Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells

Oncogene

Volumn 27, Issue 40, 2008, Pages 5288-5302

  Hanashiro, K ^a   Kanai, M ^a   Geng, Y ^b,c   Sicinski, P ^b,c   Fukasawa, K ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CDK2; Centrosome; Centrosome amplification; Cyclin A; Cyclin E; p53

Indexed keywords

CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLIN E; PROTEIN P53;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DIVISION; CENTROSOME; GENOMIC INSTABILITY; MITOSIS; MOLECULAR GENETICS; PRIORITY JOURNAL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIVIRAL AGENTS; APHIDICOLIN; CENTROSOME; CYCLIN A; CYCLIN E; DOXORUBICIN; EMBRYO, MAMMALIAN; FIBROBLASTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, DOMINANT; HUMANS; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; S PHASE; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 51649122420     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.161     Document Type: Article

References (29)

1. Balczon R, Bao L, Zimmer WE, Brown K, Zinkowski RP, Brinkley BR. (1995). Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells. J Cell Biol 130: 105-115.
2. Bennett RA, Izumi H, Fukasawa K. (2004). Induction of centrosome amplification and chromosome instability in p53-null cells by transient exposure to subtoxic levels of S-phase-targeting anticancer drugs. Oncogene 23: 6823-6829.
3. Brummelkamp TR, Bernards R, Agami R. (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553.
4. Carroll PE, Okuda M, Horn HF, Biddinger P, Stambrook PJ, Gleich LL et al. (1999). Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene 18: 1935-1944.
5. Coverley D, Laman H, Laskey RA. (2002). Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat Cell Biol 4: 523-528.
6. DeGregori J, Kowalik T, Nevins JR. (1995). Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol 15: 4215-4224.
7. Desdouets C, Sobczak-Thépot J, Murphy M, Bréchot C. (1995). Cyclin A: function and expression during cell proliferation. Prog Cell Cycle Res 1: 115-123.
8. Dodson H, Bourke E, Jeffers LJ, Vagnarelli P, Sonoda E, Takeda S et al. (2004). Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J 23: 3864-3873.
9. Fukasawa K. (2005). Centrosome amplification, chromosome instability and cancer development. Cancer Lett 230: 6-19.
10. Fukasawa K. (2007). Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 7: 911-924.
11. Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF. (1996). Abnormal centrosome amplification in the absence of p53. Science 271: 1744-1747.
12. Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S et al. (2003). Cyclin E ablation in the mouse. Cell 114: 431-443.
13. Hinchcliffe EH, Li C, Thompson EA, Maller JL, Sluder G. (1999). Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science 283: 851-854.
14. Hoffman BD, Hanauske-Abel HM, Flint A, Lalande M. (1991). A new class of reversible cell cycle inhibitors. Cytometry 12: 26-32.
15. Horn HF, Vousden KH. (2007). Coping with stress: multiple ways to activate p53. Oncogene 26: 1306-1316.
16. Joshi HC. (1994). Microtubule organizing centers and gamma-tubulin. Curr Opin Cell Biol 6: 54-62.
17. Kastan MB, Bartek J. (2004). Cell-cycle checkpoints and cancer. Nature 432: 316-323.
18. Kawamura K, Izumi H, Ma Z, Ikeda R, Moriyama M, Tanaka T et al. (2004). Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression. Cancer Res 64: 4800-4809.
19. Kawamura K, Morita N, Domiki C, Fujikawa-Yamamoto K, Hashimoto M, Iwabuchi K et al. (2006). Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure. Cancer Sci 97: 252-258.
20. Lacey KR, Jackson PK, Stearns T. (1999). Cyclin-dependent kinase control of centrosome duplication. Proc Natl Acad Sci USA 96: 2817-2822.
21. Mussman JG, Horn HF, Carroll PE, Okuda M, Tarapore P, Donehower LA et al. (2000). Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene 19: 1635-1646.
22. Ossovskaya VS, Mazo IA, Chernov MV, Chernova OB, Strezoska Z, Kondratov R et al. (1996). Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains. Proc Natl Acad Sci USA 93: 10309-10314.
23. Pihan GA, Purohit A, Wallace J, Knecht H, Woda B, Quesenberry P et al. (1998). Centrosome defects and genetic instability in malignant tumors. Cancer Res 58: 3974-3985.
24. Sweeney C, Murphy M, Kubelka M, Ravnik SE, Hawkins CF, Wolgemuth DJ et al. (1996). A distinct cyclin A is expressed in germ cells in the mouse. Development 122: 53-64.
25. Taylor WR, Stark GR. (2001). Regulation of the G2/M transition by p53. Oncogene 20: 1803-1815.
26. Tarapore P, Horn HF, Tokuyama Y, Fukasawa K. (2001). Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/ Cip1 pathway. Oncogene 20: 3173-3184.
27. Tokuyama Y, Horn HF, Kawamura K, Tarapore P, Fukasawa K. (2001). Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. Biol Chem 276: 21529-21537.
28. Wang XJ, Greenhalgh DA, Jiang A, He D, Zhong L, Brinkley BR et al. (1998). Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function. Mol Carcinog 23: 185-192.
29. Wong C, Stearns T. (2003). Centrosome number is controlled by a centrosome-intrinsic block to reduplication. Nat Cell Biol 5: 539-544.