메뉴 건너뛰기




Volumn 625, Issue 1-3, 2009, Pages 122-130

The effect of genetic variability on drug response in conventional breast cancer treatment

Author keywords

Breast cancer; Chemotherapy; Drug response; Personalized medicine; SNP

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANASTROZOLE; CAPECITABINE; CARBOPLATIN; CARBOXYLESTERASE; CISPLATIN; CYCLOPHOSPHAMIDE; CYTIDINE DEAMINASE; CYTOCHROME P450; DIHYDROPYRIMIDINE DEHYDROGENASE; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; GEMCITABINE; GLUTATHIONE TRANSFERASE P1; IRINOTECAN; LETROZOLE; METHOTREXATE; MITOMYCIN; PACLITAXEL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RIBONUCLEOTIDE REDUCTASE; SULFOTRANSFERASE 1A1; TAMOXIFEN; THYMIDYLATE SYNTHASE;

EID: 71649116290     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.08.045     Document Type: Review
Times cited : (36)

References (111)
  • 1
    • 13444249478 scopus 로고    scopus 로고
    • Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer
    • Ambrosone C.B., Ahn J., Singh K.K., Rezaishiraz H., Furberg H., Sweeney C., Coles B., and Trovato A. Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer. Cancer Res. 65 (2005) 1105-1111
    • (2005) Cancer Res. , vol.65 , pp. 1105-1111
    • Ambrosone, C.B.1    Ahn, J.2    Singh, K.K.3    Rezaishiraz, H.4    Furberg, H.5    Sweeney, C.6    Coles, B.7    Trovato, A.8
  • 2
    • 0344676392 scopus 로고    scopus 로고
    • Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes
    • Andreassen C.N., Alsner J., Overgaard M., and Overgaard J. Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. Radiother. Oncol. 69 (2003) 127-135
    • (2003) Radiother. Oncol. , vol.69 , pp. 127-135
    • Andreassen, C.N.1    Alsner, J.2    Overgaard, M.3    Overgaard, J.4
  • 4
    • 33748577313 scopus 로고    scopus 로고
    • Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM-a study based on DNA from formalin fixed paraffin embedded tissue samples
    • Andreassen C.N., Alsner J., Overgaard M., Sorensen F.B., and Overgaard J. Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM-a study based on DNA from formalin fixed paraffin embedded tissue samples. Int. J. Radiat. Biol. 82 (2006) 577-586
    • (2006) Int. J. Radiat. Biol. , vol.82 , pp. 577-586
    • Andreassen, C.N.1    Alsner, J.2    Overgaard, M.3    Sorensen, F.B.4    Overgaard, J.5
  • 6
    • 0029347105 scopus 로고
    • Structure and function of apurinic/apyrimidinic endonucleases
    • Barzilay G., and Hickson I.D. Structure and function of apurinic/apyrimidinic endonucleases. BioEssays 17 (1995) 713-719
    • (1995) BioEssays , vol.17 , pp. 713-719
    • Barzilay, G.1    Hickson, I.D.2
  • 7
    • 47549108099 scopus 로고    scopus 로고
    • Polymorphisms in manganese superoxide dismutase, myeloperoxidase and glutathione-S-transferase and survival after treatment for metastatic breast cancer
    • Bewick M.A., Conlon M.S., and Lafrenie R.M. Polymorphisms in manganese superoxide dismutase, myeloperoxidase and glutathione-S-transferase and survival after treatment for metastatic breast cancer. Breast Cancer Res. Treat. 111 (2008) 93-101
    • (2008) Breast Cancer Res. Treat. , vol.111 , pp. 93-101
    • Bewick, M.A.1    Conlon, M.S.2    Lafrenie, R.M.3
  • 8
    • 16244403039 scopus 로고    scopus 로고
    • Cancer incidence and mortality in Europe, 2004
    • Boyle P., and Ferlay J. Cancer incidence and mortality in Europe, 2004. Ann. Oncol. 16 (2005) 481-488
    • (2005) Ann. Oncol. , vol.16 , pp. 481-488
    • Boyle, P.1    Ferlay, J.2
  • 9
    • 27144540666 scopus 로고    scopus 로고
    • Mortality and survival in breast and colorectal cancer
    • Boyle P., and Ferlay J. Mortality and survival in breast and colorectal cancer. Nat. Clin. Pract. Oncol. 2 (2005) 424-425
    • (2005) Nat. Clin. Pract. Oncol. , vol.2 , pp. 424-425
    • Boyle, P.1    Ferlay, J.2
  • 10
    • 1942486406 scopus 로고    scopus 로고
    • Aromatase inhibitors: new endocrine treatment of breast cancer
    • Brueggemeier R.W. Aromatase inhibitors: new endocrine treatment of breast cancer. Semin. Reprod. Med. 22 (2004) 31-43
    • (2004) Semin. Reprod. Med. , vol.22 , pp. 31-43
    • Brueggemeier, R.W.1
  • 13
    • 0027369366 scopus 로고
    • Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes
    • Chang T.K., Weber G.F., Crespi C.L., and Waxman D.J. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Res. 53 (1993) 5629-5637
    • (1993) Cancer Res. , vol.53 , pp. 5629-5637
    • Chang, T.K.1    Weber, G.F.2    Crespi, C.L.3    Waxman, D.J.4
  • 15
    • 0030739223 scopus 로고    scopus 로고
    • Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation
    • Code E.L., Crespi C.L., Penman B.W., Gonzalez F.J., Chang T.K., and Waxman D.J. Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation. Drug Metab. Dispos. 25 (1997) 985-993
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 985-993
    • Code, E.L.1    Crespi, C.L.2    Penman, B.W.3    Gonzalez, F.J.4    Chang, T.K.5    Waxman, D.J.6
  • 16
    • 0142012164 scopus 로고    scopus 로고
    • Detoxification of electrophilic compounds by glutathione S-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs?
    • Coles B.F., and Kadlubar F.F. Detoxification of electrophilic compounds by glutathione S-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs?. BioFactors 17 (2003) 115-130
    • (2003) BioFactors , vol.17 , pp. 115-130
    • Coles, B.F.1    Kadlubar, F.F.2
  • 17
    • 0034050905 scopus 로고    scopus 로고
    • Known variant DPYD alleles do not explain DPD deficiency in cancer patients
    • Collie-Duguid E.S., Etienne M.C., Milano G., and McLeod H.L. Known variant DPYD alleles do not explain DPD deficiency in cancer patients. Pharmacogenetics 10 (2000) 217-223
    • (2000) Pharmacogenetics , vol.10 , pp. 217-223
    • Collie-Duguid, E.S.1    Etienne, M.C.2    Milano, G.3    McLeod, H.L.4
  • 20
    • 30344448851 scopus 로고    scopus 로고
    • "Phase I and Phase II" drug metabolism: terminology that we should phase out?
    • David Josephy P., Peter Guengerich F., and Miners J.O. "Phase I and Phase II" drug metabolism: terminology that we should phase out?. Drug Metab. Rev. 37 (2005) 575-580
    • (2005) Drug Metab. Rev. , vol.37 , pp. 575-580
    • David Josephy, P.1    Peter Guengerich, F.2    Miners, J.O.3
  • 21
    • 0034917716 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • Dean M., Rzhetsky A., and Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 11 (2001) 1156-1166
    • (2001) Genome Res. , vol.11 , pp. 1156-1166
    • Dean, M.1    Rzhetsky, A.2    Allikmets, R.3
  • 22
    • 30344440075 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition
    • Dey S. Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition. Expert Opin. Drug Deliv. 3 (2006) 23-35
    • (2006) Expert Opin. Drug Deliv. , vol.3 , pp. 23-35
    • Dey, S.1
  • 23
  • 28
    • 0037131893 scopus 로고    scopus 로고
    • The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans
    • Fromm M.F. The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans. Adv. Drug Deliv. Rev. 54 (2002) 1295-1310
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1295-1310
    • Fromm, M.F.1
  • 29
    • 49949097267 scopus 로고    scopus 로고
    • Prediction of paclitaxel resistance in breast cancer: is CYP1B1*3 a new factor of influence?
    • Gehrmann M., Schmidt M., Brase J.C., Roos P., and Hengstler J.G. Prediction of paclitaxel resistance in breast cancer: is CYP1B1*3 a new factor of influence?. Pharmacogenomics 9 (2008) 969-974
    • (2008) Pharmacogenomics , vol.9 , pp. 969-974
    • Gehrmann, M.1    Schmidt, M.2    Brase, J.C.3    Roos, P.4    Hengstler, J.G.5
  • 30
    • 0025245868 scopus 로고
    • The association of age with the induction of drug-metabolizing enzymes in human monocytes
    • George G., Wynne H.A., and Woodhouse K.W. The association of age with the induction of drug-metabolizing enzymes in human monocytes. Age Ageing 19 (1990) 364-367
    • (1990) Age Ageing , vol.19 , pp. 364-367
    • George, G.1    Wynne, H.A.2    Woodhouse, K.W.3
  • 33
    • 10844235689 scopus 로고    scopus 로고
    • Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes
    • Gillet J.P., Efferth T., Steinbach D., Hamels J., de Longueville F., Bertholet V., and Remacle J. Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes. Cancer Res. 64 (2004) 8987-8993
    • (2004) Cancer Res. , vol.64 , pp. 8987-8993
    • Gillet, J.P.1    Efferth, T.2    Steinbach, D.3    Hamels, J.4    de Longueville, F.5    Bertholet, V.6    Remacle, J.7
  • 35
    • 0033198464 scopus 로고    scopus 로고
    • Overexpression of ribonucleotide reductase as a mechanism of resistance to 2, 2-difluorodeoxycytidine in the human KB cancer cell line
    • Goan Y.G., Zhou B., Hu E., Mi S., and Yen Y. Overexpression of ribonucleotide reductase as a mechanism of resistance to 2, 2-difluorodeoxycytidine in the human KB cancer cell line. Cancer Res. 59 (1999) 4204-4207
    • (1999) Cancer Res. , vol.59 , pp. 4204-4207
    • Goan, Y.G.1    Zhou, B.2    Hu, E.3    Mi, S.4    Yen, Y.5
  • 37
    • 0025333289 scopus 로고
    • Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation
    • Gonzalez F.J., and Nebert D.W. Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. Trends Genet. 6 (1990) 182-186
    • (1990) Trends Genet. , vol.6 , pp. 182-186
    • Gonzalez, F.J.1    Nebert, D.W.2
  • 38
    • 38749145596 scopus 로고    scopus 로고
    • Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms
    • Gorlov I.P., Gorlova O.Y., Sunyaev S.R., Spitz M.R., and Amos C.I. Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am. J. Hum. Genet. 82 (2008) 100-112
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 100-112
    • Gorlov, I.P.1    Gorlova, O.Y.2    Sunyaev, S.R.3    Spitz, M.R.4    Amos, C.I.5
  • 39
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • Gottesman M.M., Fojo T., and Bates S.E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev., Cancer 2 (2002) 48-58
    • (2002) Nat. Rev., Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 42
    • 0027032179 scopus 로고
    • Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 14q11.2-12)
    • Harrison L., Ascione G., Menninger J.C., Ward D.C., and Demple B. Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 14q11.2-12). Hum. Mol. Genet. 1 (1992) 677-680
    • (1992) Hum. Mol. Genet. , vol.1 , pp. 677-680
    • Harrison, L.1    Ascione, G.2    Menninger, J.C.3    Ward, D.C.4    Demple, B.5
  • 43
    • 0026621245 scopus 로고
    • ABC transporters: from microorganisms to man
    • Higgins C.F. ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol. 8 (1992) 67-113
    • (1992) Annu. Rev. Cell Biol. , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 44
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 411 (2001) 366-374
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 46
    • 34250904283 scopus 로고    scopus 로고
    • Triallelic single nucleotide polymorphisms and genotyping error in genetic epidemiology studies: MDR1 (ABCB1) G2677/T/A as an example
    • Huebner C., Petermann I., Browning B.L., Shelling A.N., and Ferguson L.R. Triallelic single nucleotide polymorphisms and genotyping error in genetic epidemiology studies: MDR1 (ABCB1) G2677/T/A as an example. Cancer Epidemiol. Biomarkers Prev. 16 (2007) 1185-1192
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 1185-1192
    • Huebner, C.1    Petermann, I.2    Browning, B.L.3    Shelling, A.N.4    Ferguson, L.R.5
  • 47
    • 0000692532 scopus 로고
    • Induced protection of adrenal cortex against 7, 12-dimethylbenz(alpha)anthracene. Influence of ethionine. Induction of menadione reductase. Incorporation of thymidine-H3
    • Huggins C., and Fukunishi R. Induced protection of adrenal cortex against 7, 12-dimethylbenz(alpha)anthracene. Influence of ethionine. Induction of menadione reductase. Incorporation of thymidine-H3. J. Exp. Med. 119 (1964) 923-942
    • (1964) J. Exp. Med. , vol.119 , pp. 923-942
    • Huggins, C.1    Fukunishi, R.2
  • 48
    • 38749113914 scopus 로고    scopus 로고
    • Pharmacogenomics of tamoxifen and aromatase inhibitors
    • Ingle J.N. Pharmacogenomics of tamoxifen and aromatase inhibitors. Cancer 112 (2008) 695-699
    • (2008) Cancer , vol.112 , pp. 695-699
    • Ingle, J.N.1
  • 49
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • International HapMap Consortium
    • International HapMap Consortium. The International HapMap Project. Nature 426 (2003) 789-796
    • (2003) Nature , vol.426 , pp. 789-796
  • 50
    • 34250213645 scopus 로고    scopus 로고
    • Polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy of patients with primary invasive breast cancer
    • Jaremko M., Justenhoven C., Schroth W., Abraham B.K., Fritz P., Vollmert C., Illig T., Simon W., Schwab M., and Brauch H. Polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy of patients with primary invasive breast cancer. Pharmacogenet. Genom. 17 (2007) 529-538
    • (2007) Pharmacogenet. Genom. , vol.17 , pp. 529-538
    • Jaremko, M.1    Justenhoven, C.2    Schroth, W.3    Abraham, B.K.4    Fritz, P.5    Vollmert, C.6    Illig, T.7    Simon, W.8    Schwab, M.9    Brauch, H.10
  • 51
    • 20044377420 scopus 로고    scopus 로고
    • Human recombination hot spots hidden in regions of strong marker association
    • Jeffreys A.J., Neumann R., Panayi M., Myers S., and Donnelly P. Human recombination hot spots hidden in regions of strong marker association. Nat. Genet. 37 (2005) 601-606
    • (2005) Nat. Genet. , vol.37 , pp. 601-606
    • Jeffreys, A.J.1    Neumann, R.2    Panayi, M.3    Myers, S.4    Donnelly, P.5
  • 52
    • 0041627670 scopus 로고    scopus 로고
    • Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer
    • Kafka A., Sauer G., Jaeger C., Grundmann R., Kreienberg R., Zeillinger R., and Deissler H. Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer. Int. J. Oncol. 22 (2003) 1117-1121
    • (2003) Int. J. Oncol. , vol.22 , pp. 1117-1121
    • Kafka, A.1    Sauer, G.2    Jaeger, C.3    Grundmann, R.4    Kreienberg, R.5    Zeillinger, R.6    Deissler, H.7
  • 53
    • 0036667955 scopus 로고    scopus 로고
    • MDR1 single nucleotide polymorphisms: multiplicity of haplotypes and functional consequences
    • Kim R.B. MDR1 single nucleotide polymorphisms: multiplicity of haplotypes and functional consequences. Pharmacogenetics 12 (2002) 425-427
    • (2002) Pharmacogenetics , vol.12 , pp. 425-427
    • Kim, R.B.1
  • 54
    • 0029582977 scopus 로고
    • The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions
    • Kivisto K.T., Kroemer H.K., and Eichelbaum M. The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions. Br. J. Clin. Pharmacol. 40 (1995) 523-530
    • (1995) Br. J. Clin. Pharmacol. , vol.40 , pp. 523-530
    • Kivisto, K.T.1    Kroemer, H.K.2    Eichelbaum, M.3
  • 59
    • 34249943356 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications
    • Koepsell H., Lips K., and Volk C. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm. Res. 24 (2007) 1227-1251
    • (2007) Pharm. Res. , vol.24 , pp. 1227-1251
    • Koepsell, H.1    Lips, K.2    Volk, C.3
  • 61
    • 41349107395 scopus 로고    scopus 로고
    • Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients
    • Lal S., Wong Z.W., Sandanaraj E., Xiang X., Ang P.C., Lee E.J., and Chowbay B. Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients. Cancer Sci. 99 (2008) 816-823
    • (2008) Cancer Sci. , vol.99 , pp. 816-823
    • Lal, S.1    Wong, Z.W.2    Sandanaraj, E.3    Xiang, X.4    Ang, P.C.5    Lee, E.J.6    Chowbay, B.7
  • 62
    • 0026053092 scopus 로고
    • Low nucleotide diversity in man
    • Li W.H., and Sadler L.A. Low nucleotide diversity in man. Genetics 129 (1991) 513-523
    • (1991) Genetics , vol.129 , pp. 513-523
    • Li, W.H.1    Sadler, L.A.2
  • 63
    • 0032086074 scopus 로고    scopus 로고
    • The detoxification enzyme systems
    • Liska D.J. The detoxification enzyme systems. Altern. Med. Rev. 3 (1998) 187-198
    • (1998) Altern. Med. Rev. , vol.3 , pp. 187-198
    • Liska, D.J.1
  • 66
    • 34248569888 scopus 로고    scopus 로고
    • Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients
    • Nakajima M., Komagata S., Fujiki Y., Kanada Y., Ebi H., Itoh K., Mukai H., Yokoi T., and Minami H. Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients. Pharmacogenet. Genom. 17 (2007) 431-445
    • (2007) Pharmacogenet. Genom. , vol.17 , pp. 431-445
    • Nakajima, M.1    Komagata, S.2    Fujiki, Y.3    Kanada, Y.4    Ebi, H.5    Itoh, K.6    Mukai, H.7    Yokoi, T.8    Minami, H.9
  • 67
    • 0020393036 scopus 로고
    • Pharmacogenetics and human cancer
    • Nebert D.W. Pharmacogenetics and human cancer. IARC Sci. Publ. (1982) 365-380
    • (1982) IARC Sci. Publ. , pp. 365-380
    • Nebert, D.W.1
  • 69
    • 43949128108 scopus 로고    scopus 로고
    • Emerging evidence of the impact of kidney disease on drug metabolism and transport
    • Nolin T.D., Naud J., Leblond F.A., and Pichette V. Emerging evidence of the impact of kidney disease on drug metabolism and transport. Clin. Pharmacol. Ther. 83 (2008) 898-903
    • (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 898-903
    • Nolin, T.D.1    Naud, J.2    Leblond, F.A.3    Pichette, V.4
  • 73
    • 0028310860 scopus 로고
    • Age, environmental factors and drug metabolism
    • O'Mahony M.S., and Woodhouse K.W. Age, environmental factors and drug metabolism. Pharmacol. Ther. 61 (1994) 279-287
    • (1994) Pharmacol. Ther. , vol.61 , pp. 279-287
    • O'Mahony, M.S.1    Woodhouse, K.W.2
  • 74
    • 0029010376 scopus 로고
    • Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter
    • Parker N.J., Begley C.G., and Fox R.M. Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter. Genomics 27 (1995) 280-285
    • (1995) Genomics , vol.27 , pp. 280-285
    • Parker, N.J.1    Begley, C.G.2    Fox, R.M.3
  • 77
    • 19444380386 scopus 로고    scopus 로고
    • Hydrolysis of capecitabine to 5′-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide
    • Quinney S.K., Sanghani S.P., Davis W.I., Hurley T.D., Sun Z., Murry D.J., and Bosron W.F. Hydrolysis of capecitabine to 5′-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. J. Pharmacol. Exp. Ther. 313 (2005) 1011-1016
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 1011-1016
    • Quinney, S.K.1    Sanghani, S.P.2    Davis, W.I.3    Hurley, T.D.4    Sun, Z.5    Murry, D.J.6    Bosron, W.F.7
  • 78
    • 0034808681 scopus 로고    scopus 로고
    • Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5′-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls
    • Raida M., Schwabe W., Hausler P., Van Kuilenburg A.B., Van Gennip A.H., Behnke D., and Hoffken K. Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5′-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls. Clin. Cancer Res. 7 (2001) 2832-2839
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2832-2839
    • Raida, M.1    Schwabe, W.2    Hausler, P.3    Van Kuilenburg, A.B.4    Van Gennip, A.H.5    Behnke, D.6    Hoffken, K.7
  • 79
    • 52949148184 scopus 로고    scopus 로고
    • TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGFbeta1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemo-radiotherapy
    • Rajkumar T., Samson M., Rama R., Sridevi V., Mahji U., Swaminathan R., and Nancy N.K. TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGFbeta1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemo-radiotherapy. Breast Cancer Res. Treat. 112 (2008) 81-87
    • (2008) Breast Cancer Res. Treat. , vol.112 , pp. 81-87
    • Rajkumar, T.1    Samson, M.2    Rama, R.3    Sridevi, V.4    Mahji, U.5    Swaminathan, R.6    Nancy, N.K.7
  • 80
    • 0032574770 scopus 로고    scopus 로고
    • Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals
    • Ramana C.V., Boldogh I., Izumi T., and Mitra S. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 5061-5066
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 5061-5066
    • Ramana, C.V.1    Boldogh, I.2    Izumi, T.3    Mitra, S.4
  • 81
    • 34447137381 scopus 로고    scopus 로고
    • An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients
    • Rha S.Y., Jeung H.C., Choi Y.H., Yang W.I., Yoo J.H., Kim B.S., Roh J.K., and Chung H.C. An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. Oncologist 12 (2007) 622-630
    • (2007) Oncologist , vol.12 , pp. 622-630
    • Rha, S.Y.1    Jeung, H.C.2    Choi, Y.H.3    Yang, W.I.4    Yoo, J.H.5    Kim, B.S.6    Roh, J.K.7    Chung, H.C.8
  • 83
    • 0034531564 scopus 로고    scopus 로고
    • NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms
    • Ross D., Kepa J.K., Winski S.L., Beall H.D., Anwar A., and Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem. Biol. Interact. 129 (2000) 77-97
    • (2000) Chem. Biol. Interact. , vol.129 , pp. 77-97
    • Ross, D.1    Kepa, J.K.2    Winski, S.L.3    Beall, H.D.4    Anwar, A.5    Siegel, D.6
  • 86
    • 0036164594 scopus 로고    scopus 로고
    • Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population
    • Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., and Nakamura Y. Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. J. Hum. Genet. 47 (2002) 38-50
    • (2002) J. Hum. Genet. , vol.47 , pp. 38-50
    • Saito, S.1    Iida, A.2    Sekine, A.3    Miura, Y.4    Ogawa, C.5    Kawauchi, S.6    Higuchi, S.7    Nakamura, Y.8
  • 87
    • 0031730159 scopus 로고    scopus 로고
    • Biochemical and clinical pharmacology of 5-fluorouracil
    • Schilsky R.L. Biochemical and clinical pharmacology of 5-fluorouracil. Oncology (Willist. Park N. Y.) 12 (1998) 13-18
    • (1998) Oncology (Willist. Park N. Y.) , vol.12 , pp. 13-18
    • Schilsky, R.L.1
  • 89
    • 0032835185 scopus 로고    scopus 로고
    • The past, present and future of clinical pharmacology
    • Sjoqvist F. The past, present and future of clinical pharmacology. Eur. J. Clin. Pharmacol. 55 (1999) 553-557
    • (1999) Eur. J. Clin. Pharmacol. , vol.55 , pp. 553-557
    • Sjoqvist, F.1
  • 90
    • 0242457696 scopus 로고    scopus 로고
    • Letrozole versus tamoxifen in the treatment of advanced breast cancer and as neoadjuvant therapy
    • Smith I.E. Letrozole versus tamoxifen in the treatment of advanced breast cancer and as neoadjuvant therapy. J. Steroid Biochem. Mol. Biol. 86 (2003) 289-293
    • (2003) J. Steroid Biochem. Mol. Biol. , vol.86 , pp. 289-293
    • Smith, I.E.1
  • 91
    • 0038210242 scopus 로고    scopus 로고
    • Aromatase inhibitors in breast cancer
    • Smith I.E., and Dowsett M. Aromatase inhibitors in breast cancer. N. Engl. J. Med. 348 (2003) 2431-2442
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2431-2442
    • Smith, I.E.1    Dowsett, M.2
  • 92
    • 1042292043 scopus 로고    scopus 로고
    • Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate
    • Sohn K.J., Croxford R., Yates Z., Lucock M., and Kim Y.I. Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. J. Natl. Cancer Inst. 96 (2004) 134-144
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 134-144
    • Sohn, K.J.1    Croxford, R.2    Yates, Z.3    Lucock, M.4    Kim, Y.I.5
  • 93
    • 57049117843 scopus 로고    scopus 로고
    • Pharmacogenetics and breast cancer endocrine therapy: CYP2D6 as a predictive factor for tamoxifen metabolism and drug response?
    • Stearns V., and Rae J.M. Pharmacogenetics and breast cancer endocrine therapy: CYP2D6 as a predictive factor for tamoxifen metabolism and drug response?. Expert Rev. Mol. Med. 10 (2008) e34
    • (2008) Expert Rev. Mol. Med. , vol.10
    • Stearns, V.1    Rae, J.M.2
  • 94
    • 0346602691 scopus 로고    scopus 로고
    • Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine
    • Stearns V., Johnson M.D., Rae J.M., Morocho A., Novielli A., Bhargava P., Hayes D.F., Desta Z., and Flockhart D.A. Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J. Natl. Cancer Inst. 95 (2003) 1758-1764
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 1758-1764
    • Stearns, V.1    Johnson, M.D.2    Rae, J.M.3    Morocho, A.4    Novielli, A.5    Bhargava, P.6    Hayes, D.F.7    Desta, Z.8    Flockhart, D.A.9
  • 96
    • 34548065935 scopus 로고    scopus 로고
    • Pharmacology, pharmacokinetics and pharmacogenomics of paclitaxel
    • Steed H., and Sawyer M.B. Pharmacology, pharmacokinetics and pharmacogenomics of paclitaxel. Pharmacogenomics 8 (2007) 803-815
    • (2007) Pharmacogenomics , vol.8 , pp. 803-815
    • Steed, H.1    Sawyer, M.B.2
  • 101
    • 1942453306 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil
    • van Kuilenburg A.B. Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur. J. Cancer 40 (2004) 939-950
    • (2004) Eur. J. Cancer , vol.40 , pp. 939-950
    • van Kuilenburg, A.B.1
  • 102
    • 0034488052 scopus 로고    scopus 로고
    • Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene
    • van Kuilenburg A.B., Haasjes J., Richel D.J., Zoetekouw L., Van Lenthe H., De Abreu R.A., Maring J.G., Vreken P., and van Gennip A.H. Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene. Clin. Cancer Res. 6 (2000) 4705-4712
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4705-4712
    • van Kuilenburg, A.B.1    Haasjes, J.2    Richel, D.J.3    Zoetekouw, L.4    Van Lenthe, H.5    De Abreu, R.A.6    Maring, J.G.7    Vreken, P.8    van Gennip, A.H.9
  • 103
    • 0034901306 scopus 로고    scopus 로고
    • Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14 + 1G>A mutation causing DPD deficiency
    • van Kuilenburg A.B., Muller E.W., Haasjes J., Meinsma R., Zoetekouw L., Waterham H.R., Baas F., Richel D.J., and van Gennip A.H. Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14 + 1G>A mutation causing DPD deficiency. Clin. Cancer Res. 7 (2001) 1149-1153
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1149-1153
    • van Kuilenburg, A.B.1    Muller, E.W.2    Haasjes, J.3    Meinsma, R.4    Zoetekouw, L.5    Waterham, H.R.6    Baas, F.7    Richel, D.J.8    van Gennip, A.H.9
  • 105
    • 0018894446 scopus 로고
    • Degradation of pyrimidines and pyrimidine analogs-pathways and mutual influences
    • Wasternack C. Degradation of pyrimidines and pyrimidine analogs-pathways and mutual influences. Pharmacol. Ther. 8 (1980) 629-651
    • (1980) Pharmacol. Ther. , vol.8 , pp. 629-651
    • Wasternack, C.1
  • 108
    • 0023691250 scopus 로고
    • Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly
    • Woodhouse K.W., and Wynne H.A. Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly. Clin. Pharmacokinet. 15 (1988) 287-294
    • (1988) Clin. Pharmacokinet. , vol.15 , pp. 287-294
    • Woodhouse, K.W.1    Wynne, H.A.2
  • 109
    • 0036023452 scopus 로고    scopus 로고
    • Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells
    • Wu M.H., Yan B., Humerickhouse R., and Dolan M.E. Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells. Clin. Cancer Res. 8 (2002) 2696-2700
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2696-2700
    • Wu, M.H.1    Yan, B.2    Humerickhouse, R.3    Dolan, M.E.4
  • 110
    • 27144536311 scopus 로고    scopus 로고
    • p53 codon 72 polymorphism predicts the pathologic response to neoadjuvant chemotherapy in patients with breast cancer
    • Xu Y., Yao L., Ouyang T., Li J., Wang T., Fan Z., Lin B., Lu Y., and Xie Y. p53 codon 72 polymorphism predicts the pathologic response to neoadjuvant chemotherapy in patients with breast cancer. Clin. Cancer Res. 11 (2005) 7328-7333
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7328-7333
    • Xu, Y.1    Yao, L.2    Ouyang, T.3    Li, J.4    Wang, T.5    Fan, Z.6    Lin, B.7    Lu, Y.8    Xie, Y.9
  • 111
    • 1542405868 scopus 로고    scopus 로고
    • An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology
    • Zhu Y., Spitz M.R., Amos C.I., Lin J., Schabath M.B., and Wu X. An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology. Cancer Res. 64 (2004) 2251-2257
    • (2004) Cancer Res. , vol.64 , pp. 2251-2257
    • Zhu, Y.1    Spitz, M.R.2    Amos, C.I.3    Lin, J.4    Schabath, M.B.5    Wu, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.