Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at μ, δ, and κ opioid receptors

Journal of Medicinal Chemistry

Volumn 49, Issue 1, 2006, Pages 256-262

  Peng, Xuemei ^a   Knapp, Brian I ^b   Bidlack, Jean M ^b   Neumeyer, John L ^a  

^a MCLEAN HOSPITAL   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTORPHANOL; CYCLORPHAN; DELTA OPIATE RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; LEVORPHANOL; MCL 117; MCL 139; MCL 144; MCL 145; MCL 182; MCL 190; MCL 191; MCL 192; MCL 193; MCL 194; MCL 195; MCL 196; MCL 197; MCL 198; MCL 199; MCL 406; MCL 407; MCL 414; MCL 415; MCL 416; MORPHINE DERIVATIVE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NARCOTIC ANALGESIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; NONHUMAN; OLIGOMERIZATION; PHARMACOPHORE; STEREOCHEMISTRY;

ANIMALS; CHO CELLS; CRICETINAE; DRUG EVALUATION, PRECLINICAL; HUMANS; LIGANDS; MOLECULAR CONFORMATION; MORPHINANS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 30444447793     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050577x     Document Type: Article

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