Molecular basis of inward rectification: Polyamine interaction sites located by combined channel and ligand mutagenesis

Journal of General Physiology

Volumn 124, Issue 5, 2004, Pages 541-554

  Kurata, Harley T ^a,b   Phillips, L Revell ^a   Rose, Thierry ^c   Loussouarn, Gildas ^d   Herlitze, Stefan ^e   Fritzenschaft, Hariolf ^f   Enkvetchakul, Decha ^a   Nichols, Colin G ^a   Baukrowitz, Thomas ^f  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c INSTITUT PASTEUR   (France)

^d L INSTITUT DU THORAX   (France)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Diamine; Inward rectifier; Rectification; Selectivity filter; Spermine

Indexed keywords

CYSTEINE DERIVATIVE; DIAMINE DERIVATIVE; GLUTAMIC ACID DERIVATIVE; INWARDLY RECTIFYING POTASSIUM CHANNEL; LIGAND; POLYAMINE;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CYTOPLASM; FILTER; MUTAGENESIS; NONHUMAN; STEADY STATE;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POLYAMINES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 8644284845     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200409159     Document Type: Article

References (50)

1. Brelidze, T.I., X. Niu, and K.L. Magleby. 2003. A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification. Proc. Natl. Acad. Sci. USA. 100:9017-9022.
2. + channel. J. Biol. Chem. 278:49537-49548.
3. + conduction and selectivity. Science. 280:69-77.
4. Guo, D., and Z. Lu. 2000. Pore block versus intrinsic gating in the mechanism of inward rectification in strongly rectifying IRK1 channels. J. Gen. Physiol. 116:561-568.
5. + channels. J. Gen. Physiol. 122:485-500.
6. + channels. J. Gen. Physiol. 121:261-276.
7. Hagiwara, S., and K. Takahashi. 1974. The anomalous rectification and cation selectivity of the membrane of a starfish egg cell. J. Membr. Biol. 18:61-80.
8. Hagiwara, S., and M. Yoshii. 1979. Effects of internal potassium and sodium on the anomalous rectification of the starfish egg as examined by internal perfusion. J. Physiol. 292:251-265.
9. + channel pore through mutant cycles with a peptide inhibitor. Science. 268:307-310.
10. Hille, B., and W. Schwarz. 1978. Potassium channels as multi-ion single-file pores. J. Gen. Physiol. 72:409-442.
11. Jiang, Y., A. Lee, J. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002. The open pore conformation of potassium channels. Nature. 417:523-526.
12. Katz, B. 1949. Les constantes electriques de la membrane du muscle. Arch. Sci. Physiol. 2:285-299.
13. + channel. J. Physiol. 531:645-660.
14. Kuo, A., J.M. Gulbis, J.F. Antcliff, T. Rahman, E.D. Lowe, J. Zimmer, J. Cuthbertson, F.M. Ashcroft, T. Ezaki, and D.A. Doyle. 2003. Crystal structure of the potassium channel KirBacl.1 in the closed state. Science. 300:1922-1926.
15. + channel, Kir3.1/Kir3.4. J. Biol. Chem. 275:35831-35839.
16. +] dependence of polyamine-induced rectification in inward rectifier potassium channels (IRK1, Kir2.1). J. Gen. Physiol. 108:105-113.
17. Lopatin, A.N., and G.G. Nichols. 2001. Inward rectifiers in the heart: an update on I(K1). J. Mol. Cell. Cardiol. 33:625-638.
18. Lopatin, A.N., E.N. Makhina, and G.G. Nichols. 1995. The mechanism of inward rectification of potassium channels - long-pore plugging by cytoplasmic polyamines. J. Gen. Physiol. 106:923-955.
19. Loussouarn, G., E.N. Makhina, T. Rose, and C.G. Nichols. 2000. Structure and dynamics of the pore of inwardly rectifying K(ATP) channels. J. Biol. Chem. 275:1137-1144.
20. + channel pore. Proc. Natl. Acad. Sci. USA. 98:4227-4232.
21. + channel inner pore revealed by stoichiometric covalent modification. Neuron. 22:571-580.
22. Lu, T., Y.G. Zhu, and J. Yang. 1999b. Cytoplasmic amino and carboxyl domains form a wide intracellular vestibule in an inwardly rectifying potassium channel. Proc. Natl. Acad. Sci. USA. 96:9926-9931.
23. Lu, Z., and R. MacKinnon. 1994. A conductance maximum observed in an inward-rectifier potassium channel. J. Gen. Physiol. 104:477-486.
24. Lu, Z., A.M. Klem, and Y. Ramu. 2001. Ion conduction pore is conserved among potassium channels. Nature. 413:809-813.
25. Newman, E.A. 1993. Inward-rectifying potassium channels in retinal glial (Muller) cells. J. Neurosci. 13:3333-3345.
26. Nichols, C.G., and A.N. Lopatin. 1997. Inward rectifier potassium channels. Annu. Rev. Physiol. 59:171-191.
27. Nimigean, C.M., J.S. Chappie, and C. Miller. 2003. Electrostatic tuning of ion conductance in potassium channels. Biochemistry. 42:9263-9268.
28. Nishida, M., and R. MacKinnon. 2002. Structural basis of inward rectification. Cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution. Cell. 111:957-965.
29. 2+ block. J. Physiol. 510:675-683.
30. + channels. Biophys. J. 74:2318-2326.
31. + channel. Neuron. 9:307-313.
32. Pearson, W.L., and G.G. Nichols. 1998. Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines. J. Gen. Physiol. 112:351-363.
33. Phillips, I.R., and C.G. Nichols. 2003. Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the pore. J. Gen. Physiol. 122:795-804.
34. + channels. Neuron. 37:953-962.
35. Rose, T., and C.G. Nichols. 2003. Molecular modeling of Kir channel-polyamine interactions. Biophys. J. 84:80a.
36. Ruppersberg, P.J., E.V. Kitzing, and R. Schoepfer. 1994. The mechanism of magnesium block of NMDA receptors. The Neurosciences. 6:87-96.
37. Schulze, D., T. Krauter, H. Fritzenschaft, M. Soom, and T. Baukrowitz. 2003. Phosphatidylinositol 4,5-bisphosphate (PIP2) modulation of ATP and pH sensitivity in Kir channels. A tale of an active and a silent PIP2 site in the N terminus. J. Biol. Chem. 278:10500-10505.
38. Shyng, S., and C.G. Nichols. 1997. Octameric stoichiometry of the KATP channel complex. J. Gen. Physiol. 110:655-664.
39. Shyng, S., T. Ferrigni, and C.G. Nichols. 1997. Control of rectification and gating of cloned KATP channels by the Kir6.2 subunit. J. Gen. Physiol. 110:141-153.
40. + channel. J. Gen. Physiol. 112:211-221.
41. + fluxes through recombinant Shaker potassium channels expressed in single Xenopus oocytes. J. Gen. Physiol. 107:449-457.
42. + movement through the pore in IRK1 potassium channels. J. Gen. Physiol. 112:475-484.
43. + channels. Science. 264:844-847.
44. + channels in freshly dissociated coronary endothelial cells from guinea-pig heart. J. Physiol. 491:357-365.
45. + channels localized to a single negatively charged residue. Nature. 371:246-249.
46. Woodhull, A.M. 1973. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61:687-708.
47. Xie, L.H., S.A. John, and J.N. Weiss. 2002. Spermine block of the strong inward rectifier potassium channel Kir2.1: dual roles of surface charge screening and pore block. J. Gen. Physiol. 120:53-66.
48. Xie, L.H., S.A. John, and J.N. Weiss. 2003. Inward rectification by polyamines in mouse Kir2.1 channels: synergy between blocking components. J. Physiol. 550:67-82.
49. + channel. Neuron. 14:1047-1054.
50. Yang, J., M. Yu, Y.N. Jan, and L.Y. Jan. 1997. Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel. Proc. Natl. Acad. Sci. USA. 94:1568-1572.