Cytosolic phospholipase A2-α is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA 2-α does not regulate neutrophil NADPH oxidase activity

Journal of Biological Chemistry

Volumn 280, Issue 9, 2005, Pages 7519-7529

  Rubin, Barry B ^a,d   Downey, Gregory P ^b   Koh, Adeline ^b   Degousee, Norbert ^a   Ghomashchi, Farideh ^c   Nallan, Laxman ^c   Stefanski, Eva ^a   Harkin, Denis W ^a   Sun, ChunXiang ^b   Smart, Brian P ^c   Lindsay, Thomas F ^a   Cherepanov, Vera ^b   Vachon, Eric ^b   Kelvin, David ^d   Sadilek, Martin ^c   Brown, Glenn E ^e,f   Yaffe, Michael B ^e,f   Plumb, Jonathan ^g   Grinstein, Sergio ^g   Glogauer, Michael ^a   Gelb, Michael H ^c   more..

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF WASHINGTON   (United States)

^d TORONTO GENERAL HOSPITAL   (Canada)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; GENES; IMMUNOLOGY; LIVING SYSTEMS STUDIES;

BACTERIAL INFECTION; GENE DISRUPTION; IMMUNE RESPONSE; PLATELET-ACTIVATING FACTOR (PAF);

ENZYMES;

ARACHIDONIC ACID; CD11B ANTIGEN; LEUKOTRIENE B4; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 ALPHA; PHOSPHOLIPASE A2 INHIBITOR; PYRROLIDINE 1; PYRROLIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG; FC RECEPTOR; IONOMYCIN; OXYGEN; PHOSPHOLIPASE A; PHOSPHOLIPASE A2-ALPHA; PYRROLIDINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CELL GRANULE; CELL INFILTRATION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE DISRUPTION; GENE REPRESSION; HUMAN; HUMAN CELL; INFLAMMATORY CELL; INNATE IMMUNITY; KNOCKOUT MOUSE; LUNG INFECTION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SPECIES COMPARISON; THROMBOCYTE ACTIVATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; CYTOLOGY; DOSE RESPONSE; ENZYMOLOGY; INFLAMMATION; LUNG LAVAGE; METABOLISM; MICROBIOLOGY; NEUTROPHIL; PHYSIOLOGY; PNEUMONIA; TIME; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD11B; ARACHIDONIC ACID; BRONCHOALVEOLAR LAVAGE FLUID; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; HUMANS; INFLAMMATION; IONOMYCIN; LEUKOTRIENE B4; MICE; MICE, TRANSGENIC; NADPH OXIDASE; NEUTROPHILS; OXYGEN; PHAGOCYTOSIS; PHOSPHOLIPASES A; PLATELET ACTIVATING FACTOR; PNEUMONIA; PYRROLIDINES; RECEPTORS, IGG; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 20044362184     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407438200     Document Type: Article

References (59)

1. Kochanek, K. D., and Smith, B. L. (2004) Natl. Vital. Stat. Rep. 52, 1-47
2. Baughman, R. P. (1999) Respiration 66, 95-109
3. Zhang, P., Summer, W. R., Bagby, G. J., and Nelson, S. (2000) Immunol. Rev. 173, 39-51
4. Leslie, C. C. (1997) J. Biol. Chem. 272, 16709-16712
5. Girotti, M., Evans, J. H., Burke, D., and Leslie, C. C. (2004) J. Biol. Chem. 279, 19113-19121
6. Degousee, N., Ghomashchi, F., Stefanski, E., Singer, A., Smart, B. P., Borregaard, N., Reithmeier, R., Lindsay, T. F., Lichtenberger, C., Reinisch, W., Lambeau, G., Arm, J., Tischfield, J., Gelb, M. H., and Rubin, B. B. (2002) J. Biol. Chem. 277, 5061-5073
7. Fujishima, H., Sanchez Mejia, R. O., Bingham, C. O., III, Lam, B. K., Sapirstein, A., Bonventre, J. V., Austen, K. F., and Arm, J. P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4803-4807
8. Dana, R., Leto, T. L., Malech, H. L., and Levy, R. (1998) J. Biol. Chem. 273, 441-445
9. Shmelzer, Z., Haddad, N., Admon, E., Pessach, I., Leto, T. L., Eitan-Hazan, Z., Hershfinkel, M., and Levy, R. (2003) J. Cell Biol. 162, 683-692
10. Zhao, X., Bey, E. A., Wientjes, F. B., and Cathcart, M. K. (2002) J. Biol. Chem. 277, 25385-25392
11. Goggel, R., Winoto-Morbach, S., Vielhaber, G., Imai, Y., Lindner, K., Brade, L., Brade, H., Ehlers, S., Slutsky, A. S., Schutze, S., Gulbins, E., and Uhlig, S. (2004) Nat. Med. 10, 155-160
12. Miotla, J. M., Jeffery, P. K., and Hellewell, P. G. (1998) Am. J. Respir. Cell Mol. Biol. 18, 197-204
13. Souza, D. G., Pinho, V., Soares, A. C., Shimizu, T., Ishii, S., and Teixeira, M. M. (2003) Br. J. Pharmacol. 139, 733-740
14. Tavares, D. L., Steil, A. A., Russo, M., Starobinas, N., Teixeira, C. F., and Jancar, S. (1998) Eur. J. Pharmacol. 358, 69-75
15. Nagase, T., Ishii, S., Kume, K., Uozumi, N., Izumi, T., Ouchi, Y., and Shimizu, T. (1999) J. Clin. Investig. 104, 1071-1076
16. Bonventre, J. V., Huang, Z., Taheri, M. R., O'Leary, E., Li, E., Moskowitz, M. A., and Sapirstein, A. (1997) Nature 390, 622-625
17. Nagase, T., Uozumi, N., Ishii, S., Kume, K., Izumi, T., Ouchi, Y., and Shimizu, T. (2000) Nat. Immunol. 1, 42-46
18. Nagase, T., Uozumi, N., Ishii, S., Kita, Y., Yamamoto, H., Ohga, E., Ouchi, Y., and Shimizu, T. (2002) Nat. Med. 8, 480-484
19. Ghomashchi, F., Stewart, A., Hefner, Y., Ramanadham, S., Turk, J., Leslie, C. C., and Gelb, M. H. (2001) Biochim. Biophys. Acta 1513, 160-166
20. Singer, A. G., Ghomashchi, F., Le Calvez, C., Bollinger, J., Bezzine, S., Rouault, M., Sadilek, M., Nguyen, E., Lazdunski, M., Lambeau, G., and Gelb, M. H. (2002) J. Biol. Chem. 277, 48535-48549
21. Kruger, J., Butler, J. R., Cherapanov, V., Dong, Q., Ginzberg, H., Govindarajan, A., Grinstein, S., Siminovitch, K. A., and Downey, G. P. (2000) J. Immunol. 165, 5847-5859
22. Marshall, J., Krump, E., Lindsay, T., Downey, G., Ford, D. A., Zhu, P., Walker, P., and Rubin, B. (2000) J. Immunol. 164, 2084-2091
23. Waddell, T. K., Fialkow, L., Chan, C. K., Kishimoto, T. K., and Downey, G. P. (1994) J. Biol. Chem. 269, 18485-18491
24. Bligh, E. G., and Dyer, W. J. (1959) Can. J. Med. Sci. 37, 911-917
25. Bartoli, F., Lin, H. K., Ghomashchi, F., Gelb, M. H., Jain, M. K., and Apitz-Castro, R. (1994) J. Biol. Chem. 269, 15625-15630
26. Harrison, K. A., Clay, K. L., and Murphy, R. C. (1999) J. Mass Spectrom. 34, 330-335
27. Yaffe, M. B., Xu, J., Burke, P. A., Forse, R. A., and Brown, G. E. (1999) Surgery 126, 248-254
28. Vowells, S. J., Sekhsaria, S., Malech, H. L., Shalit, M., and Fleisher, T. A. (1995) J. Immunol. Methods 178, 89-97
29. Sajjan, U., Thanassoulis, G., Cherapanov, V., Lu, A., Sjolin, C., Steer, B., Wu, Y. J., Rotstein, O. D., Kent, G., McKerlie, C., Forstner, J., and Downey, G. P. (2001) Infect. Immun. 69, 5138-5150
30. Morgan, E., Varro, R., Sepulveda, H., Ember, J. A., Apgar, J., Wilson, J., Lowe, L., Chen, R., Shivraj, L., Agadir, A., Campos, R., Ernst, D., and Gaur, A. (2004) Clin. Immunol. 110, 252-266
31. Stroncek, D. F., Jaszcz, W., Herr, G. P., Clay, M. E., and McCullough, J. (1998) Transfusion 38, 663-668
32. Mounier, C. M., Ghomashchi, F., Lindsay, M. R., James, S., Singer, A. G., Parton, R. G., and Gelb, M. H. (2004) J. Biol. Chem. 279, 25024-25038
33. Lee, W. L., Harrison, R. E., and Grinstein, S. (2003) Microb. Infect. 5, 1299-1306
34. Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., and Zychlinsky, A. (2004) Science 303, 1532-1535
35. Baille, M. B., Standiford, T. J., Laichalk, L. L., Coffey, M. J., Strieter, R., and Peters-Golden, M. (1996) J. Immunol. 157, 5221-5224
36. Mancuso, P., Standiford, T. J., Marshall, T., and Peters-Golden, M. (1998) Infect. Immun. 66, 5140-5146
37. Snyder, F. (1995) Biochem. J. 305, 689-705
38. Woodard, D. S., Lee, T. C., and Snyder, F. (1987) J. Biol. Chem. 262, 2520-2527
39. Fonteh, A. N. (2002) Eur. J. Biochem. 269, 3760-3770
40. Lie, W. J., Homburg, C. H., Kuijpers, T. W., Knol, E. F., Mul, F. P., Roos, D., and Tool, A. T. (2003) Clin. Exp. Allergy 33, 1125-1134
41. Baker, P. R., Owen, J. S., Nixon, A. B., Thomas, L. N., Wooten, R., Daniel, L. W., O'Flaherty, J. T., and Wykle, R. L. (2002) Biochim. Biophys. Acta 1592, 175-184
42. Sakata, A., Ida, E., Tominaga, M., and Onoue, K. (1987) J. Immunol. 138, 4353-4359
43. Foubert, T. R., Burritt, J. B., Taylor, R. M., and Jesaitis, A. J. (2002) Biochim. Biophys. Acta 1567, 221-231
44. Ely, E. W., Seeds, M. C., Chilton, F. H., and Bass, D. A. (1995) Biochim. Biophys. Acta 1258, 135-144
45. Daniels, I., Lindsay, M. A., Keany, C. I., Burden, R. P., Fletcher, J., and Haynes, A. P. (1998) Clin. Diagn. Lab. Immunol. 5, 683-689
46. Gijon, M. A., Spencer, D. M., Siddiqi, A. R., Bonventre, J. V., and Leslie, C. C. (2000) J. Biol. Chem. 275, 20146-20156
47. Jackson, A. L., Bartz, S. R., Schelter, J., Kobayashi, S. V., Burchard, J., Mao, M., Li, B., Cavet, G., and Linsley, P. S. (2003) Nat. Biotechnol. 21, 635-637
48. Belaaouaj, A., McCarthy, R., Baumann, M., Gao, Z., Ley, T. J., Abraham, S. N., and Shapiro, S. D. (1998) Nat. Med. 4, 615-618
49. Gao, X. P., Standiford, T. J., Rahman, A., Newstead, M., Holland, S. M., Dinauer, M. C., Liu, Q. H., and Malik, A. B. (2002) J. Immunol. 168, 3974-3982
50. Blackwood, R. A., Transue, A. T., Harsh, D. M., Brower, R. C., Zacharek, S. J., Smolen, J. E., and Hessler, R. J. (1996) J. Leukocyte Biol. 59, 663-670
51. Haq, S., Kilter, H., Michael, A., Tao, J., O'Leary, E., Sun, X. M., Walters, B., Bhattacharya, K., Chen, X., Cui, L., Andreucci, M., Rosenzweig, A., Guerrero, J. L., Patten, R., Liao, R., Molkentin, J., Picard, M., Bonventre, J. V., and Force, T. (2003) Nat. Med. 9, 944-951
52. Allen, L. A., and Allgood, J. A. (2002) Curr. Biol. 12, 1762-1766
53. Puri, K. D., Doggett, T. A., Douangpanya, J., Hou, Y., Tino, W. T., Wilson, T., Graf, T., Clayton, E., Turner, M., Hayflick, J. S., and Diacovo, T. G. (2004) Blood 103, 3448-3456
54. Hegen, M., Sun, L., Uozumi, N., Kume, K., Goad, M. E., Nickerson-Nutter, C. L., Shimizu, T., and Clark, J. D. (2003) J. Exp. Med. 197, 1297-1302
55. Miyaura, C., Inada, M., Matsumoto, C., Ohshiba, T., Uozumi, N., Shimizu, T., and Ito, A. (2003) J. Exp. Med. 197, 1303-1310
56. Kolls, J., Peppel, K., Silva, M., and Beutler, B. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 215-219
57. Hopken, U. E., Lu, B., Gerard, N. P., and Gerard, C. (1996) Nature 383, 86-89
58. Tkalcevic, J., Novelli, M., Phylactides, M., Iredale, J. P., Segal, A. W., and Roes, J. (2000) Immunity 12, 201-210
59. Yum, H. K., Arcaroli, J., Kupfner, J., Shenkar, R., Penninger, J. M., Sasaki, T., Yang, K. Y., Park, J. S., and Abraham, E. (2001) J. Immunol. 167, 6601-6608