Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis

Journal of Molecular and Cellular Cardiology

Volumn 32, Issue 11, 2000, Pages 2007-2024

  Lopatin, A N ^a,b,c   Shantz, L M ^a,b,c   Mackintosh, C A ^a,b,c   Nichols, C G ^a,b,c   Pegg, A E ^a,b,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

K+ currents; Ornithine decarboxylase; Polyamines; Rectification

Indexed keywords

BUTRESCINE; CADAVERINE; MYOSIN HEAVY CHAIN; MYOSIN HEAVY CHAIN ALPHA; ORNITHINE DECARBOXYLASE; POLYAMINE; POTASSIUM ION; PUTRESCINE; SPERMIDINE; UNCLASSIFIED DRUG;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME KINETICS; GENE OVEREXPRESSION; HEART MUSCLE CELL; MALE; MOUSE; NONHUMAN; POLYAMINE SYNTHESIS; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

EID: 0033747576     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1232     Document Type: Article

References (57)

1. Les constantes electriques de la membrane du muscle
2. Electrical properties of cardiac muscle attributable to inward going (anomalous) rectification
3. Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions
4. + channels to intracellular spermine
5. Potassium channel block by cytoplasmic polyamnes as the mechanism of intrinsic rectification
6. + channels
7. 2+
8. + channels is caused by intracellular spermine
9. Polyamine metabolism and function
10. Polyamines
11. + channels in Rbl-1 cells
12. Depletion of intracellular polyamines relieves inward rectification of potassium channels
13. An ornithine decarboxylase-deficient mutant of Chinese hamster ovary cells
14. Role of ornithine decarboxylase in cardiac growth and hypertrophy
15. Polyamine and nucleic acid metabolism in myocardial hypertrophy of the overloaded heart
16. Inward rectification and implications for cardiac excitability
17. Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene
18. Partial deletion of both the spermine synthase gene and the Pex gene in the X-Linked hypophosphatemic, Gyro (Gy) mouse
19. Tissue-specific regulation of the a-myosin heavy chain gene promoter in transgenic mice
20. Identification of residues in ornithine decarboxylase essential for enzymatic activity and for rapid protein turnover
21. The Gy mutation: Another cause of X-linked hypophosphatemia in mouse
22. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia
23. Determination of polyamines and related compounds by reversed-phase high-perfomance liquid chromatography: Improved separation systems
24. Developmental analysis reveals mismatches in the expression of K+ channel alpha subunits and voltage-gated K+ channel currents in rat ventricular myocytes
25. Improved patch-clamp techniques for high-resolution current recording from cells and cellfree membrane patches
26. +] dependence of open-channel conductance in cloned inward rectifier potassium channels (IRK1, Kir2.1)
27. Calcium-activated chloride current in rabbit ventricular myocytes
28. 2+ in canine ventricular myocytes
29. + currents ITO1 and Iks are larger in right than left canine ventricular midmyocardium
30. Normal regional distribution of membrane current density in rat left ventricle is altered in catecholamine-induced hypertrophy
31. Potassium rectifier currents differ in myocytes of endocardial and epicardial origin
32. + currents in adult mouse ventricular myocytes
33. + current diversity in mouse ventricular myocytes
34. The mechanism of inward rectification of potassium channels: 'Long-pore plugging' by cytoplasmic polyamines
35. 2+
36. The effect of polyamines on KATP channels in guinea-pig ventricular myocytes
37. Distinct transient outward potassium current (I-to) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes
38. Characterization of a slowly inactivating outward current in adult mouse ventricular myocytes
39. Developmental changes in transient outward current in mouse ventricle
40. Modulation of potassium channel function by methionine oxidation and reduction
41. Human spermidine synthase: Cloning and primary structure
42. Molecular cloning of a cDNA encoding human spermine synthase
43. Enhanced papilloma formation in response to skin tumor promotion in transgenic mice overexpressing the human ornithine decarboxylase gene
44. Polyamines regulate expression of the neoplastic phenotype in mouse skin
45. Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase
46. Decarboxylation of ornithine and lysine in rat tissues
47. + channels in rabbit atrial myocytes. Intracellular substance-mediated mechanism of inward rectification
48. + current in rabbit and human atrial myocytes
49. Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart
50. Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel
51. Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit
52. Increases in brain polyamine concentrations in chemical kindling and single convulsion induced by pentylenetetrazol in rats
53. Polyamine metabolism in epileptic cortex
54. Effect of one hyperbaric oxygen-induced convulsion on cortical polyamine content in two strains of mice