In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: Isomeric, bivalent ligands with mu/kappa agonist properties

Neurochemical Research

Volumn 33, Issue 10, 2008, Pages 2142-2150

  Mathews, Jennifer L ^a,c   Fulton, Brian S ^b   Negus, S Stevens ^b,d   Neumeyer, John L ^b   Bidlack, Jean M ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b MCLEAN HOSPITAL   (United States)

^c ST JOHN FISHER COLLEGE   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Enantiomers; Mu opioid; Opioid dimers; Partial agonist

Indexed keywords

1 (N CYCLOBUTYLMETHYLMORPHINAN 3 YL) 10 N CYCLOBUTYLMETHYLMORPHINAN 3 YL)SEBACOLYATE; 3 HYDROXY N CYCLOBUTYLMETHYL MOPHINAN; BETA FUNALTREXAMINE; BIS(N CYCLOBUTYLMETHYL MORPHINAN 3 YL) SEBACOYLATE DIHYDROCHLORIDE; CHLORIDE; CYCLORPHAN; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; MCL 101; MCL 144; MCL 193; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG DOSE; DRUG INHIBITION; DRUG STRUCTURE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; TAIL FLICK TEST;

ALKANES; ANALGESICS; ANIMALS; BRAIN; CHO CELLS; CRICETINAE; CRICETULUS; FUMARATES; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HALF-LIFE; MALE; MORPHINANS; MORPHINE; NALTREXONE; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STEREOISOMERISM;

EID: 51749093085     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-008-9752-3     Document Type: Article

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