Activation of inwardly rectifying Kir2.x potassium channels by β3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 375, Issue 5, 2007, Pages 311-322

  Scherer, Daniel ^a   Kiesecker, Claudia ^a   Kulzer, Martin ^a   Günth, Myriam ^a   Scholz, Eberhard P ^a   Kathöfer, Sven ^a   Thomas, Dierk ^a   Maurer, Martin ^a   Kreuzer, Jörg ^a   Bauer, Alexander ^a   Katus, Hugo A ^a   Karle, Christoph A ^a   Zitron, Edgar ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

3 Adrenoceptor; Electrophysiology; Kir2.x; Potassium channels; Protein kinases A and C; Xenopus oocyte expression system

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; CHELERYTHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL KIR2.1; INWARDLY RECTIFYING POTASSIUM CHANNEL KIR2.2; INWARDLY RECTIFYING POTASSIUM CHANNEL KIR2.X; ISOPRENALINE; KT 5720; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTRIC CURRENT; ENZYME PHOSPHORYLATION; FEMALE; MICROELECTRODE; MODULATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VOLTAGE CLAMP; WILD TYPE; XENOPUS;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN KINASE C; RECEPTORS, ADRENERGIC, BETA-3; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

EID: 34250615510     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-007-0167-5     Document Type: Article

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