Functional Interactions between μ Opioid and α 2A-Adrenergic Receptors

Molecular Pharmacology

Volumn 64, Issue 6, 2003, Pages 1317-1324

  Jordan, B A ^a,b   Gomes, I ^a   Rios, C ^a,b   Filipovska, J ^a,c   Devi, Lakshmi A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; CLONIDINE; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MORPHINE; MU OPIATE RECEPTOR;

AGONIST; ANALYTIC METHOD; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CHEMICAL ANALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; DENDRITE; ENZYME ACTIVITY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; LIGAND BINDING; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL;

ANIMALS; CELL LINE; CLONIDINE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MORPHINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, OPIOID, MU;

EID: 0346996861     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.6.1317     Document Type: Article

References (30)

1. Angers S, Salahpour A, and Bouvier M (2002) Dimerization: an emerging concept for G-protein coupled receptor ontogeny and function. Annu Rev Pharmacol Toxicol 42:409-435.
2. Ciruela A, Dixon AK, Bramwell S, Gonzalez MI, Pinnock RD, and Lee K (2003) Identification of MEK1 as a novel target for the treatment of neuropathic pain. Br J Pharmacol 138:751-756.
3. Dai Y, Iwata K, Fukuoka T, Kondo E, Tokunaga A, Yamanaka H, Tachibana T, Liu Y, and Noguchi K (2002) Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and involvement in peripheral sensitization. J Neurosci 22:7737-7745.
4. Drasner K and Fields HL (1988) Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat. Pain 32:309-312.
5. Einheber S, Milner TA, Giancotti F, and Salzer JL (1993) Axonal regulation of Schawann cell integrin expression suggests a role for alpha6beta4 in myelination. J Cell Biol 123:1223-1236.
6. Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, and Palczewski K (2003) Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature (Lond) 421:127-128.
7. Gomes I, Filipovska J, and Devi LA (2003) Opioid receptor oligomerization. Detection and functional characterization of interacting receptors. Methods Mol Med 84:157-183.
8. Gomes I, Filipovska J, Jordan BA, and Devi LA (2002) Oligomerization of opioid receptors. Methods 27:358-365.
9. Gomes I, Jordan BA, Gupta A, Rios C, Trapaidze N, and Devi LA (2001) G-protein coupled receptor dimerization: implications in modulating receptor function. J Mol Med 79:226-242.
10. Jordan B and Devi LA (1998) Molecular mechanisms of opioid receptor signal transduction. Br J Anaesth 81:12-19.
11. Jordan BA and Devi LA (1999) G-protein-coupled receptor heterodimerization modulates receptor function. Nature (Lond) 399:697-700.
12. Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, and Engel A (2003) Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem 278:21655-21662.
13. Limbird LE (1988) Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms. FASEB J 2:2686-2695.
14. Macdonald RL and Nelson PG (1978) Specific-opiate-induced depression of transmitter release from dorsal root ganglion cells in culture. Science (Wash DC) 199:1449-1451.
15. Margeta-Mitrovic M, Jan YN, and Jan LY (2000) A trafficking checkpoint controls GABA)(B) receptor heterodimerization. Neuron 27:97-106.
16. Marshall FH, Jones KA, Kaupmann K, and Bettler B (1999) GABAB receptors - the first 7TM heterodimers. Trends Pharmacol Sci 20:396-399.
17. Matthes H, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, Befort K, Dierich A, Le Meur M, Dolle P, et al. (1996) Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature (Lond) 383:819-823.
18. Morita K and North RA (1981) Clonidine activates membrane potassium conductance in myenteric neurons. Br J Pharmacol 74:419-428.
19. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, and Zuker CS (2001) Mammalian sweet taste receptors. Cell 106:381-390.
20. Ossipov MH, Lopez Y, Bian D, Nichols ML, and Porreca F (1997) Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-hgation injury. Anesthesiology 86:196-204.
21. Osten P, Srivastava S, Inman GJ, Vilim FS, Khatri L, Lee LM, States BA, Einheber S, Milner TA, Hanson PI, et al. (1998) The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPS. Neuron 21:99-110.
22. Paalzow L (1974) Analgesia produced by clonidine in mice and rats. J Pharm Pharmacol 26:361-363.
23. Pagano A, Rovelli G, Mosbacher J, Lohmann T, Duthey B, Stauffer D, Ristig D, Schuler V, Meigel I, Lampert C, et al. (2001) C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors. J Neurosci 21:1189-1202.
24. Richman JG and Regan JW (1998) Alpha 2-adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells. Am J Physiol 274:C654-C662.
25. Rios CD, Jordan BA, Gomes I, and Devi LA (2001) G-protein-coupled receptor dimerization: modulation of receptor function. Pharmacol Ther 92:71-87.
26. Roerig S, O'Brien S, Fujimoto J, and Wilcox G (1984) Tolerance to morphine analgesia: decreased multiplicative interaction between spinal and supraspinal sites. Brain Res 308:360-363.
27. Saunders C and Limbird LE (1999) Localization and trafficking of alpha2-adrenergic receptor subtypes in cells and tissues. Pharmacol Ther 84:193-205.
28. Stone L, MacMillan L, Kitto K, Limbird L, and Wilcox G (1997) The alpha2 adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 18:7157-7165.
29. Wigdor S and Wilcox G (1987) Central and systemic morphine-induced antinociception in mice: contribution of descending serotonergic and noradrenergic pathways. J Pharmacol Exp Ther 242:90-95.
30. Yaksh TL (1979) Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal gray. Brain Res 160:180-185.