Effects of stability on the biological function of p53

Journal of Biological Chemistry

Volumn 284, Issue 45, 2009, Pages 30974-30980

  Khoo, Kian Hoe ^a   Mayer, Sebastian ^a   Fersht, Alan R ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC ACTIVITY; BIOLOGICAL FUNCTIONS; BODY TEMPERATURE; DENATURED PROTEINS; E3 LIGASE; FEED-BACK LOOP; IN-CELL; INTRINSIC STABILITY; INVESTIGATE EFFECTS; LIGASES; MAMMALIAN CELLS; N-TERMINAL TRANSACTIVATION; NATIVE PROTEINS; PROTEOLYTIC DEGRADATION; TRANSCRIPTIONAL ACTIVITY; TRANSCRIPTIONALLY ACTIVE; TUMOR SUPPRESSORS; WILD TYPES;

DEGRADATION; DENATURATION; ENZYMES; MAMMALS; PROTEINS; STABILITY; TRANSCRIPTION;

THERMODYNAMIC STABILITY;

PROTEIN BAX; PROTEIN P53; UBIQUITIN PROTEIN LIGASE E3;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE MUTATION; GENE REPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; THERMOSTABILITY; TRANSACTIVATION; TRANSCRIPTION INITIATION; WILD TYPE;

CELL LINE; CELL SURVIVAL; HUMANS; MUTATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

MAMMALIA;

EID: 71449108497     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.033183     Document Type: Article

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