Barium block of Kir2 and human cardiac inward rectifier currents: Evidence for subunit-heteromeric contribution to native currents

Cardiovascular Research

Volumn 59, Issue 2, 2003, Pages 328-338

  Schram, Gernot ^a,b   Pourrier, Marc ^a,b   Wang, Zhiguo ^a,b   White, Michel ^a,b   Nattel, Stanley ^a,b,c  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Arrhythmia (mechanisms); Ion channels; Ion transport; K channel; Sudden death

Indexed keywords

BARIUM; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; ELECTRIC CURRENT; GENE EXPRESSION; HEART; HEART MUSCLE BIOPSY; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IC 50; INJECTION; KINETICS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SPECIES COMPARISON; XENOPUS;

ANIMALS; BARIUM; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; HUMANS; MYOCYTES, CARDIAC; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 0142122236     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00366-3     Document Type: Article

References (25)

1. Katz B. Les constantes électrique de la membrane du muscle. Arch Sci Physiol. 3:1949;285-299.
2. Nichols C.G., Lopatin A.N. Inward rectifier potassium channels. Annu Rev Physiol. 59:1997;171-191.
3. Sakmann B., Trube G. Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart. J Physiol (Lond). 347:1984;641-657.
4. + current during the action potential of guinea pig ventricular myocytes. Biophys J. 60:1991;1534-1539.
5. Shimoni Y., Clark R.B., Giles W.R. Role of an inwardly rectifying potassium current in rabbit ventricular action potential. J Physiol (Lond). 448:1992;709-727.
6. Plaster N.M., Tawil R., Tristani-Firouzi M., et al. Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. Cell. 105:2001;511-519.
7. + channels from guinea-pig cardiomyocytes. J Physiol (Lond). 532:2001;115-126.
8. Wang Z., Yue L., White M., Pelletier G., Nattel S. Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle. Circulation. 98:1998;2422-2428.
9. Preisig-Muller R., Schlichthorl G., George T., et al. Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. Proc Natl Acad Sci USA. 99:2002;7774-7779.
10. + channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity. J Physiol (Lond). 544:(2):2002;337-349.
11. Lopatin A.N., Nichols C.G. Inward rectifiers in the heart: an update on I(K1). J Mol Cell Cardiol. 33:2001;625-638.
12. + channel. FEBS Lett. 338:1994;107-111.
13. Raab-Graham K.F., Radeke C.M., Vandenberg C.A. Molecular cloning and expression of a human heart inward rectifier potassium channel. NeuroReport. 5:1994;2501-2555.
14. + channel from human heart and brain: cloning and stable expression in a human cell line. Am J Physiol (Heart Circ Physiol). 268:1995;H506-H511.
15. + channel from human atrium. Circ Res. 76:1995;343-500.
16. +-channel. Gene. 163:1995;313-317.
17. + inward rectifier channel associated with motoneurons of cranial nerve nuclei. J Neurosci. 18:1998;4096-4105.
18. Melnyk P., Zhang L., Shrier A., Nattel S. Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle. Am J Physiol (Heart Circ Physiol). 283:2002;H1123-H1133.
19. + current of embryonic chick ventricular myocytes. Biochim Biophys Acta. 1052:1990;123-127.
20. Wahler G.M. Developmental increases in the inwardly rectifying potassium current of rat ventricular myocytes. Am J Physiol. 262:1992;C1266-C1272.
21. K1 with antisense oligonucleotides targeted to Kir2.1 mRNA. Am J Physiol. 274:1998;H892-H900.
22. Zaritsky J.J., Redell J.B., Tempel B.L., Schwarz T.L. The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes. J Physiol (Lond). 533:2001;697-710.
23. + channel proteins via their N-terminal end. FEBS Lett. 378:1996;64-68.
24. Tinker A., Jan Y.N., Jan L.Y. Regions responsible for the assembly of inwardly rectifying potassium channels. Cell. 87:1996;857-868.
25. Picones A., Keung E., Timpe L.C. Unitary conductance variation in Kir2.1 and in cardiac inward rectifier potassium channels. Biophys J. 81:2001;2035-2049.