-
2
-
-
0345299129
-
Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors
-
Zukin R.S., Eghbali M., Olive D., Unterwald E.M., and Tempel A. Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors. Proc Natl Acad Sci U S A 85 (1988) 4061-4065
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, pp. 4061-4065
-
-
Zukin, R.S.1
Eghbali, M.2
Olive, D.3
Unterwald, E.M.4
Tempel, A.5
-
3
-
-
0029949928
-
Opioid receptor types and subtypes: the delta receptor as a model
-
Zaki P.A., Bilsky E.J., Vanderah T.W., Lai J., Evans C.J., and Porreca F. Opioid receptor types and subtypes: the delta receptor as a model. Annu Rev Pharmacol Toxicol 36 (1996) 379-401
-
(1996)
Annu Rev Pharmacol Toxicol
, vol.36
, pp. 379-401
-
-
Zaki, P.A.1
Bilsky, E.J.2
Vanderah, T.W.3
Lai, J.4
Evans, C.J.5
Porreca, F.6
-
5
-
-
4644343161
-
Multiple opiate receptors: deja vu all over again
-
Pasternak G.W. Multiple opiate receptors: deja vu all over again. Neuropharmacology 47 Suppl 1 (2004) 312-323
-
(2004)
Neuropharmacology
, vol.47
, Issue.SUPPL. 1
, pp. 312-323
-
-
Pasternak, G.W.1
-
6
-
-
60249098735
-
Building a new conceptual framework for receptor heteromers
-
Ferre S., Baler R., Bouvier M., Caron M.G., Devi L.A., Durroux T., Fuxe K., George S.R., Javitch J.A., Lohse M.J., et al. Building a new conceptual framework for receptor heteromers. Nat Chem Biol 5 (2009) 131-134
-
(2009)
Nat Chem Biol
, vol.5
, pp. 131-134
-
-
Ferre, S.1
Baler, R.2
Bouvier, M.3
Caron, M.G.4
Devi, L.A.5
Durroux, T.6
Fuxe, K.7
George, S.R.8
Javitch, J.A.9
Lohse, M.J.10
-
7
-
-
0036462451
-
Oligomerization of opioid receptors: generation of novel signaling units
-
Levac B.A., O'Dowd B.F., and George S.R. Oligomerization of opioid receptors: generation of novel signaling units. Curr Opin Pharmacol 2 (2002) 76-81
-
(2002)
Curr Opin Pharmacol
, vol.2
, pp. 76-81
-
-
Levac, B.A.1
O'Dowd, B.F.2
George, S.R.3
-
8
-
-
0030760634
-
Dimerization of the delta opioid receptor: implication for a role in receptor internalization
-
Cvejic S., and Devi L.A. Dimerization of the delta opioid receptor: implication for a role in receptor internalization. J Biol Chem 272 (1997) 26959-26964
-
(1997)
J Biol Chem
, vol.272
, pp. 26959-26964
-
-
Cvejic, S.1
Devi, L.A.2
-
9
-
-
1642292051
-
Desensitization of G protein-coupled receptors and neuronal functions
-
Gainetdinov R.R., Premont R.T., Bohn L.M., Lefkowitz R.J., and Caron M.G. Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 27 (2004) 107-144
-
(2004)
Annu Rev Neurosci
, vol.27
, pp. 107-144
-
-
Gainetdinov, R.R.1
Premont, R.T.2
Bohn, L.M.3
Lefkowitz, R.J.4
Caron, M.G.5
-
10
-
-
37549019374
-
The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence
-
Martini L., and Whistler J.L. The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr Opin Neurobiol 17 (2007) 556-564
-
(2007)
Curr Opin Neurobiol
, vol.17
, pp. 556-564
-
-
Martini, L.1
Whistler, J.L.2
-
11
-
-
0037178754
-
Modulation of postendocytic sorting of G protein-coupled receptors
-
Whistler J.L., Enquist J., Marley A., Fong J., Gladher F., Tsuruda P., Murray S.R., and Von Zastrow M. Modulation of postendocytic sorting of G protein-coupled receptors. Science 297 (2002) 615-620
-
(2002)
Science
, vol.297
, pp. 615-620
-
-
Whistler, J.L.1
Enquist, J.2
Marley, A.3
Fong, J.4
Gladher, F.5
Tsuruda, P.6
Murray, S.R.7
Von Zastrow, M.8
-
12
-
-
0035138995
-
Cellular and synaptic adaptations mediating opioid dependence
-
Williams J.T., Christie M.J., and Manzoni O. Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 81 (2001) 299-343
-
(2001)
Physiol Rev
, vol.81
, pp. 299-343
-
-
Williams, J.T.1
Christie, M.J.2
Manzoni, O.3
-
13
-
-
38349074858
-
Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence
-
Using a knock-in mouse model the authors provide in vivo evidence to support the hypothesis that the inability of MOP-Rs to endocytose after morphine activation lies at the base of the establishment of morphine tolerance.
-
Kim J.A., Bartlett S., He L., Nielsen C.K., Chang A.M., Kharazia V., Waldhoer M., Ou C.J., Taylor S., Ferwerda M., et al. Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence. Curr Biol 18 (2008) 129-135. Using a knock-in mouse model the authors provide in vivo evidence to support the hypothesis that the inability of MOP-Rs to endocytose after morphine activation lies at the base of the establishment of morphine tolerance.
-
(2008)
Curr Biol
, vol.18
, pp. 129-135
-
-
Kim, J.A.1
Bartlett, S.2
He, L.3
Nielsen, C.K.4
Chang, A.M.5
Kharazia, V.6
Waldhoer, M.7
Ou, C.J.8
Taylor, S.9
Ferwerda, M.10
-
14
-
-
40549105390
-
Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain
-
This study shows that, in a clinically relevant model of inflammatory pain, the presence of endogenous opioids prevents the establishment of peripheral morphine tolerance.
-
Zollner C., Mousa S.A., Fischer O., Rittner H.L., Shaqura M., Brack A., Shakibaei M., Binder W., Urban F., Stein C., et al. Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. J Clin Invest 118 (2008) 1065-1073. This study shows that, in a clinically relevant model of inflammatory pain, the presence of endogenous opioids prevents the establishment of peripheral morphine tolerance.
-
(2008)
J Clin Invest
, vol.118
, pp. 1065-1073
-
-
Zollner, C.1
Mousa, S.A.2
Fischer, O.3
Rittner, H.L.4
Shaqura, M.5
Brack, A.6
Shakibaei, M.7
Binder, W.8
Urban, F.9
Stein, C.10
-
15
-
-
0037169345
-
Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization
-
He L., Fong J., von Zastrow M., and Whistler J.L. Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell 108 (2002) 271-282
-
(2002)
Cell
, vol.108
, pp. 271-282
-
-
He, L.1
Fong, J.2
von Zastrow, M.3
Whistler, J.L.4
-
16
-
-
20144377958
-
An opiate cocktail that reduces morphine tolerance and dependence
-
This study describes the development of a morphine-methadone cocktail that drives MOP-R homomer endocytosis. Shows that promoting endocytosis reduces tolerance and dependence.
-
He L., and Whistler J.L. An opiate cocktail that reduces morphine tolerance and dependence. Curr Biol 15 (2005) 1028-1033. This study describes the development of a morphine-methadone cocktail that drives MOP-R homomer endocytosis. Shows that promoting endocytosis reduces tolerance and dependence.
-
(2005)
Curr Biol
, vol.15
, pp. 1028-1033
-
-
He, L.1
Whistler, J.L.2
-
17
-
-
38849137816
-
Trafficking of central opioid receptors and descending pain inhibition
-
A review of the mechanism and different conditions under which DOP-Rs redistribute from large dense core vesicles to the cell surface.
-
Bie B., and Pan Z.Z. Trafficking of central opioid receptors and descending pain inhibition. Mol Pain 3 (2007) 37. A review of the mechanism and different conditions under which DOP-Rs redistribute from large dense core vesicles to the cell surface.
-
(2007)
Mol Pain
, vol.3
, pp. 37
-
-
Bie, B.1
Pan, Z.Z.2
-
18
-
-
58149395695
-
Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption
-
Margolis E.B., Fields H.L., Hjelmstad G.O., and Mitchell J.M. Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption. J Neurosci 28 (2008) 12672-12681
-
(2008)
J Neurosci
, vol.28
, pp. 12672-12681
-
-
Margolis, E.B.1
Fields, H.L.2
Hjelmstad, G.O.3
Mitchell, J.M.4
-
19
-
-
23944455412
-
Interaction with vesicle luminal protachykinin regulates surface expression of d-opioid receptors and opioid analgesia
-
Guan J.-S., Xu Z.-Z., Gao H., He S.-Q., Ma G.-Q., Sun T., Wang L.-H., Zhang Z.-N., Lena I., and Kitchen I. Interaction with vesicle luminal protachykinin regulates surface expression of d-opioid receptors and opioid analgesia. Cell 122 (2005) 619-631
-
(2005)
Cell
, vol.122
, pp. 619-631
-
-
Guan, J.-S.1
Xu, Z.-Z.2
Gao, H.3
He, S.-Q.4
Ma, G.-Q.5
Sun, T.6
Wang, L.-H.7
Zhang, Z.-N.8
Lena, I.9
Kitchen, I.10
-
20
-
-
0035478363
-
Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception
-
Cahill C.M., Morinville A., Lee M.C., Vincent J.P., Collier B., and Beaudet A. Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception. J Neurosci 21 (2001) 7598-7607
-
(2001)
J Neurosci
, vol.21
, pp. 7598-7607
-
-
Cahill, C.M.1
Morinville, A.2
Lee, M.C.3
Vincent, J.P.4
Collier, B.5
Beaudet, A.6
-
21
-
-
0037741017
-
Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice
-
Morinville A., Cahill C.M., Esdaile M.J., Aibak H., Collier B., Kieffer B.L., and Beaudet A. Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice. J Neurosci 23 (2003) 4888-4898
-
(2003)
J Neurosci
, vol.23
, pp. 4888-4898
-
-
Morinville, A.1
Cahill, C.M.2
Esdaile, M.J.3
Aibak, H.4
Collier, B.5
Kieffer, B.L.6
Beaudet, A.7
-
22
-
-
66749154689
-
Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
-
Elaborate study showing that spinal MOP-R and DOP-R each have a distinct location and a distinct function in the spinal cord.
-
Scherrer G., Imamachi N., Cao Y.Q., Contet C., Mennicken F., O'Donnell D., Kieffer B.L., and Basbaum A.I. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell 137 (2009) 1148-1159. Elaborate study showing that spinal MOP-R and DOP-R each have a distinct location and a distinct function in the spinal cord.
-
(2009)
Cell
, vol.137
, pp. 1148-1159
-
-
Scherrer, G.1
Imamachi, N.2
Cao, Y.Q.3
Contet, C.4
Mennicken, F.5
O'Donnell, D.6
Kieffer, B.L.7
Basbaum, A.I.8
-
24
-
-
0034714335
-
Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties
-
George S.R., Fan T., Xie Z., Tse R., Tam V., Varghese G., and O'Dowd B.F. Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. J Biol Chem 275 (2000) 26128-26135
-
(2000)
J Biol Chem
, vol.275
, pp. 26128-26135
-
-
George, S.R.1
Fan, T.2
Xie, Z.3
Tse, R.4
Tam, V.5
Varghese, G.6
O'Dowd, B.F.7
-
25
-
-
1842687121
-
A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia
-
Gomes I., Gupta A., Filipovska J., Szeto H.H., Pintar J.E., and Devi L.A. A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia. Proc Natl Acad Sci U S A 101 (2004) 5135-5139
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 5135-5139
-
-
Gomes, I.1
Gupta, A.2
Filipovska, J.3
Szeto, H.H.4
Pintar, J.E.5
Devi, L.A.6
-
26
-
-
15744401602
-
Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions
-
Law P.Y., Erickson-Herbrandson L.J., Zha Q.Q., Solberg J., Chu J., Sarre A., and Loh H.H. Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions. J Biol Chem 280 (2005) 11152-11164
-
(2005)
J Biol Chem
, vol.280
, pp. 11152-11164
-
-
Law, P.Y.1
Erickson-Herbrandson, L.J.2
Zha, Q.Q.3
Solberg, J.4
Chu, J.5
Sarre, A.6
Loh, H.H.7
-
27
-
-
21144439867
-
Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer
-
Wang D., Sun X., Bohn L.M., and Sadee W. Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer. Mol Pharmacol 67 (2005) 2173-2184
-
(2005)
Mol Pharmacol
, vol.67
, pp. 2173-2184
-
-
Wang, D.1
Sun, X.2
Bohn, L.M.3
Sadee, W.4
-
28
-
-
0033578005
-
G-protein-coupled receptor heterodimerization modulates receptor function
-
Jordan B.A., and Devi L.A. G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399 (1999) 697-700
-
(1999)
Nature
, vol.399
, pp. 697-700
-
-
Jordan, B.A.1
Devi, L.A.2
-
29
-
-
0036387204
-
Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype
-
Pan Y., Bolan E., and Pasternak G. Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype. Biochem Biophys Res Commun 297 (2002) 659
-
(2002)
Biochem Biophys Res Commun
, vol.297
, pp. 659
-
-
Pan, Y.1
Bolan, E.2
Pasternak, G.3
-
30
-
-
2542625998
-
A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers
-
Bhushan R.G., Sharma S.K., Xie Z., Daniels D.J., and Portoghese P.S. A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers. J Med Chem 47 (2004) 2969-2972
-
(2004)
J Med Chem
, vol.47
, pp. 2969-2972
-
-
Bhushan, R.G.1
Sharma, S.K.2
Xie, Z.3
Daniels, D.J.4
Portoghese, P.S.5
-
31
-
-
0037466476
-
Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord
-
Portoghese P.S., and Lunzer M.M. Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord. Eur J Pharmacol 467 (2003) 233-234
-
(2003)
Eur J Pharmacol
, vol.467
, pp. 233-234
-
-
Portoghese, P.S.1
Lunzer, M.M.2
-
32
-
-
0026761056
-
Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors
-
Porreca F., Takemori A.E., Sultana M., Portoghese P.S., Bowen W.D., and Mosberg H.I. Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors. J Pharmacol Exp Ther 263 (1992) 147-152
-
(1992)
J Pharmacol Exp Ther
, vol.263
, pp. 147-152
-
-
Porreca, F.1
Takemori, A.E.2
Sultana, M.3
Portoghese, P.S.4
Bowen, W.D.5
Mosberg, H.I.6
-
33
-
-
0034668742
-
Heterodimerization of mu and delta opioid receptors: a role in opiate synergy
-
Gomes I., Jordan B.A., Gupta A., Trapaidze N., Nagy V., and Devi L.A. Heterodimerization of mu and delta opioid receptors: a role in opiate synergy. J Neurosci 20 (2000) RC110
-
(2000)
J Neurosci
, vol.20
-
-
Gomes, I.1
Jordan, B.A.2
Gupta, A.3
Trapaidze, N.4
Nagy, V.5
Devi, L.A.6
-
34
-
-
72449140688
-
The delta-1 opioid receptor is a heterodimer that opposes the actions of the delta-2 receptor on alcohol intake
-
This study shows that DOP-R1 and DOP-R2s have opposing effects on alcohol consumption and represent distinct pharmacological targets that can work synergistically. Also shows that the effects of DOP-R1 require both DOP-R and MOP-R, suggesting that DOP-R1 could be a DOP/MOP-R heteromer.
-
Van Rijn R.M., and Whistler J.L. The delta-1 opioid receptor is a heterodimer that opposes the actions of the delta-2 receptor on alcohol intake. Biol Psychiatry 66 (2009) 777-784. This study shows that DOP-R1 and DOP-R2s have opposing effects on alcohol consumption and represent distinct pharmacological targets that can work synergistically. Also shows that the effects of DOP-R1 require both DOP-R and MOP-R, suggesting that DOP-R1 could be a DOP/MOP-R heteromer.
-
(2009)
Biol Psychiatry
, vol.66
, pp. 777-784
-
-
Van Rijn, R.M.1
Whistler, J.L.2
-
35
-
-
0033962799
-
delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice
-
Hosohata Y., Vanderah T.W., Burkey T.H., Ossipov M.H., Kovelowski C.J., Sora I., Uhl G.R., Zhang X., Rice K.C., Roeske W.R., et al. delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice. Eur J Pharmacol 388 (2000) 241-248
-
(2000)
Eur J Pharmacol
, vol.388
, pp. 241-248
-
-
Hosohata, Y.1
Vanderah, T.W.2
Burkey, T.H.3
Ossipov, M.H.4
Kovelowski, C.J.5
Sora, I.6
Uhl, G.R.7
Zhang, X.8
Rice, K.C.9
Roeske, W.R.10
-
36
-
-
0024331850
-
Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype
-
Clark J.A., Liu L., Price M., Hersh B., Edelson M., and Pasternak G.W. Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype. J Pharmacol Exp Ther 251 (1989) 461-468
-
(1989)
J Pharmacol Exp Ther
, vol.251
, pp. 461-468
-
-
Clark, J.A.1
Liu, L.2
Price, M.3
Hersh, B.4
Edelson, M.5
Pasternak, G.W.6
-
37
-
-
0011204773
-
Classification of multiple morphine and enkephalin binding sites in the central nervous system
-
Wolozin B.L., and Pasternak G.W. Classification of multiple morphine and enkephalin binding sites in the central nervous system. Proc Natl Acad Sci U S A 78 (1981) 6181-6185
-
(1981)
Proc Natl Acad Sci U S A
, vol.78
, pp. 6181-6185
-
-
Wolozin, B.L.1
Pasternak, G.W.2
-
38
-
-
0345803929
-
Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization
-
Pfeiffer M., Kirscht S., Stumm R., Koch T., Wu D., Laugsch M., Schroder H., Hollt V., and Schulz S. Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization. J Biol Chem 278 (2003) 51630-51637
-
(2003)
J Biol Chem
, vol.278
, pp. 51630-51637
-
-
Pfeiffer, M.1
Kirscht, S.2
Stumm, R.3
Koch, T.4
Wu, D.5
Laugsch, M.6
Schroder, H.7
Hollt, V.8
Schulz, S.9
-
39
-
-
0346056873
-
Heterodimerization and cross-desensitization between the micro-opioid receptor and the chemokine CCR5 receptor
-
Chen C., Li J., Bot G., Szabo I., Rogers T.J., and Liu-Chen L.Y. Heterodimerization and cross-desensitization between the micro-opioid receptor and the chemokine CCR5 receptor. Eur J Pharmacol 483 (2004) 175-186
-
(2004)
Eur J Pharmacol
, vol.483
, pp. 175-186
-
-
Chen, C.1
Li, J.2
Bot, G.3
Szabo, I.4
Rogers, T.J.5
Liu-Chen, L.Y.6
-
40
-
-
0346996861
-
Functional interactions between mu opioid and alpha 2A-adrenergic receptors
-
Jordan B.A., Gomes I., Rios C., Filipovska J., and Devi L.A. Functional interactions between mu opioid and alpha 2A-adrenergic receptors. Mol Pharmacol 64 (2003) 1317-1324
-
(2003)
Mol Pharmacol
, vol.64
, pp. 1317-1324
-
-
Jordan, B.A.1
Gomes, I.2
Rios, C.3
Filipovska, J.4
Devi, L.A.5
-
41
-
-
0035793079
-
Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation
-
Jordan B.A., Trapaidze N., Gomes I., Nivarthi R., and Devi L.A. Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci U S A 98 (2001) 343-348
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 343-348
-
-
Jordan, B.A.1
Trapaidze, N.2
Gomes, I.3
Nivarthi, R.4
Devi, L.A.5
-
42
-
-
57349129484
-
Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4
-
This work shows that members of the receptor transporter protein family may act as chaperones to assist cell surface targeting of DOP/MOP-R heteromers.
-
Decaillot F.M., Rozenfeld R., Gupta A., and Devi L.A. Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Proc Natl Acad Sci U S A 105 (2008) 16045-16050. This work shows that members of the receptor transporter protein family may act as chaperones to assist cell surface targeting of DOP/MOP-R heteromers.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16045-16050
-
-
Decaillot, F.M.1
Rozenfeld, R.2
Gupta, A.3
Devi, L.A.4
-
43
-
-
21144446486
-
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers
-
This work describes a ligand with novel properties on a DOP/KOP-R heteromer, distinct from those at the homomeric receptors. Demonstrates that this ligand is a tissue-selective analgesic.
-
Waldhoer M., Fong J., Jones R.M., Lunzer M.M., Sharma S.K., Kostenis E., Portoghese P.S., and Whistler J.L. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc Natl Acad Sci U S A 102 (2005) 9050-9055. This work describes a ligand with novel properties on a DOP/KOP-R heteromer, distinct from those at the homomeric receptors. Demonstrates that this ligand is a tissue-selective analgesic.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 9050-9055
-
-
Waldhoer, M.1
Fong, J.2
Jones, R.M.3
Lunzer, M.M.4
Sharma, S.K.5
Kostenis, E.6
Portoghese, P.S.7
Whistler, J.L.8
-
44
-
-
36048947671
-
Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists
-
An elegant study showing how DOP/MOP-R heteromers are formed only in the ER, and not after translocation to the cell surface.
-
Hasbi A., Nguyen T., Fan T., Cheng R., Rashid A., Alijaniaram M., Rasenick M.M., O'Dowd B.F., and George S.R. Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists. Biochemistry 46 (2007) 12997-13009. An elegant study showing how DOP/MOP-R heteromers are formed only in the ER, and not after translocation to the cell surface.
-
(2007)
Biochemistry
, vol.46
, pp. 12997-13009
-
-
Hasbi, A.1
Nguyen, T.2
Fan, T.3
Cheng, R.4
Rashid, A.5
Alijaniaram, M.6
Rasenick, M.M.7
O'Dowd, B.F.8
George, S.R.9
-
45
-
-
58549117701
-
The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers?
-
Van Rijn R.M., and Whistler J.L. The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers?. Mol Interv 8 (2008) 277-280
-
(2008)
Mol Interv
, vol.8
, pp. 277-280
-
-
Van Rijn, R.M.1
Whistler, J.L.2
-
46
-
-
11244344642
-
Receptor endocytosis counteracts the development of opioid tolerance
-
Koch T., Widera A., Bartzsch K., Schulz S., Brandenburg L.O., Wundrack N., Beyer A., Grecksch G., and Hollt V. Receptor endocytosis counteracts the development of opioid tolerance. Mol Pharmacol 67 (2005) 280-287
-
(2005)
Mol Pharmacol
, vol.67
, pp. 280-287
-
-
Koch, T.1
Widera, A.2
Bartzsch, K.3
Schulz, S.4
Brandenburg, L.O.5
Wundrack, N.6
Beyer, A.7
Grecksch, G.8
Hollt, V.9
-
47
-
-
34547930932
-
Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization
-
Qiu Y., Loh H.H., and Law P.Y. Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization. J Biol Chem 282 (2007) 22315-22323
-
(2007)
J Biol Chem
, vol.282
, pp. 22315-22323
-
-
Qiu, Y.1
Loh, H.H.2
Law, P.Y.3
-
48
-
-
0030859482
-
Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist
-
Chu P., Murray S., Lissin D., and von Zastrow M. Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist. J Biol Chem 272 (1997) 27124-27130
-
(1997)
J Biol Chem
, vol.272
, pp. 27124-27130
-
-
Chu, P.1
Murray, S.2
Lissin, D.3
von Zastrow, M.4
-
49
-
-
0034636497
-
Rewarding effects of opiates are absent in mice lacking the receptor for substance P
-
Murtra P., Sheasby A.M., Hunt S.P., and De Felipe C. Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature 405 (2000) 180-183
-
(2000)
Nature
, vol.405
, pp. 180-183
-
-
Murtra, P.1
Sheasby, A.M.2
Hunt, S.P.3
De Felipe, C.4
-
50
-
-
23944462196
-
Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence
-
Gu G., Kondo I., Hua X.Y., and Yaksh T.L. Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence. J Pharmacol Exp Ther 314 (2005) 1362-1369
-
(2005)
J Pharmacol Exp Ther
, vol.314
, pp. 1362-1369
-
-
Gu, G.1
Kondo, I.2
Hua, X.Y.3
Yaksh, T.L.4
-
51
-
-
48249144810
-
Agonist-selective signaling is determined by the receptor location within the membrane domains
-
Zheng H., Chu J., Qiu Y., Loh H.H., and Law P.Y. Agonist-selective signaling is determined by the receptor location within the membrane domains. Proc Natl Acad Sci U S A 105 (2008) 9421-9426
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 9421-9426
-
-
Zheng, H.1
Chu, J.2
Qiu, Y.3
Loh, H.H.4
Law, P.Y.5
-
52
-
-
0035811447
-
From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes
-
Portoghese P.S. From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes. J Med Chem 44 (2001) 2259-2269
-
(2001)
J Med Chem
, vol.44
, pp. 2259-2269
-
-
Portoghese, P.S.1
-
53
-
-
15444364860
-
A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes
-
Daniels D.J., Kulkarni A., Xie Z., Bhushan R.G., and Portoghese P.S. A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes. J Med Chem 48 (2005) 1713-1716
-
(2005)
J Med Chem
, vol.48
, pp. 1713-1716
-
-
Daniels, D.J.1
Kulkarni, A.2
Xie, Z.3
Bhushan, R.G.4
Portoghese, P.S.5
-
54
-
-
30044442319
-
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series
-
Daniels D.J., Lenard N.R., Etienne C.L., Law P.Y., Roerig S.C., and Portoghese P.S. Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proc Natl Acad Sci U S A 102 (2005) 19208-19213
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 19208-19213
-
-
Daniels, D.J.1
Lenard, N.R.2
Etienne, C.L.3
Law, P.Y.4
Roerig, S.C.5
Portoghese, P.S.6
-
55
-
-
34247584466
-
Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors
-
Peng X., Knapp B.I., Bidlack J.M., and Neumeyer J.L. Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors. J Med Chem 50 (2007) 2254-2258
-
(2007)
J Med Chem
, vol.50
, pp. 2254-2258
-
-
Peng, X.1
Knapp, B.I.2
Bidlack, J.M.3
Neumeyer, J.L.4
-
56
-
-
0025827095
-
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice
-
Abdelhamid E.E., Sultana M., Portoghese P.S., and Takemori A.E. Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice. J Pharmacol Exp Ther 258 (1991) 299-303
-
(1991)
J Pharmacol Exp Ther
, vol.258
, pp. 299-303
-
-
Abdelhamid, E.E.1
Sultana, M.2
Portoghese, P.S.3
Takemori, A.E.4
-
57
-
-
0242522896
-
Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors
-
Neumeyer J.L., Zhang A., Xiong W., Gu X.H., Hilbert J.E., Knapp B.I., Negus S.S., Mello N.K., and Bidlack J.M. Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. J Med Chem 46 (2003) 5162-5170
-
(2003)
J Med Chem
, vol.46
, pp. 5162-5170
-
-
Neumeyer, J.L.1
Zhang, A.2
Xiong, W.3
Gu, X.H.4
Hilbert, J.E.5
Knapp, B.I.6
Negus, S.S.7
Mello, N.K.8
Bidlack, J.M.9
-
58
-
-
30444447793
-
Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors
-
Peng X., Knapp B.I., Bidlack J.M., and Neumeyer J.L. Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. J Med Chem 49 (2006) 256-262
-
(2006)
J Med Chem
, vol.49
, pp. 256-262
-
-
Peng, X.1
Knapp, B.I.2
Bidlack, J.M.3
Neumeyer, J.L.4
-
59
-
-
33748573311
-
New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores
-
Neumeyer J.L., Peng X., Knapp B.I., Bidlack J.M., Lazarus L.H., Salvadori S., Trapella C., and Balboni G. New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem 49 (2006) 5640-5643
-
(2006)
J Med Chem
, vol.49
, pp. 5640-5643
-
-
Neumeyer, J.L.1
Peng, X.2
Knapp, B.I.3
Bidlack, J.M.4
Lazarus, L.H.5
Salvadori, S.6
Trapella, C.7
Balboni, G.8
-
60
-
-
51749093085
-
In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties
-
Mathews J.L., Fulton B.S., Negus S.S., Neumeyer J.L., and Bidlack J.M. In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties. Neurochem Res 33 (2008) 2142-2150
-
(2008)
Neurochem Res
, vol.33
, pp. 2142-2150
-
-
Mathews, J.L.1
Fulton, B.S.2
Negus, S.S.3
Neumeyer, J.L.4
Bidlack, J.M.5
-
61
-
-
0029961190
-
Kappa-opioids produce significantly greater analgesia in women than in men
-
Gear R.W., Miaskowski C., Gordon N.C., Paul S.M., Heller P.H., and Levine J.D. Kappa-opioids produce significantly greater analgesia in women than in men. Nat Med 2 (1996) 1248-1250
-
(1996)
Nat Med
, vol.2
, pp. 1248-1250
-
-
Gear, R.W.1
Miaskowski, C.2
Gordon, N.C.3
Paul, S.M.4
Heller, P.H.5
Levine, J.D.6
-
62
-
-
54349090076
-
Morphine desensitization, internalization, and down-regulation of the mu opioid receptor is facilitated by serotonin 5-hydroxytryptamine2A receptor coactivation
-
2A are endocytosed when coactivated by serotonin and morphine, but not by either drug alone.
-
2A are endocytosed when coactivated by serotonin and morphine, but not by either drug alone.
-
(2008)
Mol Pharmacol
, vol.74
, pp. 1278-1291
-
-
Lopez-Gimenez, J.F.1
Vilaro, M.T.2
Milligan, G.3
-
63
-
-
70350381113
-
Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2
-
Using reconstituted MOP-R and single molecule imaging, the authors show that MOP-R monomers are the minimal functional unit for receptor activation.
-
Kuszak A.J., Pitchiaya S., Anand J.P., Mosberg H.I., Walter N.G., and Sunahara R.K. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. J Biol Chem 284 (2009) 26732-26741. Using reconstituted MOP-R and single molecule imaging, the authors show that MOP-R monomers are the minimal functional unit for receptor activation.
-
(2009)
J Biol Chem
, vol.284
, pp. 26732-26741
-
-
Kuszak, A.J.1
Pitchiaya, S.2
Anand, J.P.3
Mosberg, H.I.4
Walter, N.G.5
Sunahara, R.K.6
-
64
-
-
70350645493
-
Construction of covalently coupled, concatameric dimers of 7TM receptors
-
Terpager M., Scholl D.J., Kubale V., Martini L., Elling E.C., and Schwartz T.W. Construction of covalently coupled, concatameric dimers of 7TM receptors. J Receptors Signal Trans 29 (2009) 235-245
-
(2009)
J Receptors Signal Trans
, vol.29
, pp. 235-245
-
-
Terpager, M.1
Scholl, D.J.2
Kubale, V.3
Martini, L.4
Elling, E.C.5
Schwartz, T.W.6
-
65
-
-
0036997276
-
Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers
-
Filizola M., and Weinstein H. Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. Biopolymers 66 (2002) 317-325
-
(2002)
Biopolymers
, vol.66
, pp. 317-325
-
-
Filizola, M.1
Weinstein, H.2
-
66
-
-
21344467203
-
The study of G-protein-coupled receptor oligomerization with computational modeling and bioinformatics
-
Filizola M., and Weinstein H. The study of G-protein-coupled receptor oligomerization with computational modeling and bioinformatics. FEBS J 272 (2005) 2926-2938
-
(2005)
FEBS J
, vol.272
, pp. 2926-2938
-
-
Filizola, M.1
Weinstein, H.2
|