메뉴 건너뛰기




Volumn 10, Issue 1, 2010, Pages 73-79

Opioid-receptor-heteromer-specific trafficking and pharmacology

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,4A,5,12,12AALPHA OCTAHYDRO 4AALPHA (3 HYDROXYPHENYL) 2 METHYLQUINOLINO[2,3 G]ISOQUINOLINE; 6' GUANIDINONALTRINDOLE; ANALGESIC AGENT; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR ANTAGONIST; ENDORPHIN; G PROTEIN COUPLED RECEPTOR; HETEROMER; KAPPA OPIATE RECEPTOR; LIGAND; MU OPIATE RECEPTOR AGONIST; NALOXONAZINE; NALTRINDOLE; OPIATE; OPIATE RECEPTOR; OXYMORPHONE; POLYMER; UNCLASSIFIED DRUG;

EID: 72449123327     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2009.09.007     Document Type: Review
Times cited : (89)

References (66)
  • 2
    • 0345299129 scopus 로고
    • Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors
    • Zukin R.S., Eghbali M., Olive D., Unterwald E.M., and Tempel A. Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors. Proc Natl Acad Sci U S A 85 (1988) 4061-4065
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 4061-4065
    • Zukin, R.S.1    Eghbali, M.2    Olive, D.3    Unterwald, E.M.4    Tempel, A.5
  • 5
    • 4644343161 scopus 로고    scopus 로고
    • Multiple opiate receptors: deja vu all over again
    • Pasternak G.W. Multiple opiate receptors: deja vu all over again. Neuropharmacology 47 Suppl 1 (2004) 312-323
    • (2004) Neuropharmacology , vol.47 , Issue.SUPPL. 1 , pp. 312-323
    • Pasternak, G.W.1
  • 7
    • 0036462451 scopus 로고    scopus 로고
    • Oligomerization of opioid receptors: generation of novel signaling units
    • Levac B.A., O'Dowd B.F., and George S.R. Oligomerization of opioid receptors: generation of novel signaling units. Curr Opin Pharmacol 2 (2002) 76-81
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 76-81
    • Levac, B.A.1    O'Dowd, B.F.2    George, S.R.3
  • 8
    • 0030760634 scopus 로고    scopus 로고
    • Dimerization of the delta opioid receptor: implication for a role in receptor internalization
    • Cvejic S., and Devi L.A. Dimerization of the delta opioid receptor: implication for a role in receptor internalization. J Biol Chem 272 (1997) 26959-26964
    • (1997) J Biol Chem , vol.272 , pp. 26959-26964
    • Cvejic, S.1    Devi, L.A.2
  • 10
    • 37549019374 scopus 로고    scopus 로고
    • The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence
    • Martini L., and Whistler J.L. The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr Opin Neurobiol 17 (2007) 556-564
    • (2007) Curr Opin Neurobiol , vol.17 , pp. 556-564
    • Martini, L.1    Whistler, J.L.2
  • 12
    • 0035138995 scopus 로고    scopus 로고
    • Cellular and synaptic adaptations mediating opioid dependence
    • Williams J.T., Christie M.J., and Manzoni O. Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 81 (2001) 299-343
    • (2001) Physiol Rev , vol.81 , pp. 299-343
    • Williams, J.T.1    Christie, M.J.2    Manzoni, O.3
  • 13
    • 38349074858 scopus 로고    scopus 로고
    • Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence
    • Using a knock-in mouse model the authors provide in vivo evidence to support the hypothesis that the inability of MOP-Rs to endocytose after morphine activation lies at the base of the establishment of morphine tolerance.
    • Kim J.A., Bartlett S., He L., Nielsen C.K., Chang A.M., Kharazia V., Waldhoer M., Ou C.J., Taylor S., Ferwerda M., et al. Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence. Curr Biol 18 (2008) 129-135. Using a knock-in mouse model the authors provide in vivo evidence to support the hypothesis that the inability of MOP-Rs to endocytose after morphine activation lies at the base of the establishment of morphine tolerance.
    • (2008) Curr Biol , vol.18 , pp. 129-135
    • Kim, J.A.1    Bartlett, S.2    He, L.3    Nielsen, C.K.4    Chang, A.M.5    Kharazia, V.6    Waldhoer, M.7    Ou, C.J.8    Taylor, S.9    Ferwerda, M.10
  • 14
    • 40549105390 scopus 로고    scopus 로고
    • Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain
    • This study shows that, in a clinically relevant model of inflammatory pain, the presence of endogenous opioids prevents the establishment of peripheral morphine tolerance.
    • Zollner C., Mousa S.A., Fischer O., Rittner H.L., Shaqura M., Brack A., Shakibaei M., Binder W., Urban F., Stein C., et al. Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. J Clin Invest 118 (2008) 1065-1073. This study shows that, in a clinically relevant model of inflammatory pain, the presence of endogenous opioids prevents the establishment of peripheral morphine tolerance.
    • (2008) J Clin Invest , vol.118 , pp. 1065-1073
    • Zollner, C.1    Mousa, S.A.2    Fischer, O.3    Rittner, H.L.4    Shaqura, M.5    Brack, A.6    Shakibaei, M.7    Binder, W.8    Urban, F.9    Stein, C.10
  • 15
    • 0037169345 scopus 로고    scopus 로고
    • Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization
    • He L., Fong J., von Zastrow M., and Whistler J.L. Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell 108 (2002) 271-282
    • (2002) Cell , vol.108 , pp. 271-282
    • He, L.1    Fong, J.2    von Zastrow, M.3    Whistler, J.L.4
  • 16
    • 20144377958 scopus 로고    scopus 로고
    • An opiate cocktail that reduces morphine tolerance and dependence
    • This study describes the development of a morphine-methadone cocktail that drives MOP-R homomer endocytosis. Shows that promoting endocytosis reduces tolerance and dependence.
    • He L., and Whistler J.L. An opiate cocktail that reduces morphine tolerance and dependence. Curr Biol 15 (2005) 1028-1033. This study describes the development of a morphine-methadone cocktail that drives MOP-R homomer endocytosis. Shows that promoting endocytosis reduces tolerance and dependence.
    • (2005) Curr Biol , vol.15 , pp. 1028-1033
    • He, L.1    Whistler, J.L.2
  • 17
    • 38849137816 scopus 로고    scopus 로고
    • Trafficking of central opioid receptors and descending pain inhibition
    • A review of the mechanism and different conditions under which DOP-Rs redistribute from large dense core vesicles to the cell surface.
    • Bie B., and Pan Z.Z. Trafficking of central opioid receptors and descending pain inhibition. Mol Pain 3 (2007) 37. A review of the mechanism and different conditions under which DOP-Rs redistribute from large dense core vesicles to the cell surface.
    • (2007) Mol Pain , vol.3 , pp. 37
    • Bie, B.1    Pan, Z.Z.2
  • 18
    • 58149395695 scopus 로고    scopus 로고
    • Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption
    • Margolis E.B., Fields H.L., Hjelmstad G.O., and Mitchell J.M. Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption. J Neurosci 28 (2008) 12672-12681
    • (2008) J Neurosci , vol.28 , pp. 12672-12681
    • Margolis, E.B.1    Fields, H.L.2    Hjelmstad, G.O.3    Mitchell, J.M.4
  • 19
    • 23944455412 scopus 로고    scopus 로고
    • Interaction with vesicle luminal protachykinin regulates surface expression of d-opioid receptors and opioid analgesia
    • Guan J.-S., Xu Z.-Z., Gao H., He S.-Q., Ma G.-Q., Sun T., Wang L.-H., Zhang Z.-N., Lena I., and Kitchen I. Interaction with vesicle luminal protachykinin regulates surface expression of d-opioid receptors and opioid analgesia. Cell 122 (2005) 619-631
    • (2005) Cell , vol.122 , pp. 619-631
    • Guan, J.-S.1    Xu, Z.-Z.2    Gao, H.3    He, S.-Q.4    Ma, G.-Q.5    Sun, T.6    Wang, L.-H.7    Zhang, Z.-N.8    Lena, I.9    Kitchen, I.10
  • 20
    • 0035478363 scopus 로고    scopus 로고
    • Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception
    • Cahill C.M., Morinville A., Lee M.C., Vincent J.P., Collier B., and Beaudet A. Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception. J Neurosci 21 (2001) 7598-7607
    • (2001) J Neurosci , vol.21 , pp. 7598-7607
    • Cahill, C.M.1    Morinville, A.2    Lee, M.C.3    Vincent, J.P.4    Collier, B.5    Beaudet, A.6
  • 21
    • 0037741017 scopus 로고    scopus 로고
    • Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice
    • Morinville A., Cahill C.M., Esdaile M.J., Aibak H., Collier B., Kieffer B.L., and Beaudet A. Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice. J Neurosci 23 (2003) 4888-4898
    • (2003) J Neurosci , vol.23 , pp. 4888-4898
    • Morinville, A.1    Cahill, C.M.2    Esdaile, M.J.3    Aibak, H.4    Collier, B.5    Kieffer, B.L.6    Beaudet, A.7
  • 22
    • 66749154689 scopus 로고    scopus 로고
    • Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
    • Elaborate study showing that spinal MOP-R and DOP-R each have a distinct location and a distinct function in the spinal cord.
    • Scherrer G., Imamachi N., Cao Y.Q., Contet C., Mennicken F., O'Donnell D., Kieffer B.L., and Basbaum A.I. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell 137 (2009) 1148-1159. Elaborate study showing that spinal MOP-R and DOP-R each have a distinct location and a distinct function in the spinal cord.
    • (2009) Cell , vol.137 , pp. 1148-1159
    • Scherrer, G.1    Imamachi, N.2    Cao, Y.Q.3    Contet, C.4    Mennicken, F.5    O'Donnell, D.6    Kieffer, B.L.7    Basbaum, A.I.8
  • 24
    • 0034714335 scopus 로고    scopus 로고
    • Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties
    • George S.R., Fan T., Xie Z., Tse R., Tam V., Varghese G., and O'Dowd B.F. Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. J Biol Chem 275 (2000) 26128-26135
    • (2000) J Biol Chem , vol.275 , pp. 26128-26135
    • George, S.R.1    Fan, T.2    Xie, Z.3    Tse, R.4    Tam, V.5    Varghese, G.6    O'Dowd, B.F.7
  • 25
    • 1842687121 scopus 로고    scopus 로고
    • A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia
    • Gomes I., Gupta A., Filipovska J., Szeto H.H., Pintar J.E., and Devi L.A. A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia. Proc Natl Acad Sci U S A 101 (2004) 5135-5139
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 5135-5139
    • Gomes, I.1    Gupta, A.2    Filipovska, J.3    Szeto, H.H.4    Pintar, J.E.5    Devi, L.A.6
  • 26
    • 15744401602 scopus 로고    scopus 로고
    • Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions
    • Law P.Y., Erickson-Herbrandson L.J., Zha Q.Q., Solberg J., Chu J., Sarre A., and Loh H.H. Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions. J Biol Chem 280 (2005) 11152-11164
    • (2005) J Biol Chem , vol.280 , pp. 11152-11164
    • Law, P.Y.1    Erickson-Herbrandson, L.J.2    Zha, Q.Q.3    Solberg, J.4    Chu, J.5    Sarre, A.6    Loh, H.H.7
  • 27
    • 21144439867 scopus 로고    scopus 로고
    • Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer
    • Wang D., Sun X., Bohn L.M., and Sadee W. Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer. Mol Pharmacol 67 (2005) 2173-2184
    • (2005) Mol Pharmacol , vol.67 , pp. 2173-2184
    • Wang, D.1    Sun, X.2    Bohn, L.M.3    Sadee, W.4
  • 28
    • 0033578005 scopus 로고    scopus 로고
    • G-protein-coupled receptor heterodimerization modulates receptor function
    • Jordan B.A., and Devi L.A. G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399 (1999) 697-700
    • (1999) Nature , vol.399 , pp. 697-700
    • Jordan, B.A.1    Devi, L.A.2
  • 29
    • 0036387204 scopus 로고    scopus 로고
    • Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype
    • Pan Y., Bolan E., and Pasternak G. Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype. Biochem Biophys Res Commun 297 (2002) 659
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 659
    • Pan, Y.1    Bolan, E.2    Pasternak, G.3
  • 30
    • 2542625998 scopus 로고    scopus 로고
    • A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers
    • Bhushan R.G., Sharma S.K., Xie Z., Daniels D.J., and Portoghese P.S. A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers. J Med Chem 47 (2004) 2969-2972
    • (2004) J Med Chem , vol.47 , pp. 2969-2972
    • Bhushan, R.G.1    Sharma, S.K.2    Xie, Z.3    Daniels, D.J.4    Portoghese, P.S.5
  • 31
    • 0037466476 scopus 로고    scopus 로고
    • Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord
    • Portoghese P.S., and Lunzer M.M. Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord. Eur J Pharmacol 467 (2003) 233-234
    • (2003) Eur J Pharmacol , vol.467 , pp. 233-234
    • Portoghese, P.S.1    Lunzer, M.M.2
  • 33
    • 0034668742 scopus 로고    scopus 로고
    • Heterodimerization of mu and delta opioid receptors: a role in opiate synergy
    • Gomes I., Jordan B.A., Gupta A., Trapaidze N., Nagy V., and Devi L.A. Heterodimerization of mu and delta opioid receptors: a role in opiate synergy. J Neurosci 20 (2000) RC110
    • (2000) J Neurosci , vol.20
    • Gomes, I.1    Jordan, B.A.2    Gupta, A.3    Trapaidze, N.4    Nagy, V.5    Devi, L.A.6
  • 34
    • 72449140688 scopus 로고    scopus 로고
    • The delta-1 opioid receptor is a heterodimer that opposes the actions of the delta-2 receptor on alcohol intake
    • This study shows that DOP-R1 and DOP-R2s have opposing effects on alcohol consumption and represent distinct pharmacological targets that can work synergistically. Also shows that the effects of DOP-R1 require both DOP-R and MOP-R, suggesting that DOP-R1 could be a DOP/MOP-R heteromer.
    • Van Rijn R.M., and Whistler J.L. The delta-1 opioid receptor is a heterodimer that opposes the actions of the delta-2 receptor on alcohol intake. Biol Psychiatry 66 (2009) 777-784. This study shows that DOP-R1 and DOP-R2s have opposing effects on alcohol consumption and represent distinct pharmacological targets that can work synergistically. Also shows that the effects of DOP-R1 require both DOP-R and MOP-R, suggesting that DOP-R1 could be a DOP/MOP-R heteromer.
    • (2009) Biol Psychiatry , vol.66 , pp. 777-784
    • Van Rijn, R.M.1    Whistler, J.L.2
  • 36
    • 0024331850 scopus 로고
    • Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype
    • Clark J.A., Liu L., Price M., Hersh B., Edelson M., and Pasternak G.W. Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype. J Pharmacol Exp Ther 251 (1989) 461-468
    • (1989) J Pharmacol Exp Ther , vol.251 , pp. 461-468
    • Clark, J.A.1    Liu, L.2    Price, M.3    Hersh, B.4    Edelson, M.5    Pasternak, G.W.6
  • 37
    • 0011204773 scopus 로고
    • Classification of multiple morphine and enkephalin binding sites in the central nervous system
    • Wolozin B.L., and Pasternak G.W. Classification of multiple morphine and enkephalin binding sites in the central nervous system. Proc Natl Acad Sci U S A 78 (1981) 6181-6185
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 6181-6185
    • Wolozin, B.L.1    Pasternak, G.W.2
  • 38
    • 0345803929 scopus 로고    scopus 로고
    • Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization
    • Pfeiffer M., Kirscht S., Stumm R., Koch T., Wu D., Laugsch M., Schroder H., Hollt V., and Schulz S. Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization. J Biol Chem 278 (2003) 51630-51637
    • (2003) J Biol Chem , vol.278 , pp. 51630-51637
    • Pfeiffer, M.1    Kirscht, S.2    Stumm, R.3    Koch, T.4    Wu, D.5    Laugsch, M.6    Schroder, H.7    Hollt, V.8    Schulz, S.9
  • 39
    • 0346056873 scopus 로고    scopus 로고
    • Heterodimerization and cross-desensitization between the micro-opioid receptor and the chemokine CCR5 receptor
    • Chen C., Li J., Bot G., Szabo I., Rogers T.J., and Liu-Chen L.Y. Heterodimerization and cross-desensitization between the micro-opioid receptor and the chemokine CCR5 receptor. Eur J Pharmacol 483 (2004) 175-186
    • (2004) Eur J Pharmacol , vol.483 , pp. 175-186
    • Chen, C.1    Li, J.2    Bot, G.3    Szabo, I.4    Rogers, T.J.5    Liu-Chen, L.Y.6
  • 40
    • 0346996861 scopus 로고    scopus 로고
    • Functional interactions between mu opioid and alpha 2A-adrenergic receptors
    • Jordan B.A., Gomes I., Rios C., Filipovska J., and Devi L.A. Functional interactions between mu opioid and alpha 2A-adrenergic receptors. Mol Pharmacol 64 (2003) 1317-1324
    • (2003) Mol Pharmacol , vol.64 , pp. 1317-1324
    • Jordan, B.A.1    Gomes, I.2    Rios, C.3    Filipovska, J.4    Devi, L.A.5
  • 41
    • 0035793079 scopus 로고    scopus 로고
    • Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation
    • Jordan B.A., Trapaidze N., Gomes I., Nivarthi R., and Devi L.A. Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci U S A 98 (2001) 343-348
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 343-348
    • Jordan, B.A.1    Trapaidze, N.2    Gomes, I.3    Nivarthi, R.4    Devi, L.A.5
  • 42
    • 57349129484 scopus 로고    scopus 로고
    • Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4
    • This work shows that members of the receptor transporter protein family may act as chaperones to assist cell surface targeting of DOP/MOP-R heteromers.
    • Decaillot F.M., Rozenfeld R., Gupta A., and Devi L.A. Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Proc Natl Acad Sci U S A 105 (2008) 16045-16050. This work shows that members of the receptor transporter protein family may act as chaperones to assist cell surface targeting of DOP/MOP-R heteromers.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16045-16050
    • Decaillot, F.M.1    Rozenfeld, R.2    Gupta, A.3    Devi, L.A.4
  • 43
    • 21144446486 scopus 로고    scopus 로고
    • A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers
    • This work describes a ligand with novel properties on a DOP/KOP-R heteromer, distinct from those at the homomeric receptors. Demonstrates that this ligand is a tissue-selective analgesic.
    • Waldhoer M., Fong J., Jones R.M., Lunzer M.M., Sharma S.K., Kostenis E., Portoghese P.S., and Whistler J.L. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc Natl Acad Sci U S A 102 (2005) 9050-9055. This work describes a ligand with novel properties on a DOP/KOP-R heteromer, distinct from those at the homomeric receptors. Demonstrates that this ligand is a tissue-selective analgesic.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9050-9055
    • Waldhoer, M.1    Fong, J.2    Jones, R.M.3    Lunzer, M.M.4    Sharma, S.K.5    Kostenis, E.6    Portoghese, P.S.7    Whistler, J.L.8
  • 44
    • 36048947671 scopus 로고    scopus 로고
    • Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists
    • An elegant study showing how DOP/MOP-R heteromers are formed only in the ER, and not after translocation to the cell surface.
    • Hasbi A., Nguyen T., Fan T., Cheng R., Rashid A., Alijaniaram M., Rasenick M.M., O'Dowd B.F., and George S.R. Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists. Biochemistry 46 (2007) 12997-13009. An elegant study showing how DOP/MOP-R heteromers are formed only in the ER, and not after translocation to the cell surface.
    • (2007) Biochemistry , vol.46 , pp. 12997-13009
    • Hasbi, A.1    Nguyen, T.2    Fan, T.3    Cheng, R.4    Rashid, A.5    Alijaniaram, M.6    Rasenick, M.M.7    O'Dowd, B.F.8    George, S.R.9
  • 45
    • 58549117701 scopus 로고    scopus 로고
    • The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers?
    • Van Rijn R.M., and Whistler J.L. The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers?. Mol Interv 8 (2008) 277-280
    • (2008) Mol Interv , vol.8 , pp. 277-280
    • Van Rijn, R.M.1    Whistler, J.L.2
  • 47
    • 34547930932 scopus 로고    scopus 로고
    • Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization
    • Qiu Y., Loh H.H., and Law P.Y. Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization. J Biol Chem 282 (2007) 22315-22323
    • (2007) J Biol Chem , vol.282 , pp. 22315-22323
    • Qiu, Y.1    Loh, H.H.2    Law, P.Y.3
  • 48
    • 0030859482 scopus 로고    scopus 로고
    • Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist
    • Chu P., Murray S., Lissin D., and von Zastrow M. Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist. J Biol Chem 272 (1997) 27124-27130
    • (1997) J Biol Chem , vol.272 , pp. 27124-27130
    • Chu, P.1    Murray, S.2    Lissin, D.3    von Zastrow, M.4
  • 49
    • 0034636497 scopus 로고    scopus 로고
    • Rewarding effects of opiates are absent in mice lacking the receptor for substance P
    • Murtra P., Sheasby A.M., Hunt S.P., and De Felipe C. Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature 405 (2000) 180-183
    • (2000) Nature , vol.405 , pp. 180-183
    • Murtra, P.1    Sheasby, A.M.2    Hunt, S.P.3    De Felipe, C.4
  • 50
    • 23944462196 scopus 로고    scopus 로고
    • Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence
    • Gu G., Kondo I., Hua X.Y., and Yaksh T.L. Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence. J Pharmacol Exp Ther 314 (2005) 1362-1369
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1362-1369
    • Gu, G.1    Kondo, I.2    Hua, X.Y.3    Yaksh, T.L.4
  • 51
    • 48249144810 scopus 로고    scopus 로고
    • Agonist-selective signaling is determined by the receptor location within the membrane domains
    • Zheng H., Chu J., Qiu Y., Loh H.H., and Law P.Y. Agonist-selective signaling is determined by the receptor location within the membrane domains. Proc Natl Acad Sci U S A 105 (2008) 9421-9426
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9421-9426
    • Zheng, H.1    Chu, J.2    Qiu, Y.3    Loh, H.H.4    Law, P.Y.5
  • 52
    • 0035811447 scopus 로고    scopus 로고
    • From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes
    • Portoghese P.S. From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes. J Med Chem 44 (2001) 2259-2269
    • (2001) J Med Chem , vol.44 , pp. 2259-2269
    • Portoghese, P.S.1
  • 53
    • 15444364860 scopus 로고    scopus 로고
    • A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes
    • Daniels D.J., Kulkarni A., Xie Z., Bhushan R.G., and Portoghese P.S. A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes. J Med Chem 48 (2005) 1713-1716
    • (2005) J Med Chem , vol.48 , pp. 1713-1716
    • Daniels, D.J.1    Kulkarni, A.2    Xie, Z.3    Bhushan, R.G.4    Portoghese, P.S.5
  • 54
    • 30044442319 scopus 로고    scopus 로고
    • Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series
    • Daniels D.J., Lenard N.R., Etienne C.L., Law P.Y., Roerig S.C., and Portoghese P.S. Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proc Natl Acad Sci U S A 102 (2005) 19208-19213
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 19208-19213
    • Daniels, D.J.1    Lenard, N.R.2    Etienne, C.L.3    Law, P.Y.4    Roerig, S.C.5    Portoghese, P.S.6
  • 55
    • 34247584466 scopus 로고    scopus 로고
    • Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors
    • Peng X., Knapp B.I., Bidlack J.M., and Neumeyer J.L. Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors. J Med Chem 50 (2007) 2254-2258
    • (2007) J Med Chem , vol.50 , pp. 2254-2258
    • Peng, X.1    Knapp, B.I.2    Bidlack, J.M.3    Neumeyer, J.L.4
  • 56
    • 0025827095 scopus 로고
    • Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice
    • Abdelhamid E.E., Sultana M., Portoghese P.S., and Takemori A.E. Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice. J Pharmacol Exp Ther 258 (1991) 299-303
    • (1991) J Pharmacol Exp Ther , vol.258 , pp. 299-303
    • Abdelhamid, E.E.1    Sultana, M.2    Portoghese, P.S.3    Takemori, A.E.4
  • 58
    • 30444447793 scopus 로고    scopus 로고
    • Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors
    • Peng X., Knapp B.I., Bidlack J.M., and Neumeyer J.L. Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. J Med Chem 49 (2006) 256-262
    • (2006) J Med Chem , vol.49 , pp. 256-262
    • Peng, X.1    Knapp, B.I.2    Bidlack, J.M.3    Neumeyer, J.L.4
  • 60
    • 51749093085 scopus 로고    scopus 로고
    • In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties
    • Mathews J.L., Fulton B.S., Negus S.S., Neumeyer J.L., and Bidlack J.M. In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties. Neurochem Res 33 (2008) 2142-2150
    • (2008) Neurochem Res , vol.33 , pp. 2142-2150
    • Mathews, J.L.1    Fulton, B.S.2    Negus, S.S.3    Neumeyer, J.L.4    Bidlack, J.M.5
  • 62
    • 54349090076 scopus 로고    scopus 로고
    • Morphine desensitization, internalization, and down-regulation of the mu opioid receptor is facilitated by serotonin 5-hydroxytryptamine2A receptor coactivation
    • 2A are endocytosed when coactivated by serotonin and morphine, but not by either drug alone.
    • 2A are endocytosed when coactivated by serotonin and morphine, but not by either drug alone.
    • (2008) Mol Pharmacol , vol.74 , pp. 1278-1291
    • Lopez-Gimenez, J.F.1    Vilaro, M.T.2    Milligan, G.3
  • 63
    • 70350381113 scopus 로고    scopus 로고
    • Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2
    • Using reconstituted MOP-R and single molecule imaging, the authors show that MOP-R monomers are the minimal functional unit for receptor activation.
    • Kuszak A.J., Pitchiaya S., Anand J.P., Mosberg H.I., Walter N.G., and Sunahara R.K. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. J Biol Chem 284 (2009) 26732-26741. Using reconstituted MOP-R and single molecule imaging, the authors show that MOP-R monomers are the minimal functional unit for receptor activation.
    • (2009) J Biol Chem , vol.284 , pp. 26732-26741
    • Kuszak, A.J.1    Pitchiaya, S.2    Anand, J.P.3    Mosberg, H.I.4    Walter, N.G.5    Sunahara, R.K.6
  • 65
    • 0036997276 scopus 로고    scopus 로고
    • Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers
    • Filizola M., and Weinstein H. Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. Biopolymers 66 (2002) 317-325
    • (2002) Biopolymers , vol.66 , pp. 317-325
    • Filizola, M.1    Weinstein, H.2
  • 66
    • 21344467203 scopus 로고    scopus 로고
    • The study of G-protein-coupled receptor oligomerization with computational modeling and bioinformatics
    • Filizola M., and Weinstein H. The study of G-protein-coupled receptor oligomerization with computational modeling and bioinformatics. FEBS J 272 (2005) 2926-2938
    • (2005) FEBS J , vol.272 , pp. 2926-2938
    • Filizola, M.1    Weinstein, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.