Selective inhibition of inward rectifier K+ channels (Kir2.2) abolishes protection by ischemic preconditioning in rabbit ventricular cardiomyocytes

Circulation Research

Volumn 95, Issue 3, 2004, Pages 325-332

  Diaz, Roberto J ^a   Zobel, Carsten ^c,d   Cho, Hee Cheol ^b   Batthish, Michelle ^a,b   Hinek, Alina ^a   Backx, Peter H ^b,c   Wilson, Gregory J ^a,b,e  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF COLOGNE   (Germany)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Cardiomyocytes; Gene transfer; Ischemia; Ischemic preconditioning; Potassium channels

Indexed keywords

BARIUM CHLORIDE; CHLORIDE CHANNEL; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; NIFEDIPINE; POTASSIUM CHANNEL BLOCKING AGENT; TRYPAN BLUE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL MEMBRANE; CELL VOLUME; CHLORIDE TRANSPORT; CONTROLLED STUDY; DOMINANT NEGATIVE MUTANT; GENE OVEREXPRESSION; GENE TRANSFER; HEART INFARCTION PREVENTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.2; MUTANT; NONHUMAN; PRIORITY JOURNAL; RABBIT; REPERFUSION; REPORTER GENE;

ADENOVIRIDAE; ANIMALS; BARIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL SURVIVAL; CELLS, CULTURED; CHLORIDES; GENETIC VECTORS; ION CHANNEL GATING; ION TRANSPORT; ISCHEMIC PRECONDITIONING; MYOCARDIAL REPERFUSION; MYOCYTES, CARDIAC; NIFEDIPINE; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RABBITS; RECOMBINANT FUSION PROTEINS; SARCOLEMMA; TRANSFECTION;

EID: 4043072233     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000137727.34938.35     Document Type: Article

References (32)

1. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986; 74:1124-1136.
2. 1 angiotensin II receptors abolishes ischemic preconditioning in isolated rabbit hearts. J Mol Cell Cardiol. 1997;29:129-139.
3. Goto M, Liu Y, Yang XM, Ardell JL, Cohen MV, Downey JM. Role of Bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ Res. 1995;77:611-621.
4. Liu GS, Thoraton J, Van Winkle DM, Stanley AWH, Olsson RA, Downey JM. Protection against infarction afforded by preconditioning is mediated by Al adenosine receptors in rabbit heart. Circulation. 1991; 84:350-356.
5. Miki T, Cohen MV, Downey JM. Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits. MoI Cell Biochem. 1998;186:3-12.
6. Batthish M, Diaz RJ, Zeng HP, Backx PH, Wilson GJ. Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition. Cardiovasc Res. 2002;55:660-671.
7. Diaz RJ, Armstrong SC, Batthish M, Backx PH, Ganote CE, Wilson GJ. Enhanced cell volume regulation: a key protective mechanism of ischemic preconditioning in rabbit ventricular myocytes. J Mol Cell Cardiol. 2003;35:45-58.
8. Diaz RJ, Losito VA, Mao GD, Ford MK, Backx PH, Wilson GJ. Chloride channel inhibition blocks the protection of ischemic preconditioning and hypo-osmotic stress in rabbit ventricular myocardium. Circ Res. 1999; 84:763-775.
9. Weiss JN, Shieh RC. Potassium loss during myocardial ischaemia and hypoxia: does lactate efflux play a role? Cardiovasc Res. 1994;28: 1125-1132.
10. Jan LY, Jan YN. Voltage-gated and inwardly rectifying potassium channels. J Physiol (Lond). 1997;505(Pt 2):267-282.
11. Doupnik CA, Davidson N, Lester HA. The inward rectifier potassium channel family. Curr Opin Neurobiol. 1995;5:268-277.
12. Nichols CG, Lopatin AN. Inward rectifier potassium channels. Annu Rev Physiol. 1997;59:171-191.
13. Kameyama M, Kakei M, Sato R, Shibasaki T, Matsuda H, Irisawa H. Intracellular Na+ activates a K+ channel in mammalian cardiac cells. Nature. 1984;309:354-356.
14. Pike MM, Kitakaze M, Marban E. 23Na-NMR measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion. Am J Physiol. 1990;259:H1767-73.
15. Armstrong SC, Ganote CE. Effects of phosphatase inhibitor mepacrine on injury in ischemic and metabolically inhibited adult isolated myocytes. Am J Pathol. 1991;138:545-555.
16. Zobel C, Cho HC, Nguyen T-T, Pekhletski R, Diaz RJ, Wilson GJ, Backx PH. Molecular dissection of inward rectifier potassium current (IK1) in rabbit cardiomyocytes - Evidence for heteromeric co-assembly of Kir2.1 and Kir2.2. J Physiol 2003;550:365-372.
17. Cho HC, Tsushima RG, Nguyen TT, Guy HR, Backx PH. Two critical cysteine residues implicated in disulfide bond formation and proper folding of Kir2.1. Biochemistry. 2000;39:4649-4657.
18. Sandhu R, Diaz RJ, Mao GD, Wilson GJ. Ischemic preconditioning: differences in protection and susceptibility to blockade with single-cycle versus multicycle transient ischemia. Circulation. 1997;96:984-995.
19. 2+ block of the ATP-sensitive K+ current of mouse pancreatic β-cells. Pflugers Arch. 1996;431:625-631.
20. Christe G. Localization of K(+) channels in the tubules of cardiomyocytes as suggested by the parallel decay of membrane capacitance, IK(1) and IK(ATP) during culture and by delayed IK(1) response to barium. J Mol Cell Cardiol. 1999;31:2207-2213.
21. Mitcheson JS, Hancox JC, Levi AJ. Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture. Pflugers Arch. 1996;431:814-827.
22. Veldkamp MW, de Jonge B, van Ginneken AC. Decreased inward rectifier current in adult rabbit ventricular myocytes maintained in primary culture: a single-channel study. Cardiovasc Res. 1999;42:424-433.
23. Schultz JE, Kwok WM, Hsu AK, Gross GJ. Terikalant, an inward-rectifier potassium channel blocker, does not abolish the cardioprotection induced by ischemic preconditioning in the rat. J Mol Cell Cardiol. 1998;30:1817-1825.
24. + current acting as pure class III antiarrhythmic agents. J Cardiovasc Pharmacol. 1992;20(suppl 2):S106-S113.
25. Jurkiewicz NK, Wang J, Fermini B, Sanguinetti MC, Salata JJ. Mechanism of action potential prolongation by RP 58866 and its enantiomer, terikalant. Circulation. 1996;94:2938-2946.
26. Irie H, Gao J, Gaudette GR, Cohen IS, Mathias RT, Saltman AE, Krukenkamp IB. Both metabolic inhibition and mitochondrial KATP channels opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current. Circulation. 2003;108(suppl II): II-341-II-347.
27. ATP channel blocker HMR 1883 does not abolish the benefit of ischemic preconditioning on myocardial infarct mass in anesthetized rabbits. Naunyn-Schmiedeberg Arch Pharmacol. 2000;361: 445-451.
28. Suzuki M, Sasaki N, Miki T, Sakamoto N, Ohmoto-Sekine Y, Tamagawa M, Seino S, Marban E, Nakaya H. Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice. J Clin Invest. 2002;109:509-516.
29. Rajashree R, Koster JC, Markova KP, Nichols C, G., Hofmann PA. Contractility and ischemic response of hearts from transgenic mice with altered sarcolemmal KATP channels. Am J Physiol Heart Circ Physiol. 2002;283:H584-H590.
30. Gumina RJ, Pucar D, Bast P, Hodgson DM, Kurtz CE, Dzeja PP, Miki T, Seino S, Terzic A. Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. Am J Physiol Heart Circ Physiol. 2003;284:H2106-H2113.
31. Sasaki N, Murata M, Guo Y, Jo S-H, Ohler A, Akao M, O'Rourke B, Xiao R-P, Bolli R, Marbán E. MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning. Circulation. 2003;107:1183-1188.
32. Gross GJ, Peart JN. KATP channels and myocardial preconditioning: an update. Am J Physiol Heart Circ Physiol. 2003;285:H921-H930.