weinberg, and P. Sicinski. 1999. Rescue of cyclin D1 deficiency by knockin cyclin E. Cell 97:767-777.
25. Geng, Y., Q. Yu, E. Sicinska, M. Das, J. E. Schneider, S. Bhattacharya, W. M. Rideout, R. T. Bronson, H. Gardner, and P. Sicinski. 2003. Cyclin E ablation in the mouse. Cell 114:431-443.
26. Habedanck, R., Y. D. Stierhof, C. J. Wilkinson, and E. A. Nigg. 2005. The Polo kinase Plk4 functions in centriole duplication. Nat. Cell Biol. 7:1140-1146.
27. Hanashiro, K., M. Kanai, Y. Geng, P. Sicinski, and K. Fukasawa. 2008. Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells. Oncogene 27:5288-5302.
28. 1. Cell 98:859-869.
29. Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclindependent kinases. Cell 75:805-816.
30. Harper, J. W., S. J. Elledge, K. Keyomarsi, B. Dynlacht, L. H. Tsai, P. Zhang, S. Dobrowolski, C. Bai, L. Connell-Crowley, E. Swindell, et al. 1995. Inhibition of cyclin-dependent kinases by p21. Mol. Biol. Cell 6:387-400.
31. Hennig, U. G., N. L. Rudd, and D. I. Hoar. 1988. Kinetochore immunofluorescence in micronuclei: a rapid method for the in situ detection of aneuploidy and chromosome breakage in human fibroblasts. Mutat. Res. 203: 405-414.
32. Hinchcliffe, E. H., C. Li, E. A. Thompson, J. L. Maller, and G. Sluder. 1999. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science 283:851-854.
33. Hinchcliffe, E. H., and G. Sluder. 2002. Two for two: Cdk2 and its role in centrosome doubling. Oncogene 21:6154-6160.
34. Kleylein-Sohn, J., J. Westendorf, M. Le Clech, R. Habedanck, Y. D. Stierhof, and E. A. Nigg. 2007. Plk4-induced centriole biogenesis in human cells. Dev. Cell 13:190-202.
35. LaBaer, J., M. D. Garrett, L. F. Stevenson, J. M. Slingerland, C. Sandhu, H. S. Chou, A. Fattaey, and E. Harlow. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:847-862.
36. Lacey, K. R., P. K. Jackson, and T. Stearns. 1999. Cyclin-dependent kinase control of centrosome duplication. Proc. Natl. Acad. Sci. U. S. A. 96:2817-2822.
37. Lundberg, A. S., and R. A. Weinberg. 1998. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18:753-761.
38. Malumbres, M., R. Sotillo, D. Santamaria, J. Galan, A. Cerezo, S. Ortega, P. Dubus, and M. Barbacid. 2004. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118:493-504.
39. Mantel, C., S. E. Braun, S. Reid, O. Henegariu, L. Liu, G. Hangoc, and H. E. Broxmeyer. 1999. p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells. Blood 93:1390-1398.
40. Matsumoto, Y., K. Hayashi, and E. Nishida. 1999. Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Curr. Biol. 9:429-432.
41. Matsumoto, Y., and J. L. Maller. 2004. A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science 306:885-888.
42. McDermott, K. M., J. Zhang, C. R. Holst, B. K. Kozakiewicz, V. Singla, and T. D. Tlsty. 2006. p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol. 4:e51.
43. -/- cells. EMBO J. 21:483-492.
44. Meraldi, P., J. Lukas, A. M. Fry, J. Bartek, and E. A. Nigg. 1999. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat. Cell Biol. 1:88-93.
45. 1-S arrest. Nat. Cell Biol. 9:160-170.
46. Miller, B. M., H. F. Zitzelsberger, H. U. Weier, and I. D. Adler. 1991. Classification of micronuclei in murine erythrocytes: immunofluorescent staining using CREST antibodies compared to in situ hybridization with biotinylated gamma satellite DNA. Mutagenesis 6:297-302.
47. Montagna, C., E. R. Andrechek, H. Padilla-Nash, W. J. Muller, and T. Ried. 2002. Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu. Oncogene 21:890-898.
48. Mussman, J. G., H. F. Horn, P. E. Carroll, M. Okuda, P. Tarapore, L. A. Donehower, and K. Fukasawa. 2000. Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene 19:1635-1646.
49. Nakayama, K., H. Nagahama, Y. A. Minamishima, M. Matsumoto, I. Nakamichi, K. Kitagawa, M. Shirane, R. Tsunematsu, T. Tsukiyama, N. Ishida, M. Kitagawa, K. Nakayama, and S. Hatakeyama. 2000. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19:2069-2081.
50. Nelsen, C. J., R. Kuriyama, B. Hirsch, V. C. Negron, W. L. Lingle, M. M. Goggin, M. W. Stanley, and J. H. Albrecht. 2005. Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy. J. Biol. Chem. 280:768-776.
51. Okuda, M., H. F. Horn, P. Tarapore, Y. Tokuyama, A. G. Smulian, P. K. Chan, E. S. Knudsen, I. A. Hofmann, J. D. Snyder, K. E. Bove, and K. Fukasawa. 2000. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103:127-140.
52. Ortega, S., I. Prieto, J. Odajima, A. Martin, P. Dubus, R. Sotillo, J. L. Barbero, M. Malumbres, and M. Barbacid. 2003. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genet. 35:25-31.
53. Padmakumar, V. C., E. Aleem, C. Berthet, M. B. Hilton, and P. Kaldis. 2009. Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53. Mol. Cell. Biol. 29:2582-2593.
54. Ray, A., M. K. James, S. Larochelle, R. P. Fisher, and S. W. Blain. 2009. p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes. Mol. Cell. Biol. 29:986-999.
55. Reddy, H. K., R. V. Mettus, S. G. Rane, X. Grana, J. Litvin, and E. P. Reddy. 2005. Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Res. 65:10174-10178.
56. Rogakou, E. P., D. R. Pilch, A. H. Orr, V. S. Ivanova, and W. M. Bonner. 1998. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273:5858-5868.
57. Saavedra, H. I., K. Fukasawa, C. W. Conn, and P. J. Stambrook. 1999. MAPK mediates RAS-induced chromosome instability. J. Biol. Chem. 274: 38083-38090.
58. Saavedra, H. I., J. A. Knauf, J. M. Shirokawa, J. Wang, B. Ouyang, R. Elisei, P. J. Stambrook, and J. A. Fagin. 2000. The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway. Oncogene 19: 3948-3954.
59. Saavedra, H. I., B. Maiti, C. Timmers, R. Altura, Y. Tokuyama, K. Fukasawa, and G. Leone. 2003. Inactivation of E2F3 results in centrosome amplification. Cancer Cell 3:333-346.
60. Sablina, A. A., A. V. Budanov, G. V. Ilyinskaya, L. S. Agapova, J. E. Kravchenko, and P. M. Chumakov. 2005. The antioxidant function of the p53 tumor suppressor. Nat. Med. 11:1306-1313.
61. Santamaría, D., C. Barriere, A. Cerqueira, S. Hunt, C. Tardy, K. Newton, J. F. Caceres, P. Dubus, M. Malumbres, and M. Barbacid. 2007. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448:811-815.
62. 1/S phase DNA damage checkpoint. Mol. Biol. Cell 19:65-77.
63. Shapiro, G. I. 2006. Cyclin-dependent kinase pathways as targets for cancer treatment. J. Clin. Oncol. 24:1770-1783.
64. 1/S progression and cellular transformation. J. Biol. Chem. 281:36124-36131.
65. Sherr, C. J., and J. M. Roberts. 2004. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18:2699-2711.
66. Sugihara, E., M. Kanai, S. Saito, T. Nitta, H. Toyoshima, K. Nakayama, K. I. Nakayama, K. Fukasawa, M. Schwab, H. Saya, and M. Miwa. 2006. Suppression of centrosome amplification after DNA damage depends on p27 accumulation. Cancer Res. 66:4020-4029.
67. Tagliati, F., A. Bottoni, A. Bosetti, M. C. Zatelli, and E. C. degli Uberti. 2005. Utilization of luminescent technology to develop a kinase assay: Cdk4 as a model system. J. Pharm. Biomed. Anal. 39:811-814.
68. Tarapore, P., H. F. Horn, Y. Tokuyama, and K. Fukasawa. 2001. Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene 20:3173-3184.
69. Thomson, E. J., and P. E. Perry. 1988. The identification of micronucleated chromosomes: a possible assay for aneuploidy. Mutagenesis 3:415-418.
70. Tokuyama, Y., H. F. Horn, K. Kawamura, P. Tarapore, and K. Fukasawa. 2001. Specific phosphorylation of nucleophosmin on Thr(199) by cyclindependent kinase 2-cyclin E and its role in centrosome duplication. J. Biol. Chem. 276:21529-21537.
71. Toledo, F., and G. M. Wahl. 2006. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer 6:909-923.
72. Tsutsui, T., B. Hesabi, D. S. Moons, P. P. Pandolfi, K. S. Hansel, A. Koff, and H. Kiyokawa. 1999. Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol. Cell. Biol. 19:7011-7019.
73. Ussar, S., and T. Voss. 2004. MEK1 and MEK2, different regulators of the G1/S transition. J. Biol. Chem. 279:43861-43869.
74. Vogelstein, B., D. Lane, and A. J. Levine. 2000. Surfing the p53 network. Nature 408:307-310.
75. Wu, L., C. Timmers, B. Maiti, H. I. Saavedra, L. Sang, G. T. Chong, F. Nuckolls, P. Giangrande, F. A. Wright, S. J. Field, M. E. Greenberg, S. Orkin, J. R. Nevins, M. L. Robinson, and G. Leone. 2001. The E2F1, E2F2, and E2F3 transcription factors are essential for cellular proliferation. Nature 414:457-462.
76. Xiong, Y., G. J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704.
77. Yu, Q., Y. Geng, and P. Sicinski. 2001. Specific protection against breast cancers by cyclin D1 ablation. Nature 411:1017-1021.