Design and Synthesis of Novel Dimeric Morphinan Ligands for κ and μ Opioid Receptors

Journal of Medicinal Chemistry

Volumn 46, Issue 24, 2003, Pages 5162-5170

  Neumeyer, John L ^a   Zhang, Ao ^a   Xiong, Wennan ^a   Gu, Xiao Hui ^a   Hilbert, James E ^b   Knapp, Brian I ^b   Negus, S Stevens ^a   Mello, Nancy K ^a   Bidlack, Jean M ^b  

^a MCLEAN HOSPITAL   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; CYCLORPHAN; ETHYLKETAZOCINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KAPPA OPIATE RECEPTOR; LEVORPHANOL; MORPHINAN DERIVATIVE; MU OPIATE RECEPTOR; PARTIAL AGONIST; SULFUR 35;

AGONIST; ANIMAL CELL; ARTICLE; CHO CELL; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; REACTION ANALYSIS;

ANIMALS; CHO CELLS; CRICETINAE; DIMERIZATION; DRUG DESIGN; HUMANS; LIGANDS; MORPHINANS; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0242522896     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030139v     Document Type: Article

References (35)

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