The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-β signaling by destabilizing ski and inducing Smad7

Journal of Biological Chemistry

Volumn 284, Issue 51, 2009, Pages 35441-35449

  Band, Arja M ^a   Björklund, Mia ^a   Laiho, Marikki ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COREPRESSORS; HEPATOCYTE GROWTH FACTOR; IN-VITRO; INSULIN-LIKE GROWTH FACTOR-1; NEGATIVE REGULATORS; ONCOPROTEINS; PHOSPHATIDYLINOSITOL; PROTEASOMES; SIGNALING CASCADES; SIGNALING MOLECULES; TRANSFORMING GROWTH FACTORS;

BIOACTIVITY; INSULIN; PEPTIDES; PHOSPHORYLATION;

SIGNALING;

INSULIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SKI; SMAD7 PROTEIN; SOMATOMEDIN C; THREONINE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE INDUCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; HEPATOCYTE GROWTH FACTOR; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; PHOSPHORYLATION; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 72149084121     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.029488     Document Type: Article

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