3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-β-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins

Journal of Biological Chemistry

Volumn 282, Issue 16, 2007, Pages 12272-12289

  Seong, Hyun A ^a   Jung, Haiyoung ^a   Kim, Kyong Tai ^b   Ha, Hyunjung ^a  

^a Chungbuk National University   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL GROWTH; CONFOCAL MICROSCOPY; ENZYME INHIBITION; GROWTH KINETICS; INSULIN; PHOSPHORYLATION; PROTEINS;

PLECKSTRIN HOMOLOGY; POSITIVE REGULATORS; SMAD PROTEINS;

MOLECULAR INTERACTIONS;

PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE B; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL GROWTH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; ANIMAL; BINDING SITE; CELL SEPARATION; GENE EXPRESSION REGULATION; HELA CELL; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; SWINE; TUMOR CELL LINE;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; CELL SEPARATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HUMANS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD PROTEINS; SWINE; TRANSFORMING GROWTH FACTOR BETA;

EID: 34249737498     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609279200     Document Type: Article

References (48)

1. Derynck, R., and Feng, X. H. (1997) Biochim. Biophys. Acta 1333, 105-150
2. Massague, J., Attisano, L., and Wrana, J. L. (1994) Trends Cell Biol. 4, 172-178
3. Piek, E., Heldin, C. H., and ten Dijke, P. (1999) FASEB J. 13, 2105-2124
4. Attisano, L., and Wrana, J. L. (2000) Curr. Opin. Cell Biol. 12, 235-243
5. Massague, J., and Wotton, D. (2000) EMBO J. 19, 1745-1754
6. Derynck, R., Zhang, Y., and Feng, X. H. (1998) Cell 95, 737-740
7. Shi, Y., and Massague, J. (2003) Cell 113, 685-700
8. Tsukazaki, T., Chiang, T. A., Davison, A. F., Attisano, L., and Wrana, J. L. (1998) Cell 95, 779-791
9. Dong, C., Li, Z., Alvarez, R., Jr., Feng, X. H., and Goldschmidt- Clermont, P. J. (2000) Mol. Cell 5, 27-34
10. Perlman, R., Schiemann, W. P., Brooks, M. W., Lodish, H. F., and Weinberg, R. A. (2001) Nat. Cell Biol. 8, 708-714
11. Onichtchouk, D., Chen, Y. G., Dosch, R., Gawantka, V., Delius, H., Massague, J., and Niehrs, C. (1999) Nature 401, 480-485
12. Zhu, H., Kavsak, P., Abdollah, S., Wrana, J. L., and Thomsen, G. H. (1999) Nature 400, 687-693
13. Pan, D., Estevez-Salmeron, L. D., Stroschein, S. L., Zhu, X., He, J., Zhou, S., and Luo, K. (2005) J. Biol. Chem. 280, 15992-16001
14. Imamura, T., Takase, M., Nishihara, A., Oeda, E., Hanai, J., Kawabata, M., and Miyazono, K. (1997) Nature 389, 622-626
15. Hata, A., Lagna, G., Massague, J., and Hemmati-Brivanlou, A. (1998) Genes Dev. 12, 186-197
16. Nakao, A., Afrakhte, M., Moren, A., Nakayama, T., Christian, J. L., Heuchel, R., Itoh, S., Kawabata, M., Heldin, N.-E., Heldin, C.-H., and ten Dijke, P. (1997) Nature 389, 631-635
17. Remy, I., Montmarquette, A., and Michnick, S. W. (2004) Nat. Cell Biol. 6, 358-365
18. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
19. Downward, J. (1998) Curr. Opin. Cell Biol. 10, 262-267
20. Sabassov dos, D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Science 307, 1098-1101
21. Fujita, N., Sato, S., Ishida, A., and Tsuruo, T. (2002) J. Biol. Chem. 277, 10346-10353
22. Sato, S., Fujita, N., and Tsuruo, T. (2002) J. Biol. Chem. 277, 39360-39367
23. Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C. P., and Alessi, D. R. (1999) Curr. Biol. 9, 393-404
24. Seong, H.-A., Jung, H., Choi, H.-S., Kim, K.-T., and Ha, H. (2005) J. Biol. Chem. 280, 42897-42908
25. Jung, H., Kim, T., Chae, H.-Z., Kim, K.-T., and Ha, H. (2001) J. Biol. Chem. 276, 15504-15510
26. Kim, T., Jung, H., Min, S., Kim, K.-T., and Ha, H. (1999) FEBS Lett. 460, 363-368
27. Seong, H.-A., Kim, K.-T., and Ha, H. (2003) J. Biol. Chem. 278, 9655-9662
28. Yao, K., Shida, S., Selvakumaran, M., Zimmerman, R., Simon, E., Schick, J., Hass, N. B., Balke, M., Ross, H., Johnson, S. W., and O'Dwyer, P. J. (2005) Clin. Cancer Res. 11, 7264-7272
29. Datta, P. K., and Moses, H. L. (2000) Mol. Cell. Biol. 20, 3157-3167
30. Prasad, N., Topping, R. S., Zhou, D., and Decker, S. J. (2000) Biochemistry 39, 6929-6935
31. Del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R., and Nunez, G. (1997) Science 278, 687-689
32. Wicks, S. J., Lui, S., Abdel-Wahab, N., Mason, R. M., and Chantry, A. (2000) Mol. Cell. Biol. 20, 8103-8111
33. Levy, L., and Hill, C. S. (2005) Mol. Cell. Biol. 25, 8108-8125
34. Conery, A. R., Cao, Y., Thompson, E. A., Townsend, C. M., Jr., Ko, T. C., and Luo, K. (2004) Nat. Cell Biol. 6, 366-372
35. Wieser, R., Wrana, J. L., and Massague, J. (1995) EMBO J. 14, 2199-2208
36. Chen, R.-H., Su, Y.-H., Chuang, R. L., and Chang, T. Y. (1998) Oncogene 17, 1959-1968
37. Chen, R.-H., Chang, M.-C., Su, Y.-H., Tsai, Y.-T., and Kuo, M. L. (1999) J. Biol. Chem. 274, 23013-23019
38. Shih, W. L., Kuo, M. L., Chuang, S. E., Cheng, A. L., and Doong, S. L. (2000) J. Biol. Chem. 275, 25858-25864
39. Vega, S., Morales, A. V., Ocana, O. H., Valdes, F., Fabregat, I., and Nieto, M. A. (2004) Genes Dev. 18, 1131-1143
40. Higaki, M., and Shimokado, K. (1999) Arteriosler. Thromb. Vasc. Biol. 19, 2127-2132
41. Bakin, A. V., Tomlinson, A. K., Bhowmick, N. A., Moses, H. L., and Arteaga, C. L. (2000) J. Biol. Chem. 275, 36803-36810
42. Song, K., Wang, H., Krebs, T. L., and Danielpour, D. (2006) EMBO J. 25, 58-69
43. Matsuura, I., Denissova, N. G., Wang, G., He, D., Long, J., and Liu, F. (2004) Nature 430, 226-231
44. Liu, F., and Matsuura, I. (2005) Cell Cycle 4, 63-66
45. Kretzschmar, M., Doody, J., Timokhina, I., and Massague, J. (1999) Genes Dev. 13, 804-816
46. Mori, S., Matsuzaki, K., Yoshida, K., Furukawa, F., Tahashi, Y., Yamagata, H., Sekimoto, G., Seki, T., Matsui, H., Nishizawa, M., Fujisawa, J., and Okazaki, K. (2004) Oncogene 23, 7416-7429
47. Yamagata, H., Matsuzaki, K., Mori, S., Yoshida, K., Tahashi, Y., Furukawa, F., Sekimoto, G., Watanabe, T., Uemura, Y., Sakaida, N., Yoshioka, K., Kamiyama, Y., Seki, T., and Okazaki, K. (2005) Cancer Res. 65, 157-165
48. Kamaraju, A. K., and Roberts, A. B. (2004) J. Biol. Chem. 280, 1024-1036