Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 28, 2005, Pages 9936-9941

  Li, Jianrong ^a   Baud, Olivier ^a   Vartanian, Timothy ^b   Volpe, Joseph J ^a   Rosenberg, Paul A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cerebral palsy; Inflammation; Lipopolysaccharide; Periventricular leukomalacia; Reactive nitrogen species

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; FREE RADICAL; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PEROXYNITRITE; PROTEIN P67; REACTIVE NITROGEN SPECIES; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; CEREBRAL PALSY; CONTROLLED STUDY; CYTOTOXICITY; ENCEPHALOMALACIA; IMMUNOCYTOCHEMISTRY; KNOCKOUT MOUSE; MICROGLIA; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; MICROGLIA; NADPH OXIDASE; NITRIC OXIDE SYNTHASE; OLIGODENDROGLIA; PEROXYNITROUS ACID; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; SUPEROXIDES;

EID: 22244470745     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0502552102     Document Type: Article

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